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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Neuromodulation with chemicals: Opportunities and challenges

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Fundamental Research 2025年第1期5卷 55-62页

作者： Pan, Yifei Pan, Cong Mao, Lanqun yu, ping Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China College of Chemistry Beijing Normal University Beijing 100875 China

Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This review introduces several chemical modulation techniques, such as microinjection, electrode/nanoparticle-based chemical delivery methods, in situ electrochemical synthesis and chemogenetics. While these techniques show promise in expanding the application of chemical neuromodulation, they currently exhibit different degrees of shortcomings and room for improvement. This review summarizes the opportunities and challenges for chemical neuromodulation methods and provide an outlook for their prospects in the future. © 2024

关键词： Brain chemistry Chemical delivery In vivo Neurochemistry Neuromodulation

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Reversible Li plating regulation on graphite anode through a barium sulfate nanofibers-based dielectric separator for fast charging and high-safety lithium-ion battery

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Journal of Energy Chemistry 2025年第2期101卷 511-523页

作者： Yaxin Zhang Long Cheng Ying-Jie Zhu Jin Wu Han-ping yu Sida Xie Dandan Li Zhaohui Wang Heng Li State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences College of Materials Science and Engineering Hunan University Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Poor Li plating reversibility and high thermal runaway risks are key challenges for fast charging lithiumion batteries with graphite ***,a dielectric and fire-resistant separator based on hybrid nanofibers of barium sulfate（BS） and bacterial cellulose（BC） is developed to synchronously enhance the battery's fast charging and thermal-safety *** regulation mechanism of the dielectric BS/BC separator in enhancing the Li+ion transport and Li plating reversibility is revealed.（1） The Max-Wagner polarization electric field of the dielectric BS/BC separator can accelerate the desolvation of solvated Li+ions,enhancing their transport kinetics.（2） Moreover,due to the charge balancing effect,the dielectric BS/BC separator homogenizes the electric field/Li+ion flux at the graphite anode-separator interface,facilitating uniform Li plating and suppressing Li dendrite ***,the fast-charge graphite anode with the BS/BC separator shows higher Coulombic efficiency（99.0% vs.96.9%） and longer cycling lifespan（100 cycles vs.59 cycles） than that with the polypropylene（PP） separator in the constantlithiation cycling test at 2 mA *** high-loading LiFePO4(15.5 mg cm-2)//graphite(7.5 mg cm-2) full cell with the BS/BC separator exhibits excellent fast charging performance,retaining 70% of its capacity after 500 cycles at a high rate of 2C,which is significantly better than that of the cell with the PP separator（retaining only 27% of its capacity after 500 cycles）.More importantly,the thermally stable BS/BC separator effectively elevates the critical temperature and reduces the heat release rate during thermal runaway,thereby significantly enhancing the battery's safety.

关键词： Fast charging Graphite anode Ion transport Lithium-ion battery Separator

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Achieving ultralow leakage current in Schottky-MIS cascode anode lateral field-effect diode based on AlGaN/GaN HEMT

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Science China(Information Sciences) 2025年第1期68卷 379-385页

作者： Fangzhou WANG Changhong GAO Guojian DING Cheng yu Zhuocheng WANG Xiaohui WANG Qi FENG ping yu Peng ZUO Wanjun CHEN Yang WANG Haiqiang JIA Hong CHEN Bo ZHANG Zeheng WANG Songshan Lake Materials Laboratory School of Microelectronics Southern University of Science and Technology State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Manufacturing Commonwealth Scientific and Industrial Research Organisation

In this paper,we design and fabricate a Schottky-metal-insulator-semiconductor（MIS） cascode anode GaN lateral field-effect diode（CA-LFED） to achieve ultralow reverse leakage current(ILEAK).The device based on AlGaN/GaN highelectron-mobility-transistor（HEMT） includes a normally-off MIS-controlled channel that is cascoded with a high barrier height Schottky *** reverse bias,the high electric-field is effectively prevented by the normally-off MIS-controlled channel *** with the high barrier height Schottky contact,this feature significantly suppresses the *** by the device fabrication,the CA-LFED with high breakdown voltage（BV）>600 V shows an ultralow ILEAKof 3.6×10-9A/mm as well as a low forward voltage drop（VF） of 2.2 *** performance suggests that the CA-LFED can be a promising candidate for ultralow ILEAKand better VF-ILEAKtrade-off GaN power diode applications.

关键词： Schottky-MIS cascode anode lateral field-effect diode (LFED) ultralow reverse leakage current ($I_{\rm{LEAK}}$) forward drop and reverse leakage trade-off AlGaN/GaN HEMTs

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Hypercoagulation after neoadjuvant immunochemotherapy as a new prognostic indicator in patients with locally advanced gastric cancer undergoing surgery

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 91-103页

作者： Tian-Hao Li Xiong Sun Cheng-Guo Li yu-ping Yin Kai-Xiong Tao Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Coagulation status is closely related to the progression of malignant *** the era of neoadjuvant immunochemotherapy(NICT),the prognostic utility of coagulation indicators in patients with locally advanced gastric cancer(LAGC)undergoing new treatments remains to be *** To determine whether hypercoagulation is an effective prognostic indicator in patients with LAGC who underwent radical resection after *** A retrospective analysis of clinical data from 104 patients with LAGC,who underwent radical resection after NICT between 2020 and 2023,was *** and fibrinogen concentrations were measured one week before NICT,and again one week before surgery,to analyze the association between these two indicators and their combined indices[non-hypercoagulation(D-dimer and fibrinogen concentrations within the upper limit of normal)vs hypercoagulation(D-dimer or fibrinogen concentrations above the upper limit of normal)]with *** radical resection,patients were followed-up *** median follow-up duration was 21 *** Data collected after NICT revealed that the three-year overall survival(OS)and disease-free survival(DFS)rates the non-hypercoagulation group were significantly better than those in the hypercoagulation group[94.4%vs 78.0%(P=0.019)and 87.0%vs 68.0%(P=0.027),respectively].Multivariate analysis indicated that hypercoagulation after NICT was an independent factor for poor postoperative OS[hazard ratio(HR)4.436,P=0.023]and DFS(HR 2.551,P=0.039).Pre-NICT data demonstrated no statistically significant difference in three-year OS between the non-hypercoagulation and hypercoagulation groups(88.3%vs 84.1%,respectively;P=0.443).CONCLUSION Hypercoagulation after NICT is an effective prognostic indicator in patients with LAGC undergoing radical gastrectomy.

关键词： Locally advanced gastric cancer Coagulation Neoadjuvant immunochemotherapy Prognosis Radical gastrectomy

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Enhanced electrochemical CO_(2)reduction coupled with urea oxidation using bifunctional atomically dispersed CuNi catalysts

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Nano Research 2025年第1期18卷 208-216页

作者： Wenjie Wu Haoyang Zhou Ying Liu Yifei Pan Qingqing Chen yu Zhang Junjie Mao Wenjie Ma ping yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry and Materials Science Anhui Normal UniversityWuhu 241002China University of Chinese Academy of Sciences Beijing 100049China

The electrochemical conversion of carbon dioxide(CO_(2))into chemical fuels represents a promising approach for addressing global carbon balance ***,this process is hindered by the kinetic limitations of anodic reactions,usually the oxygen evolution reaction,resulting in less efficient production of high value-added ***,we report an integrated electrocatalytic system that couples CO_(2)reduction reaction(CO_(2)RR)with urea oxidation reaction(UOR)using a bifunctional electrocatalyst with atomically dispersed dual-metal CuNi sites anchored on bamboo-like nitrogen-doped carbon nanotubes(CuNi-CNT),which were synthesized through a one-step pyrolysis *** bifunctional CuNi-CNT catalyst exhibits a near 100%CO Faraday efficiency for CO_(2)RR over a wide potential range and outstanding UOR performance with a negatively shifted potential of 210 mV at 10 mA·cm^(-2).In addition,we assemble a two-electrode electrolyzer using bifunctional CuNi-CNT-modified carbon fiber paper electrodes as both cathode and anode,capable of operating at a remarkably low cell voltage of 1.81 V at 10 mA·cm-2,significantly lower than conventional *** study provides a novel avenue to achieving an efficient carbon cycle with reduced electric power consumption.

关键词： electrochemical conversion bimetallic site catalyst bifunctional electrocatalyst carbon dioxide reduction urea oxidation

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Root canal therapy combined with endoscopic sinus surgery for odontogenic sinusitis:Efficacy comparison in a cohort study

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World Journal of Clinical Cases 2025年第5期13卷 13-21页

作者： Jun-Wen Xiao ping yu Zhang Zhao Department of Stomatology Wuhan No.9 HospitalWuhan 430081Hubei ProvinceChina Department of Otorhinolaryngology People's Hospital of Xishui CountyHuanggang 438200Hubei ProvinceChina Department of Otorhinolaryngology Hubei No.3 People’s Hospital of Jianghan UniversityWuhan 430033Hubei ProvinceChina

BACKGROUND Odontogenic maxillary sinusitis,often triggered by dental issues like periapical periodontitis,significantly contributes to chronic sinusitis,mainly affecting adults around 50 years old,emphasizing the need for a multidisciplinary diagnostic and treatment *** To investigate the therapeutic effect and clinical value of root canal therapy combined with nasal endoscopic surgery compared with simple root canal the-rapy in the treatment of severe odontogenic maxillary sinusitis caused by peria-pical *** The clinical data,diagnosis,and treatment of 200 patients with severe odonto-genic maxillary sinusitis caused by periapical periodontitis from October 2020 to October 2021 were analyzed *** them,63 patients were treated with simple root canal therapy as the control group,and 137 patients were treated with root canal therapy combined with nasal endoscopic surgery as the observation *** therapeutic effect,Lund-Kennedy endoscopic score,paranasal sinus Lund-Mackay score,complication rate,recurrence rate,and patient satisfaction were compared between the two *** First,we compared the effective rates:23 cases were cured,22 were improved,and 8 were ineffective in the control group,yielding a total effective rate of 84.90%.Meanwhile,97 cases were cured,34 improved,and 6 were ineffective in the observation group,resulting in a total effective rate of 95.62%.The observation group had a higher total effective rate compared with the control group(P0.05)was observed in this score between the two *** treatment,the Lund–Kennedy endoscopic score decreased in both *** Lund–Kennedy endoscopic score of the observation group at 3 and 6 mo after treatment was lower compared to that of the control group(P<0.05).Third,we compared the Lund–Mackay score of paranasal *** treatment,there was no si

关键词： Root canal therapy Nasal endoscopic surgery Periapical periodontitis Odontogenic maxillary sinusitis Therapeutic effect Clinical value

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Construction of graphene/polyurea composite with both thermal conduction and self-healing functions based on dual dynamic networks

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Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica 2025年第2期42卷 863-872页

作者： Geng, Shuang Wu, Bin Cao, Ming Chen, Peng Zhang, yu yu, ping Xia, Ru Key Laboratory of Environment-Friendly Polymeric Materials of Anhui Province School of Chemistry & Chemical Engineering Anhui University Hefei230601 China School of Environmental and Chemical Engineering Jiangsu Ocean University Lianyungang222005 China

The development of thermal conductivity materials that can be quickly repaired has attracted increasing attention. However, due to the trade-off between thermal conductivity and self-healing properties of materials, it is challenging to prepare thermal conductivity polyurea composites with self-healing properties. To solve this problem, this paper proposes to construct self-healing polyurea (D-PUA) flexible membrane by using the double dynamic network of hydrogen bonds and dynamic imine bonds. The dynamic breaking and reconstruction of hydrogen bonds and imine bonds dissipates energy continuously, which makes D-PUA have good elasticity and self-repair. The experimental results demonstrate that scratches on the D-PUA film can be completely repaired in a short time (60℃, 8 min), and the repair efficiency of tensile strength reaching 84.62% after 72 h of cutting and healing. The GNP/D-PUA composite membrane with self-healing, thermal conductivity and recyclability was prepared by incorporating graphene (GNP) as a filler. Due to the high thermal conductivity of graphene itself, the in-plane thermal conductivity of the composite film is 2.57 W·m−1·K−1 when the GNP content is 10wt%, which is 571% higher than that of the pure film. GNP10/D-PUA can also heal scratches at 90℃ for 60 min, and the repair efficiency of tensile strength after 72 h of cutting and healing is 83.94%. Additionally, due to the presence of dynamic bonds, there is no significant mechanical loss after five hot pressing remodeling of the composite film, and the repair rate of in-plane thermal conductivity is above 80.93% in all cases. © 2025 Beijing University of Aeronautics and Astronautics (BUAA). All rights reserved.

关键词： Tensile strength

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Application progress of early nutrition intervention in patients with hepatocellular carcinoma after liver transplantation

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 27-37页

作者： Shan-Shan Deng yu-ping Zhu Zhi-Tao Chen Wan Li Department of Medical Oncology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan InternationalMedical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan InternationalMedical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Critical Care Medicine Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan InternationalMedical CollegeHangzhou 310022Zhejiang ProvinceChina

Liver transplantation,as an effective therapy for patients with liver cancer,plays an important role in improving the quality of life of ***,the com-plexity and trauma of liver transplantation can easily lead to the occurrence of malnutrition in patients,and then increase the risk of postoperative complica-tions,which has aroused widespread clinical *** nutritional support can not only maintain the stability of the body’s internal environment,reduce the occurrence of complications,but also promote the recovery of liver and other organ *** recent years,with the in-depth understanding of nut-ritional metabolism after liver transplantation,the application of enteral nutrition and parenteral nutrition in nutritional support after liver transplantation has been increasingly extensive and achieved remarkable *** paper discusses the effect of early postoperative nutritional intervention on patients with liver cancer and liver transplantation,and combined with its mechanism of action,can better understand the effectiveness of intervention,and provide reference for the deve-lopment of scientific and reasonable nutritional support programs in clinical pra-ctice.

关键词： Liver cancer Liver transplantation Postoperative intervention Early nutrition Research progress Summarize

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Making stereopsis related to the ability of ocular deviation:a new paradigm for assessment of intermittent exotropia

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 308-314页

作者： Jian-Bing Li Wan-Ting Kong Tao Shen Yong-Guang yuan Chong-Lin Chen Dan-Min Peng Min-Tong Liang Xuan He Dan Luo Jia-Yi Su Wei Wang Rui-Xin Wang Xin-ping yu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510623Guangdong ProvinceChina Department of Ophthalmology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Guangzhou Xinhua University Guangzhou 510520Guangdong ProvinceChina

AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing ***:This was a prospective observational *** evaluated the control ability of intermittent exotropia(IXT)patients in three conditions:natural 2D optotype viewing,2D optotype viewing with polarized glasses,and 3D optotype viewing with polarized *** with a smartphone,we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking ***,the correlation of stereopsis were also ***:A total of 48 patients(age range:4-33y;54.17%male)participated in the *** viewing 3D optotypes with polarized glasses,their median control scores were 1(interquartile range,0-4)at distance and 0(0-1)at *** scores were significantly better than those observed under natural viewing conditions,which were 2.5(1-5)at a distance and 1(0-3)at near(Friedman test,P=0.049).Furthermore,those subjects who exhibited exophoria(realignment within 2 seconds)while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision(Kendall’sτb=-0.344,P=0.018).CONCLUSION:IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes,notably improving realignment *** expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.

关键词： intermittent exotropia stereopsis control ability

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