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Design of deformable mirrors for high power lasers

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High Power Laser Science and Engineering 2016年第2期4卷 68-74页

作者： Stefano Bonora Jan pilar Antonio Lucianetti Tomas Mocek CNR-IFN HiLASE Centre Institute of Physics AS CR Department of Physical Electronics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in Prague

We present the workflow of the design, realization and testing of deformable mirrors suitable for high power diode pumped solid-state lasers. It starts with the study of the aberration to be corrected, and then it continues with the design of the actuators position and characteristic. In this paper, we present and compare three deformable mirrors realized for multi-J level laser facilities. We show that with the same design concept it is possible to realize deformable mirrors for other types of lasers. As an example, we report the realization of a deformable mirror for femtosecond lasers and for a CW CO_2 laser.

关键词： adaptive optics closed loop deformable mirror high power lasers

Circadian rhythms in the pathogenesis of gastrointestinal diseases

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World Journal of Gastroenterology 2018年第38期24卷 4297-4303页

作者： pilar Codonr-Franch Marie Gombert Department of Pediatrics Obstetrics and GinecologyUniversity of ValenciaValencia 46010Spain Department of Pediatrics Dr.Peset University HospitalValencia 46017Spain Department of Biotechnology University of La RochelleLa Rochelle 17000France

The etiology of digestive pathologies such as irritable bowel syndrome(IBS), inflammatory bowel diseases(IBD) and cancer is not yet fully understood. In recent years, several studies have evidenced circadian variations in mechanisms involved in digestive health. In situations of disturbed circadian rhythms(chronodisruption) where the central clock and the peripheral clocks receive incoherent signals, the synchronicity is lost producing implications for health. This lack of coordination could alter the tissue function and cause long term damage to the organs. Life habits such as sleep, physical exercise, social interaction, and feeding times are determinants for stability and integrity of circadian rhythms. In recent years, experimental and clinical studies have consistently evidenced that the alteration of circadian rhythms is associated with the development of digestive pathologies mainly linked to dismotility or changes in microbiota composition. Likewise, it seems reasonable to deep into the importance of chronodisruption as a factor that may participate in the development of pathologies such as IBS, IBD and digestive cancers. Moreover, life habits respecting circadian rhythms should be promoted for the prevention of these diseases. Further studies will allow us a better understanding of the mechanisms acting at molecular level, and the development of new therapeutic targets.

关键词： Circadian rhythms Gastrointestinal diseases Irritable bowel syndrome Inflammatory bowel disease Digestive cancers

Current status of the genetic susceptibility in attenuated adenomatous polyposis

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World Journal of Gastrointestinal Oncology 2019年第12期11卷 1101-1114页

作者： Víctor Lorca pilar Garre Laboratorio de Oncología Molecular Grupo de Investigación Clínica y Traslacional en OncologíaHospital Clínico San CarlosMadrid 28040Spain Laboratorio de Oncología Molecular Servicio de OncologíaHospital Clínico San CarlosMadrid 28040Spain

Adenomatous polyposis(AP)is classified according to cumulative adenoma number in classical AP(CAP)and attenuated AP(AAP).Genetic susceptibility is the major risk factor in CAP due to mutations in the known high predisposition genes APC and ***,the contribution of genetic susceptibility to AAP is lower and less *** predisposition genes have been recently proposed,and some of them have been validated,but their scarcity hinders accurate risk estimations and prevalence *** is a heterogeneous condition in terms of severity,clinical features and ***,clinicians do not have strong discriminating criteria for the recommendation of the genetic study of known predisposition genes,and the detection rate is *** and knowledge of new AAP high predisposition genes are of great importance to offer accurate genetic counseling to the patient and family *** review aims to update the genetic knowledge of AAP,and to expound the difficulties involved in the genetic analysis of a highly heterogeneous condition such as AAP.

关键词： Attenuated adenomatous polyposis Genetic susceptibility High predisposition gene Genetic heterogeneity Colorectal cancer

Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

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Neural Regeneration Research 2020年第12期15卷 2207-2216页

作者： Francisco Bosch-Morell Victoria Villagrasa Teresa Ortega Nuria Acero Dolores Muñoz-Mingarro MEugenia González-Rosende Encarna Castillo MAmparo Sanahuja pilar Soriano Isabel Martínez-Solís Biomedical Sciences Institute Universidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Biomedical Sciences Faculty of Health SciencesUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Pharmacy Faculty of Health SciencesUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Pharmacology Pharmacognosy and BotanyUniversidad Complutense de MadridMadridSpain Department of Pharmaceutical and Health Sciences Faculty of PharmacyUniversidad San Pablo-CEUCEU UniversitiesMadridSpain Department of Chemistry and Biochemistry Faculty of PharmacyUniversidad San Pablo-CEUCEU UniversitiesMadridSpain ICBiBE-Botanical Garden University of ValenciaValenciaSpain

The retina may suffer neurodegenerative damages,as other tissues of the central nervous system do,and serious eye diseases may *** of them is age-related macular degeneration,which causes progressive loss of vision due to retina *** of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds,among others,that prevent/diminish oxidative stress and reduce neovascularisation *** phytochemicals,medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor *** review article presents the most investigated plants and natural products in relation to age-related macular degeneration,such as saffron,ginkgo,bilberry and blueberry,curcuma or turmeric,carotenoids,polyphenols,and vitamins C and *** study provides up-to-date information on the effects,treatments,safety and efficiency of these phytotherapy products.

关键词： age-related macular degeneration bilberry blueberry curcuma carotenoids ginkgo polyphenols saffron vitamins

Morphometric and kinematic sperm subpopulations in split ejaculates of normozoospermic men

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Asian Journal of Andrology 2016年第6期18卷 831-834页

作者： pilar Santolaria Caries Soler pilar Recreo Teresa Carretero Araceli Bono Jose M Berne Jesus L Yaniz TECNOGAM research group Environmental Sciences Institute (IUCA) Department of Animal Production and Food Sciences University of Zaragoza Huesca Spain Department of Functionat 8iotogy and Physical Anthropology University of Valencia 46100 Burjassot Valencia Spain R+D Department Proiser R+D Scientific Park University of Valencia 46980 Paterna Valencia Spain TECNOGAM research group Environmental Sciences Institute (IUCA) Departament of Human Anatomy and Histolosy Faculty of Health and Sport Sciences of Huesca PLaza Universidad 3 22002 Huesca Spain TECNOGAM research group Environmental Sciences Institute (IUCA) Hospital General San Jorge de Huesca Area de Urologia Av. Martinez de Velasco 36 22004 Huesca Spain

This study was designed to analyze the sperm kinematic and morphometric subpopulations in the different fractions of the ejaculate in normozoospermic men. Ejaculates from eight normozoospermic men were collected by masturbation in three fractions after 3-5 days of sexual abstinence. Analyses of sperm motility by computer-assisted sperm analysis （CASA-Mot）, and of sperm morphometry by computer-assisted sperm morphometry analysis （CASA-Morph） using fluorescence were performed. Clustering and discriminant procedures were performed to identify sperm subpopulations in the kinematic and morphometric data obtained. Clustering procedures resulted in the classification of spermatozoa into three kinematic subpopulations （slow with low ALH [35.6% of all motile spermatozoa], with circular trajectories [32.0%], and rapid with high ALH [32.4%]）, and three morphometric subpopulations （large-round [33.9% of all spermatozoa], elongated [32.0%], and small [34.10%]）. The distribution of kinematic sperm subpopulations was different among ejaculate fractions （P 〈 0.001）, with higher percentages of spermatozoa exhibiting slow movements with low ALH in the second and third portions, and with a more homogeneous distribution of kinematic sperm subpopulations in the first portion. The distribution of morphometric sperm subpopulations was also different among ejaculate fractions （P〈 0.001）, with more elongated spermatozoa in the first, and of small spermatozoa in the third, portion. It is concluded that important variations in the distribution of kinematic and morphometric sperm subpopulations exist between ejaculate fractions, with possible functional implications.

关键词： man sperm morphometry by computer-assisted sperm morphometry analysis sperm motility by computer-assisted spermanalysis sperm subpopulations split ejaculate

Role of selenium in type 2 diabetes,insulin resistance and insulin secretion

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World Journal of Diabetes 2023年第3期14卷 147-158页

作者： pilar Casanova Daniel Monleon Department of Pathology University of ValenciaValencia 46010Spain

Selenium is a trace mineral essential for life that acts physiologically through *** other actions,the endogenous antioxidant selenoprotein glutathione peroxidase and the selenium transporter in blood,selenoprotein P,seem to play an important role in type 2 diabetes mellitus and insulin resistance by weakening the insulin signaling cascade through different *** findings also suggest that selenoproteins also affect insulin biosynthesis and insulin *** review discussed the role of selenium in type 2 diabetes and the complex interplay between selenoproteins and insulin pathways.

关键词： Selenium Diabetes Insulin resistance Metabolism Antioxidants

Hepatitis B transmission by cell and tissue allografts:How safe is safe enough?

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World Journal of Gastroenterology 2014年第23期20卷 7434-7441页

作者： pilar Solves Vicente Mirabet Manuel Alvarez Blood Bank Hospital Universitari I Politècnic La FeBulevar Sur46026 ValenciaSpain

More than 2 million human tissue transplants(bone,tendon,cartilage,skin,cornea,amniotic membrane,stem cells,heart valve,blood vessel,etc.),are performed worldwide every *** and tissues are shared between countries which have different regulations and laboratory equipment and represent a risk of hepatitis B virus(HBV)transmission that has become a global safety *** the risk of transfusiontransmitted HBV infection from blood donations has been estimated,the rate of HBV transmission from donors to recipients of allografts is unknown and varies between different *** are various important ways of reducing the transmission risk,but donor screening and donor testing are still the main factors for preventing HBV *** detection is included in the routine screening tests for cell and tissue *** standard test for preventing transplant-transmitted hepatitis B is the hepatitis B surface *** implementation of methods involving nucleic acid amplification and the new generation of reactives to detect viral antibodies or antigens with an immunoassay,has increased the sensitivity and the specificity of the screening *** objective of our research was to review the literature and critically analyse the different steps for avoiding HBV transmission in cell and tissue donors,focusing on the screening tests performed.

关键词： Hepatitis B virus Tissue bank Tissue transplantation

Noninvasive diagnosis of vulnerable coronary plaque

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World Journal of Cardiology 2016年第9期8卷 520-533页

作者： Eduardo Pozo pilar Agudo-Quilez Antonio Rojas-González Teresa Alvarado María José Olivera Luis Jesús jiménez-Borreguero Fernando Alfonso Cardiology Department Hospital Universitario de La PrincesaIIS-IPUniversidad Autónoma de Madrid Radiology Department Hospital Universitario de La PrincesaIIS-IPUniversidad Autónoma de Madrid Centro Nacional de Investigaciones Cardiovasculares

Myocardial infarction and sudden cardiac death are frequently the first manifestation of coronary artery *** this reason,screening of asymptomatic coronary atherosclerosis has become an attractive field of research in cardiovascular *** studies have described histopathological changes associated with the development of acute coronary *** this regard,thin-cap fibroatheroma has been identified as the main vulnerable coronary plaque ***,many imaging techniques,such as coronary computed tomography,cardiac magnetic resonance or positron emission tomography,have tried to detect noninvasively these histomorphological characteristics with different *** this article,we review the role of these diagnostic tools in the detection of vulnerable coronary plaque with particular interest in their advantages and limitations as well as the clinical implications of the derived findings.

关键词： Atherosclerosis Vulnerable coronary plaque Diagnosis Cardiac computed tomography Cardiac magnetic resonance

One-Generated Nilpotent Bicommutative Algebras

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Algebra Colloquium 2022年第3期29卷 453-474页

作者： Ivan Kaygorodov pilar Páez-Guillán Vasily Voronin Centro de Matemática e Aplicacōes Universidade da Beira InteriorCovilhãPortugal Institute of Mathematics and Mathematical ModelingAlmatyKazakhstan University of Santiago de Compostela Santiago de CompostelaSpain University of ViennaViennaAustria Novosibirsk State University NovosibirskRussia

We give a classification of 5-and 6-dimensional complex one-generated nilpotent bicommutative algebras.

关键词： bicommutative algebras nilpotent algebras algebraic classification central extension