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Biomimetic construction of oriented lamellar Col/nHAP composite scaffolds and mediation of macrophages to promote angiogenesis and bone regeneration

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Frontiers of Materials Science 2023年第4期17卷 127-146页

作者： Tingting Huang tao Huang pin Luo Di Xiao Yiping Huang Shenyu Yang Rong Zeng Mei Tu College of Chemistry and Materials Science Jinan UniversityHuangpu Road 601Guangzhou 510632China Medical 3D Printing Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China

Pore characteristics have been identified as key design parameters for *** strategy reported here is to create an appropriate immune microenvironment by regulating pore characteristics of scaffolds,thereby promoting early angiogenesis and enhancing osteogenesis.A series of collagen/nanohydroxyapatite(Col/nHAP)composite scaffolds with ordered lamellar structures and different layer spacings were prepared by mimicking the ordered lamellar topology of the bone *** research indicated that the layer spacing and ordered topology of the scaffold exerted an important influence on phenotype transformation of macrophages and the secretion of angiogenic *** Col/nHAP-O(135)with large layer spacing not only supported cell attachment and diffusion in vitro,but also promoted early angiogenesis by timely switching from M1 to M2 macrophage *** vivo data showed that the layer spacing and the ordered structure of the scaffold synergistically regulated the inflammatory response and triggered macrophages to secrete more angiogenesis related ***/nHAP-O(135)considerably promoted the neovascularization and new bone formation in the defect site,indicating that Col/nHAPO(135)could significantly enhance the osteogenic activity of stem cells with the involvement of macrophages.

关键词： pore characteristic macrophage vascularization bone regeneration

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磷酸咯萘啶在小鼠体内的药动学过程

重庆工学院学报（自然科学版） 2009年第7期23卷 48-50页

作者：曾品涛周慧韩玉梅傅善权郑一敏胥秀英重庆理工大学化学与生物工程学院重庆400050

研究磷酸咯萘啶在小鼠体内的药动学过程.小鼠一次性灌服磷酸咯萘啶后,用高效液相色谱法检测不同时间间隔血药浓度,计算药动学参数.小鼠一次灌胃***-1的磷酸咯萘啶后其药动学参数为:t1/2=(15.053±4.764)h,Tm ax=(6.072±0.834)h.结果表... 详细信息

研究磷酸咯萘啶在小鼠体内的药动学过程.小鼠一次性灌服磷酸咯萘啶后,用高效液相色谱法检测不同时间间隔血药浓度,计算药动学参数.小鼠一次灌胃***-1的磷酸咯萘啶后其药动学参数为:t1/2=(15.053±4.764)h,Tm ax=(6.072±0.834)h.结果表明,磷酸咯萘啶在小鼠体内药动学符合二房室开放模型,该方法准确可靠,操作简便,适用于药动学研究.

关键词：磷酸咯萘啶药动学高效液相色谱法血药浓度

Dielectric Properties of Eu-Doped CaCu_3Ti_4O_(12) with Different Compensation Mechanisms

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Acta Metallurgica Sinica(English Letters) 2017年第2期30卷 97-103页

作者： Jun-Wei Liu Da-Yong Lu Xin-Yu Yu Qiao-Li Liu Qiang tao Hong Change pin-Wen Zhu State Key Laboratory of Superhard Materials Jilin University Research Center for Materials Science and Engineering Jilin Institute of Chemical Technology School of Physical Science and Technology Inner Mongolia University

To get a better understanding of the influence of rare-earth element doping,CaCu3Ti4O12（CCTO） samples with a partial substitution of Ca with Eu with different compensation mechanisms were designed and prepared by solid-state *** the ceramics were single phase,while the dielectric constants and thermally activated energy values for dielectric relaxation in Eu-doped ceramics were both lower than those of ***（0.875）Eu（0.1）Cu3Ti4O12（CECT1）exhibited a slight decrease in both the permittivity and electric resistance of grain boundaries compared with CCTO,while Ca（0.85）Eu（0.1）Cu3Ti4O12（CECT2） underwent a sharp decrease in permittivity associated with an abnormally large *** different dielectric behavior indicates that the dielectric properties of CCTO are sensitive to the valence states of cations and *** variation of permittivity is related to the localization of carriers,which,according to the XPS results,should be caused by the presence of oxygen *** formation of defect complexes between cations and oxygen vacancies leads to the increase in resistance and prevents the hopping between Cu^＋ and Cu^2＋,which is an important source of the polarization in grain boundaries.

关键词： CaCu3Ti4O12 Compensate doping Carrier localization Oxygen vacancy

广西护理工作者对安宁疗护的认知态度及从业意愿调查研究

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广东医学 2022年第2期43卷 248-253页

作者：陈林潘晓李小红潘琪妮陶品月黄惠桥李高叶广西医科大学第二附属医院护理部广西南宁530001 广西医科大学第二附属医院急诊科广西南宁530001 广西医科大学第二附属医院心血管内科广西南宁530001 广西医科大学第二附属医院麻醉科广西南宁530001 广西医科大学第一附属医院护理部广西南宁530001

目的调查广西壮族自治区内不同层级医院临床护士对于安宁疗护的认知态度及从业意愿,并分析其影响因素。方法采用便利抽样法,对广西1653名临床护士进行安宁疗护认知及从业意愿的问卷调查。结果广西壮族自治区内临床护士知识量表得分为(10... 详细信息

目的调查广西壮族自治区内不同层级医院临床护士对于安宁疗护的认知态度及从业意愿,并分析其影响因素。方法采用便利抽样法,对广西1653名临床护士进行安宁疗护认知及从业意愿的问卷调查。结果广西壮族自治区内临床护士知识量表得分为(10.21±3.75)分,态度量表得分为(34.90±3.54)分,只有455名(27.5%)护士表示如果有机会愿意从事安宁疗护相关工作,1198名(72.5%)的护士表示不愿意或不确定。多元线性回归分析显示,学历、职称、月收入、是否接受过相关教育或培训、是否有临床经验是安宁疗护知识的影响因素;学历、宗教信仰、家里是否有>60岁老人同住、是否接受过相关教育或培训是安宁疗护态度的影响因素;logistic回归分析显示,是否接受相关教育或培训、是否有临床经验影响护士安宁疗护的从业意愿。结论广西壮族自治区内护士安宁疗护知识及态度处于中等水平,对安宁疗护的从业意愿普遍不强,是否接受过安宁疗护培训是其知识、态度和从业意愿的一致影响因素。因此,扩大安宁疗护理念宣传,加强护士安宁疗护教育培训,以提高护士对安宁疗护的认知和态度,促使更多的护士能够以饱满的热情投入到安宁疗护事业的发展当中。

关键词：安宁疗护护理工作者认知态度从业意愿

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Glutamine addiction and therapeutic strategies in pancreatic cancer

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1852-1863页

作者： Lin-Lin Ren tao Mao pin Meng Li Zhang Hong-Yun Wei Zi-Bin Tian Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pathology The Affiliated Hospital of Qingdao UniversityQingdao 266000China

Pancreatic cancer remains one of the most lethal diseases worldwide owing to its late diagnosis,early metastasis,and poor *** current therapeutic options are limited,there is an urgent need to investigate novel targeted treatment *** cancer faces significant metabolic challenges,principally hypoxia and nutrient deprivation,due to specific microenvironmental constraints,including an extensive desmoplastic stromal *** cancer cells have been shown to rewire their metabolism and energy production networks to support rapid survival and *** glucose uptake and glycolytic pathway activity during this process have been extensively ***,growing evidence suggests that pancreatic cancer cells are glutamine *** a nitrogen source,glutamine directly(or indirectly via glutamate conversion)contributes to many anabolic processes in pancreatic cancer,including amino acids,nucleobases,and hexosamine *** also plays an important role in redox homeostasis,and when converted toα-ketoglutarate,glutamine serves as an energy and anaplerotic carbon source,replenishing the tricarboxylic acid cycle *** present study aims to provide a comprehensive overview of glutamine metabolic reprogramming in pancreatic cancer,focusing on potential therapeutic approaches targeting glutamine metabolism in pancreatic cancer.

关键词： Pancreatic cancer Glutamine metabolism Cancer treatment Therapeutic strategies

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肠膜明串珠菌的最适发酵培养基筛选

重庆理工大学学报（自然科学） 2010年第9期24卷 38-40页

作者：王琳琳郑一敏胥秀英傅善权李杰周慧曾品涛重庆理工大学药学与生物工程学院重庆400050

将肠膜明串珠菌接种在不同培养基上进行发酵培养,观察其生长状况。将使此菌种长势良好的几种培养基进行综合对比。用新培养基进行二次筛选,得到肠膜明串珠菌的最适发酵培养基。

关键词：肠膜明串珠菌培养基发酵

A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong,China

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World Journal of Gastroenterology 2008年第19期14卷 3059-3063页

作者： Ta o-tao Liu Ying Fang Hui Xiong tao-Yang Chen Zheng-pin Ni ]ian-Feng Luo Nai-Qing Zhao Xi-Zhong Shen Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai 200032 China Endoscopy Center Huadong Hospital Fudan University Shanghai 200040 China Chinese National Human Genome Center at Shanghai Shanghai 201203 China Qidong Liver Cancer Institute Qidong 226200 Jiangsu Province China Department of Health Statistics and Community Medicine Fudan University Shanghai 200032 China

AIM:To investigate the role of hepatitis B virus (HBV) replication in the development of hepatocellular carcinoma (HCC), a nested case-control study was performed to study the relationship between HBV DNA level and risk of HCC. METHODS:One hundred and seventy cases of HCC and 276 control subjects free of HCC and cirrhosis were selected for this study. Serum HBV DNA level was measured using fluorescein quantitative polymerase chain reaction at study entry and the last visit. RESULTS:In a binary unconditional logistic regression analysis adjusted for age, cigarette smoking, alcohol consumption and family history of chronic liver diseases, the adjusted odds ratios (95% confidence intervals) of HCC in patients with increasing HBV DNA level were 2.834 (1.237-6.492), 48.403 (14.392-162.789), 42.252 (14.784-120.750), and 14.819 (6.992-31.411) for HBV DNA levels ≥ 104 to < 105; ≥ 105 to < 106; ≥ 106 to < 107; ≥ 107 copies/mL, respectively. Forty-six HCC cases were selected to compare the serums viral loads of HBV DNA at study entry with those at the last visit. The HBV DNA levels measured at the two time points did not differ ***:The findings of this study provide strong longitudinal evidence of an increased risk of HCC associated with persistent elevation of serum HBV DNA level in the 104-107 range.

关键词： Hepatitis B surface antigen Viral replication Asvmptomatic carriers Viral load

Effects of Multiple Cleaning and Disinfection Interventions on Infectious Diseases in Children: A Group Randomized Trial in China

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Biomedical and Environmental Sciences 2015年第11期28卷 779-787页

作者： BAN Hai Qun LI tao SHEN Jin LI Jin PENG pin Zhang YE Heng ping ZHANG Liu Bo Institute of Environment Health and Related Product Safety Center for Disease Control and Prevention of China Center for Disease Control and Prevention of Xiantao city

Objective To assess the effectiveness of multiple cleaning and disinfection interventions in the homes and kindergartens, in reducing gastrointestinal and respiratory illnesses of children. Methods From October 2010 to September 2011, we performed a prospective, controlled study in China. 408 children under 5 years old were recruited and group randomized into intervention and control groups. Families and kindergartens in the intervention group were provided with antibacterial products for hand hygiene and surface cleaning or disinfection for one year. Each child＇s illness symptoms and sick leave were recorded every day. Results A total of 393 children completed the study, with similar baseline demographics in each of the 2 groups. Except for abdominal pain, the odds of symptoms （fever, cough and expectoration, runny nose and nasal congestion, diarrhea）, illness （acute respiratory illness and gastrointestinal illness）, and sick leave per person each month were significantly reduced by interventions. The rates of fever, diarrhea, acute respiratory illness, gastrointestinal illness and sick leave per person per year were significantly decreased as well. Conclusion Not only the acute respiratory children were significantly reduced by multiple and gastrointestinal illness but the sick leave rate in interventions.

关键词： Communicable disease control Child daycare centers Sick leave Antibacterial agents Hand hygiene Domestic hygiene Surface cleaning Surface disinfection

Exponentially modified Gaussian relevance to the distributions of translocation events in nanopore-based single molecule detection

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Chinese Chemical Letters 2014年第7期25卷 1029-1032页

作者： Zhen Gu Yi-Lun Ying Bing-Yong Yan Hui-Feng Wang pin-Gang He Yi-tao Long Department of Chemistry East China Normal University Key Laboratory for Advanced Materials & Department of Chemistry East China University of Science and Technology School of Information Science and Engineering East China University of Science and Technology

Nanopore technique plays an important role in single molecule detection, which illuminates the properties of an individual molecule by analyzing the blockage durations and currents. However, the traditional exponential function is lack of efficiency to describe the distributions of blockage durations in nanopore experiments. Herein, we introduced an exponentially modified Gaussian （EMG） function to fit the duration histograms of both simulated events and experimental events. In comparison with the traditional exponential function, our results demonstrated that the EMG provides a better fit while covers the entire range of the distributions. In particular, the fitted parameters of EMG could be directly used to discriminate the sequence length of the oligonucleotides at single molecule level.

关键词： Nanopore Single-molecule detection Exponentially modified Gaussian