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Characterization and QTL identification in eggplant introgression lines under two N fertilization levels

Horticultural Plant Journal(园艺学报:英文版) 2023年第5期9卷 971-985页

作者： Elena Rosa-Martínez Gloria Villanueva Ahmet Sahin pietro Gramazio María Dolores García-Martínez María Dolores Raig on Santiago Vilanova Jaime Prohens Mariola Plazas Instituto de Conservacion y Mejora de la Agrodiversidad Valenciana Universitat Politecnica de ValenciaCamino de Vera 1446022 ValenciaSpain Instituto de Biología Molecular y Celular de Plantas Consejo Superior de Investigaciones Científicas-Universitat Politecnica de ValenciaCamino de Vera 1446022 ValenciaSpain

Lowering nitrogen inputs is a major goal for sustainable *** the present study,a set of 10 Solanum melongena introgression lines(ILs)developed using Solanum incanum as the exotic donor parent were grown under two nitrogen fertilization doses supplied with the irrigation system:1)8.25 mmol·L-1NH4NO3,corresponding to the high nitrogen treatment(HN),and 2)no external nitrogen supply,corresponding to the low nitrogen treatment(LN).Twenty traits,including plant growth and yield parameters,fruit size and morphology,nitrogen and carbon content in leaf and fruit,and phenolics content in fruit,were *** aim was to select of potential materials for eggplant breeding under low N inputs,as well as to identify and locate putative QTLs associated with the traits *** significant differences were observed between the soil characteristics of the HN and LN treatments,except for nitrogen and iron content,which was slightly lower in the HN,probably as a consequence of higher nutrient removal from soil by plants in the latter *** of variance showed that lowering nitrogen inputs did not significantly affect the final yield,fruit morphology,size and phenolics *** agronomic traits were highly and positively correlated with each other under both treatments,as well as total phenolics with chlorogenic acid *** assessment of the differences between each IL and the recipient parent resulted in the identification of 36 QTLs associated with most of the traits—12 were specific to the HN,17 specific to the LN,and 7 were stable across *** introgressed fragment of *** generally had a negative effect on the trait,except for QTLs for fruit dry matter,for fruit length on chromosome 10 under the HN,and for fruit pedicel length on chromosome 9 under the *** increase over AN-S-26 of the allele of *** for the QTLs detected ranged between-73.98% and 26.03% in HN and-73.67%and 34.43% in *** findings provide useful tools fo

关键词： Solanum melongena Solanum incanum Wild relatives N fertilization Abiotic stress QTL

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Liver involvement in patients with COVID-19 infection:A comprehensive overview of diagnostic imaging features

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World Journal of Gastroenterology 2023年第5期29卷 834-850页

作者： Davide Ippolito Cesare Maino Federica Vernuccio Roberto Cannella Riccardo Inchingolo Michele Dezio Riccardo Faletti pietro Andrea Bonaffini Marco Gatti Sandro Sironi Milano Bicocca School of Medicine and Surgery Milano 20126Italy Fondazione IRCCS San Gerardo dei Tintori Monza 20900Italy Institute of Radiology(DIMED) University Hospital of PadovaPadova 35128Italy Section of Radiology-Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Department of Health Promotion Mother and Child CareInternal Medicine and Medical Specialties(PROMISE)University of PalermoPalermo 90127Italy Division of Interventional Radiology Department of RadiologyMadonna delle Grazie HospitalMatera 75100Italy Department of Surgical Sciences University of TurinTurin 10126Italy Department of Diagnostic Radiology Papa Giovanni XXIII HospitalBergamo 24127Italy Department of Diagnostic Radiology University of TurinTurin 10126Italy

During the first wave of the pandemic,coronavirus disease 2019(COVID-19)infection has been considered mainly as a pulmonary ***,different clinical and radiological manifestations were observed over time,including involvement of abdominal ***,the liver is considered one of the main affected abdominal *** involvement may be caused by either a direct damage by the virus or an indirect damage related to COVID-19 induced thrombosis or to the use of different *** clinical assessment,radiology plays a key role in the evaluation of liver ***(US),computed tomography(CT)and magnetic resonance imaging(MRI)may be used to evaluate liver *** is widely available and it is considered the first-line technique to assess liver involvement in COVID-19 infection,in particular liver steatosis and portal-vein *** and MRI are used as second-and third-line techniques,respectively,considering their higher sensitivity and specificity compared to US for assessment of both parenchyma and *** review aims to the spectrum of COVID-19 liver involvement and the most common imaging features of COVID-19 liver damage.

关键词： Liver Fatty liver Hepatomegaly Hepatic infarction Liver diseases Liver failure Biliary tract diseases COVID-19 SARS-CoV-2 Infection X-Ray computed tomography Magnetic resonance imaging Ultrasonography Adults Pediatrics

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Any role for transarterial radioembolization in unresectable intrahepatic cholangiocarcinoma in the era of advanced systemic therapies?

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World Journal of Hepatology 2023年第12期15卷 1284-1293页

作者： Alessandra Elvevi Alice Laffusa Federica Elisei Sabrina Morzenti Luca Guerra Antonio Rovere pietro Invernizzi Sara Massironi Division of Gastroenterology and Center for Autoimmune Liver Diseases Department of Medicine and SurgeryUniversity of Milano-Bicocca and European Reference Network on Hepatological Diseases(ERN RARELIVER)Fondazione IRCCS San Gerardo dei Tintori HospitalMonza 20900Italy Department of Nuclear Medicine Fondazione IRCCS San Gerardo dei Tintori University of Milano BicoccaMonza 20900Italy Medical Physics Fondazione IRCCS San Gerardo dei TintoriMonza 20900Italy Department of Radiology and Interventional Radiology Fondazione IRCCS San Gerardo dei Tintori HospitalMonza 20900Italy

Intrahepatic cholangiocarcinoma(iCCA)is recognized as the second most frequently diagnosed liver malignancy,following closely after hepatocellular *** incidence has seen a global upsurge in the past several ***,due to the lack of well-defined risk factors and limited diagnostic tools,iCCA is often diagnosed at an advanced stage,resulting in a poor *** surgery is the only potentially curative option,it is rarely ***,there are ongoing investigations into various treatment approaches for unresectable iCCA,including conventional chemotherapies,targeted therapies,immunotherapies,and locoregional *** study aims to explore the role of transarterial radioembolization(TARE)in the treatment of unresectable iCCA and provide a comprehensive *** findings suggest that TARE is a safe and effective treatment option for unresectable iCCA,with a median overall survival(OS)of 14.9 months in the study *** on TARE for unresectable iCCA,both as a first-line treatment(as a neo-adjuvant down-staging strategy)and as adjuvant therapy,have reported varying median response rates(ranging from 34%to 86%)and median OS(12-16 mo).These differences can be attributed to the heterogeneity of the patient population and the limited number of participants in the *** studies have identified tumor burden,portal vein involvement,and the patient’s performance status as key prognostic ***,a phase 2 trial evaluated the combination of TARE and chemotherapy(cisplatin-gemcitabine)as a first-line therapy for locally advanced unresectable *** results showed promising outcomes,including a median OS of 22 mo and a 22%achievement in down-staging the *** conclusion,TARE represents a viable treatment option for unresectable iCCA,and its combination with systemic chemotherapy has shown promising ***,it is important to consider treatment-independent factors that can influence ***

关键词： Intrahepatic cholangiocarcinoma Transarterial radioembolization Locoregional treatment Overall Survival Response rates Neo-adjuvant therapy Combined Therapies Prognostic factors

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Role of brain-derived neurotrophic factor during the regenerative response after traumatic brain injury in adult zebrafish

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Neural Regeneration Research 2018年第6期13卷 941-944页

作者： pietro Cacialli Antonio Palladino Carla Lucini Department of Veterinary Medicine University of Naples Federico Ⅱ

Several mammalian animal models of traumatic brain injury have been used, mostly rodents. However, reparative mechanisms in mammalian brain are very limited, and newly formed neurons do not survive for long time. The brain of adult zebrafish, a teleost fish widely used as vertebrate model, possesses high regenerative properties after injury due to the presence of numerous stem cells niches. The ventricular lining of the zebrafish dorsal telencephalon is the most studied neuronal stem cell niche because its dorso-lateral zone is considered the equivalent to the hippocampus of mammals which contains one of the two constitutive neurogenic niches of mammals. To mimic TBI, stab wound in the dorso-lateral telencephalon of zebrafish was used in studies devoted to fish regenerative properties. Brain-derived neurotrophic factor, which is known to play key roles in the repair process after traumatic brain lesions, persists around the lesioned area of injured telencephalon of adult zebrafish. These results are extensively compared to reparative processes in rodent brain. Considering the complete repair of the damaged area in fish, it could be tempting to consider brain-derived neurotrophic factor as a factor contributing to create a permissive environment that enables the establishment of new neuronal population in damaged brain.

关键词： brain-derived neurotrophic factor neurotrophins neurotrophic factors brain telencephalon teleost fish traumatic brain injury lesion neurons

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New application of open source data and Rock Engineering System for debris flow susceptibility analysis

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Journal of Mountain Science 2021年第12期18卷 3200-3217页

作者： Sabrina BONETTO pietro MOSCA Federico VAGNON Davide VIANELLO Department of Earth Science University of TorinoTorino 10125Italy Institute of Geosciences and Earth Resources National Research Council(CNR)Torino 10125Italy

This research describes a quantitative,rapid,and low-cost methodology for debris flow susceptibility evaluation at the basin scale using open-access data and *** proposed approach can aid decision makers in land management and territorial planning,by first screening for areas with a higher debris flow *** environmental predisposing factors,namely,bedrock lithology,fracture network,quaternary deposits,slope inclination,and hydrographic network,were selected as independent parameters and their mutual interactions were described and quantified using the Rock Engineering System(RES)*** each parameter,specific indexes were proposed,aiming to provide a final synthetic and representative index of debris flow susceptibility at the basin *** methodology was tested in four basins located in the Upper Susa Valley(NW Italian Alps)where debris flow events are the predominant natural *** proposed matrix can represent a useful standardized tool,universally applicable,since it is independent of type and characteristic of the basin.

关键词： Debris flow Interaction matrix Rock Engineering System(RES) Susceptibility analysis Open source data Debris flow predisposing factors

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Diagnostic performance of endoscopic ultrasound-guided tissue acquisition of splenic lesions:systematic review with pooled analysis

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Gastroenterology Report 2022年第1期10卷 356-362页

作者： Andrea Lisotti Stefano Francesco Crino` Benedetto Mangiavillano Anna Cominardi Andrew Ofosu Nicole Brighi Flavio Metelli Rocco Maurizio Zagari Antonio Facciorusso pietro Fusaroli Gastroenterology Unit Hospital of ImolaUniversity of BolognaImolaItaly Department of Medicine Gastroenterology and Digestive Endoscopy UnitThe Pancreas InstituteUniversity Hospital of VeronaVeronaItaly Gastrointestinal Endoscopy Unit Humanitas—Mater Domini CastellanzaVareseItaly Gastroenterology and Hepatology Stanford UniversityStanfordCAUSA Department of Medical Oncology IRCSS Istituto Romagnolo per lo Studio dei Tumori(IRST)“Dino Amadori”MedolaItaly Department of Medical and Surgical Sciences—DIMEC University of BolognaBolognaItaly Department of Surgical and Medical Sciences Section of GastroenterologyUniversity of FoggiaFoggiaItaly

Background Focal splenic lesions are usually incidentally discovered on radiological *** percutaneous tissue acquisition(TA)under trans-abdominal ultrasound guidance is a well-established technique for obtaining cyto-histological diagnosis of focal splenic lesions,endoscopic ultrasound(EUS)-guided TA has been described in several studies,reporting different safety and *** aimwas to assess the pooled safety,adequacy,and accuracy of EUS-TA of splenic *** A comprehensive review of available evidence was conducted at the end of November *** studies including more than five patients and reporting about the safety,adequacy,and accuracy of EUS-TA of the spleen were *** Six studies(62 patients)were identified;all studies have been conducted using fine-needle aspiration(FNA)*** specimen adequacy and accuracy of EUS-TA for spleen characterization were 92.8%[95%confidence interval(CI),86.3%–99.3%]and 88.2%(95%CI,79.3%–97.1%),*** pooled incidence of adverse events(six studies,62 patients)was 4.7%(95%CI,0.4%–9.7%).Conclusion EUS-FNA of the spleen is a safe technique with high diagnostic adequacy and *** EUS-guided approach could be considered a valid alternative to the percutaneous approach for spleen TA.

关键词： biopsy cancer lymphoma metastasis leukemia

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Autoimmune liver diseases

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World Journal of Gastroenterology 2008年第21期14卷 3290-3291页

作者： pietro Invernizzi Ian R Mackay Division of Internal Medicine and Liver Unit San Paolo Hospital School of MedicineUniversity of MilanMilan 20142ItalyDivision of RheumatologyAllergyand Clinical ImmunologyUniversity of California at DavisDavisCAUnite States Department of Biochemistry & Molecular Biology Monash UniversityClaytonVictoria 3800Australia

The liver was one of the earliest recognized sites among autoimmune diseases yet autoimmune hepatitis,primary biliary cirrhosis,primary sclerosing cholangitis,and their overlap forms,are still problematic in diagnosis and *** contributions herein comprise 'pairs of articles' on clinical characteristics,and concepts of etiopathogenesis,for each of the above diseases,together with childhood autoimmune liver disease,overlaps,interpretations of diagnostic serology,and liver *** issue is timely,since we are witnessing an ever increasing applicability of immunology to a wide variety of chronic diseases,hepatic and non-hepatic,in both developed and developing *** 11 invited expert review articles capture the changing features over recent years of the autoimmune liver diseases,the underlying immunomolecular mechanisms of development,the potent albeit still unexplained genetic influences,the expanding repertoire of immunoserological diagnostic markers,and the increasingly effective therapeutic possibilities.

关键词：自体免疫肝疾病临床免疫学肝炎

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Uncovering variation in social insect communication

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Current Zoology 2021年第5期67卷 515-518页

作者： Alessandro CINI Luca pietro CASACCI Volker NEHRING Centre for Biodiversity&Environment Research University College LondonGower StreetLondonWC1E 6BTUK Dipartimento di Biologia Universita`degli Studi di FirenzeVia Madonna del PianoSesto FiorentinoFirenze50019Italy Department of Life Sciences and Systems Biology University of TurinVia Accademia Albertina 13Turin10123Italy Department of Evolutionary Biology and Ecology Institute of Biology I(Zoology)University of FreiburgHauptstraße 1Freiburg(Brsg.)79104Germany

Introduction Social life within insect societies is regulated by a sophisticated multimodal communication *** blends of chemical compounds are integrated with vibrational,acoustic,and visual signals to control the division of labor in the colony,from colony defense to brood care(d’Ettorre and Moore 2008;Richard and Hunt 2013;Cervo et al.2015).It is no surprise that the study of communication has historically represented a fruitful area of investigation,leading to marvelous discoveries such as the complexities of the honeybee dance communication(von Frisch 1967;I’Anson Price and Gru¨ter 2015)and the sophisticated multimodal deception strategies adopted by socially parasitic species to exploit their hosts(Lenoir et al 2001;Nash and Boomsma 2008;Barbero et al.2009;Casacci et al.2021).

关键词： communication modal covering

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Explaining and evaluating the quality of“light”in religious environments and its effect on spirituality

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Frontiers of Architectural Research 2021年第4期10卷 803-820页

作者： pietro Matracchi Ali Sadeghi habibabad Department of Architecture(DIDA) University of FlorenceUNIFI(Universita`Degli Studi di Firenze)FlorenceItaly

The current study aimed to investigate the quality of the interior architecture of the religious spaces regarding inducing the sense of spirituality with an emphasis on ***,the authors introduced the best option by simulating the light intensity of the interior environment of the Nasir Al-Mulk Mosque,Shiraz,in software and developing a visual standard questionnaire with a statistical population including the *** research was a field,and survey study and computational software were used to simulate the light intensity of the interior environment of the mosque in the first ***,the researcher-made visual questionnaire was ***,this questionnaire was sent to the experts online due to the current situations due to the Covid-19 *** statistical population was selected using the purposive sampling method from the universities of Iran,Malaysia,India,and Turkey,whose expertise was architecture,environmental psychology,and sacred arts.

关键词： Islamic architecture Spirituality Tranquility Religious spaces Environmental psychology Light

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Analyses of BioVOCs variation related to vegetation predominance in the Natural Park of Ampezzo Dolomites, UNESCO world heritage area of Dolomites

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Journal of Forestry Research 2013年第3期24卷 439-448页

作者： Luca Raveane Francesco Tisato Ilena Isak pietro Traldi National Council of Researches ISTM Corso Stati Uniti n°435127 Padova Italy National Council of Researches -ICIS Corso Stati Uniti n°435127 Padova Italy

The determination of emitted Biogenic Volatile Compounds （BioVOCs） profile via Field Air Analysis （FAA） - Solid Phase Micro Extraction （75μm Carboxen/PDMS portable field sampler） was performed using GC-MS. The six sampling sites located in the Natural Park of Ampezzo Dolomites, part of the UNESCO＇s World Heritage List, are characterized by different predominating vegetation. The ubiquitous compound hexanal was chosen as internal standard, in order to compare the amounts of the different compound in the different sites. The main terpenes identified were α-pinene, 13-pinene, 6-3-carene and d-limonene, while 1,8 cineole was the highest abundant oxygenated terpene. In the site next the＇national road a higher amount of benzene derivatives （ben- zene, toluene, o-xylene, p-xylene and ethylbenzene） were observed. In the site relatively close to the road a marked decrease of benzene deriva- tives was observed. In the sites close to conifers （i.e. Fir, Pine and Larch） the terpenic content observed was higher than in the site close to the mixed forest （mainly large-leaf and some conifers）. Some terpenes were observed also in the high-quote meadow site, although of lower abun- dance than in the other sites. The highest abundance of terpenes was ob- served in the Pinus cerebra （Swiss Pine） site.

关键词： Solid phase microExtraction organic volatile compound Terpene plant emission mass spectrometry gas chromatography.

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