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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-Xiang Gu Xian-Xia Yan hong-Wei Fan Ming-Ming zhang Yu Qiao Xiao-Die Liu Bao-Juan Li Ming-Hui Wang Hai-Long Dong Hao-hong Li Peng-Cheng Huang Yun-qing Li wu-Gang Hou Jin-lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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临床药师对我院贝伐珠单抗不良反应的监测研究

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海峡药学 2024年第8期36卷 102-105页

作者：李素素马曾庆张红史红军吴连平南京市高淳人民医院药学部江苏南京211300

目的监测并分析我院贝伐珠单抗不良反应(Adverse reactions,ADR),促进患者用药安全。方法临床药师主动监测2022年1月1日~2023年8月31日在我院使用贝伐珠单抗治疗且发生ADR的173例肿瘤患者,分析患者ADR发生情况及特点。结果83名患者中,... 详细信息

目的监测并分析我院贝伐珠单抗不良反应(Adverse reactions,ADR),促进患者用药安全。方法临床药师主动监测2022年1月1日~2023年8月31日在我院使用贝伐珠单抗治疗且发生ADR的173例肿瘤患者,分析患者ADR发生情况及特点。结果83名患者中,男48例(57.83%),女35例(42.17%);65~74岁的患者占53.01%;ADR表现主要在血液系统和胃肠道系统,其中白细胞降低(15.03%)、骨髓抑制(16.76%)、胃肠道反应(16.76%)和高血压(7.51%)发生率较高;ADR发生时间多在30d以内(83.82%);治疗方案中,合并两种药物(66.47%)最多;130例经治疗后好转。结论临床应加强药品ADR监测力度,提高用药合理性和安全性,减少ADR发生。

关键词：药品不良反应贝伐珠单抗合理用药药学监护

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植物发酵剂对育肥羔羊消化性能和瘤胃菌群结构的影响

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饲料研究 2024年第5期47卷 7-11页

作者：李永亮宋连杰赵心念苏东遥董晴吴丽卿张会文高玉红河北农业大学河北保定071000 承德市农林科学院河北承德067000 河北省畜牧良种工作站河北石家庄050000 承德市兽药管理站河北承德067000

试验旨在研究饮水中添加植物发酵剂对育肥羔羊消化性能和瘤胃菌群结构的影响。选择90只3月龄小尾寒羊,随机分为3组,每组5个重复,每个重复6只羔羊。按照不同植物发酵剂∶饮用水的比例,设低剂量组(1∶1 000,T1组)和高剂量组(1∶500,T2组)... 详细信息

试验旨在研究饮水中添加植物发酵剂对育肥羔羊消化性能和瘤胃菌群结构的影响。选择90只3月龄小尾寒羊,随机分为3组,每组5个重复,每个重复6只羔羊。按照不同植物发酵剂∶饮用水的比例,设低剂量组(1∶1 000,T1组)和高剂量组(1∶500,T2组),另设不添加发酵剂的对照组(C组)。试验期120 d。结果显示,与C组相比,T2组羔羊的平均日增重显著增加(P<0.05),料重比显著降低(P<0.05);T1组和T2组羔羊对粗蛋白、粗脂肪和中性洗涤纤维的表观消化率极显著升高(P<0.01),T2组羔羊的瘤胃纤维素酶、脂肪酶和α-淀粉酶活性显著升高(P<0.05)。与C组相比,植物发酵剂组瘤胃OTU数目,PD_whole_tree指数和Shannon指数均有提高趋势;T2组瘤胃厚壁菌门的相对丰度明显增加,拟杆菌门的相对丰度明显降低;T1组的优势菌理研菌科RC9肠道群的相对丰度明显升高,T2组非优势菌鼠李属的相对丰度明显增加。研究表明,饮水中添加植物发酵剂(1∶500)有效改善了羔羊的消化性能和瘤胃微生物结构。

关键词：植物发酵剂育肥羔羊消化性能瘤胃微生物

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Growth characteristics and grain yield of machine-transplanted medium indica hybrid rice with high daily yield

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Journal of Integrative Agriculture 2022年第9期21卷 2547-2558页

作者： DENG Fei HE lian-hua CHEN Duo zhang Chi TIAN qing-lan wu Zhen-yuan LI Qiu-ping ZENG Yu-ling Zhong Xiao-yuan CHEN hong WANG Li REN Wan-jun Key Laboratory of Crop Ecophysiology and Farming Systems in Southwest China Ministry of Agriculture and Rural Affairs/Crop Ecophysiology and Cultivation Key Laboratory of Sichuan ProvinceSichuan Agricultural UniversityChengdu 611130P.R.China

High-yield rice varieties with a suitable growth duration are required for mechanical transplanting in multiple cropping systems. Daily yield is an appropriate criterion for the selection of machine-transplanted rice varieties. The aim of this study was to investigate the growth characteristics and grain production in machine-transplanted medium indica hybrid rice with a high daily yield. We conducted a field experiment on 20 medium indica hybrid rice varieties in 2017 and *** yield decreased significantly with growth duration between jointing and heading, but it increased with dry matter accumulation, growth rate between jointing and heading, dry matter partitioning to the stem plus sheath at heading, daily yield, and number of spikelets per panicle. Compared with the medium and low daily yield variety types, the high daily yield variety type increased shoot biomass by improving crop growth rate and dry matter accumulation amount between jointing and heading and after heading. The high daily yield variety type decreased the growth duration pre-heading and the proportions of dry matter partitioned to the leaf lamina at heading and maturity, but it also increased the post-heading accumulated dry matter in the grain and the remobilization of dry matter stored in the vegetative organs. Furthermore,the high daily yield variety type significantly increased the occurrence rate of tillers, which is beneficial for the formation of a larger panicle size and an increase in the grain-filling rate. These changes contributed to a 6.51–23.16% relative increase in grain yield of the high daily yield variety type. In conclusion, the selection of high daily yield indica hybrid rice varieties with shorter pre-heading growth duration, greater tiller occurrence rate and spikelet numbers per panicle, higher post-jointing growth rates and stem plus sheath dry matter accumulation at heading is suitable for machine-transplanted rice.

关键词： daily yield dry matter production grain yield machine-transplanted rice

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Laboratory scoring system to predict hepatic indocyanine green clearance ability during fluorescence imaging-guided laparoscopic hepatectomy

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1442-1453页

作者： Zhen-Rong Chen qing-Teng Zeng Ning Shi hong-Wei Han Zhi-hong Chen Yi-Ping Zou Yuan-Peng zhang Fan wu lian-Qun Xu Hao-Sheng Jin Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Hepatobiliary Surgery Shenzhen Hospital of Traditional Chinese MedicineShenzhen 518000Guangdong ProvinceChina Medical College Shantou UniversityShantou 515000Guangdong ProvinceChina

BACKGROUND Indocyanine green(ICG)fluorescence played an important role in tumor localization and margin delineation in hepatobiliary ***,the preoperative regimen of ICG administration was still *** associated with tumor fluorescence staining effect were *** To investigate the preoperative laboratory indexes corelated with ICG fluorescence staining effect and establish a novel laboratory scoring system to screen specifical patients who need ICG dose *** To investigate the predictive indicators of ICG fluorescence characteristics in patients undergoing laparoscopic hepatectomy from January 2018 to January 2021 were *** laboratory tests were completed within 1 wk before *** patients received 5 mg ICG injection 24 h before surgery for preliminary tumor *** software was used to measure the fluorescence intensity values of regions of *** analysis was used to identify risk factors.A laboratory risk model was established to identify individuals at high risk for high liver background *** There were 110 patients who were enrolled in this study from January 2019 to January *** mean values of fluorescence intensity of liver background(FI-LB),fluorescence intensity of gallbladder,and fluorescence intensity of target area were 18.87±17.06,54.84±33.29,and 68.56±36.11,*** receiver operating characteristic(ROC)curve showed that FI-LB was a good indicator for liver clearance ability[area under the ROC curve(AUC)=0.984].Correlation analysis found pre-operative aspartate aminotransferase,alanine aminotransferase,gammaglutamyl transpeptidase,adenosine deaminase,and lactate dehydrogenase were positively associated with FI-LB and red blood cell,cholinesterase,and were negatively associated with *** laboratory risk score(TLRS)was calculated according to ROC curve(AUC=0.848,sensitivity=0.773,specificity=0.885).When TLRS was greater than 6.5,the liver

关键词： Indocyanine green Fluorescence Laparoscopic Hepatectomy Predictive biomarkers Blood index

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Optimization of sgRNA expression strategy to generate multiplex gene-edited pigs

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Zoological Research 2022年第6期43卷 1005-1008页

作者： Ju-qing zhang Jian-Xiong Guo Xiao-Jie wu Yu Wang Wei Yue Zhuo-Hui Li Wei Wang Xin-Fang Wei Xiao-Long wu Qiao-Yan Shen An-Min Lei hong-Jiang Wei Jin-lian Hua College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F University State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural University College of Animal Sciences&Technology Northwest A&F University National Institute of Biological Sciences

DEAR EDITOR,The use of CRISPR/Cas9 technology to breed polygenicmodified animals with desired traits holds great promise in agriculture and biomedicine. However, as most studies are based on human and mouse models, whether different single guide RNA(sg RNA) expression strategies affect multiplex gene-editing efficiency in domestic animals remains elusive.

关键词： CRISPR/Cas9 holds desired

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Diffusion Bonding of Ti_3Al Base Alloy

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Journal of Materials Science & Technology 1996年第6期12卷 467-469页

作者： Yi GUO Jinman ZHU Zhijing HE pifen lian and qing wu (Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China)(To whom correspondence should be addressed)hong zhang (Weihai University, Weihai 260000, China) Institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China Weihai University Weihai 260000 China

: The effects of diffusion bonding temperature and holding time on the joint strength of Ti3Al base alloy has been investigated in this paper. The shear strength of Ti-14Al-21Nb-3Mo-V alloy diffusion bonding joint under pressure of 12 MPa at 990℃ for 70 min was obtained to 797.6 MPa which approaches the base material strength. In addition, a short-time diffosion bonding process was studied in order to decrease the bonding cost. With the deformation of the specimens of 2.5% and the bonding temperature of 990℃ for 15 min, the bonding strength could reach 801 MPa.

关键词： Ti Al Diffusion Bonding of Ti3Al Base Alloy

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Distribution patterns of landslides triggered by the 2022 Ms 6.8 Luding earthquake,Sichuan,China

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山地科学学报（英文） 2023年第3期20卷 607-623页

作者： zhang Jian-qiang YANG Zong-ji MENG qing-kai WANG Jiao HU Kai-heng GE Yong-gang SU Feng-huan ZHAO Bo zhang Bo JIANG Ning HUANG Yu MING Zai-yang zhang Yi-fan LIU Zhen-xing wu Chun-hao ZHOU Wen-tao lianG Xin-yue SUN Yu-qing YANG lian-bing YAO hong-kun FENG Pei-hua LIU Jia-li Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Bejing 100049China East China University of Technology Nanchang 330013China Institute of Geographic Sciences and Natural Resources Research Beijing 100101China Chongqing Jiaotong University Chongqing 400074China

At 12:52 pm on September 5,2022,an Ms 6.8 earthquake occurred in Luding County,Sichuan Province,*** on high-resolution aerial photographs and satellite imageries obtained after the earthquake,as well as field investigation,a total of 8685 earthquake-triggered landslides(EQTLs)were *** landslides covered an area of 30.7km^(2),with a source area of 9.4 km^(2).These EQTLs were mainly distributed in areas with a seismic intensity of VIII and *** of the landslides were small and medium in size,and their types included landslide,rockfall,and rock *** landslide distributions were found,EQTLs were distributed along the Xianshuihe fault,landslide area decreased gradually with an increased distance to the fault;EQTLs were distributed along the Daduhe River and roads;besides,landslide distribution was associated with ground deformation caused by the ***’characteristics indicated that,a large number of EQTLs were located near the foot of the slope;the full area of EQTLs and their source area followed a power *** study concluded that Luding EQTLs were greater in number and area but relatively smaller in terms of affected *** on geo-hazards post-earthquake and risk assessment were proposed in the earthquake-stricken area to support the rehabilitation and reconstruction.

关键词： 2022 Luding earthquake Earthquaketriggered landslide Landslide inventory Distribution patterns

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Diagnosis and surgical treatment of pancreatic endocrine tumors in 36 patients:a single-center report

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Chinese Medical Journal 2007年第17期120卷 1487-1490页

作者： LIU hong zhang Su-zhan wu Yu-lian FANG He-qing LI Jiang-tao SHENG hong-wei WANG Yong Department of Surgery Second Affiliated Hospital ZhejiangUniversity School of Medicine Hangzhou 310006 China

Background Pancreatic endocrine tumors （PETs） are rare and their surgical treatment is often debated. The purpose of this retrospective study was to analyze the diagnosis and surgical strategy of functioning and non-functioning PETs. Methods From May 1980 to March 2006, 36 patients with pancreatic endocrine tumors at the Second Affiliated Hospital of Zhejiang University were retrospectively studied. Results Among the 36 patients, 29 （81%） had functioning tumors, and 7 （19%） had nonfunctioning tumors. Ninety-two percent of insulinomas were benign, whereas 4 （57%） of nonfunctioning PETs were malignant. The size of functioning tumors was （2.3i-0.3） cm, that of nonfunctioning tumors was less than （5.1^-0.5） cm. The combination CT and transabdominal ultrasonography resulted in a diagnostic sensitivity of 84%. Thirty-three primary lesions were precisely located in 32 patients （89%）. Atypical tumor resection was performed for 73% of functioning tumors, while typical pancreatectomy was performed for 6 （85%） of nonfunctioning tumors. Moreover, 5 liver resections and 1 lymph node dissection were performed. During the follow-up, fifteen complications occurred in 12 （36%） patients after operation. The 5-year survival rate for patients with benign tumors was 92% compared to 50% for those with malignant tumors. Surgical cure was achieved in 95% of patients with benign insulinomas. Conclusions Surgical strategy for PETs depends on the size and location of the tumor and the risk of malignancy. The optimal surgical procedure is key to prevent postoperative complication. Radical resection including initial and metastatic lesion may benefit patients with maliqnant PETs.

关键词： pancreatic endocrine tumor, insulinoma diagnosis surgery

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Effectiveness and safety of human umbilical cord-mesenchymal stem cells for treating type 2 diabetes mellitus

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World Journal of Diabetes 2022年第10期13卷 877-887页

作者： Xiao-Fen lian Dong-Hui Lu hong-Li Liu Yan-Jing Liu Xiu-Qun Han Yang Yang Yuan Lin qing-Xiang Zeng Zheng-Jie Huang Feng Xie Cai-Hao Huang hong-Mei wu Ai-Mei Long Ling-Ping Deng Fan zhang Department of Endocrinology Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Department of Research&Development Zhejiang MaiDa Gene Tech Co.LtdZhoushan 316000Zhejiang ProvinceChina Department of Endocrinology Huizhou Central People's HospitalHuizhou 516000Guangdong ProvinceChina Department of Endocrinology Longgang District Central Hospital of ShenzhenShenzhen 518000Guangdong ProvinceChina

BACKGROUND Progressive pancreaticβ-cell dysfunction is a fundamental part of the pathology of type 2 diabetes mellitus(T2DM).Cellular therapies offer novel opportunities for the treatment of T2DM to improve the function of isletβ-*** To evaluate the effectiveness and safety of human umbilical cord-mesenchymal stem cell(hUC-MSC)infusion in T2DM *** Sixteen patients were enrolled and received 1×10^(6) cells/kg per week for 3 wk as intravenous hUC-MSC *** effectiveness was evaluated by assessing fasting blood glucose,C-peptide,normal glycosylated hemoglobin A1c(HbA1c),insulin resistance index(homeostatic model assessment for insulin resistance),and isletβ-cell function(homeostasis model assessment ofβ-cell function).The dosage of hypoglycemic agents and safety were evaluated by monitoring the occurrence of any adverse events(AEs).RESULTS During the entire intervention period,the fasting plasma glucose level was significantly reduced[baseline:9.3400(8.3575,11.7725),day 14±3:6.5200(5.2200,8.6900);P<0.01].The HbA1c level was significantly reduced on day 84±3[baseline:7.8000(7.5250,8.6750),day 84±3:7.150(6.600,7.925);P<0.01].The patients’isletβ-cell function was significantly improved on day 28±3 of intervention[baseline:29.90(16.43,37.40),day 28±3:40.97(19.27,56.36);P<0.01].The dosage of hypoglycemic agents was reduced in all patients,of whom 6(50%)had a decrement of more than 50%and 1(6.25%)discontinued the hypoglycemic *** patients had transient fever,which occurred within 24 h after the second or third *** patient(2.08%)had asymptomatic nocturnal hypoglycemia after infusion on day 28±*** liver damage or other side effects were *** The results of this study suggest that hUC-MSC infusion can improve glycemia,restore isletβ-cell function,and reduce the dosage of hypoglycemic agents without serious ***,hUC-MSC infusion may be a novel option for the treatment of T2DM.

关键词： Type 2 diabetes Human umbilical cord mesenchymal stem cells Blood glucose Homeostasis model assessment ofβ-cell function Hypoglycemic agents

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