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Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats

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Neural Regeneration Research 2021年第6期16卷 1052-1061页

作者： Qiu-Shi Gao Ya-Han Zhang Hang Xue Zi-Yi Wu Chang Li ping zhao Department of Anesthesiology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent *** classical Rice-Vannucci model was used to induce hypoxic-ischemic injury,and newborn(postnatal day 7)rats were treated with 2.4%sevoflurane for 30 minutes after hypoxic-ischemic *** results showed that sevoflurane postconditioning significantly improved the learning and memory function of rats,decreased astrogliosis and glial scar formation,increased numbers of dendritic spines,and protected the histomorphology of the ***,sevoflurane postconditioning decreased expression of von Hippel-Lindau of hypoxia-inducible factor-1α and increased expression of *** of 1.52μg of the hypoxia-inducible factor-1αinhibitor YC-1(Lificiguat)into the left lateral ventricle 30 minutes before hypoxic-ischemic injury reversed the neuroprotection induced by *** finding suggests that sevoflurane can effectively alleviate astrogliosis in the hippocampus and reduce learning and memory impairments caused by glial scar formation after hypoxic-ischemic *** underlying mechanism may be related to upregulated DJ-1 expression,reduced ubiquitination of hypoxia-inducible factor-1α,and stabilized hypoxiainducible factor-1α*** study was approved by the Laboratory Animal Care Committee of China Medical University,China(approval No.2016PS337K)on November 9,2016.

关键词： brain injury brain central nervous system in vivo injury model plasticity rat recovery regeneration repair

A wave-shaped electrode flexible sensor capable of sensitively responding to wrinkle excitation for a multifunctional human-computer interaction system

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Nano Research 2024年第5期17卷 4454-4461页

作者： Yongyang Chen Zhiyi Wu Chengcheng Han Zhi Cao Yiran Hu ping zhao Yuanyu Wang College of Materials and Metallurgy Guizhou UniversityGuizhou 550025China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Geological Brigade 105 Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang 550018China

Human-machine interactions(HMIs)have advanced rapidly in recent decades in the fields of healthcare,work,and ***,people with disabilities and other mobility problems do not have corresponding high-tech aids for them to enjoy the convenience of *** this paper,we propose a sensor with a wave-shaped(corrugated)electrode embedded in a friction layer,which exhibits high sensitivity to skin fold excitation and enormous potential in *** to the wave-shaped electrode design,it has no built-in cavities,and its small size allows it to flexibly cope with folds at different *** specifying the carbon nanotube hybrid silicone film as the electrode layer material and silicone film as the friction layer,good electrical output performance,tensile properties,and biocompatibility can be ***,the sensor is tested on various joints and skin folds of the human body,the output signals of which can be distinguished between normal physiological behavior and test *** on this sensor,we designed a medical alarm system,a robotic arm assistive system,and a cell phone application control system for the disabled to help them in the fields of healthcare,work,and *** conclusion,our research presents a feasible technology to enhance HMIs and makes a valuable contribution to the development of high-tech aids for the disabled.

关键词： flexible sensors multifunctionality wrinkle excitation triboelectric nanogenerator human-machine interaction

Fuzzy Neural Model for Flatness Pattern Recognition

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Journal of Iron and Steel Research International 2008年第6期15卷 33-38页

作者： JIA Chun-yu SHAN Xiu-ying LIU Hong-min NIU zhao-ping School of Mechanical Engineering Yanshan University Qinhuangdao 066004 Hebei China

For the problems occurring in a least square method model, a fuzzy model, and a neural network model for flatness pattern recognition, a fuzzy neural network model for flatness pattern recognition with only three-input and three output signals was proposed with Legendre orthodoxy polynomial as basic pattern, based on fuzzy logic expert experiential knowledge and genetic-BP hybrid optimization algorithm. The model not only had definite physical meanings in its inner nodes, but also had strong self-adaptability, anti interference ability, high recognition precision, and high velocity, thereby meeting the demand of high-precision flatness control for cold strip mill and providing a convenient, practical, and novel method for flatness pattern recognition.

关键词： flatness pattern recognition Legendre orthodoxy polynomial genetic-BP algorithm fuzzy neural network

Analysis of reconstructed annual precipitation from tree-rings for the past 500 years in the middle Qilian Mountain

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Science China Earth Sciences 2012年第5期55卷 770-778页

作者： TIAN QinHua ZHOU XiuJi GOU XiaoHu zhao ping FAN ZeXin Samuli HELAMA National Climate Center Beijing 100081China Center for Arid Environment and Paleoclimate Research(CAEP) Key Laboratory of Western China's Environment Systems MOELanzhou UniversityLanzhou 730000China Chinese Academy of Meteorological Sciences Beijing 100081China National Meteorological Information Center Beijing 100081China Xishuangbanna Tropical Botanical Garden Chinese Academy of SciencesKunming 650223China Arctic Centre University of LaplandRovaniemi 96101Finland

The ring-width chronology of a Juniperus przewalskii tree from the middle of the Qilian Mountain was constructed to estimate the annual precipitation (from previous August to current July) since AD *** reconstruction showed four major alternations of drying and wetting over the past 521 *** rainy 16th century was followed by persistent drought in the 17th ***,relatively wet conditions persisted from the 18th to the beginning of 20th century until the recurrence of a drought during the 1920s and *** on the Empirical Mode Decomposition method,eight Intrinsic Mode Functions (IMFs) were extracted,each representing unique fluctuations of the reconstructed precipitation in the time-frequency *** high amplitudes of IMFs on different timescales were often consistent with the high amount of precipitation,and vice *** IMF of the lowest frequency indicated that the precipitation has undergone a slow increasing trend over the past 521 *** 2-3 year and 5-8 year time-scales reflected the characteristics of inter-annual variability in precipitation relevant to regional atmospheric circulation and the El Ni?o-Southern Oscillation (ENSO),*** 10-13 year scale of IMF may be associated with changing solar ***,an amalgamation of previous and present data showed that droughts were likely to be a historically persistent feature of the Earth's climate,whereas the probability of intensified rainfall events seemed to increase during the course of the 19th and 20th *** changing characteristics in precipitation indicate an unprecedented alteration of the hydrological cycle,with unknown future *** reconstruction complements existing information on past precipitation changes in the Qilian Mountain,and provides additional low-frequency information not previously available.

关键词： Qilian Mountain tree-ring reconstruction empirical mode decomposition multi-scale precipitation variability not previously available

Two Zinc(Ⅱ) Complexes Based on 7rany-(1R,2R)-cyclohexanediamine: Molecular Structure Analyses and Preparation of Composite Membrane

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Chemical Research in Chinese Universities 2019年第5期35卷 749-754页

作者： WANG Dawei WANG Ying ZHUANG Changfu zhao ping YANG Jing SHI Zhengjun Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China Ministry of EducationSouthwest Forestry UniversityKunming 650224P.R.China Key L aboratory of State Forestry Administration on Highly-efficient Utilization of Forestry Biomass Resources in Southwest China Southwest Forestry UniversityKunming 650224P.R.China

Two novel complexes Zn2(chda)2(TPA)Cl2(1) and [Zn(chda)2(H2O)2](TPAXH2O)2(2)[chda is a chiral ligand of trans-(1R,2R)-cyclohexanediamine, H2TPA is terephthalic acid] were synthesized at room temperature. The molecular structures of complexes 1 and 2 were identified by single-crystal X-ray diffraction measurement. The results showed that complex 1 had a binuclear structure, each Zn(Ⅱ) ion was four coordinated by two N atoms of chda, one O atom of TPA and one Cl atom, to construct a distorted tetrahedral geometry. For complex 2, the Zn(Ⅱ) ion was six coordinated by two chda molecules and two water molecules to form a ZnN4O2 octahedral geometry. Complexes 1 and 2 further extended into three-dimensional supramolecular frameworks by hydrogen-bonding interactions. Hirshfeld surface analysis and fingerprint plots were used to further analyze the contribution of diflerent intermolecular interactions. Further, a composite membrane [Zn(chda)2(H2O)2](TPA)(H2O)2/CA was prepared by adding 10%(mass fraction) of complex 2 into cellulose acetate using acetone/chloroform( V:V-1:1) as solvent.

关键词： Zinc(Ⅱ) complex Trans-(1R,2R)-cyclohexanediamine Hirshfeld surface analysis Composite membrane

Catalytical oxidation of styrene by molecularly imprinted polymer with phenylacetic acid as template and hemin as co-monomer

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Chinese Chemical Letters 2007年第8期18卷 981-984页

作者： Jun Wang Zhi Yong Chen Mei ping zhao Yuan Zong Li The Key Laboratory of Bioorganic Chemistry and Molecular Engineering College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

This letter used the molecular imprinting technology to build up the microenvironment around co-monomer bemin to mimic the cytochrome P450 catalyzing the epoxidation of styrene. The results showed that the conversion rates of products were obviously enhanced by molecularly imprinted polymers, compared to free heroin solution, using three kinds of oxidants. The used axial ligand in polymers synthesis also improved the total conversion rates.

关键词： Molecularly imprinted polymers Enzyme mimic Cytochrome P450 Styrene Epoxidation

Hybrid fabricating of silica micro/nanofibers

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Frontiers of Optoelectronics 2011年第3期4卷 338-342页

作者： ping zhao zhao WU Kaisheng CHEN Xinliang ZHANG Wuhan National Laboratory for Optoelectronics College of Optoelectronic Science and EngineeringHuazhong University of Science and Technology

We report a hybrid two-step approach for fabricating silica micro/nanofibers with different diameters(the minimum one down to 180 nm). Due to tapering and etching techniques introduced to this approach, the time is reduced from hundreds of minutes to several minutes to manufacture silica nanofibers by etching and the complexity of tapering mechanical system is brought down,because this approach has the ability to control the micro/nanofiber diameter on a nanometer-scale. Uniform nanofibers with losses as low as 0.05 dB/mm at 1.55 μm wavelength are obtained suggesting the advantage of the hybrid approach to build up micro/nanofiber-based devices, especially in locally changing the structure of micro/nanofiber.

关键词： nano-fabrication micro/nanofiber sub-wavelength-diameter fiber nanophotonics

Characteristics of gas geochemistry in Yangbajing geothermal field, Tibet

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Chinese Science Bulletin 1998年第21期43卷 1770-1777页

作者： ping zhao Ji Dor Tingli Liang Jian Jin Haizheng Zhang Chinese Acad Sci Inst Geol Beijing 100029 Peoples R China Tibet Bur Geol & Mineral Resources Geothermal Geol Team Lhasa 851400 Peoples R China

CO 2 is a main component of gases in the Yangbajing geothermal field, usually higher than 85 in volume; others are N 2, H 2S, H 2, CH 4, etc. Helium R/R a ratios, ranging from 0.14 to 0.46, indicate a crustal component to be dominant in the gases. δ 13C-CO 2 values and δ 34S-H 2S values are in the range -7.72‰--11.33‰ and 0.2‰-8.3‰, respectively. The gases are inferred to mostly derive from the partial melting of the Nyainqentanglha core complex. The gases of shallow and deep reservoirs are distinctive in chemical compositions and δ 34S-H 2S values, which shows their different flowing paths and physical-chemical processes. Sulphur does not approach isotopic equilibrium between H 2S and SO 2- 4 species in both reservoirs. Significance of steam chemical monitoring is also discussed.

关键词： gas geochemistry isotope reservoir Yangbajing Tibet.

Latest insights into the global epidemiological features,screening,early diagnosis and prognosis prediction of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第20期30卷 2638-2656页

作者： Yi-Xin zhao He-ping zhao Meng-Yao zhao Yan Yu Xi Qi Ji-Han Wang Jing Lv Department of Clinical Laboratory Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710072Shaanxi ProvinceChina

As a highly invasive carcinoma,esophageal cancer(EC)was the eighth most prevalent malignancy and the sixth leading cause of cancer-related death worldwide in *** squamous cell carcinoma(ESCC)is the major histological subtype of EC,and its incidence and mortality rates are decreasing *** to the lack of specific early symptoms,ESCC patients are usually diagnosed with advanced-stage disease with a poor prognosis,and the incidence and mortality rates are still high in many countries,especially in ***,enormous challenges still exist in the management of ESCC,and novel strategies are urgently needed to further decrease the incidence and mortality rates of *** the key molecular mechanisms underlying ESCC pathogenesis have not been fully elucidated,certain promising biomarkers are being investigated to facilitate clinical *** the advent and advancement of highthroughput technologies,such as genomics,proteomics and metabolomics,valuable biomarkers with high sensitivity,specificity and stability could be identified for ***,we aimed to determine the epidemiological features of ESCC in different regions of the world,especially in China,and focused on novel molecular biomarkers associated with ESCC screening,early diagnosis and prognosis prediction.

关键词： Esophageal squamous cell carcinoma Epidemiology Diagnosis Genomics Proteomics Metabolomics