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Urine Cystatin C Determination in the Establishment of Reference Interval in the Diagnosis and Treatment of Renal Injury

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Natural Science 2022年第1期14卷 13-17页

作者： Xiaoyu Jiang Lihua Qin Jing Wei Guosheng Su Xiaoye Su Aihua Lu Jiansheng huang Feng Lu Taixin Lu pinchun huang Buqing Su Department of Laboratory Medicine Third People’s Hospital of Nanning Nanning China Guangxi-ASEAN Economic and Technological Development Zone People’s Hospital Nanning China The Department of Nephrology & Laboratory Medicine of Tenth People’s Hospital of Nanning Nanning China Department of Nursing Graduate School of Everlasting University of the Philippines Fuzhou China Department of Critical Care Medicine Fuzhou Second People’s Hospital Fuzhou China Department of Nursing Liaoning Vocational College of Medicine Shenyang China

Objective: To establish the diagnostic concentration range of urine cystatin C and the control level of urine cystatin C for patients with renal injury, and to help promote the establishment of standardization of urine cystatin C detection. Methods: 150 urine specimens and blood specimens from kidney injury patients and healthy people were collected, and stored in the refrigerator at -80°C for later use. After the specimens were collected, they were uniformly tested. Comparing the difference of blood and urine cystatin C between the kidney injury group and the healthy control group, the application value of urine cystatin C in the diagnosis and treatment of kidney injury was put forward. Results: The concentrations of cystatin C in urine and blood of renal injury group were 1.04 ± 2.14 mg/L and 1.94 ± 2.36 mg/L respectively;the concentrations of cystatin C in urine and blood of healthy control group were 0.11 ± 0.05 mg/L and 0.83 ± 0.20 mg/L respectively. The urine and blood cystatin C of the kidney injury group were significantly higher than those of the healthy control group. Compared the results of the two groups, the t values were 5.3210 and 5.7399, respectively. The P value is 0.0000;the difference is statistically significant;in comparison of urine and blood cystatin C in the kidney injury group, the value is that t = 3.4600, P = 0.0003;in comparison of urine and blood cystatin C in the healthy control group, the value is that t = 42.7744, P = 0.0000. By investigating the urine cystatin C concentration of patients with kidney injury, whether it is kidney injury or healthy controls, urine cystatin C is significantly lower than blood cystatin C. Conclusion: According to the results of this study, the concentration of urinary cystatin C in the healthy control group is 0.11 ± 0.05 mg/L. The reference interval of urinary cystatin C proposed in this study is 0.06 - 0.16 mg/L, which can be established by comprehensive multi center research. Through a multi-center stu

关键词： Urine Cystatin C Kidney Injury Concentration Interval Standardization

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