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COMPrompter: reconceptualized segment anything model with multiprompt network for camouflaged object detection

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Science China(Information Sciences) 2025年第1期68卷 189-203页

作者： Xiaoqin ZHANG Zhenni YU Li ZHAO Deng-ping FAN Guobao XIAO Zhejiang Province key Laboratory of Intelligent Informatics for Safety and Emergency Wenzhou University Nankai International Advanced Research Institute (SHENZHEN FUTIAN) College of Computer Science Nankai University School of Computer Science and Technology Tongji University

We rethink the segment anything model(SAM) and propose a novel multiprompt network called COMPrompter for camouflaged object detection(COD). SAM has zero-shot generalization ability beyond other models and can provide an ideal framework for COD. Our network aims to enhance the single prompt strategy in SAM to a multiprompt strategy. To achieve this, we propose an edge gradient extraction module, which generates a mask containing gradient information regarding the boundaries of camouflaged objects. This gradient mask is then used as a novel boundary prompt, enhancing the segmentation process. Thereafter, we design a box-boundary mutual guidance module, which fosters more precise and comprehensive feature extraction via mutual guidance between a boundary prompt and a box prompt. This collaboration enhances the model's ability to accurately detect camouflaged objects. Moreover, we employ the discrete wavelet transform to extract high-frequency features from image embeddings. The high-frequency features serve as a supplementary component to the multiprompt ***, our COMPrompter guides the network to achieve enhanced segmentation results, thereby advancing the development of SAM in terms of COD. Experimental results across COD benchmarks demonstrate that COMPrompter achieves a cutting-edge performance, surpassing the current leading model by an average positive metric of 2.2% in COD10k. In the specific application of COD, the experimental results in polyp segmentation show that our model is superior to top-tier methods as well. The code will be made available at https://***/guobaoxiao/COMPrompter.

关键词： segment anything model camouflaged object detection boundary prompt

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Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus:A Narrative Review

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Chinese Journal of Integrative Medicine 2025年第2期31卷 157-169页

作者： ZHU Bo-yu LIU Zhi-chao ZHAO Zhen-xi HUANG Hui-ping ZHANG Na XIA Jia CHEN Wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLE from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

Node ranking based on graph curvature and PageRank

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CHINESE PHYSICS B 2025年第2期34卷 496-507页

作者： Qu, Hongbo Song, Yu-Rong Li, Ruqi Li, Min Jiang, Guo-ping Nanjing Univ Posts & Telecommun Sch Comp Sci Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun Coll Automat Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun Coll Artificial Intelligence Nanjing 210023 Peoples R China

Identifying key nodes in complex networks is crucial for understanding and controlling their dynamics. Traditional centrality measures often fall short in capturing the multifaceted roles of nodes within these networks. The PageRank algorithm, widely recognized for ranking web pages, offers a more nuanced approach by considering the importance of connected nodes. However, existing methods generally overlook the geometric properties of networks, which can provide additional insights into their structure and functionality. In this paper, we propose a novel method named Curv-PageRank (C-PR), which integrates network curvature and PageRank to identify influential nodes in complex networks. By leveraging the geometric insights provided by curvature alongside structural properties, C-PR offers a more comprehensive measure of a node's influence. Our approach is particularly effective in networks with community structures, where it excels at pinpointing bridge nodes critical for maintaining connectivity and facilitating information flow. We validate the effectiveness of C-PR through extensive experiments. The results demonstrate that C-PR outperforms traditional centrality-based and PageRank methods in identifying critical nodes. Our findings offer fresh insights into the structural importance of nodes across diverse network configurations, highlighting the potential of incorporating geometric properties into network analysis.

关键词： important nodes graph curvature complex networks network geometry 89.75.-k 89.75.Fb 02.40.-k

Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-Xia Xu Jian-Dang Liu Bang-Jiao Ye Zi-Wen Pan Jun Lin Jin-Liang Song Jian-Qing Cao Chao Yan Ying-ping Hao Jin-Xing Cheng Qing-Bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 k,873 k and 1173 k)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum

Targeting ASk1 by CS17919 alleviates kidney-and liver-related diseases in murine models

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Animal Models and Experimental Medicine 2025年第1期8卷 102-113页

作者： Guoqiang Liao Qianjiao Yang Xuhua Mao Yiru Zhao Beizhong Chen kun Zhang Yu Zhang ping Zhang Zhengli Chen Shengjian Huang Chengdu Chipscreen Pharmaceutical Corp. Ltd.ChengduSichuanP.R.China Laboratory of Experimental Animal Disease Model College of Veterinary MedicineSichuan Agricultural UniversityChengduSichuanP.R.China Shenzhen Chipscreen Biosciences Co. Ltd.ShenzhenGuangdongP.R.China

Background:Apoptosis signal-regulating kinase 1(ASk1)is a MAP3k kinase in the MAPk signaling pathway activated by stressors and triggers downstream biological effects such as inflammation and apoptosis;therefore,inhibition of ASk1 kinase ac-tivity can protect cells from pathological *** this study,we designed and synthe-sized a novel selective ASk1 inhibitor,CS17919,and investigated its pharmacological effects in various animal models of metabolic ***:First,we validated the ability of CS17919 to inhibit ASk1 in vitro and then tested the safety profile of CS17919 in cell lines compared with Selonsertib(GS-4997),a phase III ASk1 *** then conducted pharmacokinetic(Pk)studies in ***,we tested the in vivo efficacy of CS17919 in murine models of chronic kidney disease(CkD)and non-alcoholic steatohepatitis(NASH).Results:Compared to GS-4997,CS17919 demonstrated comparable inhibition of ASk1 in vitro,exhibited lower toxicity,and provided greater protection in palmitic acid-treated LO2 ***17919 also showed pronounced pharmacokinetic prop-erties such as a high plasma *** the unilateral ureteral obstruction model(UUO),CS17919 and GS-4997 preserved kidney function and showed a non-significant tendency to alleviate kidney *** the diabetic kidney disease(DkD)model,CS17919 significantly improved serum creatinine and glomerular *** the NASH model,the combination of CS17919 and a THRβagonist(CS27109)was found to significantly improve liver inflammation and substantially reduced liver ***:CS17919 showed cell protective,anti-inflammatory,and antifibrotic ef-fects in vitro and in vivo,suggesting its therapeutic potential for metabolic-related kidney and liver diseases.

关键词： ASk1_(1) CkD_(4) CS17919_(2) GS-4997_(3) NASH_(5)

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3k/AkT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3k/AkT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3k/AkT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3k/AkT signaling pathway in astrocytes.

关键词： AkT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3k

Role of retained austenite in advanced high-strength steel:ductility and toughness

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Journal of Iron and Steel Research International 2024年第9期31卷 2079-2089页

作者： Vung lam Nuam Hao Zhang Ying-chun Wang Zhi-ping Xiong National key Laboratory of Science and Technology on Materials under Shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Tangshan key Laboratory of High-Performance Metals and Ceramics Tangshan Research Institute BITTangshan063000HebeiChina

Enhancing the ductility and toughness of advanced high-strength steels is essential for the wide range of promising *** retained austenite(RA)is a key phase due to the austenite-to-martensite transformation and its transformation-induced plasticity *** is commonly accepted that slow RA-to-martensite transformation is beneficial to ductility;therefore,the RA fraction and stability should be carefully *** RA stability is related to its morphology,size,carbon content,neighboring phase and ***,these factors are *** is noteworthy that the influence of RA on ductility and fracture toughness is not consistent because of their difference in stress *** is no clear relationship between fracture toughness and tensile ***,it is important to understand the role of RA in *** toughness is enhanced during the RA-to-martensite transformation,while the fracture toughness is decreased due to the formation of fresh and brittle *** a result,the findings regarding to the effect of RA on fracture toughness are *** investigations should be conducted in order to fully understand the effects of RA on ductility and fracture toughness,which can optimize the combination of ductility and toughness in AHSSs.

关键词： Retained austenite Ductility Toughness TRIP effect Steel

Environmental threats to the Three Gorges Reservoir Region:Are mutagenic and genotoxic substances important?

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Journal of Environmental Sciences 2015年第12期27卷 172-174页

作者： Paul k.S.lam State key Laboratory in Marine Pollution Department of Biology and ChemistryCity University of Hong Kong

The Three Gorges Dam project（TGDP）,with a total static investment of 95.46 billion RMB（US$10.97 billion）based on the 1993 price level,commenced in 1994 and was completed in *** creation of the Three Gorges Reservoir following the completion of the TGDP had brought about significant changes to the Three Gorges Reservoir Region（TGRR）,stretching from the town of Sandouping in Hubei Province to the Jiangjin District of Chongqing *** TGDP has led to progressive urbanization and industrialization of the TGRR,accompanied by increased shipping activities,greater

关键词： Three Gorges Dam Persistent organic pollutants Yangtze River Sediment Water

Disclosure of charge storage mechanisms in molybdenum oxide nanobelts with enhanced supercapacitive performance induced by oxygen deficiency

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Rare Metals 2021年第9期40卷 2447-2454页

作者： ping Qin Shi-Qing Zhang ken-kin-lam Yung Zhi-Feng Huang Biao Gao Department of Physics Golden Meditech Centre for NeuroRegeneration SciencesHong Kong Baptist University(HKBU)Kowloon 999077Hong KongChina Institute of Advanced Materials State Key Laboratory of Environmental and Biological AnalysisHong Kong Baptist University(HKBU)Kowloon 999077Hong KongChina HkBU Institute of Research and Continuing Education Shenzhen 518000China State key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University of Science and TechnologyWuhan 430081China

Molybdenum oxide(MoO_(3)), with superior features of multi-electrochemical states, high theoretical capacitance, and low cost, is a desirable supercapacitor electrode material but suffers from low conductivity and insufficient active sites. The MoO_(3) capacitance can be largely amplified by introducing oxygen(O) vacancies, but the mechanisms at the atomic scale are still ***, O vacancies are created at the O2 and O3 sites in the MoO_(3) nanobelts by carbonization to maximize the supercapacitance in the MoO_(2.39). The supercapacitive storage is mainly ascribed to the proton adsorption at the O1 sites to create Mo–OH, leading to an expansion of the interlayer spacing along the lattice B-axis. Roughly 98% of the initial supercapacitance is retained after 1000 cycles,due to the reversible change in the interlayer spacing. Our results provide an insight into the oxygen deficiency-related mechanisms of the supercapacitive performance at the atomic scale and devise a facile method to enhance the supercapacitance for energy storage and conversion.

关键词： Charge storage mechanisms Oxygen vacancies MoO3 nanobelts Supercapacitance