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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin zeng Le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： yong-Chang zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

An overview on integrated localization and communication towards 6G

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Science China(Information Sciences) 2022年第3期65卷 5-50页

作者： Zhiqiang XIAO yong zeng National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories

While the fifth generation(5 G) cellular system is being deployed worldwide, researchers have started the investigation of the sixth generation(6 G) mobile communication networks. Although the essential requirements and key usage scenarios of 6 G are yet to be defined, it is believed that 6 G should be able to provide intelligent and ubiquitous wireless connectivity with Terabits per second(Tbps) data rate and submillisecond(sub-ms) latency over three-dimensional(3 D) network coverage. To achieve such goals, acquiring accurate location information of the mobile terminals is becoming extremely useful, not only for locationbased services but also for improving wireless communication performance in various ways such as channel estimation, beam alignment, medium access control, routing, and network optimization. On the other hand, the advancement of communication technologies also brings new opportunities to greatly improve the localization performance, as exemplified by the anticipated centimeter-level localization accuracy in 6 G by extremely large-scale multiple-input multiple-output(MIMO) and millimeter wave(mm Wave) *** this regard, a unified study on integrated localization and communication(ILAC) is necessary to unlock the full potential of wireless networks for dual purposes. While there are extensive studies on wireless localization or communications separately, the research on ILAC is still in its infancy. Therefore, this article aims to give a tutorial overview on ILAC towards 6 G wireless networks. After a holistic survey on wireless localization basics, we present the state-of-the-art results on how wireless localization and communication inter-play with each other in various network layers, together with the main architectures and techniques for localization and communication co-design in current two-dimensional(2 D) and future 3 D networks with aerial-ground integration. Finally, we outline some promising future research directions for ILAC.

关键词： wireless localization integrated localization and communication cellular networks B5G 6G

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Molecular dynamics studies of the inhibitory mechanism of copper(Ⅱ) on aggregation of amyloid β-peptide

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Chinese Chemical Letters 2007年第3期18卷 357-360页

作者： yong Jiao pin Yang Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University Taiyuan 030006 China

The inhibitory mechanism of copper（Ⅱ） on the aggegation of amyloid β-peptide （Aβ） was investigated by molecular dynamics simulations. The binding mode ofcopper（Ⅱ） with Aβ is characterized by the imidazole nitrogen atom, Nπ, of the histidine residue H 13, acting as the anchoring site, and the backbone＇s deprotoned amide nitogen atoms as the main binding sites. Drove by the coordination bonds and their induced hydrogen bond net, the conformations of Aβ converted from β-sheet non-β-sheet conformations, which destabilized the aggregation of Aβ into fibrils.

关键词： Copper(Ⅱ) Amyloid β-peptide Inhibitory mechanism Alzheimer's disease Molecular dynamics Radial distribution function (RDF)

Effect of dissolved oxygen on electrochemical corrosion behavior of 2205 duplex stainless steel in hot concentrated seawater

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Journal of Materials Science & Technology 2021年第7期66卷 177-185页

作者： Hongtao zeng yong Yang Minhang zeng Moucheng Li Institute of Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200072China

The corrosion behavior of 2205 duplex stainless steel was investigated in hot concentrated seawater with different dissolved oxygen(DO) concentration by electrochemical measurement techniques and surface analysis methods. DO obviously enhances the cathodic reaction process, the formation of passive film and polarization resistance. With increasing the DO concentration from 0.34 to 3.06 mg L^(-1), the relative contents of Fe_(2)O_(3) and Cr_(2)O_(3) and the Cr-enrichment gradually enlarge in the passive film. The higher DO concentrations result in lower defect densities and thicker of space charge layers in the passive films,whichmayeffectively inhibit the intrusion of aggressive chloride ions. The increment inDOconcentration clearly increases the pitting potential, but decreases the repassivation potential. It may weaken both the occurrence and repassviation tendencies of stable pitting corrosion.

关键词： Dissolved oxygen Pitting corrosion 2205 duplex stainless steel Hot concentrated seawater Passivation

Molecular modeling of the inhibitory mechanism of copper(II) on aggregation of amyloidβ-peptide

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Science China Chemistry 2005年第6期48卷 580-590页

作者： JIAO yong HAN Daxiong YANG pin Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan 030006China

Aggregation of amyloid ?-peptide (A?) into insoluble fibrils is a key pathological event in Alzheimer’s disease (AD). Under certain conditions, Cu(II) exhibits strong inhibitory ef-fect on the Zn(II)-induced aggregation, which occurs significantly even at nearly physiological concentrations of zinc ion in vitro. Cu(II) is considered as a potential factor in the normal brain preventing A? from aggregating. The possible mechanism of the inhibitory effect of Cu(II) is in-vestigated for the first time by molecular modeling method. In the mono-ring mode, the Y10 residue promotes typical quasi-helix conformations of A?. Specially, [Cu-H13(Np)-Y10(OH)] complex forms a local 3.010 helix conformation. In the multi-ring mode, the side chains of Q15 and E11 residues collaborate harmoniously with other chelating ligands producing markedly low energies and quasi-helix conformations. [Cu-3N-Q15(O)-E11(O1)] and [Cu-H13(Np)-Y10(OH)] complex with quasi-helix conformations may prefer soluble forms in solution. In addition, hydro-gen-bond interactions may be the main driving force for A? aggregation. All the results will pro-vide helpful clues for an improved understanding of the role of Cu(II) in the pathogenesis of AD and contribute to the development of an “anti-amyloid” therapeutic strategy.

关键词： copper(II) amyloid β-peptide inhibitory mechanism, Alzheimer’s disease molecular modeling

Molecular modeling of the ion channel-like nanotube structure of amyloid β-peptide

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Chinese Science Bulletin 2007年第11期52卷 1576-1580页

作者： JIAO yong YANG pin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular Science ShanxiUniversity Taiyuan 030006 China

The ion channel-like nanotube structure of the oligomers of amyloid β-peptide (Aβ) was first investi-gated by molecular modeling. The results reveal that the hydrogen bond net is one of the key factors to stabilize the structure. The hydrophobicity distribution mode of the side chains is in favor of the structure inserting into the bilayers and forming a hydrophilic pore. The lumen space is under the control of the negative potential,weaker but spreading continuously,to which the cation selectivity attributes; meanwhile,the alternate distribution of the stronger positive and negative potentials makes the electrostatic distribution of the structure framework balance,which is also one of the key factors stabilizing the structure. The results lay the theoretical foundation for illuminating the structure stability and the ion permeability,and give a clue to elucidating the molecular mechanism of Alzheimer's dis-ease (AD) and designing novel drugs to prevent or reverse AD at the root.

关键词： β-缩氨酸淀粉分子模型结构纳米管

Benchmark solutions of large-strain cavity contraction for deep tunnel convergence in geomaterials

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第3期12卷 596-607页

作者： pin-Qiang Mo yong Fang Hai-Sui Yu State Key Laboratory for Geomechanics and Deep Underground Engineering School of Mechanics and Civil EngineeringChina University of Mining and TechnologyXuzhou221116China Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu610031China School of Civil Engineering University of LeedsLeedsLS29JTUK

To provide precise prediction of tunnelling-induced deformation of the surrounding geomaterials,a framework for derivation of rigorous large-strain solutions of unified spherical and cylindrical cavity contraction is presented for description of confinement-convergence responses for deep tunnels in *** the tunnelling-induced large deformation,logarithmic strains are adopted for cavity contraction analyses in linearly elastic,non-associated Mohr-Coulomb,and brittle Hoek-Brown *** with approximate solutions,the approximation error indicates the importance of release of small-strain restrictions for estimating tunnel convergence profiles,especially in terms of the scenarios with high stress condition and stiffness degradation under large *** ground reaction curve is therefore predicted to describe the volume loss and stress relaxation around the tunnel *** stiffness of circular lining is calculated from the geometry and equivalent modulus of the supporting structure,and a lining installation factor is thus introduced to indicate the time of lining installation based on the prediction of spherical cavity contraction around the tunnel opening *** study also provides a general approach for solutions using other sophisticated geomaterial models,and serves as benchmarks for analytical developments in consideration of nonlinear large-deformation behaviour and for numerical analyses of underground excavation.

关键词： Convergence-confinement method(CCM) Cavity contraction analysis Tunnel convergence

Tensile and compressive behavior of Ti-based bulk metallic glass composites

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International Journal of Minerals,Metallurgy and Materials 2013年第6期20卷 582-588页

作者： yong-sheng Wang Guo-jian Hao Jun-pin Lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing

This article focuses on the tensile and compressive characteristics of a Ti-based bulk metallic glass composite （BMGC）. It is found that the yield stress, maximum strength, and fracture strain are 1380 MPa, 1516 MPa, and 4.3% for uniaxial tension, but 1580 MPa, 4010 MPa, and 29% for uniaxial compression, respectively. The composite displays a linear ＂work hardening＂ capacity under compression; however, the ＂work softening＂ behavior is observed in the true engineering stress-strain curve upon tensile loading. The fracture surfaces of specimens also exhibit dissimilar properties under the different loadings.

关键词： metallic glass composite materials tensile testing compression testing fracture