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Effect of existence state of asphaltenes on the asphaltenes-wax interaction in wax deposition

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Petroleum Science 2023年第1期20卷 507-514页

作者： Yun Lei Han Wang Shuang-Shuang Li Xue-Qian Liu hao-Ran Zhu Yu-Ming Gao hao-ping Peng Peng-Fei Yu Jiangsu Key Laboratory of Oil and Gas Storage&Transportation Technology Changzhou UniversityJiangsu213164China

Asphaltenes are the most elusive substances in waxy crude oil,especially the complex structures,which leads to significant precipitation and aggregation characteristics of asphaltenes,and affects the asphaltenes-wax *** this study,the concept of the existence state of asphaltenes was introduced to semi-quantitatively investigate the precipitation and aggregation characteristics of *** this basis,the influence of the existence state of asphaltenes on wax deposition was studied by coldfinger device and high-temperature gas chromatography,and the composition and properties of the deposits were *** main findings were made:(1)As the asphaltene concentration increases,the existence state of asphaltenes gradually transitions from dispersed state to aggregated state,and the asphaltene concentration of 0.30 wt%in this study is the starting point of the transition.(2)The existence state of asphaltenes in crude oil does affect the process of wax deposition,as shown in the fact that the dispersed asphaltenes promote the occurrence of wax deposition,while the aggregated asphaltenes can inhibit wax deposition.(3)In the presence of the aggregated asphaltenes,that is,when the asphaltene concentration is higher than 0.30 wt%,the shedding phenomenon of deposit layer was observed,and with the increase of aggregated asphaltenes,the deposit layer fell off earlier.(4)With the increase of the dispersed asphaltenes,the wax appearance temperature(WAT)and wax content of the deposits all showed an increasing trend,while with the appearance of the aggregated asphaltenes,the above situation was *** findings of this study can help for better understanding of the interaction between the asphaltenes and wax in wax deposition.

关键词： Asphaltenes Precipitation/aggregation Existence state of asphaltenes Deposition

Influence of Si content on interface reaction of iron-based hot-dip aluminizing on Fe sheet

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Journal of Central South University 2022年第11期29卷 3581-3591页

作者： PENG hao-ping MA Ming XI Shi-heng LIU Ya LEI Yun SU Wei SU Xu-ping Jiangsu Key Laboratory of Materials Surface Science and Technology Changzhou UniversityChangzhou 213164China Jiangsu Key Laboratory of Oil&Gas Storage and Transportation Technology Changzhou UniversityChangzhou 213164China Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering Changzhou UniversityChangzhou 213164China

Based on the diffusion channel,the influence of Si content on the microstructure evolution of iron-based hot-dip Al-χSi coating was analyzed(χ=0,1.5 wt%,3.0 wt% and 7.0 wt%).The results show that the introduction of Si makes the reaction interface change from the lingual-tooth interface of hot-dip Al to the flat interface of hot-dip *** also reduces the thickness of the alloy layer in the coating,especially the Fe_(2)Al_(5) *** the Si content is 1.5 wt%or 3.0 wt%,the diffusion channel crosses the conjugate line of the two-phase region(FeAl_(3)+liquid phase)into the FeAl_(3) single-phase region,and then moves to the region with higher Si ***,the diffusion channel cuts off the conjugate line of FeAl_(3)phase,τ_(1)/τ_(9) phase,and Fe_(2)Al_(5)phase,which promotes the form ofτ_(1)/τ_(9) *** formedτ_(1)/τ_(9) phase inhibits the diffusion between Fe and Al *** the Si content is 7.0 wt%,the diffusion channel passes through the two-phase region(liquid phase+τ_(5))and enters theτ_(5) single-phase *** form ofτ_(5) single-phase region has a strong inhibitory effect on the interatomic diffusion of Fe and Al,thereby reducing the thickness of the coating,especially the Fe_(2)Al_(5)layer.

关键词： hot-dip Al-Si diffusion channel interface reaction microstructure evolution coating

Recent Advances in Carbon-Based Adsorbents for Adsorptive Separation of Light Hydrocarbons

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Research 2022年第4期2022卷 261-281页

作者： Yong-Sheng Wang Xue-Jie Zhang Ya-Qi Ba Tian-Yi Li Guang-ping hao An-Hui Lu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China

Light hydrocarbons(LHs)separation is an important process in petrochemical *** current separation technology predominantly relies on cryogenic distillation,which results in considerable energy *** separation using porous solids has received widespread attention due to its lower energy footprint and higher ***,tremendous efforts have been devoted to the design and synthesis of high-performance porous *** them,porous carbons display exceptional stability,tunable pore structure,and surface chemistry and thus represent a class of novel adsorbents upon achieving the matched pore structures for LHs *** this review,the modulation strategies toward advanced carbonbased adsorbents for LHs separation are firstly ***,the relationships between separation performances and key structural parameters of carbon adsorbents are discussed by exemplifying specific separation *** research findings on the control of the pore structures as well as the quantification of the adsorption sites are ***,the challenges of carbonaceous adsorbents facing for LHs separation are given,which would motivate us to rationally design more efficient absorbents and separation processes in future.

关键词： separation adsorbent porous

微小RNA-1246靶向糖原合成酶激酶3β激活Wnt/β-连环蛋白信号通路促进前列腺癌细胞的迁移、侵袭和增殖

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中华实验外科杂志 2024年第1期41卷 83-86页

作者：齐强元刘皎林陈西良平浩临沂市中心医院泌尿外科临沂276400 首都医科大学附属北京同仁医院泌尿外科北京100730

目的探讨微小RNA(miR)-1246靶向糖原合成酶激酶3β(GSK3β)对前列腺癌(PCa)细胞迁移、侵袭和增殖的作用及分子机制。方法采用miRNA-Seq技术检测PCa组织及癌旁组织中差异表达的miRNA;采用实时荧光定量聚合酶连反应(qRT-PCR)技术检测PCa... 详细信息

目的探讨微小RNA(miR)-1246靶向糖原合成酶激酶3β(GSK3β)对前列腺癌(PCa)细胞迁移、侵袭和增殖的作用及分子机制。方法采用miRNA-Seq技术检测PCa组织及癌旁组织中差异表达的miRNA;采用实时荧光定量聚合酶连反应(qRT-PCR)技术检测PCa患者癌组织和血清中miR-1246的表达水平;采用生物信息学分析、荧光素酶报告基因实验、qRT-PCR、蛋白质印迹法分析miR-1246对GSK3β的靶向调控关系。人PCa细胞DU145和LNCaP分别转染miR-1246类似物(mimics)/阴性对照(NC mimics)或miR-1246抑制剂(inhibitor)/阴性对照(NC inhibitor),通过细胞计数试剂盒(CCK-8)法检测细胞的增殖能力,通过划痕实验和Transwell迁移实验检测细胞的迁移侵袭能力。两组间比较采用独立样本t检验。结果miRNA-Seq结果显示,与癌旁组织比较,PCa组织中有15个miRNA表达显著升高,51个miRNA表达显著降低,其中miR-1246在PCa患者组织及血清中表达显著升高(组织:7.93±2.39比1.00±0.16,t=10.070,P<0.01;血清:15.23±2.77比1.01±0.09,t=17.770,P<0.01)。生物信息分析结果显示,miR-1246与GSK3β有互补的核苷酸序列,miR-1246 mimics+WT-GSK3β组细胞荧光素酶活性显著低于NC mimics+WT-GSK3β组(0.58±0.09比1.00±0.14,t=8.128,P<0.01)。蛋白质免疫印迹结果显示,miR-1246 inhibitor组GSK3β的表达明显高于NC inhibitor组(2.43±0.29比1.00±0.09,t=10.180,P<0.01),miR-1246 mimics组GSK3β的表达明显低于NC mimics组(0.51±0.07比1.01±0.12,t=5.120,P<0.05)。在DU145和LNCaP细胞中,miR-1246 mimics组细胞增殖能力、细胞迁移率和细胞侵袭数显著高于NC mimics组,miR-1246 inhibitor组细胞增殖能力、细胞迁移率和细胞侵袭数显著低于NC inhibitor组。蛋白质免疫印迹实验结果显示,miR-1246 inhibitor组Wnt3a和β-catenin的表达低于NC inhibitor组(Wnt3a:0.39±0.05比1.00±0.12,t=6.620,P<0.01;β-catenin:0.54±0.09比0.98±0.10,t=6.032,P<0.01)。结论miR-1246通过抑制GSK3β,激活Wnt/β-catenin信号通路,促进PCa细胞的迁移、侵袭和增殖。

关键词：前列腺癌糖原合成酶激酶3β 迁移侵袭增殖

MRI-derived radiomics models for diagnosis,aggressiveness,and prognosis evaluation in prostate cancer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第8期24卷 663-681页

作者： Xuehua ZHU Lizhi Shao Zhenyu LIU Zenan LIU Jide HE Jiangang LIU hao ping Jian LU Department of Urology Peking University Third HospitalBeijing 100191China CAS Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100080China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Engineering MedicineBeihang UniversityBeijing 100191China Key Laboratory of Big Data-Based Precision Medicine(Beihang University) Ministry of Industry and Information Technology of the People’s Republic of ChinaBeijing 100191China Department of Urology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Prostate cancer(PCa)is a pernicious tumor with high heterogeneity,which creates a conundrum for making a precise diagnosis and choosing an optimal treatment *** magnetic resonance imaging(mp-MRI)with anatomical and functional sequences has evolved as a routine and significant paradigm for the detection and characterization of ***,using radiomics to extract quantitative data has emerged as a promising field due to the rapid growth of artificial intelligence(AI)and image data *** acquires novel imaging biomarkers by extracting imaging signatures and establishes models for precise *** models provide a reliable and noninvasive alternative to aid in precision medicine,demonstrating advantages over traditional models based on clinicopathological *** purpose of this review is to provide an overview of related studies of radiomics in PCa,specifically around the development and validation of radiomics models using MRI-derived image *** current landscape of the literature,focusing mainly on PCa detection,aggressiveness,and prognosis evaluation,is reviewed and *** than studies that exclusively focus on image biomarker identification and method optimization,models with high potential for universal clinical implementation are ***,we delve deeper into the critical concerns that can be addressed by different models and the obstacles that may arise in a clinical *** review will encourage researchers to design models based on actual clinical needs,as well as assist urologists in gaining a better understanding of the promising results yielded by radiomics.

关键词： Magnetic resonance imaging(MRI) Radiomics Prostate cancer Predictive model

脊柱内镜技术处理腰椎关节突关节毗邻出口神经根伴随动脉的解剖学应用研究

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四川解剖学杂志 2024年第1期32卷 1-3,17页

作者：苗莹莹张浩平王斌李宽宽新乡医学院三全学院人体解剖学教研室新乡453003 河南省直第三人民医院椎间盘中心郑州450002 新乡医学院三全学院生物化学与分子生物学教研室新乡453003

目的:探讨脊柱内镜技术处理腰椎关节突关节毗邻出口神经根伴随动脉的解剖学应用.方法:选择新鲜人体标本男、女各5具为研究对象.采取剥离显露腰椎脊柱及关节突关节周围组织结构方法,观察该区域血管形态、走行规律及与周围毗邻组织关系.结... 详细信息

目的:探讨脊柱内镜技术处理腰椎关节突关节毗邻出口神经根伴随动脉的解剖学应用.方法:选择新鲜人体标本男、女各5具为研究对象.采取剥离显露腰椎脊柱及关节突关节周围组织结构方法,观察该区域血管形态、走行规律及与周围毗邻组织关系.结果:腰椎关节突关节毗邻出口神经根处血管网与内镜工作通道,或者环锯距离,在L3/4节段,男性为(11.39±0.72)mm,女性为(11.03±0.52)mm;在L4/5节段,男性为(11.78±1.26)mm,女性为(11.29±0.38)mm;在L5/S1节段,男性为(11.1±0.98)mm,女性为(10.45±0.45)mm.在男、女性的L3/4、L4/5及L5/S1节段中,该出口神经根处血管网与内镜工作通道或者环锯的距离左、右两侧比较,差异均无统计学意义(P>0.05).结论:采取人体尸体标本解剖研究,从开放角度探讨关节突关节毗邻出口神经根伴随动脉的走行与周围组织的关系,可指导施术者术中穿刺及工作通道置入,降低甚至避免术中出血量或术后血肿发生率.

关键词：脊柱内镜腰椎关节突关节脊神经根脊髓血管解剖学

Heat distribution model under hydrogen-rich low-carbon conditions in blast furnace

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Journal of Iron and Steel Research International 2024年第3期31卷 584-594页

作者： Gang Wang Jun Xu Kun He Zhong-ping Zou hao Bai School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China CISDI Low-Carbon Blast Furnace Research Office MCC Low-Carbon Technology Research InstituteChongqing 401122China

Low carbon development of blast furnaces is one of the key technological directions in the current development of *** to the differences in the physical and chemical properties of hydrogen and carbon,hydrogen-rich media entering a blast furnace will change the heat distribution,thus affecting the stability of ***,a heat distribution model was proposed to study the temperature distribution in a blast furnace,simultaneously considering gas-solid heat exchange,slag and iron melting,and chemical *** model was used to analyze the temperature distribution of a 2300 m^(3) blast furnace and was verified via comparison with actual production ***,the effects of the injection rate of hydrogen-rich media,H2 concentration,and oxygen enrichment rate of the blast on the temperature distribution were *** indicated that the increase in the injection rate of the hydrogen-rich media decreased the amount of direct reduction and led to an increase in the furnace ***,an increase in the oxygen enrichment rate led to a decrease in the furnace temperature,but could reduce the solid fuel ratio,while the change in H2 concentration had less effect on the temperature *** combination of hydrogen-rich media injection and the increase in the oxygen enrichment rate would help to adjust the temperature distribution to the same level as the conventional blast furnace conditions.

关键词： Heat distribution Blast furnace Low-carbon condition Hydrogen enrichment Calculation model

Quantitative method for calculating spatial release region for laser-guided bomb

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Journal of Systems Engineering and Electronics 2024年第4期35卷 1053-1062页

作者： YANG ping XIAO Bing CHEN Xin hao Yuntao Air Force Early Warning Academy Wuhan 430019China Unit 93175 of the PLA Changchun 136000China

The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of *** are guided by semi-active laser ground-seek-ing technology,which means that atmospheric conditions can affect their *** spatial release region(SRR)of LGBs is difficult to calculate precisely,especially when there is a poor field of *** can result in a lower real hit *** increase the hit probability of LGBs in tough atmospheric situa-tions,a novel method for calculating the SRR has been *** method is based on the transmittance model of the 1.06μm laser in atmospheric species and the laser diffuse reflection model of the target surface to determine the capture target time of the laser ***,it calculates the boundary ballistic space starting position by ballistic model and gets the spatial scope of the spatial release *** method can determine the release region of LGBs based on flight test data such as instantaneous velocity,altitude,off-axis angle,and atmospheric *** more effectively employing aircraft release conditions,atmospheric visibility and other factors,the SRR calculation method can improve LGB hit probabi-lity by 9.2%.

关键词： laser-guided bombs(LGBs) hit probability atmo-spheric transmittance spatial release region(SRR)boundary ballistic

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“机械振动”课程项目化改革与创新实践

教育教学论坛 2024年第8期 61-67页

作者：郑恩来姚昊萍周永清薛金林南京农业大学工学院江苏南京210031

为使学生掌握机械系统振动的基本理论知识和分析方法,培养学生对复杂工程问题进行力学建模、运动规律分析和应用振动理论解决工程实际问题的能力,提出“机械振动”课程内容项目化改革与创新。为实现对学生从基础教学层、应用基础教学层... 详细信息

为使学生掌握机械系统振动的基本理论知识和分析方法,培养学生对复杂工程问题进行力学建模、运动规律分析和应用振动理论解决工程实际问题的能力,提出“机械振动”课程内容项目化改革与创新。为实现对学生从基础教学层、应用基础教学层到应用教学层逐步螺旋阶梯式上升的培养模式,构建了课程内容与科研项目双向转化的课程教学体。通过将科研项目课程化,推动课程项目化,真正实现产教融合一体。采用启发式、讲练结合式、同类对比式及项目化等多元教学方法,借助线上线下的混合教学模式,实行差异性考核评价,实现因材施教,培养学生自主学习、创新研究及工程实践的素质及能力。实践表明,该教学模式有利于学生对课程内容的掌握,极大地调动了学生的积极性,取得了良好的效果。

关键词：工程力学机械振动项目化教学改革