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系统功能语法的隐性语法本质

外语学刊 2024年第3期 19-25页

作者：王品上海交通大学外国语学院上海200240

系统功能语法关注语言中的显性类型,同时更加注重在隐性类型方面探赜钩深。隐性类型指不依靠外在形态体现的潜在语法特征,这一概念最早由美国语言学家Whorf提出。系统功能语法的创始人Halliday将Whorf的这一创见称颂为20世纪语言学的主... 详细信息

系统功能语法关注语言中的显性类型,同时更加注重在隐性类型方面探赜钩深。隐性类型指不依靠外在形态体现的潜在语法特征,这一概念最早由美国语言学家Whorf提出。系统功能语法的创始人Halliday将Whorf的这一创见称颂为20世纪语言学的主要贡献之一,其开创的系统功能语法也在多方面借鉴隐性类型的思想,英语小句语法的诸多方面本质上都是隐性语法。本文回顾隐性类型的提出,阐释系统功能语法的隐性语法本质,介绍系统功能语法作为隐性语法的描写方式,并探讨隐性语法对汉语系统功能语法研究的借鉴意义。

关键词：系统功能语法隐性类型隐性语法

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雪隐于雪

钟山 2024年第1期 4-32页

作者：孙频江苏省作协

自从父亲把他那只小船留给我之后,我也开始划着船回六极岛。六极岛是父亲的岛,准确地说,他是在这个岛上出生并长大的,上初中的时候才第一次离开这座小岛,去隔海相望的雷州半岛上学。

关键词：雷州半岛初中小船

Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

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World Journal of Diabetes 2024年第5期15卷 958-976页

作者： Hong Xu Li-Bo Zhang Yi-Yi Luo Ling Wang Ye-pin Zhang Pei-Qi Chen Xue-Ying Ba Jian Han Heng Luo Department of Ophthalmology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Precision Medicine Center of Chuxiong Yi Autonomous Prefecture The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Endocrinology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Pathology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina

BACKGROUND Synaptotagmins(SYTs)are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and ***,few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy(DR)through Ca2+/glucose transporter-1(GLUT1)and the possible regulatory mechanism of *** To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of *** DR was induced by streptozotocin in C57BL/6J mice and by high glucose medium in human retinal pigment epithelial cells(ARPE-19).Bioinformatics analysis,reverse transcriptase-polymerase chain reaction,Western blot,flow cytometry,ELiSA,HE staining,and TUNEL staining were used for *** Six differentially expressed proteins(SYT2,SYT3,SYT4,SYT7,SYT11,and SYT13)were found between the DR and control groups,and SYT4 was highly *** induces SYT4 overexpression,manipulates Ca2+influx to induce GLUT1 fusion with the plasma membrane,promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake,induces ARPE-19 cell apoptosis,and promotes DR *** deficiency inhibits the proteasomal degradation of SYT4 in DR,resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane,and these effects were blocked by oe-Parkin ***,dysregulation of the myelin transcription factor 1(Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process,and this process was inhibited in the oe-MYT1-treated *** Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

关键词： Diabetic retinopathy Glucose transporter-1 Synaptotagmin 4 Parkin Myelin transcription factor 1

intermittent fasting boosts antitumor immunity by restricting CD11b^(+)Ly6C^(low)Ly6G^(low) cell viability through glucose metabolism in murine breast tumor model

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Food Science and Human Wellness 2024年第4期13卷 2327-2345页

作者： Chenghao Fu Zhehao Liang Zemiao Niu Ning Chen Yuemin Li Zhenhua Liang Yanwei Huo Hao Xi Rong Wang Yonghuan Yan Xiaoruo Gan Mengtian Wang Yun Huang Yan Zhang Mingming Gao pin Lü Postdoctoral Station for Basic Medicine Cardiovascular Medical Science CenterDepartment of Cell BiologyKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Laboratory of Lipid Metabolism Department of Biochemistry and Molecular BiologyKey Laboratory of Medical Biotechnology of Hebei ProvinceShijiazhuang 050017China

intermittent fasting can benefit breast cancer patients undergoing chemotherapy or ***,it is still uncertain how to select immunotherapy drugs to combine with intermittent *** we observed that two cycles of fasting treatment significantly inhibited breast tumor growth and lung tissue metastasis,as well as prolonged overall survival in mice bearing 4T1 and 4T07 breast *** this process,both the immunosuppressive monocytic-(M-)and granulocytic-(G-)myeloid-derived suppressor cell(MDSC)decreased,accompanied by an increase in interleukin(iL)7R^(+)and granzyme B^(+)T cells in the tumor ***,we observed that Ly6G^(low)G-MDSC sharply decreased after fasting treatment,and the cell surface markers and protein mass spectrometry data showed potential therapeutic *** investigation revealed that glucose metabolism restriction suppressed the splenic granulocytemonocyte progenitor and the generation of colony-stimulating factors and iL-6,which both contributed to the accumulation of *** the other hand,glucose metabolism restriction can directly induce the apoptosis of Ly6G^(low)G-MDSC,but not Ly6G^(high)*** summary,these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3^(+)T cells,providing potential solutions for enhancing immune-based cancer interventions.

关键词： intermittent fasting Ly6G^(low)myeloid-derived suppressor cell apoptosis Extramedullary hematopoiesis Colony stimulating factor Glucose metabolism restriction

Biogeochemistry of sedimentary organic matter in the Yongjiang River estuary in the southern part of Hangzhou Bay,China,since the Late Pleistocene

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Journal of Oceanology and Limnology 2024年第3期42卷 772-786页

作者： Dongqin HUANG Xiaolong Li Zilong Li Pei Sun LOH Jianxiong HU Jianfang CHEN Yuan-pin CHANG Chin-Wen YANG Qin GAO institute of Marine Geology and Resources Ocean CollegeZhejiang UniversityZhoushan 316021China Ministry of Water Resources of the People’s Republic of China Beijing 100054China Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Department of Oceanography Sun Yat-sen UniversityKaohsiung 80424China

A sediment core(YJK19-02)collected from the southern outlet of Hangzhou Bay near the Yongjiang River estuary in East China was analyzed for grain size,lignin,bulk elemental composition,stable carbon isotope,and rare earth elements(REEs)to determine the sources and diagenesis of sedimentary organic matter(OM)of the estuary and adjacent areas since the Late Pleistocene.δ^(13)C values(-24.80‰–-23.60‰),total organic carbon/total nitrogen(TOC/TN)molar ratios(8.00–12.14),and light rare earth element/heavy rare earth element ratios(LREE/HREE=8.34–8.91)revealed the predominance of terrestrial sources of OM,mainly from the Changjiang(Yangtze)*** lignin parameters of syringyl/vanillyl(S/V=0.20–0.73)and cinnamyl/vanillyl(C/V=0.03–0.19)ratios indicate the predominance of nonwoody angiosperms,and the vanillic acid/vanillin ratios[(Ad/Al)_(V)=0.32–1.57]indicate medium to high degrees of lignin *** increasing trend ofΛ(total lignin in mg/100-mg OC)values from ca.14500 a BP to ca.11000 a BP reflected the increase in temperature during the Late ***,a time lag effect of temperature on vegetation abundance was also *** relatively higher and stableΛvalues correspond to the higher temperature during the mid-Holocene from ca.8500 a BP to ca.4500 a BP.Λvalues decreased from ca.4000 a BP to the present,corresponding to historical temperature fluctuations during this *** results show that the vegetation abundance in the Yongjiang River Basin since the Late Pleistocene was related to the temperature fluctuation duo to climate change.

关键词： Yongjiang River estuary sedimentary organic matter lignin environmental change Late Pleistocene

好氧颗粒污泥中硫酸化多糖的生成、提取及表征

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中国环境科学 2024年第6期44卷 3160-3166页

作者：魏子涵卢毅鹏高品东华大学环境科学与工程学院上海201620

以厌氧颗粒污泥作为接种污泥,在序批式活性污泥反应器(SBR)中驯化培养好氧颗粒污泥,通过好氧颗粒污泥胞外聚合物(EPS)提取和硫酸化多糖纯化方法的优化,探究好氧颗粒污泥SBR反应器中硫酸化多糖的生成变化.结果表明,好氧颗粒污泥SBR反应... 详细信息

以厌氧颗粒污泥作为接种污泥,在序批式活性污泥反应器(SBR)中驯化培养好氧颗粒污泥,通过好氧颗粒污泥胞外聚合物(EPS)提取和硫酸化多糖纯化方法的优化,探究好氧颗粒污泥SBR反应器中硫酸化多糖的生成变化.结果表明,好氧颗粒污泥SBR反应器运行效果稳定,对污水COD、NH_(4)^(+)-N、TN和TP的去除效果分别可达90%、97%、70%和93%以上.采用超声、水浴和碱处理的组合方法可有效地提取好氧颗粒污泥EPS和硫酸化多糖,经脱蛋白纯化后,硫酸化多糖可达56.6mg/g EPS,约为接种厌氧颗粒污泥中硫酸化多糖含量的1.4倍,表明好氧颗粒污泥有助于生成硫酸化多糖,为污水污泥有机质的高值转化和资源化提供了一种有效途径.

关键词：好氧颗粒污泥硫酸化多糖胞外聚合物污水资源化

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考虑副产品入侵的制造商废料处理策略

中国管理科学 2024年第4期32卷 218-226页

作者：金力徐和周品华中科技大学管理学院湖北武汉430074 华中农业大学经济管理学院湖北武汉430070

考虑单制造商和单废料处理商构成的供应链结构,制造商在生产主产品过程中产生的废料优先销售给下游处理商,经过处理转化的副产品在主产品低端市场销售;剩余废料由制造商通过传统方式自行处理。综合考虑废料销售实现副产品协同所带来处... 详细信息

考虑单制造商和单废料处理商构成的供应链结构,制造商在生产主产品过程中产生的废料优先销售给下游处理商,经过处理转化的副产品在主产品低端市场销售;剩余废料由制造商通过传统方式自行处理。综合考虑废料销售实现副产品协同所带来处理成本的节约和处理商通过副产品销售对主产品市场的侵入效应,本文研究了制造商的最优废料处理策略和主副产品的最优产量决策。研究结果表明,上游制造商会通过调整废料批发价格实现不同的废料处理策略。当废料批发价格由低到高时,制造商将依次选择“全部出售”“部分出售部分自处理”和“不出售完全自处理”三种策略。制造商废料批发价格和主产品产量策略受到废料处理成本影响,成本增加会导致批发价格上涨,主产品产量先减少后增加最后保持不变。副产品质量影响制造商废料出售意愿,质量越高,出售意愿越大,但是全部出售意愿先减少后增加。此外,通过算例分析可得到,随着质量的提高,制造商利润不会像处理商一样一直增加,由于副产品协同导致的销售利润下降和处理成本下降,制造商利润先减少后增加。

关键词：副产品协同产量决策产品竞争产品入侵

中国英语学习者词汇联想组织模式及网络结构的历时对比研究

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外语教学理论与实践 2024年第3期 10-18,9页

作者：张萍马宇晗苏州大学

本研究对比了两代(2005/2023)英语专业学生词汇联想网络的语义组织及整体网络变化。结果显示:1)两代学习者英语心理词库均以语义组织为主,高低水平者对词汇搭配和层级知识的侧重不同,现阶段学生的屈折派生知识显著提高;2)两代学习者的... 详细信息

本研究对比了两代(2005/2023)英语专业学生词汇联想网络的语义组织及整体网络变化。结果显示:1)两代学习者英语心理词库均以语义组织为主,高低水平者对词汇搭配和层级知识的侧重不同,现阶段学生的屈折派生知识显著提高;2)两代学习者的联想网络结构均符合“小世界”特性,网络疏密度随语言水平而增大至稳定,稳定性随小世界程度的加深而减弱。本研究为英语词汇学习提供了历时发展图景,对词汇学习诊断有启示。

关键词：词汇联想组织模式网络结构语义和网络分析历时对比

Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS

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Nuclear Science and Techniques 2024年第2期35卷 85-93页

作者： Jie-Ming Xue Song Feng Yong-Hao Chen Han Yi Min Xiao pin-Jing Cheng Xin-Xiang Li Rong Liu Yi-Wei Yang Zi-Jie Han Da-Jun Zhao Hao-Qiang Wang Bao-Qian Li Ji-Rong Zhao Lei-Xun Tang Wen Luo Bo Zheng School of Nuclear Science and Technology University of South ChinaHengyang 421001China institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron *** energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission *** on-beam background was determined using Co,in,Ag,and Cd *** excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling *** present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,ENDF/B-Viii.0,JEFF-3.3,JENDL-5,CENDL-3.2,and BROND-3.1),and the theoretical calculation *** agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding *** measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy *** provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.

关键词： Neutron-induced total cross section Natural lead Time-of-flight TALYS-1.96 CSNS Back-n white neutron beamline