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Type XIX collagen: a promising biomarker from the basement membranes

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Neural Regeneration Research 2020年第6期15卷 988-995页

作者： Ana C.Calvo Laura Moreno Leticia Moreno Janne M.Toivonen Raquel Manzano Nora Molina Miriam de la Torre Tresa López Francisco J.Miana-Mena María J.Munoz pilar Zaragoza pilar Larrodé Alberto García-Redondo Rosario Osta Laboratory of Genetics and Biochemistry(LAGENBIO) University of ZaragozaFaculty of Veterinary SciencesInstituto de Investigación Sanitaria de Aragón(IIS)IA2CIBERNEDZaragozaSpain Hospital Clínico Universitario Lozano Blesa ZaragozaSpain Neurology Department ALS UnitCIBERER U-723Health Research InstituteMadridSpain

Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological *** XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this *** collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different *** molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to *** most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of *** physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in ***,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic *** XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis *** novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis.

关键词： anti-tumor and anti-angiogenic properties C1 domain COL19A1 gene and protein levels compensatory effect FACIT collagens hippocampal interneurons matricryptins multiplexins NC1 domain regenerative response skeletal muscle type XIX collagen

Management of Crohn’s disease in smokers:Is an alternative approach necessary?

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World Journal of Gastroenterology 2011年第31期17卷 3567-3574页

作者： pilar Nos Eugeni Domènech Gastroenterology Unit La Fe University Hospital Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CI-BEREHD) MadridSpain Digestive Disease Department Germans Trias i Pujol Hospital

Inflammatory bowel disease(IBD) is a chronic condition with a pathogenic background that involves both genetic and environmental *** important progress has been made regarding the former in the last decade,scarce knowledge is available for the *** this sense,smoking remains the most important environmental factor in *** smoking increases the risk of developing Crohn's disease(CD).Moreover,CD patients who start or continue smoking after disease diagnosis are at risk for poorer outcomes such as higher therapeutic requirements and disease-related complications,as compared to those patients who quit smoking or who never ***,the harmful effect of active smoking is not uniform in all patients or in all clinical *** designed to facilitate smoking cessation may impact the course of the *** this article,the available evidence of the deleterious effects of smoking on CD is reviewed in detail,and alternative therapeutic approaches to CD in smokers are proposed.

关键词： Tobacco Crohn's disease Therapy Smoking cessation Recurrence Complications

Synthesis and Structural Characterization of Monocrystalline α-V₂O₅ Nanowires

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Materials Sciences and Applications 2016年第9期7卷 484-495页

作者： María Luisa Tafoya Ronquillo Patricia Santiago Jacinto pilar Ovalle Luis Rendón Vázquez Elizabeth Chavira Martínez Ernesto Marinero Vicente Garibay Instituto de Física UNAM Circuito de la Investigación s/n Ciudad Universitaria México D.F. México Instituto de Investigaciones en Materiales UNAM Circuito de la Investigación s/n Ciudad Universitaria México D.F. México Purdue University Purdue Mall West Lafayette IN USA Instituto Mexicano del Petróleo IMP México D.F. México

A stable one-dimensional system in an orthorhombic α-V2O5 nanowires monocrystalline structure was obtained by a solvothermal method from a polymorphic V2O5 structure. The starting material was firstly submitted to acid hydrolysis in H2O2 followed by a solvothermal treatment. The outcome of this procedure, a metastable phase of the one-dimensional system V10O24·12H2O/V3O7·H2O, was subsequently reoxidized by controlled heating in an open air system. The final product was an orange crystalline solid mainly formed by monocrystalline nanowires of α-V2O5 having lengths of tens of micrometers and widths of about 75 nm with a preferential [200] growth direction. It was found that the pH value of the initial solution plays an important role in the formation of the crystalline phase in the final products. Characterization was performed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HRTEM). This study offers an alternate route for the synthesis of vanadium oxides and related compounds.

关键词： Nanostructures Oxides Crystal Growth X-Ray Diffraction Crystal Structure

Interleukin 6 and interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic Leishmania infantum region

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Infectious Diseases of Poverty 2023年第1期12卷 62-70页

作者： LuisÁlvarez Pablo-Jesús Marín-García pilar Rentero-Garrido Celia pilar Martinez-jimenez Lola Llobat Department of Animal Production and Health Public Health and Food Science and TechnologyVeterinary Medicine FacultyFacultad de VeterinariaUniversidad Cardenal Herrera-CEUCEU UniversitiesValenciaSpain Precision Medicine Unit INCLIVA Biomedical Research InstituteValenciaSpain Helmholtz Pioneer Campus(HPC) Helmholtz Zentrum MünchenNeuherbergGermany

Background The Ibizan Hound is a canine breed native to the Mediterranean region,where leishmaniasis is an endemic *** studies indicate a low prevalence of this disease in Ibizan Hound dogs,whereas other canine breeds present a high ***,the underlying molecular mechanisms still remain *** aim of this work is to analyse the relationship between serum levels of cytokines and the genomic profiles in two canine breeds,Ibizan Hound(resistant canine breed model)and Boxer(susceptible canine breed model).Methods In this study,we analyse the haplotypes of genes encoding cytokines related to immune response of Leishmania infantum infection in twenty-four Boxers and twenty-eight Ibizan Hounds apparently healthy using CanineHD DNA Analysis BeadChip including 165,480 mapped *** *** extension of *** was used to perform a General Linear Model(GLM)regression to estimate the magnitude of individual haplotype effects within each *** Mean levels of interferon gamma(IFN-γ),interleukin 2(IL-2)and IL-18 in Boxer dogs were 0.19±0.05 ng/ml,46.70±4.54 ng/ml,and 36.37±30.59 pg/ml,whereas Ibizan Hound dogs present 0.49±0.05 ng/ml,64.55±4.54 ng/ml,and 492.10±31.18 pg/ml,*** GLM regression shows fifteen haplotypes with statistically significant effect on the cytokine serum levels(P<0.05).The more relevant are IL6-CGAAG and IFNG-GCA haplotypes,which increase and decrease the IL-2,IL-8 and IFN-γserum levels,*** Haplotypes in the IFNG and IL6 genes have been correlated to serum levels of IFN-γ,IL-2 and IL-18,and a moderate effect has been found on IL8 haplotype correlated to IL-8 and IL-18 serum *** results indicate that the resistance to *** infection could be a consequence of certain haplotypes with a high frequency in the Ibizan Hound dog breed,while susceptibility to the disease would be related to other specific haplotypes,with high frequency in *** studies are nee

关键词： Cytokine Haplotype Dog Immune response Regulatory mechanism Resistance Susceptibility

Clinical value of rapid urine trypsinogen-2 test strip, urinary trypsinogen activation peptide, and serum and urinary activation peptide of carboxypeptidase B in acute pancreatitis

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World Journal of Gastroenterology 2005年第46期11卷 7261-7265页

作者： Jesús Sáez Juan Martínez Celia Trigo José Sánchez-Payá Luis Compay Raquel Laveda pilar Grió Cristina García Miguel Pérez-Mateo Section of Gastroenterology and Department of Internal Medicine Hospital General Universitario de Alicante Alicante Spain Service of Clinical Laboratory Hospital General Universitario de Alicante Alicante Spain Service of Preventive Medicine Hospital General Universitario de Alicante Alicante Spain Section of Gastroenterology and Department of Internal MedicineHospital General Universitario de Alicante AlicanteSpain

AIM: To assess the usefulness of urinary trypsinogen-2 test strip, urinary trypsinogen activation peptide (TAP),and serum and urine concentrations of the activation peptide of carboxypeptidase B (CAPAP) in the diagnosisof acute ***: Patients with acute abdominal pain and hospitalized within 24 h after the onset of symptoms were prospectively studied. Urinary trypsinogen-2 was considered positive when a clear blue line was observed (detection limit 50 μg/L). Urinary TAP was measured using a quantitative solid-phase ELISA, and serum and urinary CAPAP by a radioimmunoassay ***: Acute abdominal pain was due to acute pancreatitis in 50 patients and turned out to be extrapancreatic in origin in 22 patients. Patients with acute pancreatitis showed significantly higher median levels of serum and urinary CAPAP levels, as well as amylase and lipase than extrapancreatic controls. Median TAP levels were similar in both groups. The urinary trypsinogen-2 test strip was positive in 68% of patients with acute pancreatitis and 13.6% in extrapancreatic controls (P<0.01). Urinary CAPAP was the most reliable test for the diagnosis of acute pancreatitis (sensitivity 66.7%, specificity 95.5%, positive and negative predictive values 96.6% and 56.7%, respectively), with a 14.6 positive likelihood ratio for a cut-off value of 2.32 nmol/***: In patients with acute abdominal pain,hospitalized within 24 h of symptom onset, CAPAP in serum and urine was a reliable diagnostic marker of acute pancreatitis. Urinary trypsinogen-2 test strip showed a clinical value similar to amylase and *** TAP was not a useful screening test for the diagnosis of acute pancreatitis.

关键词： Acute pancreatitis Urinary trypsinogen-2 Urinary trypsinogen activation peptide Activation peptide of carboxypeptidase B Acute abdominal pain

Medical consultation in ulcerative colitis:Key elements for improvement

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World Journal of Gastroenterology 2023年第6期29卷 917-925页

作者： Yago González-Lama Elena Ricart Ana Cábez pilar Fortes Susana Gómez Francesc Casellas Inflammatory Bowel Disease Unit Department of Gastroenterology and HepatologyHospital Universitario Puerta de Hierro-MajadahondaMadrid 28222Spain Inflammatory Bowel Disease Unit Department of GastroenterologyHospital ClínicBarcelona 08036Spain Biomedical Research Networking Center in Hepatic and Digestive Diseases(CIBERehd) Barcelona 08036Spain Department of Medical Pfizer SpainMadrid 28108Spain Servicio de Reumatología Hospital Universitario de SalamancaSalamanca 37007Spain Department of Gastroenterology Vall d'Hebron Research InstituteBarcelona 08035Spain

Ulcerative colitis(UC)is a chronic inflammatory disease with a high *** order to improve patient outcomes,the clinician-patient relationship in daily practice is *** guidelines provide a framework for UC diagnosis and ***,standard procedures and the medical content focused upon medical consultations in UC patients has not yet been ***,UC is a complex disease,given that patient characteristics and patient needs have been proven to vary during clinical consultation since establishing the diagnosis and upon the course of the *** this article,we have discussed the key elements and specific objectives to consider in medical consultation,such as diagnosis,first visits,follow-up visits,active disease patients,patients on topical therapies,new treatment initiation,refractory patients,extra-intestinal manifestations,as well as challenging *** key elements have been mentioned to comprise effective communication techniques,motivational interviewing(MI),as well as information and educational aspects,or organizational *** key elements to be implemented in daily practice were reported to comprise several general principles like duly prepared consultations,in addition to honesty and empathy with patients,as well as effective communication techniques,MI,information and educational points,or organizational *** role of other healthcare professionals such as specialized nurses,psychologists,or the use of checklists was also discussed and commented on.

关键词： Ulcerative colitis Patient experience Shared decision making Medical consultation Motivational interviewing Patient education

In the era of rapid mRNA-based vaccines:Why is there no effective hepatitis C virus vaccine yet?

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World Journal of Hepatology 2021年第10期13卷 1234-1268页

作者： Natalia Echeverria Victoria Comas Fabian Aldunate Paula Perbolianachis pilar Moreno Juan Cristina Laboratorio de Virologia Molecular Centro de Investigaciones NuclearesFacultad de CienciasUniversidad de la RepublicaMontevideo 11400Uruguay Laboratorio de Evolucion Experimental de Virus Institut PasteurMontevideo 11400Uruguay Departamento de Desarrollo Biotecnologico Instituto de HigieneFacultad de MedicinaUniversidad de la RepublicaMontevideo 11600Uruguay

Hepatitis C virus(HCV)is responsible for no less than 71 million people chronically infected and is one of the most frequent indications for liver transplanta-tion *** direct-acting antiviral therapies fuel optimism in controlling HCV infections,there are several obstacles regarding treatment accessibility and reinfection continues to remain a ***,the majority of new HCV infections in developed countries occur in people who inject drugs and are more plausible to get *** achieve global epidemic control of this virus the development of an effective prophylactic or therapeutic vaccine becomes a *** coronavirus disease 19(COVID-19)pandemic led to auspicious vaccine development against severe acute respiratory syndrome coronavirus-2(SARSCoV-2)virus,which has renewed interest on fighting HCV epidemic with *** aim of this review is to highlight the current situation of HCV vaccine candidates designed to prevent and/or to reduce HCV infectious cases and their *** will emphasize on some of the crossroads encountered during vaccine development against this insidious virus,together with some key aspects of HCV immunology which have,so far,ham-pered the progress in this *** main focus will be on nucleic acid-based as well as recombinant viral vector-based vaccine candidates as the most novel vaccine approaches,some of which have been recently and successfully employed for SARS-CoV-2 ***,some ideas will be presented on which methods to explore for the design of live-attenuated vaccines against HCV.

关键词： Hepatitis C virus Vaccine candidates Nucleic acid-based vaccines Recombinant vector-based vaccines Challenges COVID-19

Current approach to treatment of minimal hepatic encephalopathy in patients with liver cirrhosis

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World Journal of Gastroenterology 2021年第22期27卷 3050-3063页

作者： Segundo Moran Marlene López-Sánchez María del pilar Milke-García Gustavo Rodríguez-Leal Laboratory of Hepatology Research Centro Médico NacionalSiglo XXIMexican Institute of Social SecurityMexico City 06720Mexico Division of Nutrition National Institute of NutritionSalvador ZubiránMexico City 14080Mexico

Minimal hepatic encephalopathy(MHE)corresponds to the earliest stage of hepatic encephalopathy(HE).MHE does not present clinically detectable neurological-psychiatric abnormalities but is characterized by imperceptible neurocognitive alterations detected during routine clinical examination via neuropsychological or psychometrical *** may affect daily activities and reduce job performance and quality of *** can increase the risk of accidents and may develop into overt encephalopathy,worsening the prognosis of patients with liver *** a lack of consensus on the therapeutic indication,interest in finding novel strategies for prevention or reversion has led to numerous clinical trials;their results are the main objective of this *** studies address the treatment of MHE,which is mainly based on the strategies and previous management of overt *** alternatives for the management of MHE include measures to maintain nutritional status while avoiding sarcopenia,and manipulation of intestinal microbiota with non-absorbable disaccharides such as lactulose,antibiotics such as rifaximin,and administration of different *** review analyzes the results of clinical studies that evaluated the effects of different treatments for MHE.

关键词： Minimal hepatic encephalopathy Sarcopenia Probiotics Non-absorbable disaccharides,Rifaximin L-ornithine-L-aspartate

Short and long term fate of human AMSC subcutaneously injected in mice

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World Journal of Stem Cells 2011年第6期3卷 53-62页

作者： pilar López-Iglesias Alejandro Blázquez-Martínez Jorge Fernández-Delgado Javier Regadera Manuel Nistal Maria P De Miguel Cell Engineering Laboratory IdiPazLa Paz Hospital Research Institute Department of Plastic Surgery and Center for Comprehensive Breast Treatment Santa Cristina Hospital Department of Histology and Neuroscience Autonomous University of Madrid 28046Spain Department of Pathology La Paz Hospital

AIM:To study the ability of human adipose-derived mesenchymal stem cells(AMSCs)to survive over the short and long term,their biodistribution and their biosafety in vivo in tumor-prone ***:We subcutaneously injected human AMSCs from different human donors into immunodeficient SCID mice over both short-(2 and 4 mo)and long-(17 mo)term in young,and aged tumor-prone *** of human cells was studied by immunohistochemistry and polymerase chain reaction analysis in all organs of injected ***:Subcutaneously injected AMSCs did not form teratomas at any time *** did not migrate but remained at the site of injection regardless of animal age,and did not fuse with host cells in any organ *** survived in vivo for at least 17 mo after injection,and differentiated into fibroblasts of the subdermic connective tissue and into mature adipocytes of fat tissue,exclusively at the site of ***:Our results support the assertion that AMSC may be safe candidates for therapy when injected subcutaneously because of their long term inability to form teratomas.

关键词： Adipose-derived stem cells Cell transplant SCID mice Teratoma Mesenchymal stem cells Cell therapy Biosafety