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Temporal-spatial Generation of Astrocytes in the Developing Diencephalon

Neuroscience Bulletin 2024年第1期40卷 1-16页

作者： Wentong Hong pifang gong Xinjie Pan Zhonggan Ren Yitong Liu Guibo Qi Jun-Liszt Li Wenzhi Sun Woo-Ping Ge Chun-Li Zhang Shumin Duan Song Qin Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTexas 75390-9148USA Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaZhejiang University School of MedicineHangzhou 310058China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200032China

tAstrocytes are the largest glial population in the mammalian brain.However,we have a minimal understanding of astrocyte development,especially fate specification in different regions of the brain.Through lineage tracing of the progenitors of the third ventricle(3V)wall via in-utero electroporation in the embryonic mouse brain,we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V wall.Unexpectedly,radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types:radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the diencephalon.With genetic fate mapping analysis,we reveal that the first population of astrocytes appears along the zona incerta in the diencephalon.Astrogenesis occurs at an early time point in the dorsal region relative to that in the ventral region of the developing diencephalon.With transcriptomic analysis of the region-specific 3V wall and lateral ventricle(LV)wall,we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal diencephalon.Together,these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon.

关键词： Radial glia Astrocyte specification Lineage tracing Diencephalon Third ventricle

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Specific knockout of Sox2 in astrocytes greatly reduces reactive astrocyte formation and promotes recovery after early postnatal TBI in mouse cortex

Specific knockout of Sox2 in astrocytes greatly reduces reac...

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中国解剖学会2021年年会

作者： Liu Yitong Hong Wentong gong pifang Pan Xinjie Qi Guibo Qin Song Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan University

Reactive astrocytes are a double-edged sword for traumatic brain injury (TBI),whether their overall effect on injury is beneficial or harmful depends on the balance between the loss and gain of function.However,the mechanism of reactive astrocytes after TBI is poorly understood.Recently more and more studies have been conducted to regulate the gene expression of astrocytes as a target to treat the disease.

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Specific knockout of Sox2 in astrocytes greatly reduces reactive astrocyte formation and promotes recovery after early postnatal TBI in mouse cortex

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解剖学杂志 2021年第S1期44卷 110-110页

作者： Liu Yitong Hong Wentong gong pifang Pan Xinjie Qi Guibo Qin Song Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032

Reactive astrocytes are a double edged sword for traumatic brain injury(TBD),whether their overall effect on injury is beneficial or harmful depends on the balance between the loss and gain of function.However,the mechanism of reactive astrocytes after TBI is poorly understood.Recently more and more studies have been conducted to regulate the gene expression of astrocytes as a target to treat the disease.Here,we generated early postnatal TBI in the mouse cortex,indicating typical reactive astrocytes and glial scar were observed around damaged area;We next deleted Sox2 in astrocytes to observe its effects on reactive astrocytes and tissue repair after postnatal injury in the mouse cortex.As a result,specific deletion of Sox2 in astrocytes greatly inhibited the formation of reactive astrocytes and glial scars,and significantly promoted nerve regeneration in the damaged area and post injured repair.Together,our study indicate that Sox2 plays an important role in reactive astrocytes after early postnatal TBI in the mouse cortex.Therefore,Sox2 in astrocytes may be a putative target to develop new therapeutic tools for TBI treatment.

关键词： TBI astrocytes inhibited

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