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The Production, Scientific and Therapeutic Use of Human Embryonic Stem Cell: the Ethic Concern

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Journal of Reproduction and Contraception 2002年第2期13卷 117-122页

作者： pilar Calva

This article presents opinions on use of embryonic stem cells in the scientific and ethical literature and in public opinion. Given the growing relevance of the debate on the limits and licitness of the production and use of such cells, there is a pressing need to reflect on the ethical implications, which are present in this article.

关键词： embryonic stem cell ethic

Beam shaping in the high-energy kW-class laser system Bivoj at the HiLASE facility

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High Power Laser Science and Engineering 2023年第6期11卷 130-138页

作者： Tomáš Paliesek Petr Navrátil Jan pilar Martin Divoký Martin Smrž Tomáš Mocek HiLASE Centre Institute of Physics of the Czech Academy of SciencesDolni BrezanyCzech Republic Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in PraguePragueCzech Republic

A fully automatic fail-safe beam shaping system based on a liquid crystal on a silicon spatial light modulator has been implemented in the high-energy kilowatt-average-power nanosecond laser system *** shaping system corrects for gain nonuniformity and wavefront aberrations of the front-end of the *** beam intensity profile and the wavefront at the output of the front-end were successfully improved by *** beam homogeneity defined by the beam quality parameters was improved two to three *** root-mean-square value of the wavefront was improved more than 10 ***,the shaped beam from the second preamplifier led to improvement of the beam profile at the output of the first main *** shaping system is also capable of creating nonordinary beam shapes,imprinting cross-references into the beam,or masking certain parts of the beam.

关键词： beam shaping high-average-power laser high-energy laser liquid crystal on silicon spatial light modulator wavefront shaping

Collective Action in Common Pool Resource Management, Including Heterogeneity of Opportunities and Exit Options

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Natural Resources 2013年第8期4卷 483-489页

作者： pilar Useche Department of Food and Resource Economics & Center for Latin American Studies University of Florida Gainesville USA

The mechanism through which exit options and outside opportunities affect cooperation outcomes has not been well studied in the resource management literature, since a deep analysis of the concepts of “exit options” and “outside opportunities” is missing. This article analyzes these concepts across the common pool resource management literature, investigates the factors that underlie “opting out” decisions, and reviews potential ways to operationalize these concepts for empirical analysis. It also explores how the relationship of cooperation and exit options may be influenced by broad economic processes, such as economic integration.

关键词： Natural Resource Management Collective Action Common Pool Resources Environmental Economics Economic Development

Experimental evidence of Bloch surface waves on photonic crystals with thin-film LiNbO_3 as a top layer

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光子学研究：英文版 2017年第6期5卷 168-172页

作者： TATIANA KOVALEVICH DJAFFAR BELHARET LAURENT ROBERT MYUN-SIK KIM HANS PETER HERZIG THIERRY GROSJEAN MARIA-pilar BERNAL Département d'Optique P.M.Duffieux Institut FEMTO-ST UMR 6174 CNRS Université Bourgogne Franche-Comté Optics & Photonics Technology Laboratory Ecole Polytechnique Fédérale de Lausanne (EPFL)

Strong nonlinear, electro-optical, and thermo-optical properties of lithium niobate(LN) have gained much attention. However, the implementation of LiNbO_3 in real devices is not a trivial task due to difficulties in manufacturing and handling thin-film LN. In this study, we investigate an optical device where the Bloch surface wave(BSW) propagates on the thin-film LN to unlock its properties. First, access to the LN film from air(or open space) is important to exploit its properties. Second, for sustaining the BSW, one-dimensional photonic crystal(1DPhC) is necessary to be fabricated under the thin-film LN. We consider two material platforms to realize such a device: bulk LN and commercial thin-film LN. Clear reflectance dips observed in far-field measurements demonstrate the propagation of BSWs on top of the LN surface of the designed 1DPhCs.

关键词： LN Li Experimental evidence of Bloch surface waves on photonic crystals with thin-film LiNbO3 as a top layer

Design of a kJ-class HiLASE laser as a driver for inertial fusion energy

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High Power Laser Science and Engineering 2014年第2期2卷 1-10页

作者： Antonio Lucianetti Magdalena Sawicka Ondrej Slezak Martin Divoky Jan pilar Venkatesan Jambunathan Stefano Bonora Roman Antipenkov Tomas Mocek HiLASE Project Institute of Physics AS CR Na Slovance 2 18221 Prague Czech Republic CNR-IFN Via Trasea 7 35131 Padova Italy ELI Beamlines Project Institute of Physics AS CR Na Slovance 2 18221 Prague Czech Republic

We present the results of performance modeling of a diode-pumped solid-state HiLASE laser designed for use in inertial fusion energy power plants. The main amplifier concept is based on a He-gas-cooled multi-slab architecture similar to that employed in Mercury laser system. Our modeling quantifies the reduction of thermally induced phase aberrations and average depolarization in Yb3+:YAG slabs by a combination of helium cryogenic cooling and properly designed(doping/width) cladding materials.

关键词： ASE birefringence cryogenic cooling slab lasers thermooptic effects

Narcea—an unknown,ancient cultivated rose variety from northern Spain

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Horticulture Research 2020年第1期7卷 2217-2228页

作者： María-Carmen Martínez José-Luis Santiago Susana Boso pilar Gago InmaculadaÁlvarez-Acero María-Estela De Vega Miguel Martínez-Bartolomé RafaelÁlvarez-Nogal pilar Molíst Matteo Caser Valentina Scariot Daniel Gómez-García Misión Biológica de Galicia(CSIC) Carballeira 8Salcedo 36143 PontevedraSpain Instituto de Ciencia y Tecnología de Alimentos y Nutrición(CSIC)(Spain) C/JoséAntonio Novais 1028040 MadridSpain Departamento de Biología Molecular-Área de Biología Celular Universidad de LeónCampus de Vegazana s/n24071 LeónSpain Grupo Neurolamb Biología funcional y Ciencias de la SaludUniversidad de Vigo(Spain)36310 As Lagoas-MarcosendeSpain Department of Agricultural Forest and Food SciencesUniversity of TorinoLargo Paolo Braccini 210095 GrugliascoTurinItaly Instituto Pirenaico de Ecología(CSIC) Dpto.Conservación de Ecosistemas NaturalesAvda.Montaña S/NZaragoza50016 ZaragozaSpain

The present work reports the discovery and the complete characterisation of an ancient cultivated rose variety found growing in a private garden in the southwest of the Principality of Asturias(northern Spain).The variety is here given the name *** majority of roses currently cultivated belong to the so-called group of‘Modern Roses’,all of which were obtained after 1867 via artificial crosses and improvement *** are destined for ornamental *** the 19th century,the great majority of the many ancient cultivated roses in Europe were used in perfumery and cosmetics,or had medicinal *** damascena and Rosa centifollia are still grown and used by the French and Bulgarian perfume *** Asturian Massif of the Cantabrian Mountain Range provides a natural habitat for some 75%of the wild members of the genus Rosa,but until now there was no evidence that this area was home to ancient cultivated roses.A complete botanical description is here provided for a discovered ancient *** is also characterised according to a series of sequence tagged microsatellite sites,and its agronomic features are *** addition,a histological description(optical and scanning electronic microscope studies)of the petals is offered,along with an analysis of the volatile compounds present in these organs as determined by solid phase microextraction and gas chromatography-mass *** results reveal the uniqueness of this ancient type of rose and suggest it may be of interest to the perfume industry.

关键词： ancient southwest majority

Type XIX collagen: a promising biomarker from the basement membranes

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Neural Regeneration Research 2020年第6期15卷 988-995页

作者： Ana C.Calvo Laura Moreno Leticia Moreno Janne M.Toivonen Raquel Manzano Nora Molina Miriam de la Torre Tresa López Francisco J.Miana-Mena María J.Munoz pilar Zaragoza pilar Larrodé Alberto García-Redondo Rosario Osta Laboratory of Genetics and Biochemistry(LAGENBIO) University of ZaragozaFaculty of Veterinary SciencesInstituto de Investigación Sanitaria de Aragón(IIS)IA2CIBERNEDZaragozaSpain Hospital Clínico Universitario Lozano Blesa ZaragozaSpain Neurology Department ALS UnitCIBERER U-723Health Research InstituteMadridSpain

Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological *** XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this *** collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different *** molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to *** most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of *** physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in ***,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic *** XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis *** novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis.

关键词： anti-tumor and anti-angiogenic properties C1 domain COL19A1 gene and protein levels compensatory effect FACIT collagens hippocampal interneurons matricryptins multiplexins NC1 domain regenerative response skeletal muscle type XIX collagen

Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism

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World Journal of Gastroenterology 2017年第28期23卷 5246-5252页

作者： Fernando Díaz-Fontenla Marta Castillo-Pradillo Arantxa Díaz-Gómez Luis Ibanez-Samaniego pilar Gancedo Juan Adan Guzmán-de-Villoria pilar Fernández-García Rafael Banares-Canizares Rita García-Martínez Unidad de Hepatología Servicio de Aparato DigestivoHospital General Universitario Gregorio Maranón Instituto de Investigación Sanitaria Hospital Gregorio Maranón Servicio de Aparato Digestivo Hospital Santa Bárbara Servicio de Radiodiagnóstico Hospital General Universitario Gregorio Maranón Centro de Investigación Biomédica en Red de Salud Mental Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Facultad de Medicina Universidad San Pablo CEU

Hepatic encephalopathy(HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE is an uncommon but serious condition that requires the search of hidden precipitating events(i.e.,portosystemic shunt) and alternative diagnosis. Hypothyroidism shares clinical manifestations with HE and is usually considered within the differential diagnosis of HE. Here,we describe a patient with refractory HE who presented a large portosystemic shunt and post-ablative hypothyroidism. Her cognitive impairment,hyperammonaemia,electroencephalograph alterations,impaired neuropsychological performance,and magnetic resonance imaging and spectroscopy disturbances were highly suggestive of HE,paralleled the course of hypothyroidism and normalized after thyroid hormone replacement. There was no need for intervention over the portosystemic shunt. The case findings support that hypothyroidism may precipitate HE in cirrhotic patients by inducing hyperammonaemia and/or enhancing ammonia brain toxicity. This case led us to consider hypothyroidism not only in the differential diagnosis but also as a precipitating factor of HE.

关键词： Hepatic encephalopathy Hypothyroidism Cognitive impairment Cirrhosis Portosystemic shunt Magnetic resonance spectroscopy

Therapy with stem cells in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1211-1227页

作者： María del pilar Martínez-Montiel Gonzalo Jesús Gómez-Gómez Ana Isabel Flores IBD Unit Department of Gastroenterology Universitary Hospital 12 Octubre Medicine Regenerative Group Investigation Center 12 Octubre Investigation Institute

Inflammatory bowel disease (IBD) affects a part of the young population and has a strong impact upon quality of life. The underlying etiology is not known, and the existing treatments are not curative. Furthermore, a significant percentage of patients are refractory to therapy. In recent years there have been great advances in our knowledge of stem cells and their therapeutic applications. In this context, autologous hematopoietic stem cell transplantation (HSCT) has been used in application to severe refractory Crohn’s disease (CD), with encouraging results. Allogenic HSCT would correct the genetic defects of the immune system, but is currently not accepted for the treatment of IBD because of its considerable risks. Mesenchymal stem cells (MSCs) have immune regulatory and regenerative properties, and low immunogenicity (both autologous and allogenic MSCs). Based on these properties, MSCs have been used via the systemic route in IBD with promising results, though it is still too soon to draw firm conclusions. Their local administration in perianal CD is the field where most progress has been made in recent years, with encouraging results. The next few years will be decisive for defining the role of such therapy in the management of IBD.

关键词： Mesenchymal stem cell, Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Haematopoietic stem cell transplantation