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Influence on Time to Cryopreservation in Umbilical Cord Blood Units

International Journal of Clinical Medicine 2011年第4期2卷 399-403页

作者： Isidro Prat-Arrojo Laura Ponce-Verdugo María del Carmen Hernández-Lamas Rebeca Rodríguez-Pena Cristina Antúnez Francisco Sánchez-gordo gracia garcía-gemar pilar gómez-maldonado 不详

It is accepted that the Umbilical Cord Blood (UCB) units can be cryopreserved to 48 h after their harvest and the delay in this procedure influences the final quality. The aim of this study was to determine the influence on time to cryopreservation in Umbilical Cord Blood Units. A selection of the 2134 samples arrived to the UCB Bank from 36 Andalusian linked hospitals was analyzed for a period of six months. The date and hour of collection, hospital of origin, time in the hospital, time of transport, time of arrival to the bank to cryopreservation, viability and CD34+ cells were determined. Our results showed that the median time from harvest to cryopreservation was 27.9 h. However, a great variability was found (range: 5.3 to 47.6 h), which was dependent on transport variables: time from collection to leave the hospital (median 12.6 h, range: 0.1 - 28.8), time of transport from hospital to UCB Bank (median 1.8 h, range: 0.1 - 20.6) and time kept in the bank before freezing. Viability of cells were reduced directly proportional in samples that took longer to be cryopreserved (93.9 vs 96.6%, p = 0.001), by contrast, CD34+ count did not differ significant at shorter or longer times of cryopreservation. In conclusion, the delay in transport time and in processing reduce the umbilical cord units quality, consequently, the time of transport and storage previous to cryopreservation must be reduced less than 36 h.

关键词： Cord Blood Viability CD34+ Cryopreservation

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Adaptation of international coronavirus disease 2019 and breast cancer guidelines to local context

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World Journal of Clinical Oncology 2021年第1期12卷 31-42页

作者： guillermo Arturo Valencia Silvia Neciosup Henry L gómez Maria Del pilar Benites Silvia Falcón David Moron Karin Veliz Mike maldonado Rodrigo Auqui Department of Medical Oncology Instituto Nacional de Enfermedades Neoplásicas(INEN)Surquillo 15000LimaPeru Clínica Oncosalud–AUNA Surquillo 15000LimaPeru Breast Cancer Unit Hospital Nacional Edgardo Rebagliati MartinsLima 15000Peru Department of Medical Oncology Centro Oncológico AliadaLima 15000Peru Department of Medical Oncology Hospital Nacional Carlos Alberto Seguín EscobedoArequipa 04001Peru Department of Medical Oncology Hospital Nacional Ramiro PrialéPrialéHuancayo 12000Peru Department of Medical Oncology Instituto Regional de Enfermedades Neoplásicas(IREN)Trujillo 13001Peru Department of Medical Oncology Hospital Nacional Almanzor Aguinaga AsenjoChiclayo 14001Peru

BACKgROUND The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(a novel coronavirus),which was first identified amid an outbreak of respiratory illness cases in Wuhan,China and declared a global health emergency,is currently considered an additional challenge in the management of patients with breast cancer(BC).Cancer patients are more vulnerable to becoming infected with severe acute respiratory syndrome coronavirus 2 and are more likely to suffer additional complications that can increase *** those BC patients who require more urgent therapy than others in the current situation is *** recommendations are based on and have been adapted from those similarly published by international scientific societies for BC *** are divided mainly by clinical stage(early,advanced),subtype[luminal,human epidermal growth factor receptor 2(HER2),triple-negative],or type of medical treatment and setting(neoadjuvant,adjuvant,metastatic).Recommendations for HER2 and triplenegative subtypes are similar,whereas in luminal subtype there are various options of *** objective is to adapt guidelines to local context through relevant decision-makers,avoiding duplication of efforts and optimizing use or *** hope that these recommendations will help medical oncologists provide the best quality care to BC patients during the COVID-19 pandemic with information tailored to our healthcare *** To establish and adapt recommendations from those published by international scientific societies for BC *** The Peruvian Society of Medical Oncology developed a consensus and propose here a manuscript with recommendations for oncological medical treatment of BC during the COVID-19 *** Peruvian Society of Medical Oncology invited a panel of experts and opinion leaders on BC working in major health care systems around *** experts selected three international clin

关键词： Breast cancer COVID-19 guidelines Recommendations Oncology Medical treatment

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Nucleation of Fe-Rich Intermetallic Phases on α-Al_(2)O_(3) Oxide Films in Al-Si Alloys

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Journal of Minerals and Materials Characterization and Engineering 2015年第1期3卷 15-25页

作者： pilar Orozco-gonzalez Manuel Castro-Roman Simitrio maldonado-Ruiz Sergio Haro-Rodriguez Fabian Equihua-guillen Rodrigo Muniz-Valdez Salvador Luna-Alvarez Miguel Montoya-Davila Alejandra Hernandez-Rodriguez Academic Unit of Engineering Autonomous University of ZacatecasZacatecasMexico CINVESTAV Saltillo SaltilloMexico Faculty of Engineering Autonomous University of CoahuilaMexico

Nucleation of Fe-rich intermetallic phases on α-Al2O3 oxide films was analyzed in five experimental Al-Fe-Mn-Si alloys. In an attempt to verify the role of α-Al2O3 films in nucleating Fe-rich intermetallics, experiments have been conducted under conditions where formed in situ oxide films were present. Some Fe-rich intermetallics are observed to be related with the oxide films in the microstructure, the present results are in accordance with some research that suggest that the Fe-rich intermetallic phases nucleate upon the oxide films. The intermetallic phases and α-Al2O3 films were unambiguously identified with the help of complementary techniques such as thermal analysis, SEM/EDS and X-ray diffraction.

关键词： Aluminum Alloys Intermetallics Nucleation Crystal growth Oxide Films

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