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Potential impact of autonomous vehicles in mixed traffic from simulation using real traffic flow

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Journal of Intelligent and Connected Vehicles

Journal of Intelligent and Connected Vehicles 2023年第1期6卷 1-15页

作者： Eleonora Andreotti Selpi pinar Boyraz Department of Mechanics and Maritime Sciences Chalmers University of TechnologySE-41296 GöteborgSweden CINECA Supercomputing Inter-University Consortium40033 BolognaItaly Department of Computer Science and Engineering Chalmers University of TechnologySE-41296 GöteborgSweden

This work focuses on the potential impacts of the autonomous vehicles in a mixed traffic condition represented in traffic simulator Simulation of Urban MObility(SUMO)with real traffic ***,real traffic flow and speed data collected in 2002 and 2019 in Gothenburg were used to simulate daily flow variation in *** order to predict the most likely drawbacks during the transition from a traffic consisting only manually driven vehicles to a traffic consisting only fully-autonomous vehicles,this study focuses on mixed traffic with different percentages of autonomous and manually driven *** realize this aim,several parameters of the car following and lane change models of autonomous vehicles are investigated in this *** with the fundamental diagram,the number of lane changes and the number of conflicts are analyzed and studied as measures for improving road safety and *** study highlights that the autonomous vehicles’features that improve safety and efficiency in 100%autonomous and mixed traffic are different,and the ability of autonomous vehicles to switch between mixed and autonomous driving styles,and vice versa depending on the scenario,is necessary.

关键词： automated driving autonomous vehicles(AVs) mixed-traffic traffic simulations driving style realistic conditions

Hypochlorous Acid Induces Caspase Dependent Apoptosis in <i>Saccharomyces cerevisiae</i>

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Journal of Biosciences and Medicines 2021年第4期9卷 42-53页

作者： Nur Kaluç pinar B. Thomas Department of Medical Biology and Genetics Faculty of Medicine Maltepe University Istanbul Turkey

Hypochlorous acid (HOCl) is a strong oxidant produced by activated neutrophils via the myeloperoxidase (MPO) enzyme in order to fight against infections. Because of their antimicrobial and antiviral properties, stabilized HOCl solutions were produced to be used as a disinfectant and became a recommended disinfectant against COVID-19 by the US Environmental Protection Agency. Aberrant MPO enzyme activity results in abundant HOCl production which is related to the development and/or progression of several diseases including atherosclerosis, cardiovascular and neurodegenerative diseases. Previous studies investigating the effect of HOCl on the mode of cell death in different cell types reported that HOCl induces both apoptosis and necrosis depending on its concentration. However, the data on the apoptotic pathway triggered by HOCl is controversial. In this study, we investigated the mode of cell death induced by different concentrations of HOCl in Saccharomyces cerevisiae. Our data revealed that HOCl leads to cell death within 1 minute at 170 μM and above. At 340 μM, HOCl causes a rapid necrosis, while 170 μM HOCl leads to apoptosis. HOCl-induced apoptosis is mostly caspase dependent and Aif1 doesn’t have a significant role.

关键词： Hypochlorous Acid Saccharomyces cerevisiae Viability Apoptosis

含黄酮的三价铁配合物合成及其药理性质(英文)

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无机化学学报 2010年第10期26卷 1743-1749页

作者： Emel Yildiz Sadet Karabulut Neslihan S.pinar Yusuf Karatas Figen Doran Cukurova大学文理学院化学系 Cukurova大学医学院药理学系 Cukurova大学医学院病理学系

3,3,4,7-四羟基黄酮与1,3-二环己基碳二亚胺在4-二甲胺吡啶存在下反应,得到2,2-双(3,3,4,7-四羟基黄酮)1,3-二环己基碳二亚胺。三价金属离子与上述合成得到的配体螯合,对此四面体结构的双核Fe(Ⅲ)配合物的血液学及病理学数据进行了讨论... 详细信息

3,3,4,7-四羟基黄酮与1,3-二环己基碳二亚胺在4-二甲胺吡啶存在下反应,得到2,2-双(3,3,4,7-四羟基黄酮)1,3-二环己基碳二亚胺。三价金属离子与上述合成得到的配体螯合,对此四面体结构的双核Fe(Ⅲ)配合物的血液学及病理学数据进行了讨论,同时研究了合成的配体作为螯合剂清除鼠肝胰组织中超载的铁的能力。结果表明作为口服药其作为双齿配体的螯合能力与市售用于治疗地中海贫血的药物"去铁敏"相近。

关键词：螯合黄酮铁(Ⅲ)离子药物治疗地中海贫血

Corneal properties in children with congenital isolated growth hormone deficiency

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 317-320页

作者： pinar Nalcacioglu-Yuksekkaya Emine Sen Ufuk Elgin Mumin Hocaoglu Faruk Ozturk Sebahat Agladioglu Yilmaz Havva Nur Kendirci Semra etinkaya Zehra Aycan Department of Pediatric Ophthalmology Dr Sami Ulus Children's Health and Disease Training and Research Hospital Ulucanlar Eye Research Hospital Department of Pediatric Endocrinology Dr Sami Ulus Children's Health and Disease Training and Research Hospital

AIM:To compare the corneal parameters of children with congenital isolated growth hormone deficiency and healthy ***:In this cross-sectional,prospective study,50 cases with growth hormone(GH)deficiency treated with recombinant GH and 71 healthy children underwent a complete ophthalmic *** corneal hysteresis(CH),corneal resistance factor(CRF),Goldmann-correlated intraocular pressure(IOPg)and corneal-compensated intraocular pressure(IOPcc)were measured with the Ocular Response Analyzer(ORA).Central corneal thickness(CCT)was measured by a ultrasonic ***:The mean age was 13.0±3.0 years in the GH deficiency group consisting of 21 females and 29 males and 13.4±2.4 years in the healthy children group consisting of 41 females and 30 *** was no statistically significant difference between the groups for gender or age(Chi-square test,P=0.09;independent ttest,P=0.28,respectively).The mean duration of recombinant GH therapy was 3.8±2.4y in the study *** mean CH,CRF,IOPg and IOPcc values were 11.0±2.0,10.9±1.9,15.1±3.3,and 15.1±3.2 mm Hg respectively in the study *** same values were 10.7±1.7,10.5±1.7,15.2±3.3,and 15.3±3.4 mm Hg respectively in the control *** mean CCT values were 555.7±40.6,545.1±32.5μm in the study and control groups *** was no statistically significant difference between the two groups for CH,CRF,IOPg,IOPcc measurements or CCT values(independent t-test,P=0.315,0.286,0.145,0.747,0.13 respectively).CONCLUSION:Our study suggests that GH deficiency does not have an effect on the corneal parameters and CCT *** observation could be because of the duration between the beginning of disease and the diagnosis and beginning of GH therapy.

关键词： child corneal biomechanical parameters central corneal thickness growth hormone deficiency

The in-vivo assessment of Turkish propolis and its nano form on testicular damage induced by cisplatin

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Journal of Integrative Medicine 2021年第5期19卷 451-459页

作者： pinar Tatli Seven Ismail Seven Selcan Karakus Seda Iflazoglu Mutlu Seyma Ozer Kaya Gozde Arkali Merve Ilgar Ezgi Tan Yesim Muge Sahin Deniz Ismik Ayben Kilislioglu Department of Animal Nutrition and Nutritional Diseases Faculty of Veterinary MedicineFirat UniversityElazig23119Turkey Department of Plant and Animal Production Vocation School of SivriceFtrat UniversityElazig 23119Turkey Department of Chemistry Faculty of EngineeringIstanbul University-CerrahpasaIstanbul 34320Turkey Department of Reproduction and Artificial Insemination Faculty of Veterinary MedicineFirat UniversityElazig 231J9Turkey Department of Physiology Faculty of Veterinary MedicineFirat UniversityElazig 23119Turkey Istanbul Arel University ArelPOTKAM(Polymer Technologies and Composite Application and Research Center)Istanbul 34537Turkey Department of Biomedical Engineering Faculty of Engineering and ArchitectureIstanbul Arel UniversityIstanbul 34537Turkey Department of Electrical Electronics Engineering Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul 34083Turkey

Objective: Chemotherapeutic drugs, such as cisplatin(CP), which are associated with oxidative stress and apoptosis, may adversely affect the reproductive system. This study tests whether administration of propolis and nano-propolis(NP) can alleviate oxidative stress and apoptosis in rats with testicular damage induced by ***: In this study, polymeric nanoparticles including propolis were synthesized with a green sonication method and characterized using Fourier transform-infrared spectroscopy, Brunauer-EmmettTeller, and wet scanning transmission electron microscopy techniques. In total, 56 rats were divided into the following seven groups: control, CP, propolis, NP-10, CP + propolis, CP + NP-10, and CP + ***(100 mg/kg), NP-10(10 mg/kg), and NP-30(30 mg/kg) treatments were administered by gavage daily for 21 d, and CP(3 mg/kg) was administered intraperitoneally in a single dose. After the experiment,oxidative stress parameters, namely, malondialdehyde(MDA), glutathione(GSH), glutathione peroxidase(GPx), and catalase(CAT), and apoptotic pathways including B cell leukemia/lymphoma-2 protein(Bcl-2)and Bcl-2-associated X protein(Bax) were measured in testicular tissues. Furthermore, sperm quality and weights of the testis, epididymis, right cauda epididymis, seminal vesicles and prostate were ***: Propolis and NP(especially NP-30) were able to preserve oxidative balance(decreased MDA levels and increased GSH, CAT, and GPx activities) and activate apoptotic pathways(decreased Bax and increased Bcl-2) in the testes of CP-treated rats. Sperm motility in the control, CP, and CP + NP-30 groups were 60%, 48.75%, and 78%, respectively(P<0.001). Especially, NP-30 application completely corrected the deterioration in sperm features induced by ***: The results show that propolis and NP treatments mitigated the side effects of CP on spermatogenic activity, antioxidant situation, and apoptosis in rats.

关键词： Cisplatin Nano-propolis Reproductive system Testicular damage

Validation of the PAGE-B score to predict hepatocellular carcinoma risk in caucasian chronic hepatitis B patients on treatment

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World Journal of Gastroenterology 2022年第6期28卷 665-674页

作者： pinar Gokcen Fatih Guzelbulut Gupse Adali Ayca Gokce Degirmenci Salturk Oguzhan Ozturk Ozgur Bahadir Emine Kanatsiz Mevlut Kiyak Kamil Ozdil Hamdi Levent Doganay Department of Gastroenterology Health Sciences UniversityUmraniye Teaching and Research HospitalIstanbul 34764Turkey Department of Gastroenterology Health Sciences UniversityHaydarpasa Numune Teaching and Research HospitalIstanbul 34668Turkey

BACKGROUND Several risk scores have been developed to predict hepatocellular carcinoma(HCC)risk in chronic hepatitis B(CHB)*** majority of risk scores are based on pretreatment variables that are no longer considered risk factors for HCC development due to the suppression of hepatitis B virus replication early in the course of potent antiviral treatment in most *** PAGE-B score,which is based on platelet levels,age and sex,has been shown to accurately predict HCC risk in CHB patients on antiviral treatment in various *** We aimed to evaluate the PAGE-B score in predicting HCC risk in Turkish CHB patients on antiviral *** In this study,we recruited 742 CHB patients who had been treated with tenofovir disoproxil fumarate or entecavir for≥1 *** groups were determined according to the PAGE-B scores as follows:≤9,low;10-17,moderate and≥18,*** cumulative HCC incidences in each risk group were computed using Kaplan-Meier analysis and were compared using the log-rank *** accuracy of the PAGE-B score in predicting HCC risk was evaluated using a timedependent area under the receiver operating characteristic(AUROC)curve at all study time *** and multivariate logistic regression analyses were used to assess the risk factors for HCC *** The mean follow-up time was 54.7±1.2 *** was diagnosed in 26 patients(3.5%).The cumulative HCC incidences at 1,3,5 and 10 years were 0%,0%,0%and 0.4%in the PAGE-B low-risk group;0%,1.2%,1.5%and 2.1%in the PAGE-B moderate-risk group;and 5%,11.7%,12.5%,and 15%in the PAGE-B high-risk group,respectively(log-rank P<0.001).The AUROCs of the PAGE-B score in the prediction of HCC development at 1,3,5 and 10 years were 0.977,0.903,0.903 and 0.865,*** the multivariable analysis,older age,male sex,lower platelet levels,presence of cirrhosis,and absence of alanine aminotransferase normalization at month 6 were associated with HCC development(all P<0.05).C

关键词： Chronic hepatitis B Hepatocellular carcinoma PAGE-B score Surveillance

Anaplastic Pleomorphic Xanthoastrocytoma: Morphological and Molecular Features of Three Cases

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Open Journal of Pathology 2015年第4期5卷 117-124页

作者： Nil Comunoglu pinar Karabagli Sebnem Batur Buge Oz Department of Pathology Faculty of MedicineIstanbul UniversityIstanbulTurkey Department of Pathology Faculty of MedicineSelcuk UniversityKonyaTurkey

Pleomorphic xanthoastrocytoma (PXA) is usually a low grade astrocytic tumor. However, some cases show significant mitotic activity (5 or more mitosis per 10 High Power Field) and/or necrosis. These tumors are described as pleomorphic xanthoastrocytomas with anaplastic features and display increased risk of recurrence. We aimed to evaluate histopathological, immunohistochemical and molecular features of PXAs with anaplastic features, by reporting three primary cases displaying recurrence. Histopathologically we observed rhabdoid-like monomorphic atypical tumoral cells with increased mitotic activity, vascular endothelial proliferation and necrosis. Immunohistochemically, astrocytic and neuronal components displayed different specific staining properties. In 2 cases p53 was immunopositive. We detected BRAF V600E mutation in 2 cases and p16 mutation in one case, by fluorescence in situ hybridization (FISH) method. Anaplastic pleomorphic xanthoastrocytoma (APXA) is a rare tumor. We have presented 3 primary APXA cases displaying all characteristic histopathological features. Two of these cases were immunopositive for p53. Therefore, we think that this marker may not be so useful in differentiating APXA from glioblastoma (GBM). Two of our three cases display BRAF V600E mutation, which is compatible with the literature.

关键词： Anaplastic Pleomorphic Xanthoastrocytoma Fluorescence in Situ Hybridization Immunohistochemistry

Antimicrobial activity against periodontopathogenic bacteria,antioxidant and cytotoxic effects of various extracts from endemic Thermopsis turcica

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Asian Pacific Journal of Tropical Biomedicine 2014年第7期4卷 505-514页

作者： Elif Burcu Bali Leyla Acik Glin Akca Meral Sarper Mualla pinar Eli Ferit Avcu Mecit Vural Health Services Vocational School.University of Gazi Department of Biology Faculty of Science.University of Gazi Department of Medical Microbiology Faculty of DentistryUniversity of Gazi Cancer and Stem Cell Research Center Gulhane Military Medical School Department of Hematology Cancer and Stem Cell Research Center.Gulhane Military Medical School

Objective:To investigate the in vitro antimicrobial potential of Thermopsis turcica Kit Tan,Vural&Kckdk against periodoutopathogenie bacteria,its antioxidant activity and cytotoxic effect on various cancer cell ***:In vitro antimicrobial activities of ***,ethyl acetate(ElAc,n-hexane and water extracts of Thermopsis turcica herb against periodontopathogenic bacteria,Aggregatibacter actinnmycelemconilans ATCC 29523 and Porphyromonas gingivalis ATCC 33277 were tested by agar well diffusion,minimum inhibitory concentration(MIC)and minimal bactericidal concentration(MBC),Antioxidant properties of the extracts were evaluatod by 1,1-diphenyl-2-picryl-hydrazyl radical scavenging activity and p-carotene bleaching *** of phenolic contents of the extracts were also analysed by using the Folin-Ciocalteu ***,cytotoxic activity of the extracts on androgcn-insensilivc prostate cancer,androgen—sensitive prostate cancer,chronic myelogenous leukemia and acute promyelocytic leukemia bunian cancer cell lines were determined by 3-4,5-dimelhylthiazol-2-yh-2,5-diphenyltclrazolium bromide *** gingival fibroblast cells were used as a ***:Our data showed that ELAc extract had the highest antimicrobial effect on Aggregatibacter actinomycetemitans(MIC:1.562 mg/ml_MHC:3.124 mg/ml.)and Porph yromonas gingiralis(MIC:0.781 mg/mL,MBC:1.562 mg/mL).In antioxidant *** extract exhibited also the highest radical scavenging activity[IC_(50)=(30.0±0.3)μg/ml.]and the highest inhibition[(74.35±0.30)%]|against lineloic acide *** amount of phenolic content of it was also the highest[(l62.5±l.2)μg/mg gallic acid].In cytotoxic assay,only etbanol[IC_(50)=(80.00±1.21)μg/ml.]and EtAc extract[IC_(50)=(70.0±0.9)μg/ml]were toxic on acute promyeloeytic leukemia cells at 20—100μg/mL.P.However,no toxic effect was observed on human gingival fibroblast ***:According to our findings,owing to its antioxidant and

关键词： Thermopsis turcica Antimicrobial activity Periodontopathogenic bacteria Antioxidant effect Phenolic content Cytotoxic effect Human gingival fibroblast Acute promyelocytic leukemia

Photogrammetric Analysis of Multiple Implant Abutment Impressions under Different Conditions

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Open Journal of Stomatology 2017年第9期7卷 408-418页

作者： Funda Bayindir Melike pinar Yildirim Nuran Dinckal Yanikoglu Department of Prosthodontics Faculty of DentistryAtatürk UniversityErzurumTurkey Beyhekim Oral and Dental Healthy Center SelcukluTurkey

Purpose: The aim of this investigation was to evaluate and compare the dimensional accuracy of hydrophilic polysiloxane, vinyl polysiloxane (VPS), and polyether (PE) impression materials under dry, moist and wet conditions. Methods: An acrylic master model including 6 implants was formed, and 108 impressions were made up of this acrylic model at total. In this study, the materials of hydrophilic polysiloxane impression material, 1 hydrophilic vinyl polysiloxane impression material and 1 polyether impression material were tested. Twelve impression of each material were created under dry, moist and wet respectively. Two reference distances were evaluated on each study model by using a graphics-editing program whereas for comparison of mean dimensional changes one-way analysis of variance and Student t-test were used. Results: One-way analysis of variance revealed significant differences between impression materials and conditions (P P Conclusions: All impression materials showed a statistically significant difference under dry, moist and wet conditions.

关键词： Photogrammetric Analysis Implant Abutment Impressions