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Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing

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Chinese Journal of Natural Medicines 2020年第10期18卷 738-748页

作者： KIM Ji-yun LEE young-Min PARK Jong-pil LIM Kye-Taek LEE Sei-Jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610Republic of Korea Department of Food Science and Technology Chung-Ang UniversityAnseong 17546Republic of Korea Division of Animal Science Chonnam National UniversityGwangju61186Republic of Korea

Dioscorea batatas Decne(DBD)has been used to heal various illnesses of the kidney and intestine as an herbal medicine in *** a source of therapeutic agents,many glycoproteins have been isolated from mushrooms and plants,but the functional role of glycoprotein in intestinal epithelial wound healing has not been understood *** the present study,we investigated the wound healing potentials of the 30 kDa glycoprotein(DBD glycoprotein)isolated from DBD in human intestinal epithelial(INT-407)*** found that DBD glycoprotein(100μg·mL^-1)significantly increased the motility of INT-407 cells for 24 h by activating protein kinase C(PKC).DBD glycoprotein stimulated the activation of p38 mitogen-activated protein kinase(MAPK),which is responsible for the phosphorylation of NF-κB inhibitorα(IκBα).DBD glycoprotein increased the level of profilin-1(PFN1),α-actinin and F-actin expression via activation of transcription factor,nuclear factor-kappa B(NF-κB)during its promotion of cell *** mouse colitis was induced by adding dextran sulfate sodium(DSS)to the drinking water at a concentration of 4%(W/V)for 7 *** figured out that administration of DBD glycoprotein(10 and 20 mg·kg-1)lowers the levels of disease activity index and histological inflammation in DSS-treated ICR *** this regard,we suggest that DBD glycoprotein has ability to promote the F-actin-related migration signaling events via activation of PKC and NF-κB in intestinal epithelial cells and prevent inflammatory bowel disease.

关键词： Cell migration Dioscorea batatas Decne(DBD)glycoprotein Intestinal epithelial cells p38 MAPK F-actin Mouse colitis

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Optimal Center-of-Mass Pivot Effect of Spinal Motion in Feline Galloping

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Journal of Bionic Engineering 2020年第5期17卷 970-977页

作者： young Kook Kim Dongwon yun LV R&D team Electro-technology R&D CenterLS ELECTRIC Co.LtdCheongju 28437South Korea Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988South Korea

In this paper,we studied the acceleration behavior of a quadruped animal during a galloping *** the development of many quadruped robotic systems has been focused on dynamic movements,it is obvious that guidance from the dynamic behavior of quadruped animals is needed for robotics *** fulfill this demand,this paper deals with analysis of the galloping motions of a domestic cat,which is well known for its excellent acceleration performance among four-legged *** on the planar motion capture environment,the movement data of a galloping feline was acquired and the dynamic motions were estimated using a spring-mass *** particular,the effects of the position and angle of the center-of-mass of the cat,angular displacement of the spine,and angular velocity of the spine were analyzed and are discussed *** this process,it was possible to understand the dynamic movement characteristics of the cat,and to understand the relationships between,and the influences of,these *** this analysis,we provide significant data applicable to the design of joint movements in quadruped robot systems.

关键词： quadrupedalism feline galloping domestic cat center-of-mass

Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder

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World Journal of Gastroenterology 2015年第1期21卷 269-275页

作者： Sung pil yun Nari Shin Hyung Il Seo Department of Surgery Biomedical Research InstitutePusan National University HospitalBusan 602-739South Korea Department of Pathology Biomedical Research InstitutePusan National University HospitalBusan 602-739South Korea

AIM: To compare the demographics and survival rates between gallbladder adenocarcinoma(GB-adenocarcinoma) and small cell neuroendocrine carcinoma of the gallbladder(GB-NEC-SCC).METHODS: From March 2007 to September 2012,patients who underwent resection of tumor stage T2/T3 GB cancer were enrolled for this *** patients were included in this study,including 38 diagnosed with GB-adenocarcinoma and four diagnosed with *** the GB-adenocarcinoma group,a radical operation was performed in 28 patients,and ten patients underwent simple *** the GB-NEC-SCC group,a radical operation was performed in three patients,and one patient underwent simple *** analysis of the two groups was performed,including clinicopathologic features and survival ***: The median age of the patients was 68 y(range: 35-83 years) and females comprised 26/42 of the ***-adenocarcinoma patients were significantly older than GB-NEC-SCC patients(67.89 ± 11.15 vs 55.75 ± 10.31 years; P = 0.029).The median tumor size in GB-adenocarcinoma patients was 2.56 ± 1.75 cm and 3.98 ± 3.74 cm in GB-NEC-SCC patients; however,there was no significant difference between the two *** tumors > 2 cm,T stage(T2 vs T3),lymphovascular invasion,perineural invasion,lymph node metastasis and lymph node ratio showed no significant differences between the two *** overall survival rate of the 42 patients at five years was 77.0%.In the GB-adenocarcinoma group,the overall five-year survival rate was 74.8%,and survival in the GB-NEC-SCC group was 100%,which was not significantly different between the two ***: The strategy for treating patients with GB-NEC-SCC should be similar to that used for treating GB-adenocarcinoma,including radical cholecystectomy and liver resection.

关键词： Gallbladder adenocarcinoma Gallbladder cancer Radi

Evidence of Specific MJO Phase Occurrence with Summertime California Central Valley Extreme Hot Weather

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Advances in Atmospheric Sciences 2019年第6期36卷 589-602页

作者： yun-young LEE Richard GROTJAHN Asia-Pacific Economic Cooperation Climate Center Department of Land Air and Water Resources University of California

This study examines associations between California Central Valley(CCV) heat waves and the Madden Julian Oscillation(MJO). These heat waves have major economic impact. Our prior work showed that CCV heat waves are frequently preceded by convection over the tropical Indian and eastern Pacific oceans, in patterns identifiable with MJO phases. The main analysis method is lagged composites(formed after each MJO phase pair) of CCV synoptic station temperature, outgoing longwave radiation(OLR), and velocity potential(VP). Over the CCV, positive temperature anomalies occur only after the Indian Ocean(phases 2-3) or eastern Pacific Ocean(phases 8-1) convection(implied by OLR and VP fields). The largest fractions of CCV hot days occur in the two weeks after onset of those two phase pairs. OLR and VP composites have significant subsidence and convergence above divergence over the CCV during heat waves, and these structures are each part of larger patterns having significant areas over the Indian and Pacific Oceans. Prior studies showed that CCV heat waves can be roughly grouped into two clusters: Cluster 2 is preceded by a heat wave over northwestern North America, while Cluster 1 is not. OLR and VP composite analyses are applied separately to these two clusters. However, for Cluster 2, the subsidence and VP over the CCV are not significant, and the large-scale VP pattern has low correlation with the MJO lagged composite field. Therefore, the association between the MJO convection and subsequent CCV heat wave is more evident in Cluster 1 than Cluster 2.

关键词： MJO heat wave large-scale meteorological pattern extratropical response tropical convection

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Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice

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Translational Neurodegeneration 2019年第1期8卷 317-332页

作者： Hyeon Joo Ham Sang-Bae Han Jaesuk yun In Jun Yeo young Wan Ham Se Hyun Kim pil-Hoon Park Dong-young Choi Jin Tae Hong College of Pharmacy and Medical Research Center Chungbuk National UniversityOsongsaengmyeong 1-roOsong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea Department of Chemistry Utah Valley University800 W University PkwyOremUT 84058USA INISTst Co. LTD767Sinsu-roSuji-guYongin-si 16827Gyeonggi-doRepublic of Korea College of Pharmacy Yeungnam University280 Daehak RoadGyeonsanGyeongbuk 38541Republic of Korea

Background:Neuroinflammation and accumulation ofβ-amyloid(Aβ)play a significant role in the onset and progression of Alzheimer’s disease(AD).Our previous study demonstrated that signal transducer and activator of transcription-3(STAT3)plays a major role in neuroinflammation and ***:In the present study,we investigated the inhibitory effect of bee venom phospholipase A2(bvPLA2)on memory deficiency in Tg2576 mice,which demonstrate genetic characteristics of AD and the mechanism of its action at the cellular and animal *** in vivo study,we examined the effect of bvPLA2 on improving memory by conducting several behavioral tests with the administration of bvPLA2(1 mg/kg)to Tg2576 *** in vitro study,we examined the effect of bvPLA2 on amyloidogenesis and neuroinflammation by treating bvPLA2 on LPSactivated BV2 ***:We found that bvPLA2 alleviated memory impairment in Tg2576 mice,as demonstrated in the behavioral tests assessing *** the bvPLA2-treated group,Aβ,amyloid precursor protein(APP),and β-secretase 1(BACE1)levels and β-secretase activity were significantly *** of pro-inflammatory cytokines and inflammation-related proteins decreased in the brain of bvPLA2-treated group,whereas anti-inflammatory cytokines *** addition,bvPLA2 reduced STAT3 phosphorylation in the brains of the bvPLA2-treated *** the cellular level,bvPLA2 inhibits production of nitric oxide,pro-inflammatory cytokines,and inflammation-related proteins including ***,bvPLA2 inhibits the production of Aβin cultured BV-2 *** from the docking experiment,pull-down assay,and the luciferase assay show that bvPLA2 directly binds STAT3 and,thus,regulates gene expression ***,when the STAT3 inhibitor and bvPLA2 were administered together,the anti-amyloidogenic and anti-inflammatory effects were further enhanced than when they were administered ***:These results suggest that bvPLA2 could r

关键词： Bee venom phospholipase A2 Alzheimer’s disease Amyloidogenesis Neuroinflammation STAT3

Preparation of Highly Crystalline Graphitic Nanocarbon for the Electro-Oxidation of Methanol

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Nano Research 2011年第1期4卷 92-102页

作者： Ji Bong Joo Nam Dong Kim Hyeong Jin yun pil Kim Jongheop Yi World Class University （WCU） program of Chemical Convergence for Energy ＆ Environment （C2E2） School of Chemical and Biological Engineering Seoul National University Shinlim-dong Kwanak-ku Seoul 151-742 Republic of Korea School of Environmental and Chemical Engineering Specialized Graduate School of Hydrogen and Fuel Cell Engineering Chonbuk National University Jeonju 561-756 Republic of Korea

Highly crystalline graphitic nanocarbons （GNC） have been prepared by the wet-air treatment of hydrothermally- derived graphitic porous carbon. The materials were characterized by scanning electron microscopy, X-ray diffraction, Raman spectroscopy, and electrochemical methods. The experimental results revealed that the treatment temperature has a significant effect on the morphology and degree of graphitic crystallinity. When GNC was treated at 450 ~C under a wet-air atmosphere, the product （GNC-450） consisted of aggregates of silkworm-shaped carbon nanoparticles with enhanced graphitic characteristics. GNC-450 was evaluated as a catalyst support in the electro-oxidation of methanol. The Pt/GNC-450 catalyst contained smaller Pt particles and had a higher electrochemically active surface area than a commercial carbon black-supported Pt catalyst. In the electro-oxidation of methanol, the Pt/GNC-450 catalyst showed the highest performance among the Pt catalysts examined in this study. The superior catalytic performance appears to be closely related to the enhanced graphitic characteristics with highly dispersed Pt nanoparticles on the graphitic layers, which have a positive effect on the electrochemical performance.

关键词： Graphitic nanostructured carbon wet-air treatment enhanced crystallinity Pt catalyst

Effects of Initial and Boundary Conditions on Heavy Rainfall Simulation over the Yellow Sea and the Korean Peninsula:Comparison of ECMWF and NCEP Analysis Data Effects and Verification with Dropsonde Observation

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Advances in Atmospheric Sciences 2024年第9期41卷 1787-1803页

作者： Jiwon HWANG Dong-Hyun CHA Donghyuck YOON Tae-young GOO Sueng-pil JUNG Department of Civil Urban Earth and Environmental Engineering Ulsan National Institute of Science and TechnologyUlsan 44919South Korea Program in Atmospheric and Oceanic Sciences Princeton UniversityPrincetonNew Jersey 08544USA National Institute of Meteorological Sciences NIMSJeju 63568South Korea

This study evaluated the simulation performance of mesoscale convective system(MCS)-induced precipitation,focusing on three selected cases that originated from the Yellow Sea and propagated toward the Korean *** evaluation was conducted for the European Centre for Medium-Range Weather Forecasts(ECMWF)and National Centers for Environmental Prediction(NCEP)analysis data,as well as the simulation result using them as initial and lateral boundary conditions for the Weather Research and Forecasting ***,temperature and humidity profiles from 3D dropsonde observations from the National Center for Meteorological Science of the Korea Meteorological Administration served as validation *** showed that the ECMWF analysis consistently had smaller errors compared to the NCEP analysis,which exhibited a cold and dry bias in the lower levels below 850 *** model,in terms of the precipitation simulations,particularly for high-intensity precipitation over the Yellow Sea,demonstrated higher accuracy when applying ECMWF analysis data as the initial *** advantage also positively influenced the simulation of rainfall events on the Korean Peninsula by reasonably inducing convective-favorable thermodynamic features(i.e.,warm and humid lower-level atmosphere)over the Yellow *** conclusion,this study provides specific information about two global analysis datasets and their impacts on MCS-induced heavy rainfall simulation by employing dropsonde observation ***,it suggests the need to enhance the initial field for MCS-induced heavy rainfall simulation and the applicability of assimilating dropsonde data for this purpose in the future.

关键词： initial conditions dropsonde heavy rainfall forecast global model analysis evaluation

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Multiple actions of lysophosphatidylcholine in human Jurkat T cells

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Acta Pharmacologica Sinica 2006年第6期27卷 700-707页

作者： young-jinIM yun-kyungLEE Hae-young CHUNG Dong-soon IM Laboratories of Pharmacology Busan 609-735 Korea Aging Biochemistry College of Pharmacy and Research Institute for Drug DevelopmentPusan National UniversityBusan 609-735Korea

Aim:To obtain pathophysiological meanings of lysophosphatidylcholine（LPC）through the investigation of the effects of LPC in Jurkat T ***:Wemeasured ROS generation,[Ca2+]i,and mitochondrial membrane potential（MMP）by fluorescent spectrometry in Jurkat,T ***:We observed that LPCsignificantly increased the reactive oxygen species（ROS）level in human Jurkat *** structurally-related lysolipids and eleven synthetic LPCs with dif-ferent acyl chain lengths,palmitoyl LPC increased ROS to the highest level,α-Tocopherol,an antioxidant,and rottlerin PKCδ inhibitor were inhibitory effects onLPC-induced ROS *** rapidly depolarized MMP and markedly el-evated [Ca2+]iby Ca2+influx across the plasma ***,LPC-inducedROS increase seemed to not be related with LPC-induced depolarization of MMPor [Ca2+]iincrease.G2A family G protein-coupled receptors（GPCR）for lysolipidswere expressed in Jurkat T cells,however,evidence indicated that GPCR was notinvolved in LPC ***:LPC induced several cellular changes inJurkat T cells,including an increase of ROS generation in a PKCδ-dependent andGPCR-independent manner,increase of [Ca2+]ithrough Ca2+influx,and decreaseof ***-induced actions in Jurkat T cells represent novel action modes ofLPC that do not involve GPCR and multiple independent changes of intracellularsignaling molecules.

关键词： lysophosphatidylcholine reactive oxygen species calcium protein kinase C mitochondrial membrane potential

Amelioration effects of traditional Chinese medicine on alcohol-induced fatty liver

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World Journal of Gastroenterology 2005年第35期11卷 5512-5516页

作者： Hyun-Jeong Kwon yun-young Kim Se-young Choung Department of Hygienic Chemistry College of Pharmacy Kyung Hee University Seoul 130-701 South Korea

AIM： To examine the effects of traditional Chinese medicine （TCM） on alcohol-induced fatty liver in rats. TCM consists of Astragalus membranaceus, Morus alba, Crataegus pinnatifida, Alisma orientale, Salvia miltiorrhiza, and Pueraria lobata. METHODS： The rats were separated randomly into five groups. One （the CD group） was fed a control diet for 10 wk, another （the ED group） fed an ethanol-containing isocaloric liquid diet for 10 wk, and the last three （the TCM group） were fed an ethanol-containing isocaloric liquid diet for 10 wk and dosed orally with TCM （222 mg/kg.d, TCM222; 667 mg/kg·d, TCM667; and 2 000 mg/kg.d, TCM2000, respectively） weekly during the last 4 wk. RESULTS： ED group developed fatty liver according to lipid profile and liver histological findings. Compared with the control group, liver/body weight, serum triglyceride （TG） and total cholesterol （TC）, liver TG and TC, serum alanine aminotransferase （ALT） and aspartic aminotransferase （AST） significantly increased in the ED group. Whereas, in the rats administered with TCM, liver/body weight, serum TG and TC, liver TG and TC, serum ALT and AST were significantly decreased, and the degree of hepatic lipid droplets was markedly improved compared with those in the ED group. CONCLUSION： TCM treatment causes significant reduction in alcohol-induced lipid hepatic accumulation, reversing fatty liver and liver damage, and can be used as a remedy for alcoholic fatty liver.

关键词： Fatty liver Alcohol Astragalus membranaceus,Horus alba Crataegus pinnatifida Alisma orientale Salvia miltiorrhiza Pueraria Iobata