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Heat Flux Through Slag Film and Its Crystallization Behavior

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Journal of Iron and Steel Research International 2008年第4期15卷 7-11,20页

作者： TANG ping XU chu-shao WEN Guang-hua ZHAO Yan-hong QI Xin College of Materials Science and Engineering Chongqing University Chongqing 400044 China

An experimental apparatus for simulating copper mold is used to quantify the heat flux through the slag film and to obtain a solid slag for further determining its crystallization behavior. The result indicates that both the chemical composition of the mold powder and the cooling rate have an important influence on the heat flux through the slag film. With increasing the binary basicity, the heat flux of slag film decreases at first, reaches the minimum at the basicity of 1.4, and then increases, indicating that the maximum binary basicity is about 1.4 for selecting ＂mild cooling＂ mold powder. The heat transfer through the slag film can be specified in terms of the crystalline ratio and the thickness of the slag film. Recrystallization of the solid slag occurs and must be considered as an important factor that may influence the heat transfer through the solid slag layer.

关键词： continuous casting mold powder slag film heat flux crystallization

BF_3·Et_2O promoted conjugate addition of ethanethiol to electron-deficient alkynes

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Chinese Chemical Letters 2012年第6期23卷 639-642页

作者： Qing Fa Zhou Xue ping chu Shen Zhao Tao Lu Wei Fang Tang Department of Organic Chemistry China Pharmaceutical University Nanjing 210009 China

An effective method for the synthesis of vinyl thioethers through the conjugate addition of ethanethiol to electron-deficient alkynes promoted by ***20 has been developed. Electron-deficient internal alkynes react with ethanethiol in this system to yield mainly Z-isomer of vinyl thioether adducts, while electron-deficient terminal alkynes afford mainly E-isomer of vinyl thioether adducts.

关键词： Vinyl thioether Electron-deficient alkyne Conjugate addition Synthesis

Study of the imaging property of a fluorescent confocal microscopy with a phase-only filter in an extended source

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Optoelectronics Letters 2007年第4期3卷 299-302页

作者： YANG chu-ping KUANGWei-min Li Hai PhysicsDepartment SouthChinaAgriculturalUniversityGuangzhou510642China

The phase information of an enlarged source is reconstructed with an annular two-zone phase-only filter in a fluorescent confocal scanning optical microscope for resolution improvement. The dependences of its resolution on the source size and on the phase transmission of the outer annular zone of the falter are investigated theoretically by use of its three-dimensional optical transfer function （3D OTF ）. The increased source size and the required phase value of the outer annular zone of the phase-only falter for an optimal 3D OTF of the optical system are presented.

关键词：成像特性荧光共焦显微镜滤光器相位信息

Research on fault location technology based on BP neural network in DWDM optical network

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Optoelectronics Letters 2008年第6期4卷 452-455页

作者： LIAO Xiao-min ZHANG Yin-fa YANG Shi-ping LIN chu-shan Optical Communication Laboratory of Xi＇an Communication Institute Xi ＇an 710106 China

BP neural network is introduced to the fault location field of DWDM optical network in this paper. The alarm characteris-tics of the optical network equipments are discussed,and alarm vector and fault vector diagrams are generated by analyzing some typical instances. A 17×14×18 BP neural network structure is constructed and trained by using MATLAB. By comparing the training performances,the best training algorithm of fault location among the three training algorithms is chosen. Numerical simulation results indicate that the sum squared error (SSE) of fault location is less than 0.01,and the processing time is less than 100 ms. This method not only well deals with the missing alarms or false alarms,but also improves the fault location accuracy and real-time ability.

关键词：断层定位 DWDM BP 神经网络光学应用

Whole-exome sequencing identified compound heterozygous variants in MMKS in a Chinese pedigree with Bardet-Biedl syndrome

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Science China(Life Sciences) 2017年第7期60卷 739-745页

作者： Zhan Qi Ying Shen Qian Fu Wei Li Wei Yang Wenshan Xu ping chu Yaxin Zhang Hui Wang Beijing Key Laboratory for Genetics of Birth Defects Key Laboratory of Major Diseases in Children of Ministry of Education Center for Medical Genetics Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Beijing Key Laboratory for Chronic Renal Disease and Blood Purification Key Laboratory of Major Diseases in Children of Ministry of Education Nephrology Department Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Beijing Key Laboratory for Pediatric Disease of Otolaryngology Head and Neck Surgery Key Laboratory of Major Diseases in Children of Ministry of Education Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beij'ing 100045 China School of Pediatrics Capital Medical University Beijing 100069 China

Bardet-Biedl syndrome(BBS) is a genetically heterogeneous disorder characterized by retinal dystrophy, polydactyly, obesity,developmental delay, and renal defects. At least 21 candidate BBS-associated genes(BBS1-19, NPHP1, and IFT172) have previously been identified, and all of them play important roles in ciliary function. Here, we collected a BBS pedigree with four members and performed whole-exome sequencing on the proband. The variants were analyzed and evaluated to confirm their pathogenicity. We found compound heterozygous variants(c.1192C>T, p.Q398* and c.1175C>T, p.T392M) in MKKS in both the siblings, and these were likely to be pathogenic variants. We also found a missense variant(c.2029G>C, p.E677Q) in NPHP1 and a missense variant(c.2470C>T, p.R824C) in BBS9 in the proband only, which are variants of uncertain significance. The compound heterozygous variants were probably responsible for the BBS phenotype in this Chinese pedigree and the missense mutations in NPHP1 and BBS9 might contribute to the mutation load.

关键词： Bardet-Biedl syndrome MKKS BBS6 NPHP1 whole-exome sequencing

Interferon-alpha restrains growth and invasive potential of hepatocellular carcinoma induced by hepatitis B virus X protein

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World Journal of Gastroenterology 2008年第36期14卷 5564-5569页

作者： Jian-Qing Yang Guang-Dong Pan Guang-ping chu Zhen Liu Qiang Liu Yi Xiao Lin Yuan Department of Surgery The People's Hospital of Liuzhou City Liuzhou 545001Guangxi Zhuang Autonomous Region China

AIM: To investigate the effects of interferon-alpha (IFN-α) to restrain the growth and invasive potential of hepatocellular carcinoma (HCC) induced by hepatitis B virus (HBV) X protein. METHODS: The pcDNA3.1-HBx plasmid was transfected into Chang cells by Lipofectamine in vitro, and Chang/HBx was co-cultured with IFN-α. Cell survival growth curve and clonogenicity assay were used to test the growth potential of Chang/pcDNA3.1, Chang/HBx and IFN-α-Chang/HBx in vitro. Growth assay in nude mice was used to detect the growth potential of Chang/ pcDNA3.1, Chang/HBx and IFN-α-Chang/HBx in vivo. Wound healing and transwell migration assays were used to detect the invasive ability of Chang/pcDNA3.1, Chang/HBx and IFN-α-Chang/HBx. RESULTS: Compared with CCL13 cells transfected with pcDNA3.1, CCL13 with stable expression of hepatitis B virus X protein showed the characteristics of malignant cells with high capability of growth and invasion by detecting their growth curves, colony forming efficiency, wound healing , transwell migration assays and growth assays in nude mice. Its capability of growth and invasion could be controlled by IFN-α. CONCLUSION: IFN-α can restrain the growth and invasive potential of HCC cells induced by HBx protein, which has provided an experimental basis for IFN-α therapy of HCC.

关键词： Hepatitis B virus X protein Interferon-alpha Hepatocellular carcinoma Growth Invasion

Reversal of multi-drug resistance by pSUPER-shRNA-mdr1 in vivo and in vitro

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World Journal of Gastroenterology 2009年第4期15卷 431-440页

作者： Guang-Dong Pan Jian-Qing Yang Lv-Nan Yan Guang-ping chu Qiang Liu Yi Xiao Lin Yuan Department of General Surgery People's Hospital of Liuzhou Medical Universityof Guangxi Liuzhou 545001 Guangxi Zhuang Autonomous Region China

AIM： To explore the possibility of reversing multi-drug resistance （MDR） to HepG2/mdr1 in vitro and in vivo with RNA interference （RNAi）. METHODS： HepG2/mdr1 was obtained by cloning the whole gene mdrl into HepG2 cells, shRNA targeting sequence was designed to be homologous to the P-gp encoding MDR1 mRNA consensus sequence, pSUPER- shRNA/mdrl was constructed using the enzyme- digested technique. HepG2/mdrl cells were transfected with vectors of pSUPER-shRNA/mdrl to measure their efficacy by real-time PCR for mdrl mRNA, flow cytometry （FCM） for P-gp expression, and Rhodamine efflux, MTT method for HepG2/mdrl function, respectively. In vivo, mice tumors were treated by injecting pSUPER-shRNA/mdrl in situ and into intra- abdominal cavity. Tumors were collected to create cell suspension and cryosections after chemothearpy with adiramycin and mytomycin. The cell suspension was incubated in RPMI-1640 supplemented with G418 to screen stable cells for appreciating the reversal of MDR. Cryosections were treated with immunohistochemistry technique to show the effectiveness of transfection and the expression of ***： pSUPER-shRNA/mdrl was successfully constructed, which was confirmed by sequencing. The MDR phenotype of HepG2/mdr1 was decreased significantly in vitro transfection. HepG2/mdr1 showing its MDR was reversed notably in P-gp expression （11.0% vs 98.2%, P 〈 0.01）. Real-time PCR showed that mRNA/mdrl was lower in test groups than in control groups （18.73± 1.33 vs 68.03±2.21, P 〈 0.001）. Compared with HepG2, the sensitivity of HepG2/ mdrl and HepG2/mdr1-dsRNA cells to ADM was decreased by 1.64 times and 15.6 times, respectively. The accumulation of DNR in positive groups was decreased evidently. In vivo, the p-gp expression in positive groups was significantly lower than that in control groups （65.1% vs 94.1%, P 〈 0.05）. The tumor suppressing rate in test groups was 57.8%. After chemotherapy, the growth rate in test groups was lower than that in control groups （

关键词： Hepatocellular carcinoma Multi-drugresistance RNA interference

Would a North-South Free Trade Agreement Hurt Unskilled Labor in the North？

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2015年第4期10卷 629-642页

作者： chu-ping Lo Department of Agricultural Economics National Taiwan University Taipei Taiwan China

I present a simple model to examine the impact of international outsourcing on the welfare of skilled and unskilled labor. In this model, specialized business services are to facilitate manufacturing production, creating additional welfare gains in the presence of positive production externalities. Policies that favor the business service sector contribute to the development of a larger bundle of specialized business services, generating more welfare gains to not only skilled but also unskilled labor. Thus, a country＇s unskilled labor is not necessarily worse off with open trade if the country is prosperous in business service provisions.

关键词： international outsourcing wage inequality free trade agreement

Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1(COX-1) inhibitors

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Chinese Chemical Letters 2013年第2期24卷 120-122页

作者： Xue-ping chu Qing-Fa Zhou Shen Zhao Fei-Fei Ge Mian Fu Jia-Peng Chen Tao Lu Department of Organic Chemistry China Pharmaceutical University

Received 2 December 2012 Received in revised form 21 December 2012 Accepted 27 December 2012 Available online 4 February 2013

关键词： 3-Amino-2-pyroneBiological activityCOX-l-selective inhibitorSynthesis