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RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry ping shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology.It is also an emerging omics technique for metabolic profiling to shape precision medicine.However,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is problematic.Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction.Here,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral fidelity.It can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human interference.The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established techniques.With this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint region.It precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse applications.This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

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Design of photonic crystal fiber with elliptical air-holes to achieve simultaneous high birefringence and nonlinearity

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Chinese Physics B 2018年第1期27卷 385-389页

作者：刘敏侯静云杨虚赵昺玥 ping shum College of Communication Engineering Chongqing University Ministry of Education Key Laboratory of Optoelectronic Technology and Systems Chongqing University School of Electrical & Electronic Engineering Nanyang Technological University

A new type of V-shaped photonic crystal fiber with elliptical air-holes is proposed to realize simultaneous high bire- fringence and nonlinearity at a wavelength of 1.55 μm. The full vector finite element method was adopted to investigate its characteristics, including birefringence, nonlinearity, and dispersion. The PCF exhibited a very high birefringence of 2.89x10-2 and very high nonlinear coefficient of 102.69 W-1 .km 1. In particular, there were two zero-dispersion wave- lengths （ZDWs） in the visible （X： 640-720 nm and Y： 730-760 nm） and near-infrared regions （X： 1050-1606 nm and Y： 850-1500 nm）. The combination of high birefringence and nonlinearity allowed the PCF to maintain the polarization state and generate a broadband super continuum, with potential applications in nonlinear optics.

关键词： photonic crystal fiber birefringence nonlinearity zero dispersion

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High Azimuthal Index Doughnut Beam Generated by Liquid Crystal Spiral Phase Plates

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光学学报 2003年第S1期23卷 859-860页

作者： ping shum School of Electrical & Electronic Engineering Nanyang Technological UniversityNanyang Avenue Singapore

A novel technique of producing azimuthal index 1>1 doughnut beam of good quality by use of multi-liquid crystal cells is presented, it has the advantages of high conversion efficiency and flexibility.

关键词： by as In high be than High Azimuthal Index Doughnut Beam Generated by Liquid Crystal Spiral Phase Plates in that LG of

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Experimental Investigation of Macro-Bending Loss in Large Mode Area Photonic Crystal Fibers

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光学学报 2003年第S1期23卷 -页

作者： Joo Hin Chong ping shum Network Technological Research Centre School of Electrical and Electronic Engineering Nanyang Technological University SingaporeNetwork Technological Research Centre School of Electrical and Electronic Engineering Nanyang Technological University Singapore

We measured macro-bending losses for two large mode area photonic crystal fibers. Experimental results show that macro-bending loss and loss window are dependent on the parameter d/∧ and number of air-holes ring in t... 详细信息

关键词： PCF on be as of Experimental Investigation of Macro-Bending Loss in Large Mode Area Photonic Crystal Fibers mode in

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Widely Tunable Fiber Ring Laser with High Concentration Erbium-Doped Fiber

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光学学报 2003年第S1期23卷 145-146页

作者： Hwayaw Tam Nam Quoc Ngo ping shum Department of Electrical Engineering The Hong Kong Polytechnic University Hong KongNetwork Technology Research Center School of Electrical & Electronics Engineering Nanyang Technological University SingaporeNetwork Technology Research Center School of Electrical & Electronics Engineering Nanyang Technological University Singapore

We report a high power and widely tunable erbium-doped fiber (EDF) ring laser using 1480nm pump and high concentration EDF. Large tuning range up to 105nm (1513-1618 nm) has been obtained by optimizing of the EDF length.

关键词： EDFA as in Widely Tunable Fiber Ring Laser with High Concentration Erbium-Doped Fiber that for than with been length ASE nm

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Rayleigh backscattering noise in single-fiber Ioopback duplex WDM-PON architecture

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Frontiers of Optoelectronics 2012年第4期5卷 435-438页

作者： Duan LIU Songnian FU Ming TANG ping shum Deming LIU National Engineering Laboratory of Next Generation Intemet Access System School of Optical&Electronic InformationHuazhong University of Science and TechnologyWuhan 430074China

This paper investigated the impact of Rayleigh backscattering （RB） noise in the proposed wavelength- division-multiplexed （WDM） single-fiber loopback access network. RB noise＇s impacts on the downstream and upstream service were discussed in details. It was found that the receiver sensitivity was less sensitive when the seeding-light power was below - 12.6 dBm. And for the uplink RB noise, a higher reflective semiconductor optical amplifier （RSOA）＇s bias current results in lower receiver sensitivity.

关键词： passive optical network （PON） reflectivesemiconductor optical amplifier （RSOA） Rayleigh back-scattering （RB）

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A review of geometry-confined perovskite morphologies:From synthesis to efficient optoelectronic applications

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Nano Research 2022年第8期15卷 7402-7431页

作者： Jinshuai Zhang Perry ping shum Lei Su School of Engineering and Materials Science Queen Mary University of LondonLondon E14NSUK College of Engineering Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhen 518055China

With the continuous study of metal halide perovskite,geometry-confined technologies have been widely applied to reduce the material dimensionality and to produce pre-designed structures,which can tune optical reflectance,scattering,and absorption,thereby optimizing the performance of perovskite-based optoelectronic devices and improving their commercial competitiveness.The morphologies of perovskite active layer play a pivotal role in optoelectronic properties and the resulting device performances.In this review,we systematically summarized recent progress in the preparation and manufacture of various perovskite geometry-confined morphologies,as well as their promising advances in different optoelectronic applications,including photodetectors,solar cells(SCs),lasers,and light-emitting diodes(LEDs).In addition,the remaining challenges and further improvements of preparation unique geometry-confined perovskite morphologies for next-generation high quality optoelectronic devices are discussed.

关键词： geometry confinement metal halide perovskite controllable morphology optoelectronics

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Splicing on Condensed Photonic Crystal Fiber Using CO_2 Laser

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光学学报 2003年第S1期23卷 -页

作者： Joo Hin Chong Yinian Zhu M.K.Rao ping shum Nanyang Technological University School of Electrical & Electronic EngineeringNanyang Technological University School of Electrical & Electronic EngineeringNanyang Technological University School of Electrical & Electronic EngineeringNanyang Technological University School of Electrical & Electronic Engineering

Condensation in the air-holes of photonic crystal fiber results in bubble development during the electric arc splicing is first reported. The condensation can be removed by laser splicing; and 1.4dB splice loss has be... 详细信息

关键词： PCF of in for on Splicing on Condensed Photonic Crystal Fiber Using CO2 Laser been than mode

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Dynamics of cavity soliton driven by chirped optical pulses in Kerr resonators

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Frontiers of Optoelectronics 2022年第1期15卷 156-163页

作者： Jianxing Pan Chaoyu Xu Zhichao Wu Jing Zhang Tianye Huang Perry ping shum School of Mechanical Engineering and Electronic Information China University of Geosciences(Wuhan)Wuhan 430074China Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China

Recent researches have demonstrated that pulsed driving is an effective method to increase the temporal overlap between cavity soliton(CS)and pump field,thereby increasing the pump-to-comb conversion efficiency.The amplitude-modulated inhomogeneity of the background wave causes the solitons to drift toward edges of the driving pulse.To eliminate the mul-tiple temporal trapping positions,induced by the spontaneous symmetry breaking,we propose the chirped pulse driving for deterministic single soliton generation.We theoretically explain the physical mechanism of the chirp pulse driving,as the combination of amplitude and phase modulation.Our numerical simulations demonstrate the chirp is responsible for the single soliton generation.A detailed investigation for dynamics of CSs sustained by chirped pulses,shows the recovery of spontaneous symmetry breaking.In addition,the desynchronized chirped pulse driving is also considered here.Considering a weak chirp parameter,the desynchronization-dependent trapping position diagram is divided into multiple areas including two CSs,a single CS,two oscillating CSs,and no CS.With a sufficient chirp parameter considered,the trapping position curve becomes a monotonous function of the desynchronized drift velocity,which indicates deterministic single soliton generation.

关键词： Cavity soliton(CS) Chirped pulse driving Deterministic single soliton

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Coupling Considerations for Fabrication of Acoustooptic Tunable Filter

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光学学报 2003年第S1期23卷 189-190页

作者： Joo Hin Chong Enli Huang Huanyi Ye MK Rao ping shum Network Technology Research School of Electrical & Electronic Engineering Nanyang Technological University SingaporeNetwork Technology Research School of Electrical & Electronic Engineering Nanyang Technological University SingaporeNetwork Technology Research School of Electrical & Electronic Engineering Nanyang Technological University SingaporeNetwork Technology Research School of Electrical & Electronic Engineering Nanyang Technological University SingaporeNetwork Technology Research School of Electrical & Electronic Engineering Nanyang Technological University Singapore

Induced acoustic wave to bare fiber through various types of horn are examined. The center wavelength and extinction ratio of the notch filter are dynamically tunable and dependent on the RF signals.

关键词： for in it be as of AOTF Coupling Considerations for Fabrication of Acoustooptic Tunable Filter

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