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Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus

World Journal of Gastroenterology 2005年第47期11卷 7436-7443页

作者： Elena Piazuelo Carmelo Cebrián Alfredo Escartín pilar Jiménez Fernando Soteras Javier Ortego Angel Lanas Instituto Aragonés de Ciencias de la Salud Unidad Mixta de InvestigaciónC/Domingo Miral s/n 50009 ZaragozaSpain Service of Pathology Hospital Clínico Universitario "Lozano Blesa"Avenida San Juan Bosco15 50009 ZaragozaSpain Unidad Mixta de Investigatión University of ZaragozaDomingo Miral s/n 50009 ZaragozaSpain Unidad Mixta de Investigación University of ZaragozaDomingo Miral s/n 50009 ZaragozaSpain Service of Gastroenterology Hospital Clínico Universitario "Lozano Blesa"Avenida San Juan Bosco15 50009 ZaragozaSpain

AIM： To test whether antioxidant treatment could prevent the progression of Barrett＇s esophagus to adenocarcinoma. METHODS： In a rat model of gastroduodenoesophageal reflux by esophagojejunal anastomosis with gastric preservation, groups of 6-10 rats were randomized to receive treatment with superoxide dismutase （SOD） or vehicle and followed up for 4 too. Rat＇s esophagus was assessed by histological analysis, superoxide anion and peroxinitrite generation, SOD levels and DNA oxidative damage. RESULTS： All rats undergoing esophagojejunostomy developed extensive esophageal mucosal ulceration and inflammation by mo 4. The process was associated with a progressive presence of intestinal metaplasia beyond the anastomotic area （9% 1st mo and 50% 4th too）（94% at the anastomotic level） and adenocarcinoma （11% 1^ST mo and 60% 4th too）. These changes were associated with superoxide anion and peroxinitrite mucosal generation, an early and significant increase of DNA oxidative damage and a significant decrease in SOD levels （P〈0.05）. Exogenous administration of SOD decreased mucosal superoxide levels, increased mucosal SOD levels and reduced the risk of developing intestinal metaplasia beyond the anastomotic area （odds ratio = 0.326; 95%CI： 0.108-0.981; P = 0.046）, and esophageal adenocarcinoma （odds ratio = 0.243; 95%CI： 0.073-0.804; P = 0.021）. CONCLUSION： Superoxide dismutase prevents the progression of esophagitis to Barrett＇s esophagus and adenocarcinoma in this rat model of gastrointestinal reflux, supporting a role of antioxidants in the chemoprevention of esophageal adenocarcinoma.

关键词： Barrett's esophagus Esophageal adenocarcinoma Free radicals Oxidative damage Superoxide dismutase

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Isotopic niche provides an insight into the ecology of a symbiont during its geographic expansion

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Current Zoology 2022年第2期68卷 185-197页

作者： Enrique GONZALEZ-ORTEGON Marta PEREZ-MIGUEL Jose I.NAVAS pilar DRAKE Jose A.CUESTA Instituto de Ciencias Marinas de Andalucia(ICMAN-CSIC) Campus Universitario Rio San PedroAvda.Republica Saharaui211519CadizPuerto RealSpain Unidad Asociada Crecimiento Azul CSIC-IFAPA El Puerto de Santa Maria SpainSpain Instituto de Investigacion y Formacion Agraria y Pesquera IFAPA-Centro Agua del PinoCtra.EI Rompido-Punta Umbriakm 3.821459 EI RompidoHuelvaSpain

The study of the recent colonization of a symbiont and its interaction with host communities in new locations is an opportunity to understand how they *** use of isotopic ratios in trophic ecology can provide measurements of a species'isotopic niche,as well as knowledge about how the isotopic niches between symbiont and host species *** isotope measurements were used to assess the sources of carbon assimilated by the host species(the bivalves Mytilus galloprovincialis and Scrobicularia plana)and their associated symbiont pea crab Afropinnotheres monodi,which occurs within these bivalves'mantle *** mixing model estimates suggest that all of them assimilate carbon from similar sources,particularly from pseudofaeces and particulate organic matter in this symbiotic system based on filter *** symbiotic species occupy comparable trophic levels and its association seems to be commensal or parasitic depending on the duration of such *** pea crab *** reflects a sex-specific diet,where males are more generalist than the soft females because the latter's habitat is restricted to the host *** high isotopic overlap between soft females and *** may reflect a good commensal relationship with the host.

关键词： bivalves commensal kleptoparasitism parasitism stable isotope trophic position

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Adaptation of international coronavirus disease 2019 and breast cancer guidelines to local context

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World Journal of Clinical Oncology 2021年第1期12卷 31-42页

作者： Guillermo Arturo valencia Silvia Neciosup Henry L Gómez Maria Del pilar Benites Silvia Falcón David Moron Karin Veliz Mike Maldonado Rodrigo Auqui Department of Medical Oncology Instituto Nacional de Enfermedades Neoplásicas(INEN)Surquillo 15000LimaPeru Clínica Oncosalud–AUNA Surquillo 15000LimaPeru Breast Cancer Unit Hospital Nacional Edgardo Rebagliati MartinsLima 15000Peru Department of Medical Oncology Centro Oncológico AliadaLima 15000Peru Department of Medical Oncology Hospital Nacional Carlos Alberto Seguín EscobedoArequipa 04001Peru Department of Medical Oncology Hospital Nacional Ramiro PrialéPrialéHuancayo 12000Peru Department of Medical Oncology Instituto Regional de Enfermedades Neoplásicas(IREN)Trujillo 13001Peru Department of Medical Oncology Hospital Nacional Almanzor Aguinaga AsenjoChiclayo 14001Peru

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(a novel coronavirus),which was first identified amid an outbreak of respiratory illness cases in Wuhan,China and declared a global health emergency,is currently considered an additional challenge in the management of patients with breast cancer(BC).Cancer patients are more vulnerable to becoming infected with severe acute respiratory syndrome coronavirus 2 and are more likely to suffer additional complications that can increase *** those BC patients who require more urgent therapy than others in the current situation is *** recommendations are based on and have been adapted from those similarly published by international scientific societies for BC *** are divided mainly by clinical stage(early,advanced),subtype[luminal,human epidermal growth factor receptor 2(HER2),triple-negative],or type of medical treatment and setting(neoadjuvant,adjuvant,metastatic).Recommendations for HER2 and triplenegative subtypes are similar,whereas in luminal subtype there are various options of *** objective is to adapt guidelines to local context through relevant decision-makers,avoiding duplication of efforts and optimizing use or *** hope that these recommendations will help medical oncologists provide the best quality care to BC patients during the COVID-19 pandemic with information tailored to our healthcare *** To establish and adapt recommendations from those published by international scientific societies for BC *** The Peruvian Society of Medical Oncology developed a consensus and propose here a manuscript with recommendations for oncological medical treatment of BC during the COVID-19 *** Peruvian Society of Medical Oncology invited a panel of experts and opinion leaders on BC working in major health care systems around *** experts selected three international clin

关键词： Breast cancer COVID-19 Guidelines Recommendations Oncology Medical treatment

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Design of a kJ-class HiLASE laser as a driver for inertial fusion energy

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High Power Laser Science and Engineering 2014年第2期2卷 1-10页

作者： Antonio Lucianetti Magdalena Sawicka Ondrej Slezak Martin Divoky Jan pilar Venkatesan Jambunathan Stefano Bonora Roman Antipenkov Tomas Mocek HiLASE Project Institute of Physics AS CR Na Slovance 2 18221 Prague Czech Republic CNR-IFN Via Trasea 7 35131 Padova Italy ELI Beamlines Project Institute of Physics AS CR Na Slovance 2 18221 Prague Czech Republic

We present the results of performance modeling of a diode-pumped solid-state HiLASE laser designed for use in inertial fusion energy power plants. The main amplifier concept is based on a He-gas-cooled multi-slab architecture similar to that employed in Mercury laser system. Our modeling quantifies the reduction of thermally induced phase aberrations and average depolarization in Yb3+:YAG slabs by a combination of helium cryogenic cooling and properly designed(doping/width) cladding materials.

关键词： ASE birefringence cryogenic cooling slab lasers thermooptic effects

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Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism

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World Journal of Gastroenterology 2017年第28期23卷 5246-5252页

作者： Fernando Díaz-Fontenla Marta Castillo-Pradillo Arantxa Díaz-Gómez Luis Ibanez-Samaniego pilar Gancedo Juan Adan Guzmán-de-Villoria pilar Fernández-García Rafael Banares-Canizares Rita García-Martínez Unidad de Hepatología Servicio de Aparato DigestivoHospital General Universitario Gregorio Maranón Instituto de Investigación Sanitaria Hospital Gregorio Maranón Servicio de Aparato Digestivo Hospital Santa Bárbara Servicio de Radiodiagnóstico Hospital General Universitario Gregorio Maranón Centro de Investigación Biomédica en Red de Salud Mental Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Facultad de Medicina Universidad San Pablo CEU

Hepatic encephalopathy(HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE is an uncommon but serious condition that requires the search of hidden precipitating events(i.e.,portosystemic shunt) and alternative diagnosis. Hypothyroidism shares clinical manifestations with HE and is usually considered within the differential diagnosis of HE. Here,we describe a patient with refractory HE who presented a large portosystemic shunt and post-ablative hypothyroidism. Her cognitive impairment,hyperammonaemia,electroencephalograph alterations,impaired neuropsychological performance,and magnetic resonance imaging and spectroscopy disturbances were highly suggestive of HE,paralleled the course of hypothyroidism and normalized after thyroid hormone replacement. There was no need for intervention over the portosystemic shunt. The case findings support that hypothyroidism may precipitate HE in cirrhotic patients by inducing hyperammonaemia and/or enhancing ammonia brain toxicity. This case led us to consider hypothyroidism not only in the differential diagnosis but also as a precipitating factor of HE.

关键词： Hepatic encephalopathy Hypothyroidism Cognitive impairment Cirrhosis Portosystemic shunt Magnetic resonance spectroscopy

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Narcea—an unknown,ancient cultivated rose variety from northern Spain

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Horticulture Research 2020年第1期7卷 2217-2228页

作者： María-Carmen Martínez José-Luis Santiago Susana Boso pilar Gago InmaculadaÁlvarez-Acero María-Estela De Vega Miguel Martínez-Bartolomé RafaelÁlvarez-Nogal pilar Molíst Matteo Caser Valentina Scariot Daniel Gómez-García Misión Biológica de Galicia(CSIC) Carballeira 8Salcedo 36143 PontevedraSpain Instituto de Ciencia y Tecnología de Alimentos y Nutrición(CSIC)(Spain) C/JoséAntonio Novais 1028040 MadridSpain Departamento de Biología Molecular-Área de Biología Celular Universidad de LeónCampus de Vegazana s/n24071 LeónSpain Grupo Neurolamb Biología funcional y Ciencias de la SaludUniversidad de Vigo(Spain)36310 As Lagoas-MarcosendeSpain Department of Agricultural Forest and Food SciencesUniversity of TorinoLargo Paolo Braccini 210095 GrugliascoTurinItaly Instituto Pirenaico de Ecología(CSIC) Dpto.Conservación de Ecosistemas NaturalesAvda.Montaña S/NZaragoza50016 ZaragozaSpain

The present work reports the discovery and the complete characterisation of an ancient cultivated rose variety found growing in a private garden in the southwest of the Principality of Asturias(northern Spain).The variety is here given the name *** majority of roses currently cultivated belong to the so-called group of‘Modern Roses’,all of which were obtained after 1867 via artificial crosses and improvement *** are destined for ornamental *** the 19th century,the great majority of the many ancient cultivated roses in Europe were used in perfumery and cosmetics,or had medicinal *** damascena and Rosa centifollia are still grown and used by the French and Bulgarian perfume *** Asturian Massif of the Cantabrian Mountain Range provides a natural habitat for some 75%of the wild members of the genus Rosa,but until now there was no evidence that this area was home to ancient cultivated roses.A complete botanical description is here provided for a discovered ancient *** is also characterised according to a series of sequence tagged microsatellite sites,and its agronomic features are *** addition,a histological description(optical and scanning electronic microscope studies)of the petals is offered,along with an analysis of the volatile compounds present in these organs as determined by solid phase microextraction and gas chromatography-mass *** results reveal the uniqueness of this ancient type of rose and suggest it may be of interest to the perfume industry.

关键词： ancient southwest majority

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Type XIX collagen: a promising biomarker from the basement membranes

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Neural Regeneration Research 2020年第6期15卷 988-995页

作者： Ana C.Calvo Laura Moreno Leticia Moreno Janne M.Toivonen Raquel Manzano Nora Molina Miriam de la Torre Tresa López Francisco J.Miana-Mena María J.Munoz pilar Zaragoza pilar Larrodé Alberto García-Redondo Rosario Osta Laboratory of Genetics and Biochemistry(LAGENBIO) University of ZaragozaFaculty of Veterinary SciencesInstituto de Investigación Sanitaria de Aragón(IIS)IA2CIBERNEDZaragozaSpain Hospital Clínico Universitario Lozano Blesa ZaragozaSpain Neurology Department ALS UnitCIBERER U-723Health Research InstituteMadridSpain

Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological *** XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this *** collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different *** molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to *** most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of *** physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in ***,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic *** XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis *** novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis.

关键词： anti-tumor and anti-angiogenic properties C1 domain COL19A1 gene and protein levels compensatory effect FACIT collagens hippocampal interneurons matricryptins multiplexins NC1 domain regenerative response skeletal muscle type XIX collagen

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Therapy with stem cells in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1211-1227页

作者： María del pilar Martínez-Montiel Gonzalo Jesús Gómez-Gómez Ana Isabel Flores IBD Unit Department of Gastroenterology Universitary Hospital 12 Octubre Medicine Regenerative Group Investigation Center 12 Octubre Investigation Institute

Inflammatory bowel disease (IBD) affects a part of the young population and has a strong impact upon quality of life. The underlying etiology is not known, and the existing treatments are not curative. Furthermore, a significant percentage of patients are refractory to therapy. In recent years there have been great advances in our knowledge of stem cells and their therapeutic applications. In this context, autologous hematopoietic stem cell transplantation (HSCT) has been used in application to severe refractory Crohn’s disease (CD), with encouraging results. Allogenic HSCT would correct the genetic defects of the immune system, but is currently not accepted for the treatment of IBD because of its considerable risks. Mesenchymal stem cells (MSCs) have immune regulatory and regenerative properties, and low immunogenicity (both autologous and allogenic MSCs). Based on these properties, MSCs have been used via the systemic route in IBD with promising results, though it is still too soon to draw firm conclusions. Their local administration in perianal CD is the field where most progress has been made in recent years, with encouraging results. The next few years will be decisive for defining the role of such therapy in the management of IBD.

关键词： Mesenchymal stem cell, Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Haematopoietic stem cell transplantation

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Current approach to treatment of minimal hepatic encephalopathy in patients with liver cirrhosis

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World Journal of Gastroenterology 2021年第22期27卷 3050-3063页

作者： Segundo Moran Marlene López-Sánchez María del pilar Milke-García Gustavo Rodríguez-Leal Laboratory of Hepatology Research Centro Médico NacionalSiglo XXIMexican Institute of Social SecurityMexico City 06720Mexico Division of Nutrition National Institute of NutritionSalvador ZubiránMexico City 14080Mexico

Minimal hepatic encephalopathy(MHE)corresponds to the earliest stage of hepatic encephalopathy(HE).MHE does not present clinically detectable neurological-psychiatric abnormalities but is characterized by imperceptible neurocognitive alterations detected during routine clinical examination via neuropsychological or psychometrical *** may affect daily activities and reduce job performance and quality of *** can increase the risk of accidents and may develop into overt encephalopathy,worsening the prognosis of patients with liver *** a lack of consensus on the therapeutic indication,interest in finding novel strategies for prevention or reversion has led to numerous clinical trials;their results are the main objective of this *** studies address the treatment of MHE,which is mainly based on the strategies and previous management of overt *** alternatives for the management of MHE include measures to maintain nutritional status while avoiding sarcopenia,and manipulation of intestinal microbiota with non-absorbable disaccharides such as lactulose,antibiotics such as rifaximin,and administration of different *** review analyzes the results of clinical studies that evaluated the effects of different treatments for MHE.

关键词： Minimal hepatic encephalopathy Sarcopenia Probiotics Non-absorbable disaccharides,Rifaximin L-ornithine-L-aspartate

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In the era of rapid mRNA-based vaccines:Why is there no effective hepatitis C virus vaccine yet?

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World Journal of Hepatology 2021年第10期13卷 1234-1268页

作者： Natalia Echeverria Victoria Comas Fabian Aldunate Paula Perbolianachis pilar Moreno Juan Cristina Laboratorio de Virologia Molecular Centro de Investigaciones NuclearesFacultad de CienciasUniversidad de la RepublicaMontevideo 11400Uruguay Laboratorio de Evolucion Experimental de Virus Institut PasteurMontevideo 11400Uruguay Departamento de Desarrollo Biotecnologico Instituto de HigieneFacultad de MedicinaUniversidad de la RepublicaMontevideo 11600Uruguay

Hepatitis C virus(HCV)is responsible for no less than 71 million people chronically infected and is one of the most frequent indications for liver transplanta-tion *** direct-acting antiviral therapies fuel optimism in controlling HCV infections,there are several obstacles regarding treatment accessibility and reinfection continues to remain a ***,the majority of new HCV infections in developed countries occur in people who inject drugs and are more plausible to get *** achieve global epidemic control of this virus the development of an effective prophylactic or therapeutic vaccine becomes a *** coronavirus disease 19(COVID-19)pandemic led to auspicious vaccine development against severe acute respiratory syndrome coronavirus-2(SARSCoV-2)virus,which has renewed interest on fighting HCV epidemic with *** aim of this review is to highlight the current situation of HCV vaccine candidates designed to prevent and/or to reduce HCV infectious cases and their *** will emphasize on some of the crossroads encountered during vaccine development against this insidious virus,together with some key aspects of HCV immunology which have,so far,ham-pered the progress in this *** main focus will be on nucleic acid-based as well as recombinant viral vector-based vaccine candidates as the most novel vaccine approaches,some of which have been recently and successfully employed for SARS-CoV-2 ***,some ideas will be presented on which methods to explore for the design of live-attenuated vaccines against HCV.

关键词： Hepatitis C virus Vaccine candidates Nucleic acid-based vaccines Recombinant vector-based vaccines Challenges COVID-19

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