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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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Observed Long-and Short-lived North Atlantic Oscillation Events:Role of the Stratosphere

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Advances in Atmospheric Sciences 2020年第12期37卷 1338-1358页

作者： Jie song Jingjing zhao State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Utilizing three different sets of reanalysis data,this study examines the long-and short-lived observed positive North Atlantic Oscillation(NAO)events(referred to as NAO+_LE and NAO+_SE)and long-and short-lived observed negative NAO events(referred to as NAO−_LE and NAO−_SE).Composite results indicate that the NAO-like circulation anomalies associated with the long-lived NAO events can reach the stratosphere,while they are primarily confined to the troposphere in the short-lived NAO ***,the coupling/connection of stratospheric and tropospheric circulation anomalies is much better(worse)in the long-lived(short-lived)NAO events.A series of modified stratospheric initial-value experiments conducted with a simplified model indicate that a better(worse)connection between stratospheric and tropospheric circulation anomalies in the initial-value fields tend to gradually induce the NAO-like tropospheric circulation anomalies in the troposphere on the subsequent days,and thus naturally elongate(reduce)the lifetimes of the original NAO events by altering the tropospheric synoptic eddy vorticity flux over the North Atlantic region.

关键词： North Atlantic Oscillation lifetimes stratosphere eddy forcing

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An application of matching pursuit time-frequency decomposition method using multi-wavelet dictionaries

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Petroleum Science 2012年第3期9卷 310-316页

作者： zhao Tianzi song Wei Library of China University of Petroleum Beijing 102249China CNPC Key Laboratory of Geophysical Exploration China University of PetroleumBeijing 102249China

In the time-frequency analysis of seismic signals, the matching pursuit algorithm is an effective tool for non-stationary signals, and has high time-frequency resolution and a transient structure with local self-adaption. We expand the time-frequency dictionary library with Ricker, Morlet, and mixed phase seismic wavelets, to make the method more suitable for seismic signal time-frequency decomposition. In this paper, we demonstrated the algorithm theory using synthetic seismic data, and tested the method using synthetic data with 25% noise. We compared the matching pursuit results of the time-frequency dictionaries. The results indicated that the dictionary which matched the signal characteristics better would obtain better results, and can reflect the information of seismic data effectively.

关键词： Matching pursuit seismic attenuation wavelet transform Wigner Ville distribution time- frequency dictionary

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Stochastic Stability of Discrete Time Positive Markov Jump Nonlinear Systems

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Journal of Systems Science & Complexity 2023年第5期36卷 1949-1960页

作者： zhao ping zhao Yan song Xinmin NIU Ben School of Information Science and Engineering Shandong Normal UniversityJinan 250358China School of Mathematical Sciences University of JinanJinan 250022China

This paper investigates the stochastic stability of discrete time positive Markov jump nonlinear systems(PMJNS).Some definitions on stochastic stability for discrete time PMJNS are introduced ***,using the multiply max-separable Lyapunov function method,some stochastic stability criterions of discrete time PMJNS are provided,and some corresponding criterions are also provided for discrete time positive Markov jump linear systems(PMJLS).Different from previous conclusions that require subsystems to be stable or marginally stable,the obtained results allow some subsystems to be *** on the proposed criterions,the stochastic stability behavior of discrete time positive Markov jump systems can be obtained just from the algebraic properties of the system function and the probability characteristics of the Markov *** illustrate the main results,two simulation examples are provided at the end.

关键词： Markov jump system nonlinear system positive system stochastic stability

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Catalytic Graphitization of Phenolic Resin

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Journal of Materials Science & Technology 2011年第3期27卷 266-270页

作者： Mu zhao Huaihe song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China Chinergy Co. Ltd Beijing 100084 China

The catalytic graphitization of thermal plastic phenolic-formaldehyde resin with the aid of ferric nitrate （FN） was studied in detail. The morphologies and structural features of the products including onion-like carbon nanoparticles and bamboo-shaped carbon nanotubes were investigated by transmission electron microscopy （TEIVI）, high-resolution transmission electron microscopy （HRTEM）, X-ray diffraction and Raman spectroscopy measurements. It was found that with the changes of loading content of FN and residence time at 1000℃, the products exhibited various morphologies. The TEM images showed that bamboo-shaped carbon nanotube consisted of tens of bamboo sticks and onion-like carbon nanoparticle was made up of quasi-spherically concentrically closed carbon nanocages.

关键词： Nanostructures Polymers Heat treatment

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Investigation of the effect of filling level on the wear and vibration of a SAG mill by DEM

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Particuology 2022年第4期20卷 24-34页

作者： Changhua Xie Yuan zhao Tao song Yongzhi zhao Institute of Process Equipment Zhejiang UniversityHangzhou 310027China State Key Laboratory of Process Automation in Mining & Metallurgy.Beijing 100160 China Beijing Key Laboratory of Process Automation in Mining & Metallurgy Beijing 100160China

Semi-autogenous grinding(SAG)mill is widely used in the grinding process of coal and ores because of its strong applicability,large capacity and low consumption of grinding ***,the research of SAG mill is still of great important practical *** those parameters of the SAG mill,the flling level is very important for it is not only directly related to the processing capacity of the mill,but also affects the operation cost and stability of *** this paper,combined with shear impact energy model(SIEM)and discrete element method(DEM),the particle collision energy spectrum was applied to analyze the influence of ore flling level and media flling level on the power draw of the mill,the impact energy on ore,and the wear of liner and media in a slice of an industrial SAG *** was found that increasing the ore flling level would increase energy consumption and reduce the energy efficiency and the wear of liner and grinding ***,the vibration of mill was explored from the collision energy on *** results showed that the low frequency but high energy ollision between grinding media and liner was the main reason for liner wear and mill vibration.

关键词： Flling level SAG mill Collision energy DEM Wear Vibration

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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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Novel Cr^(3+)-activated far-red emitting phosphors withβ-Ca_(3)(PO_(4))_(2)-type structure for indoor plant cultivation

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1286-1294页

作者： Fangyi zhao Zhen song Quanlin Liu Beijing Municipal Key Laboratory of New Energy Materials and Technologies School of Materials Sciences and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Cr^(3+)-activated far-red and near-infrared phosphors have drawn considerable attention owing to their adjustable emission wavelengths and wide ***,we reported a series of Cr^(3+)-doped phosphors withβ-Ca_(3)(PO_(4))_(2)-type structure,of which Ca_(9)Ga(PO_(4))_(7):Cr^(3+) possessed the highest far-red emission *** an excitation of 440 nm,the Ca_(9)Ga(PO_(4))_(7):Cr^(3+) phosphors exhibited a broad emission band ranging from 650 to 850 nm and peaking at 735 nm,and the broadband superimposed two sharp lines centering at 690 and 698 *** optimal sample Ca_(9)Ga_(0.97)(PO_(4))_(7):0.03 Cr^(3+) had an internal quantum efficiency of 55.7%.The luminescence intensity of the Ca_(9)Ga_(0.97)(PO_(4))_(7):0.03 Cr^(3+) phosphor obtained at 423 K could maintain 68.5%of that at room temperature,demonstrating its outstanding luminescence thermal stability.A phosphor-conversion light-emitting diode was fabricated,indicating that the Ca_(9)Ga(PO_(4))_(7):Cr^(3+) phosphor has potential applications in indoor plant cultivation.

关键词： far-red near-infrared luminescence trivalent chromium ion plant cultivation

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Energy Control of Plug-In Hybrid Electric Vehicles Using Model Predictive Control With Route Preview

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IEEE/CAA Journal of Automatica Sinica 2021年第12期8卷 1948-1955页

作者： Yang zhao Yanguang Cai Qiwen song Department of Mechanical and Electrical Engineering Guangdong University of Science and TechnologyDongguan 523083China School of Automation Guangdong University of TechnologyGuangzhou 510006China Transport Infrastructure Investment Company Guangzhou 510620China

The paper proposes an adoption of slope,elevation,speed and route distance preview to achieve optimal energymanagement of plug-in hybrid electric vehicles(PHEVs).Theapproach is to identify route features from historical and real-time traffic data,in which information fusion model and trafficprediction model are used to improve the information ***,dynamic programming combined with equivalent con-sumption minimization strategy is used to compute an optimalsolution for real-time energy *** solution is thereference for PHEV energy management control along the *** improve the system's ability of handling changing situation,the study further explores predictive control model in the real-time control of the energy.A simulation is performed to modelPHEV under above energy control strategy with route *** results show that the average fuel consumption of PHEValong the previewed route with model predictive control(MPC)strategy can be reduced compared with optimal strategy andbase control strategy.

关键词： Energy management model predictive control(MPC) optimal control plug-in hybrid electric vehicle(PHEV)

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Pr-Tb synergistic strengthening on coercivity of Nd-Ce-Fe-B magnets grain boundary diffused with Pr-Tb-Al-Ga alloys

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Journal of Rare Earths 2024年第9期42卷 1704-1709,I0003页

作者： Ruifang song Hang zhao Haibo Feng Institute of Functional Materials Central Iron&Steel Research InstituteBeijing100081China

Sintered Nd-Ce-Fe-B magnets were grain boundary diffused(GBDed) with Pr_(x)Tb_(80-x)Al_(10)Ga_(10)(at%)(x=0,20,40,60,80) *** effect of Pr/Tb content in diffusion source on magnetic properties,microstructure and elements distribution of GBDed magnets was *** Pr is used to substitute for 75% Tb in diffusion source,Tb consumption per unit coercivity improvement of GBDed magnet reduces by 77%,compared with the Tb_(80)Al_(10)Ga_(10) diffused *** element diffuses into magnets and then forms Tb-rich shell with high magneto-crystalline anisotropy field surrounding main phase grains,resulting in substantial coercivity *** with low melting point diffuses deeply along liquid grain boundary phase during GBD *** can eliminate some sharp defects of main phase grains and make grain boundaries smooth,which provides diffusion channels for further diffusion of Tb ***,there are more diffusion channels for Tb and less Tb enriched at surface region,making Tb diffuse more deeply and improving Tb utilization *** method significantly improves the coercivity,and realizes the green,efficient and high-quality utilization of heavy rare earth(HRE)elements.

关键词： Grain boundary diffusion Rare earths Microstructure Synergistic strengthening

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