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Multifractal methods for rapeseed nitrogen nutrition qualitative diagnosis modeling

International Journal of Biomathematics 2016年第4期9卷 285-297页

作者： Jian-Hui Li Fang Wang Jin-Wei Li Rui-Biao Zou Gui-ping liao Agricultural Information Institute Hunan Agricultural University Changsha 410128 P. R. China Southern Regional Collaborative Innovation Center for Grain and Oil Crops in China Changsha 410128 P. R. China College of Science Hunan Agricultural University Changsha 410128 P. R. China

Nutrition diagnosis plays a key role in the crop’s growth, which has mainly been carried out in the field by agricultural workers. Currently, automatic nutrition recognition technologies have been widely used in this field. A procedure is proposed in this paper to diagnose nitrogen nutrition non-destructively for rapeseed qualitatively based on the multifractal theory. Twelve texture parameters are given by the method of multifractal detrended fluctuation (MF-DFA), which contains six generalized Hurst exponents and six relative multifractal parameters that are used as features of the rapeseed leaf images for identifying the two nitrogen levels, namely, the N -mezzo and the N -wane. For the base leaves, central leaves and top leaves of the rapeseed plant and the three-section mixed samples, three parameters combinations are selected to conduct the work. Five classifiers of Fisher’s linear discriminant algorithm (LDA), extreme learning machine (ELM), support vector machine and kernel method (SVMKM), random decision forests (RF) and K -nearest neighbor algorithm (KNN) are employed to calculate the diagnosis accuracy. An interesting finding is that the best diagnose accuracy is from the base leaves of the rapeseed plant. It is explained that the base leaf is the most sensitive to the nitrogen deficiency. The diagnose effect by the base leaves samples is outshining the existing result significantly for the same leaves samples. For the mixed samples, the averaged discriminant accuracy reaches 97.12% and 97.56% by SVMKM and RF methods with the 1 0 -fold cross-validation respectively. The resulting high accuracy on N -levels identification shows the feasibility and efficiency of our method.

关键词：多重分形理论诊断模型氮素营养油菜 Fisher线性判别分形方法识别技术供氮水平

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Effect of ozonated water on normal vaginal microecology and Lactobacillus

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Chinese Medical Journal 2019年第9期132卷 1125-1127页

作者： Qiong-Qiong Zhang Lei Zhang Ying Liu Ying Wang Rui Chen Zhen-Yu Huang Tao Lyu Qin-ping liao School of Clinical Medicine Tsinghua UniversityBeijing 100084China Department of Obstetrics and Gynecology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

To the Editor:The female vagina is a complex microecology system.Generally,the vaginal microbiota of healthy women is dominated by H2O2-producing Lactobacillus,which decomposes glycogen in vaginal epithelial cells int... 详细信息

关键词： Editor vagina cells

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Sciban Shu-ning and lhor Pidhainy,eds.Reading Wang Wenxing:Critical Essays

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2018年第4期12卷 709-712页

作者： ping-hui liao University of catifornia San Diego

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Advanced nano drug delivery systems for neuroprotection against ischemic stroke

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Chinese Chemical Letters 2024年第2期35卷 151-162页

作者： Chenchen Xie Jun liao Ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China Department of Pharmaceutical Science School of PharmacyNaval Medical UniversityShanghai 200433China Department of pharmacy the International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200040China

Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and disability rates.The efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB)and limited bioavailability.Conversely,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations.This review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS.By examining these systems,researchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery systems.Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS.

关键词： Target Blood-brain barrier Ischemic stroke Nano drug delivery Neuroprotection

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Ion Channel Genes and Epilepsy:Functional Alteration,Pathogenic Potential,and Mechanism of Epilepsy

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Neuroscience Bulletin 2017年第4期33卷 455-477页

作者： Feng Wei Li-Min Yan Tao Su Na He Zhi-Jian Lin Jie Wang Yi-Wu Shi Yong-Hong Yi Wei-ping liao Institute of Neuroscience Department of Neurology of The Second Affiliated Hospital of Guangzhou Medical UniversityKey Laboratory of Neurogenetics and Channelopathies of Guangdong Province and Ministry of Education of ChinaGuangzhou Medical University Department of Neurology Guangdong Second Provincial General Hospital

Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations（funotypes）, and phenotypes of these mutations. Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A. These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene.

关键词： Epilepsy Ion channel gene Epilepsy gene Genetics Gene function Pathogenic mechanism

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A conserved region in the 3' untranslated region of the human LIMK1 gene is critical for proper expression of LIMK1 at the post-transcriptional level

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Neuroscience Bulletin 2013年第3期29卷 348-354页

作者： Guang-Fei Deng Shu-Jing Liu Xun-Sha Sun Wei-Wen Sun Qi-Hua Zhao Wei-ping liao Yong-Hong Yi Yue-Sheng Long Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory for Major Obstetric Diseases of Guangdong Province and Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes Guangzhou Medical University

LIM kinase 1 （LIMK1）, a cytosolic serine/threonine kinase, regulates actin filament dynamics and reorganization and is involved in neuronal development and brain function. Abnormal expression of LIMK1 is associated with several neurological disorders. In this study, we performed a conservation analysis using Vector NTI （8.0） software. The dualluciferase reporter assay and real-time quantitative RT-PCR were used to assess the protein and mRNA levels of the reporter gene, respectively. We found that a region ranging from nt ＋884 to ＋966 in the human LIMK1 3＇ untranslated region （UTR） was highly conserved in the mouse Limkl 3＇ UTR and formed a structure containing several loops and stems. Luciferase assay showed that the relative luciferase activity of the mutated construct with the conserved region deleted, pGL4-hLIMK1-3U-M, in SH-SY5Y and HEK-293 cells was only -60% of that of the wild-type construct pGL4-hLIMK1-3U, indicating that the conserved region is critical for the reporter gene expression. Real-time quantitative RT-PCR analysis demonstrated that the relative Luc2 mRNA levels in SH-SY5Y and HEK293 cells transfected with pGL4-hLIMK1-3U-M decreased to50% of that in cells transfected with pGL4-hLIMK1- 3U, suggesting an important role of the conserved region in maintaining Luc2 mRNA stability. Our study suggests that the conserved region in the LIMK1 3＇ UTR is involved in regulating LIMK1 expression at the post-transcriptional level, which may help reveal the mechanism underlying the regulation of LIMK1 expression in the central nervous system and explore the relationship between the 3＇-UTR mutant and neuroloqical disorders.

关键词： LIM kinase 1 region post-transcriptsecondary structurethree-prime untranslatedonal regulation RNA

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A new linearly-combined bi-exponential model for kinetic analysis of the isometric relaxation process of Bufo gastrocnemius under electric stimulation in vitro

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第12期8卷 867-874页

作者： GUO Rui LI Sheng-bing ZHAO Li-na ZHAO Yun-sheng LU Wei YUAN Pei DENG ping liao Fei Unit of Biochemical Pharmacology and Protein Biotechnology Chongqing Key Laboratory of Biochemistry and Moleczdar Pharmacology College of Pharmaceutical Sciences Chongqing Medical University Chongqing 400016 China

There was a slow-relaxing tail of skeletal muscles in vitro upon the inhibition of Ca2+-pump by cyclopiazonic acid (CPA). Herein, a new linearly-combined bi-exponential model to resolve this slow-relaxing tail from the fast-relaxing phase was investigated for kinetic analysis of the isometric relaxation process of Bufo gastrocnemius in vitro, in comparison to the single exponential model and the classical bi-exponential model. During repetitive stimulations at a 2-s interval by square pulses of a 2-ms duration at 12 V direct currency (DC), the isometric tension of Bufo gastrocnemius was recorded at 100 Hz. The relaxation curve with tensions falling from 90% of the peak to the 15th datum before next stimulation was analyzed by three exponential models using a program in MATLAB 6.5. Both the goodness of fit and the distribution of the residuals for the best fitting sup- ported the comparable validity of this new bi-exponential model for kinetic analysis of the relaxation process of the control muscles. After CPA treatment, however, this new bi-exponential model showed an obvious statistical superiority for kinetic analysis of the muscle relaxation process, and it gave the estimated rest tension consistent to that by experimentation, whereas both the classical bi-exponential model and the single exponential model gave biased rest tensions. Moreover, after the treatment of muscles by CPA, both the single exponential model and the classical bi-exponential model yielded lowered relaxation rates, nevertheless, this new bi-exponential model had relaxation rates of negligible changes except much higher rest tensions. These results suggest that this novel linearly-combined bi-exponential model is desirable for kinetic analysis of the relaxation process of muscles with altered Ca2+-pumping activity.

关键词：腓肠肌电刺激运动分析线性双指数模型

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor prognosis.Human-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system diseases.In this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying mechanism.Our results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral hemorrhage.Additionally,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory microenvironment.RNA sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier integrity.Treatment with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these effects.In summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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基于安卓的便携式重金属浓度检测系统设计

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仪表技术与传感器 2023年第4期 58-61页

作者：岑唯王刚廖平中南大学高性能复杂制造国家重点实验室湖南长沙410083

为了能更准确地识别阳极溶出伏安曲线溶出峰和基线,提升峰电流的测量精度,提出一种基于安卓的便携式重金属检测系统的设计方案,并在原理分析的基础上进行了实验测试。首先设计了包含MCU、恒电位模块、微电流检测模块、电源模块的下位机... 详细信息

为了能更准确地识别阳极溶出伏安曲线溶出峰和基线,提升峰电流的测量精度,提出一种基于安卓的便携式重金属检测系统的设计方案,并在原理分析的基础上进行了实验测试。首先设计了包含MCU、恒电位模块、微电流检测模块、电源模块的下位机用于采样信号,然后用阳极溶出法对重金属溶液进行检测,最后在手机上通过算法处理分析采样数据。实验结果显示:该系统能准确测量溶出峰的峰电流,具有较高的检测精度和便携性,适合需要“就地取样,就地检测”的场合使用。

关键词：阳极溶出法重金属检测峰值检测微电流检测

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矩阵最小奇异值的下界

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贵州师范大学学报（自然科学版） 2022年第5期40卷 114-116,124页

作者：廖平四川职业技术学院四川遂宁629000

利用矩阵的Hermite部及半正负定矩阵的性质,给出Hermite矩阵特征值与奇异值的关系,得到矩阵最小奇异值的几个新下界,所得下界改进了现有的一些估计结果。

关键词：最小奇异值下界矩阵

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