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Synergistic effects of ethnomedicinal plants of Apocynaceae family and antibiotics against clinical isolates of Acinetobacter baumannii

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Asian Pacific Journal of Tropical Medicine 2014年第6期7卷 456-461页

作者： Sasitorn Chusri Thanyaluck Siriyong pinanong na-phatthalung Supayang Piyawan Voravuthikunchai Faculty of Traditional Thai Medicine Prince of Songkla University natural Product Research Center of Excellence Prince of Songkla University Department of Microbiology Faculty of SciencePrince of Songkla University

Objective:To investigate the efficacy of 17 ethnomedicinal plants belonging to Apocynaceae family used in combination with 16 conventional antibiotics against non-multidrug resistant-,multidrug resistant(MDR)-.and extensive drug resistant(XDR) Acinetobacter baumannii(***).Methods:Antibacterial activity and resistance modifying ability of 272combinations were determined by growth inhibition assays and further confirmed by time-kill ***:Among the combinations of the antibiotics with Apocynaceae ethanol extracts on this pathogen,15(5%) had synergistic effects,23(8%) had partial synergistic effects and 234(86%) had no *** activity was observed mostly when the Apocynaceae extracts were combined with rifampicin or ***.10 out of 17 combinations between the extracts and rifampicin displayed synergistic or partial synergistic *** antidysenterica extract was additionally tested to restore rifampicin activity against clinical isolates of MDR and XDR *** respect to total or partial synergy,70%was XDR *** isolates and 66%was MDR *** ***:Holarrhena antidysenterica extract clearly demonstrated the ability to restore rifampicin activity against both *** ATCC19606 and clinically isolated *** studies examining its active principles as well as nieclianisms of actions such as the effects on efflux pumps and outer membrane permeability alterations are recommended.

关键词： Acinetobacter baumannii Antibacterial activity Resistance modifying agents Apocynaceae Combination Synergistic effect

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Macrophage-Mediated Defensive Mechanisms Involving Zinc Homeostasis in Bacterial Infection

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Infectious Microbes & Diseases 2021年第4期3卷 175-182页

作者： pinanong na-phatthalung Junxia Min Fudi Wang School of Public Health The First Affiliated HospitalInstitute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiangChina

Zinc homeostasis in macrophages is essential for maintaining their antimicrobial functions,and a growing body of evidence indicates that both zinc depletion and excess zinc in myeloid cells decrease bacterial *** macrophages,maintaining intracellular and extracellular zinc levels via zinc transporter proteins,including Slc30a and Slc39a family members,plays an important role in the response to immunological signals and ***,studies have found that macrophages utilize a variety of zinc-modulating mechanisms,thus expanding our knowledge regarding the role that zinc plays in response to bacterial ***,we review recent progress with respect to altered zinc metabolism in macrophages and the consequences with respect to fighting invading pathogens.

关键词： zinc zinc depletion zinc toxicity macrophage bacterial infection

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