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Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma

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World Journal of Gastroenterology 2008年第33期14卷 5210-5216页

作者： Tian-Jie Qin Xin-Han Zhao Jun Yun Ling-Xiao Zhang Zhi-ping ruan Bo-Rong Pan Department of Medical Oncology First Affiliated Hospital of Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Outpatient Department of Oncology Cancer Institute Fourth Military Medical University Xi'an 710032 Shaanxi Province China Department of the Third General Surgery Xijing Hospital Fourth Military Medical University Xi'an 710032 Shaanxi Province China

AIM: To evaluate the efficacy and safety of gemcitabine-oxaliplatin (GEMOX) combined with huachansu (cinobufagin) injection treatment in patients with locally advanced or metastatic gallbladder carcinoma (GBC), and to assess the quality of life (QOL) of such patients. METHODS: Twenty-fi ve patients with locally advanced or metastatic GBC were treated with intravenous gemcitabine (1000 mg/m2) over 30 min on days 1 and 8, 2 h infusion of oxaliplatin (120 mg/m2) on day 1, and 2-3 h infusion of huachansu (20 mL/m2) on days -3-11, every 3-4 wk. Treatment was continued until occurrence of unacceptable toxicity or disease progression. QOL of patients was assessed by the EORTC QLQ-C30 at baseline, at the end of the fi rst, third and sixth chemotherapy cycles, and 1 mo after the treatment. RESULTS: Among the 25 patients with a median age of 64 years (range 42-78 years), 23 were evaluable in the study. A total of 137 cycles of therapy were performed and the median cycle was 5 (range 1-8) per patient. Out of the 23 patients whose response couldbe evaluated, 8 partial responses (PR) were observed (34.8%), while 7 patients (30.4%) demonstrated a stable disease (SD). The disease control rate was 65.2%. Progression of cancer was observed in 8 (34.8%) patients. The median progression-free and overall survival time was 5.8 mo (95% CI: 4.5-7.1 mo) and 10.5 mo, respectively. The therapy was well tolerated, with moderate myelosuppression as the main toxicity. Anemia grade 2 was seen in 16.0%, neutropenia grade 3 in 8.0% and thrombocytopenia grade 3 in 24.0% of patients, respectively. Non-hematologic toxicity ranged from mild to moderate. No death occurred due to toxicity. The QOL of patients was improved after chemotherapy, and the scores of QOL were increased by 10 to 20 points. CONCLUSION: GEMOX combined with huachansu (cinobufagin) injection is well tolerated, effective, thus improving the QOL of patients with advanced GBC.

关键词： Gallbladder carcinoma Gemcitabine Oxaliplatin Huachansu injection Quality of life

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The CalderSn-Zygmund Decomposition and Interpolation on Weighted Hardy Spaces

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Acta Mathematica Sinica,English Series 2011年第10期27卷 1967-1978页

作者： Zhuo ping ruan Department of Mathematics Beijing Normal University Beijing 100875 P. R. China

We apply discrete Littlewood Paley Stein theory, developed by Han and Lu, to establish Calderon Zygmund decompositions and interpolation theorems on weighted Hardy spaces Hp for w C A∞ in both the one-parameter and t... 详细信息

关键词： Calderdn Zygmund decomposition interpolation weighted Hardy spaces discrete Little- wood Paley analysis

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Studies on the Structure and Properties of Multiphase Al_2O_3 Abrasion-resistant Ceramics

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Chinese Journal of Structural Chemistry 2006年第7期25卷 805-810页

作者： WU Ren-ping YU Yan ruan Yu-Zhong College of Materials Science and Engineering Fuzhou University Fuzhou 350002 China

The Al2O3 abrasion-resistant ceramics is successfully prepared by using waste aluminum sludge as the main raw material with the addition of a little clay, talc and barium carbonate. The crystal structure and microstructure of ceramic are characterized by means of XRD, SEM, etc., and the physical and mechanical properties are also tested. The results show that besides the phase of corundum, a little mullite, Mg-Al spinel and hyalophane phases also exist in the product. These phases are produced via reaction in-situ, which can inhibit the overgrowth of Al2O3 grain in grain boundary, and improve the integral property of the material.

关键词： Al2O3 ceramic crystal structure property in-situ synthesis

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Diagnosis,fetal risk and treatment of pemphigoid gestationis in pregnancy:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10645-10651页

作者： Hai-Ning Jiao Ye-ping ruan Yan Liu Meng Pan Hui-ping Zhong Department of Obstetrics and Gynecology Rui-Jin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology Rui-Jin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

BACKGROUND Pemphigoid gestationis(PG)is a rare autoimmune blistering disease that usually presents in the second or third trimester,with an incidence of 1 per 50000 *** tends to recur with an earlier onset and a more severe course in subsequent *** biopsy markers can be confirmed by direct immunofluorescence *** SUMMARY Our patient was diagnosed with PG at 8 mo of gestation with fresh bullous lesion marks on the abdomen and *** of the pregnancy was performed by cesarean section at 37+4 wk of *** patient delivered an infant weighing 3620 *** infant had urticaria-like and vesicular skin lesions and was diagnosed with *** patient was discharged on prednisolone and in a satisfactory *** infant was discharged after anti-inflammatory therapy for one *** PG is a rarely reported disease,and 10%of newborns develop mild clinical symptoms consisting of urticaria-like or vesicular skin *** intend to remind clinicians to consider this condition when a patient presents with such lesions so that treatment can be started early and neonatal morbidity can be taken into account.

关键词： Pemphigoid gestationis Pregnancy Newborn Pemphigus Fluorescent antibody techniqu Case report

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Occupational Radiation Exposure and Changes in Thyroid Hormones in a Cohort of Chinese Medical Radiation Workers

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Biomedical and Environmental Sciences 2021年第4期34卷 282-289页

作者： GUO Qi Shan ruan ping HUANG Wei Xu HUANG Dai Zheng QIU Jia Chu School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310GuangdongChina Guangdong Province Engineering&Technology Research Center for Medical 3D Printer and Personalized Medicine Guangzhou 510006GuangdongChina Department of Biomedical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006GuangdongChina Guangdong Prevention and Treatment Center for Occupational Disease Guangzhou 510300GuangdongChina Department of Biomedical Engineering Guangxi Medical UniversityNanning 530021GuangxiChina

Objective This study aimed to evaluate the association between occupational radiation exposure and changes in thyroid hormone levels among medical radiation *** This retrospective cohort study included 2,946 radiation workers from 20 Guangzhou *** on general characteristics,participant radiation dosimetry,and thyroid function test results[thyroid-stimulating hormone(TSH),triiodothyronine(T3),and thyroid hormone(T4)]were extracted from dosimetry and medical *** generalized estimating equation was used to evaluate the trend of changes in thyroid hormone levels over time and was adjusted for age,gender,and *** The average annual effective dose was very low and showed a general downward *** the follow-up period,changes in T3 and T4 levels among radiation workers were-0.015[95% confidence interval(CI)-0.018 to-0.012]nmol/L per year and-2.294(95%CI-2.426 to-2.162)nmol/L per year,*** hormone levels were significantly different between males and females.T3 levels in the group of upper quartile of dose were significantly higher than in the lower quartile group(P=0.006).No significant decreased trend in thyroid hormone levels was observed with increasing average effective *** Thyroid hormone secretion might be affected even in low-dose radiation exposure environments.

关键词： Occupational radiation Thyroid function Cohort

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Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy

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World Journal of Gastroenterology 2014年第30期20卷 10249-10261页

作者： Li-Li Han Yi Lv Hui Guo Zhi-ping ruan Ke-Jun Nan Department of Medical Oncology The First Affiliated Hospital of Medical CollegeXi’an Jiaotong University Departments of Hepatobiliary Surgery The First Affiliated Hospital of Medical CollegeXi’an Jiaotong University

Hepatocellular carcinoma(HCC)is one of the most frequent tumors worldwide and accounts for approximately one-third of all *** the past decade,advances have been made to improve the prognosis of HCC,including improvement in the clinical diagnosis of early-stage HCC using molecular biomarkers and molecular-targeted therapy to treat advanced ***,the diagnosis,pathogenesis and targeted therapy of HCC are not completely independent,and should be comprehensively *** example,a number of tumor markers provide useful clinical information not only for prognosis,but also in pathogenesis and treatment ***,this review will focus on the role of several specific biomarkers implicated in the pathogenesis of HCC and several promising molecular-targeted drugs that target the biomarkers of HCC.

关键词： Biomarkers Pathogenesis Hepatocellular carcinoma Targeted therapy MicroRNAs

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Expression of MMIF, HIF-1α and VEGF in Serum and Endometrial Tissues of Patients with Endometriosis

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Current Medical Science 2018年第3期38卷 499-504页

作者： Fan ZHANG Xiao-ling LIU Wan WANG Hong-ling DONG Yu-fang XIA Li-ping ruan Li-ping LIU Department of Obstetrics and Gynecology Wuhan 6th Hospital Affiliated to Jianghan University Wuhan 430000 China Department of Obstetrics and Gynecology Wuhan Children's Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430000 China

The aim of this study was to investigate the expression of macrophage migration inhibitory factor （MMIF）, hypoxia-inducible factor- 1 α（HIF- 1α ）and vascular endothelial growth factor （VEGF） in the serum and endometrial tissues of patients with endometriosis （EM） and the clinical significance. Eighty EM patients [American Reproductive Association stage Ⅰ （n=20）, stage Ⅱ （n=22）, stage Ⅲ （n=21） and stage Ⅳ （n=17）] were enrolled and divided into mild （10- 14 points, n=28）, moderate （16-24 points, n=27） and severe （26-30 points, n=25） dysmenorrhea groups. The control group included 40 healthy women of childbearing age who underwent routine healthcare examinations in the enrolment period. The expression of MMIF, HIF- 1α and VEGF in the serum and endometrial tissues was measured by enzyme-linked immunosorbent assay and Western blotting, respectively. Meanwhile, the sensitivity and specificity of serum MMIF, HIF-1α, and VEGF when separately used as single indexes or jointly used as one index were examined as well. The results showed that serum concentrations of MMIF, HIF-1α, and VEGF were significantly higher in EM patients than in controls （P〈0.05）. The expression of all three proteins in both serum and endometrial tissues increased significantly with the R-AFS stage （P〈0.05） and with dysmenorrheal severity （P〈0.05）. The sensitivity and specificity of the combined detection of serum MMIF, HIF-1α, and VEGF levels were significantly higher than those of single index detection （P〈0.05）. In conclusion, the expression of MMIF, HIF-1α, and VEGF in the serum and endometrial tissues may be used to assess the stage of EM and the severity of dysmenorrhea. Combined evaluation of MMIF, HIF-1α, and VEGF significantly improves the diagnostic sensitivity and specificity.

关键词： macrophage migration inhibitory factor hypoxia-inducible factor-1α vascular endothelial growth factor endometriosis diagnosis

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一种消象旋传动机构的设计与精度分析

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光子学报 2000年第2期29卷 190-192页

作者：阮萍中国科学院西安光学精密机械研究所 710068

本文提出了一种消象旋机构的结构形式 .并对齿轮传动的结构方式做了重点介绍 .通过对齿轮传动进行精度分析。

关键词：齿轮精度分析棱镜消象旋转动机构望远镜

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Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk a multicenter maternal-fetal medicine study

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World Journal of Pediatrics 2024年第6期20卷 621-632页

作者： Huan Wang Yan-ping ruan Sheng Ma Ya-Qi Wang Xiao-Yu Wan Yi-Hua He Jing Li Zhi-Yong Zou Institute of Child and Adolescent Health School of Public HealthNational Health Commission Key Laboratory of Reproductive HealthPeking UniversityNo.38 Xueyuan RdHaidian DistrictBeijing 100191China Echocardiography Medical Center Beijing Anzhen Hospital.Capital Medical UniversityMaternal-Fetal Medicine center in Fetal Heart DiseaseBeijing Anzhen HospitalNo.2 Anzhen RdChaoyang DistrictBeijing 100029China

Background Evidence remains limited on the association between maternal ozone(O,)exposure and congenital heart defects(CHDs)in offspring,and few studies have investigated the interaction and modification of paternal smoking on this *** Using a sample including pregnant women at high risk of fetal CHD(with metabolic disease,first-trimester viral infection,family history of CHD,etc.)from a maternal-fetal medicine study covering 1313 referral hospitals in China during 2013-2021,we examined the associations between maternal O_(3)exposure during 3-8 weeks of gestational age and fetal CHD in offspring and investigated the interaction and modification of paternal smoking on this *** was diagnosed by fetal echocardiograms,maximum daily 8-hour average O,exposure data at a 10 km×10 km spatial resolution came from the Tracking Air Pollution in China dataset,and paternal smoking was collected using *** regression models were used to estimate adjusted odds ratios(ORs)and 95%confidence intervals(CIs).Results Among 27,834 pregnant women at high risk of fetal CHD,17.4%of fetuses were diagnosed with *** 10μg/m^(3)increase in maternal O_(3)exposure was associated with a 17%increased risk of CHD in offspring(OR=1.17,95%CI=1.14-1.20).Compared with paternal nonsmoking and maternal low O_(3)exposure,the ORs(95%CI)of CHD for smoking and low O_(3)exposure,nonsmoking and high O_(3)exposure,and smoking and high O_(3)exposure were 1.25(1.08-1.45),1.81(1.56-2.08),and 2.23(1.84-2.71),*** smoking cessation seemingly mitigated the increased risk of *** Maternal O_(3)exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring,which calls for effective measures to decrease maternal exposure to O_(3)pollution and secondhand smoke for CHDprevention.

关键词： Congenital heart defects Fetal heart development Ozone exposure Tobacco smoking

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Inverse Calculation and Regularization Process for the Solar Aspect System(SAS) of HXI Payload on ASO-S Spacecraft

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Research in Astronomy and Astrophysics 2024年第4期24卷 13-34页

作者： Ji-Rui Yu ping ruan Yang Su Ying-Hong He Jin-You Tao Zhe Zhang Song Guo Bin Xue Jian-Feng Yang Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of Sciences Xi'an 710119China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 20034China School ofAstronomy and Space Science Universityof Science and Technology of ChinaHefei 230026China

For the ASO-S/HXI payload, the accuracy of the flare reconstruction is reliant on important factors such as the alignment of the dual grating and the precise measurement of observation orientation. To guarantee optimal functionality of the instrument throughout its life cycle, the Solar Aspect System (SAS) is imperative to ensure that measurements are accurate and reliable. This is achieved by capturing the target motion and utilizing a physical model-based inversion algorithm. However, the SAS optical system’s inversion model is a typical ill-posed inverse problem due to its optical parameters, which results in small target sampling errors triggering unacceptable shifts in the solution. To enhance inversion accuracy and make it more robust against observation errors, we suggest dividing the inversion operation into two stages based on the SAS spot motion model. First, the as-rigid-aspossible (ARAP) transformation algorithm calculates the relative rotations and an intermediate variable between the substrates. Second, we solve an inversion linear equation for the relative translation of the substrates, the offset of the optical axes, and the observation orientation. To address the ill-posed challenge, the Tikhonov method grounded on the discrepancy criterion and the maximum a posteriori (MAP) method founded on the Bayesian framework are utilized. The simulation results exhibit that the ARAP method achieves a solution with a rotational error of roughly±3 5 (1/2-quantile);both regularization techniques are successful in enhancing the stability of the solution, the variance of error in the MAP method is even smaller—it achieves a translational error of approximately±18μm (1/2-quantile) in comparison to the Tikhonov method’s error of around±24μm (1/2-quantile). Furthermore, the SAS practical application data indicates the method’s usability in this study. Lastly, this paper discusses the intrinsic interconnections between the regularization methods.

关键词： methods:data analysis Sun:flares Sun:X-rays gamma rays

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