检索结果-南通市图书馆

The curative effect of fucoidan on visceral leishmaniasis is mediated by activation of MAP kinases through specific protein kinase C isoforms

引用

Cellular & Molecular Immunology 2014年第3期11卷 263-274页

作者： Gunjan Sharma Susanta kar Writoban Basu Ball kuntal Ghosh pijush k.das nfectious Diseases and Immunology Division CSIR-Indian Institute of Chemical Biology Kolkata India Department of Biochemistry Calcutta University Kolkata India

Fucoidan can cure both antimony-sensitive and antimony-resistant visceral leishmaniasis through immune activation. However, the signaling events underlying this cellular response remain uncharacterized. The present study reveals that fucoidan induces activation of p38 and ERkI/2 and NF-κB DNA binding in both normal and Leishmania *** macrophages, as revealed by western blotting and electrophoretic mobility shift assay （EMSA）, respectively. Pharmacological inhibition of p38, ERkI/2 or the NF-κB pathway markedly attenuated fucoidan-induced pro-inflammatory cytokine synthesis and inducible nitric oxide synthase （iNOS） gene transcription, resulting in a reduction of parasite clearance. To decipher the underlying mechanism of fucoidan-mediated parasite suppression, the expression and functionality of various protein kinase C （PkC） isoforms were evaluated by immunoblotting and enzyme activity assay. Fucoidan elicited an increase in expression and activity of PkC-α, -β1 and -βⅡ isoforms in infected macrophages. Functional knockdown of PkC-α and -β resulted in downregulation of p38 and ERkI/2, along with a marked reduction of IL-12 and TNF-α production in fucoidan-treated infected macrophages. Collectively, these results suggest that the curative effect of fucoidan is mediated by PkC-dependent activation of the mitogen-activated protein kinase （MAPk）/NF-κB pathway, which ultimately results in the production of nitric oxide （NO） and disease-resolving pro-inflammatory cytokines.

关键词： fucoidan MAPk NF-κB PkC visceral leishmaniasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Salinity Stress on Growth and Yield of Forage Genotypes

引用

Agricultural Sciences 2021年第9期12卷 949-959页

作者： pijush kanti Ghosh Md. Shafiqul Islam Sarder Safiqul Islam Agrotechnology Discipline Khulna University Khulna Bangladesh

Salinity is the major limiting factor for forage productivity in southwestern coastal region of Bangladesh. Some introduced forage cultivars have been shown promising adaptability in saline conditions. The objective of this study was to assess the productivity and measure the agronomic characteristics of several introduced grass species with different created soil salinity levels. This study was conducted at the net house of Dr. Purnendu Gain Field Laboratory, Agrotechnology Discipline, and khulna University during the period from December 2017 to February 2018. The experiment was laid out in a factorial randomized complete block design with seven replications. The experiment consisted of two factor viz. soil salinity levels (S1 = 0.48, S2 = 5.8, S3 = 7.9, S4 = 9.4, S5 = 15 d·Sm−1) and thirteen forage genotypes. Salinity levels and forage genotypes significantly (p 1 at 90 das while the shortest plant (24.53 cm) was obtained in S5 at 90 das. Soil salinity had a significant difference (p das. The highest numbers of tillers (3.36) were found in S1, whereas the lowest (0.48) was in S5 at 75 das. Soil salinity had a significant difference (p das. The highest biomass wt. (29.14 g) was found in S1, while the lowest biomass wt. (3.52 g) was obtained in S5 at 60 das. Soil salinity had a significant difference (p das. The highest dry matter% (DM%) (21.24%) was found in S4, while the lowest DM (18.74%) was obtained in S1 at 60 das. Soi

关键词： Effect Salinity Stress Growth Yield of Forage Genotypes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：