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Neural Regeneration Research 2014年第22期9卷 1943-1948页

作者： Alba C.de Luca Stephanie P.Lacour Wassim Raffoul pietro g.di summa EPFL Centre for NeuroprostheticsLaboratory for Soft Bioelectronic InterfacesStation 171015 LausanneSwitzerland Department of Plastic Reconstructive and Hand SurgeryUniversity Hospital of Lausanne (CHUV)LausanneSwitzerland

Peripheral nerve injury is a serious problem affecting signiifcantly patients’ life. Autografts are the“gold standard” used to repair the injury gap, however, only 50% of patients fully recover from the trauma. Artiifcial conduits are a valid alternative to repairing peripheral nerve. They aim at conifning the nerve environment throughout the regeneration process, and providing guidance to axon outgrowth. Biocompatible materials have been carefully designed to reduce inlfamma-tion and scar tissue formation, but modiifcations of the inner lumen are still required in order to optimise the scaffolds. Biomicking the native neural tissue with extracellular matrix ifllers or coatings showed great promises in repairing longer gaps and extending cell survival. In addition, extracellular matrix molecules provide a platform to further bind growth factors that can be released in the system over time. Alternatively, conduit ifllers can be used for cell transplantation at the injury site, reducing the lag time required for endogenous Schwann cells to proliferate and take part in the regeneration process. This review provides an overview on the importance of ex-tracellular matrix molecules in peripheral nerve repair.

关键词： peripheral nerve repair extracellular matrix nerve conduits surface modification fillers growth factors

Tissue-engineered constructs for peripheral nerve repair:current research concepts and future perspectives

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Plastic and Aesthetic Research 2015年第1期2卷 213-219页

作者： Alba C.de Luca Wassim Raffoul Francesco giacalone Maddalena Bertolini pietro g.di summa EPFL Centre for NeuroprostheticsLaboratory for Soft Bioelectronic Interfaces1015 LausanneSwitzerland Department of Plastic Reconstructive and Hand SurgeryUniversity Hospital of Lausanne(Centre Hospitalier Universitaire Vaudois)1011 LausanneSwitzerland Department of Hand Surgery and Microsurgery CTO-Maria Adelaide Trauma Center10126 TorinoItaly

Traumatic injuries resulting in peripheral nerve lesions lead to important morbidity with devastating social and economic *** the lesioned nerve cannot be sutured directly,a nerve graft is generally required to bridge the *** autologous nerve grafting is still the first choice for reconstruction,it has the severe disadvantage of the sacrifice of a functional *** in tissue engineering and nerve regeneration may have a dramatic impact on clinical and surgical treatment of such nerve *** authors review the latest concepts in tissue engineering for nerve repair,including scaffold engineering of neural guides,biomaterial modification,cell therapy,growth factors delivery,and electrical *** literature is reviewed in detail,pointing out the most interesting present achievements and perspectives for future clinical *** search of the literature was performed using MEDLINE,Embase,and the Cochrane Library to identify research studies on peripheral nerve regeneration through tissue-engineered *** following medical subject headings were used to carry out a systematic search of the literature:“nerve regeneration”,“stem cells”,“biomaterial”,“extracellular matrix”,“functional regeneration”,“growth factors”and“microchannels”.Included literature was published between 1991 and *** reference lists from the retrieved articles were also reviewed for additional *** total,76 articles were included in this study.

关键词： Cell transplantation extracellular matrix growth factors nerve guidance conduit peripheral nerve repair surface modification

Synergy of human platelet lysate and laminin to enhance the neurotrophic effect of human adipose-derived stem cells

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Neural Regeneration Research 2022年第10期17卷 2200-2202页

作者： pietro g.di summa Srinivas Madduri Department of Plastic Reconstructive and Hand SurgeryUniversity Hospital of LausanneUniversity of LausanneLausanneSwitzerland Department of Surgery Bioengineering and NeuroregenerationUniversity of GenevaUniversity Hospital GenevaGenevaSwitzerland

Despite the spontaneous regenerative capacity of the peripheral nervous system,clinical nerve repair often results in poor functional recovery with the high socio-economic *** presence of peripheral nerve injuries and when distal nerve transfers are not possible,nerve autografts,are the solution of choice to cross a critical nerve ***,these are associated with donor site morbidity and offer only suboptimal functional ***,the need to improve the rate of effective regeneration has directed research attention towards stem cell therapy and nerve tissue engineering.

关键词： injuries donor spite

Autoimmune pancreatitis:Cornerstones and future perspectives

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World Journal of gastroenterology 2024年第8期30卷 817-832页

作者： Camilla gallo giulia dispinzieri Nicola Zucchini pietro Invernizzi Sara Massironi division of gastroenterology and Center for Autoimmune Liver diseases Department of Medicine and SurgeryFondazione IRCCS San Gerardo dei TintoriUniversity of Milano-BicoccaMonza 20900Italy Department of Pathology Fondazione IRCCS San Gerardo dei TintoriMonza 20900Italy

Autoimmune pancreatitis(AIP)is an autoimmune subtype of chronic pancreatitis resulting from the aberrant immune response against the pancreas,leading to inflammation and *** AIP is rare,its incidence is increasing and is often misdiagnosed as other pancreatic *** is commonly classified into two *** 1 AIP(AIP-1)is typically associated with elevated serum immunoglobulin g4(Igg4)levels and systemic manifestations,while type 2 AIP is typically a more localized form of the disease,and may coexist with other autoimmune disorders,especially inflammatory bowel ***,there is emerging recognition of a third type(type 3 AIP),which refers to immunotherapy-triggered AIP,although this classification is still gaining acceptance in medical *** clinical manifestations of AIP mainly include painless jaundice and weight *** serum Igg4 levels are particularly characteristic of *** relies on a combination of clinical,laboratory,radiological,and histological findings,given the similarity of AIP symptoms to other pancreatic *** mainstay of treatment for AIP is steroid therapy,which is effective in most *** cases might require additional imm-unosuppressive *** review aims to summarize the current knowledge of AIP,encompassing its epidemiology,etiology,clinical presentation,diagnosis,and treatment *** also address the challenges and controversies in diagnosing and treating AIP,such as distinguishing it from pancreatic cancer and managing long-term treatment,highlighting the need for increased awareness and knowledge of this complex disease.

关键词： Autoimmunity Pancreatitis Autoimmune pancreatitis Immunoglobulin g4 Steroids Relapse

Indocyanine green:The guide to safer and more effective surgery

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World Journal of gastrointestinal Surgery 2024年第3期16卷 641-649页

作者： pietro Fransvea Maria Michela Chiarello Valeria Fico Maria Cariati giuseppe Brisinda Emergency Surgery and Trauma Center Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Department of Surgery Azienda Sanitaria Provinciale di CrotoneCrotone 88900Italy Department of Abdominal and Endocrine Metabolic Medical and Surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

In this editorial we comment on the article by Kalayarasan and co-workers published in the recent issue of the World Journal of gastrointestinal *** authors present an interesting review on the use of indocyanine green fluo-rescence in different aspects of abdominal *** also highlight future perspectives of the use of indocyanine green in mini-invasive ***-cyanine green,used for fluorescence imaging,has been approved by the Food and Drug Administration and is safe for use in *** can be administered in-travenously or *** its advent,there have been several advance-ments in the applications of indocyanine green,especially in the surgical field,such as intraoperative mapping and biopsy of sentinel lymph node,measurement of hepatic function prior to resection,in neurosurgical cases to detect vascular anomalies,in cardiovascular cases for patency and assessment of vascular ab-normalities,in predicting healing following amputations,in helping visualization of hepatobiliary anatomy and blood vessels,in reconstructive surgery,to assess flap viability and for the evaluation of tissue perfusion following major trauma and *** these reasons,the intraoperative use of indocyanine green has become common in a variety of surgical specialties and transplant ***-lorectal surgery has just lately begun to adopt this technique,particularly for perfusion visualization to prevent anastomotic *** regular use of in-docyanine green coupled with fluorescence angiography has recently been pro-posed as a feasible tool to help improve patient *** the best available data,it has been shown that routine use of indocyanine green in colorectal surgery reduces the rates of anastomotic *** use of indocyanine green is proven to be safe,feasible,and effective in both elective and emergency ***,additional robust evidence from larger-scale,high-quality studies is essential before incorporating indocyanine g

关键词： Indocyanine green Colorectal surgery Fluorescence-guided surgery gastrointestinal surgery Hepato-biliary surgery Pancreatic surgery Surgical oncology

Extravasated contrast volumetric assessment on computed tomography angiography in gastrointestinal bleeding:A useful predictor of positive angiographic findings

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World Journal of Radiology 2024年第5期16卷 115-127页

作者： Laura Maria Cacioppa Chiara Floridi Alessandra Bruno NicolòRossini Tommaso Valeri Alessandra Borgheresi Riccardo Inchingolo Francesco Cortese giacomo Novelli Alessandro Felicioli Mario Torresi pietro Boscarato Letizia Ottaviani Andrea giovagnoni division of Interventional Radiology Department of Radiological SciencesUniversity Politecnica Delle MarcheAncona 60126Italy Department of Clinical Special and Dental SciencesUniversity Politecnica Delle MarcheAncona 60126Italy division of Radiology Department of Radiological SciencesUniversity Hospital"Azienda Ospedaliero Universitaria Delle Marche"Ancona 60126Italy Interventional Radiology Unit "F Miulli"Regional General HospitalAcquaviva delle Fonti 70021Italy Department of Radiology IRCCS INRCAAncona 60126Italy

BACKgROUND gastrointestinal bleeding(gIB)is a severe and potentially life-threatening condition,especially in cases of delayed *** tomography angiography(CTA)plays a pivotal role in the early identification of upper and lower gIB and in the prompt treatment of the *** To determine whether a volumetric estimation of the extravasated contrast at CTA in gIB may be a predictor of subsequent positive angiographic *** In this retrospective single-centre study,35 patients(22 men;median age 69 years;range 16-92 years)admitted to our institution for active gIB detected at CTA and further submitted to catheter angiography between January 2018 and February 2022 were ***-three(65.7%)patients underwent endoscopy before *** volumetry was evaluated in both arterial and venous phases via a semi-automated dedicated *** rate was obtained from volume change between the two phases and standardised for unit *** were divided into two groups,according to the angiographic signs and their concordance with *** Upper bleeding accounted for 42.9%and lower gIB for 57.1%.Mean haemoglobin value at the admission was 7.7 g/dL.A concordance between positive CTA and direct angiographic bleeding signs was found in 19(54.3%)*** no significant differences in terms of bleeding volume in the arterial phase(0.55 mL vs 0.33 mL,P=0.35),a statistically significant volume increase in the venous phase was identified in the group of patients with positive angiography(2.06 mL vs 0.9 mL,P=0.02).In the latter patient group,a significant increase in bleeding rate was also detected(2.18 mL/min vs 0.19 mL/min,P=0.02).CONCLUSION In gIB of any origin,extravasated contrast volumetric analysis at CTA could be a predictor of positive angiography and may help in avoiding further unnecessary procedures.

关键词： gastrointestinal haemorrhage Computed tomography angiography Volumetric analysis Computer-assisted image interpretation Therapeutic embolization Transcatheter arterial embolization

Craving variations in patients with substance use disorder and gambling during COVID-19 lockdown:The Italian experience

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World Journal of Clinical Cases 2022年第3期10卷 882-890页

作者： Maria Chiara Alessi giovanni Martinotti Domenico De Berardis Antonella Sociali Chiara di Natale gianna Sepede Daniela Pia Rosaria Cheffo Laura Monti pietro Casella Mauro Pettorruso Stefano Sensi Massimo di giannantonio Department of Neuroscience ImagingClinical SciencesUniversity G.d'AnnunzioChieti-Pescara 66100Italy Department of Pharmacy PharmacologyClinical SciencesUniversity of HertfordshireHertfordshire AL109ABUnited Kingdom National Health Care System Mazzini HospitalTeramo 64100Italy Department of Mental Health UOS Psicologia Ospedaliera Fondazione Policlinico Gemelli IRCSSRome 00118Italy Department of Mental Health and Addiction Services ASL Roma 1Rome 00118Italy

BACKgROUND Following the development of the coronavirus disease-2019(COVID-19)pandemic in Italy,a strict lockdown was imposed from March 9 to May 5,*** risks of self-medication through alcohol or psychoactive substance abuse were increased,as well as the tendency to adopt pathological behaviors,such as gambling and internet *** To evaluate the impact of the COVID-19 pandemic and associated containment measures on craving in a group of patients suffering from substance use disorder and/or gambling.disorder who were in treatment in outpatient units or in residency programs as *** One hundred and fifty-three patients completed a structured questionnaire evaluating craving and other behaviors using a visual analogue scale(VAS).Forty-one subjects completed a pencil and paper questionnaire during the *** clinician provided an online questionnaire to 112 patients who had virtual assessments due to lockdown *** analyses were performed using Statistica version *** parameters are presented as the mean±SD and qualitative parameters as number and percentage per *** Kolmogorov-Smirnov test was used to check for normality of *** of variance and Duncan post hoc test were employed to analyze differences among subgroup *** associations between variables were measured using Pearson's correlation.A P value ofg between the present and the month before showed VASrelated reductions of craving in 57%,increases in 24%,and no significant change in 19%of the *** level of craving was significantly higher(F=4.36;Pg in their own home during the quarantine compared with inpatients(n=56;mean=2.8±2.8)in residential *** for tetrahydrocannabinol was the greatest(4.94,Pg various preferred *** The unexpected result of this study may be explaine

关键词： Substance use disorder Addiction COVID-19 Craving Psychopathology

A Chopper Negative-R Delta-Sigma ADC for Audio MEMS Sensors

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Computer Modeling in Engineering & Sciences 2022年第2期130卷 607-631页

作者： Jamel Nebhen pietro M.Ferreira College of Computer Engineering and Sciences Prince Sattam bin Abdulaziz UniversityAlkharj11942Saudi Arabia Universit´e Paris-Saclay Centrale SupelecCNRSLaboratory de G´enie Electrique et Electronique de ParisGif-sur-Yvette91192France Sorbonne Universite CNRSLab.de Genie Electrique et Electronique de ParisParis75252France

This paper presents a proposed low-noise and high-sensitivity Internet of Thing(IoT)system based on an M&NEMS *** IoT device consists of an M&NEMS resistive accelerometer associated with an electronic readout circuit,which is a silicon nanowire and a Continuous-Time(CT)△∑*** first integrator of the△∑ADC is based on a positive feedback DC-gain enhancement two-stage amplifier due to its high linearity and low-noise *** mitigate both the offset and 1/f noise,a suggested delay-time chopper negative-R stabilization technique is applied around the first integrator.A 65-nm CMOS process implements the CT△∑*** supply voltage of the CMOS circuit is 1.2-V while 0.96-mW is the power consumption and 0.1-mm^(2) is the silicon *** M&NEMS microphone and△∑ADC complete circuit are fabricated and *** a working frequency bandwidth of 20-kHz,the measurement results of the proposed IoT system reach a signal to noise ratio(SNR)of ***,it has a measured dynamic range(DR)of 108-dB and a measured signal to noise and distortion ratio(SNDR)of 101.3-dB.

关键词： M&NEMS sensor △∑ ADC chopper negative-R IoT 1/f noise SNR

digital holography as metrology tool at micronanoscale for soft matter

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Light(Advanced Manufacturing) 2022年第1期3卷 128-153页

作者： Zhe Wang Lisa Miccio Sara Coppola Vittorio Bianco Pasquale Memmolo Volodymyr Tkachenko Vincenzo Ferraro Ernesto di Maio Pier Luca Maffettone pietro Ferraro CNR-ISASI Institute of Applied Sciences and Intelligent Systems"E.Caianiello"Via Campi Flegrei 3480078 PozzuoliNapoliItaly dipartimento di Ingegneria Chimica dei Materiali e della Produzione Industriale Universitàdegli Studi di Napoli"Federico II"Piazzale Tecchio 8080125 NapoliItaly NEAPoLIS Numerical and Experimental Advanced Program on Liquids and Interface SystemsJoint Research Center CNR Universitàdegli Studi di Napoli"Federico II"NapoliItaly

The appearance of the first laser approximately 12 years after the invention of holography by gabor(1948)revolutionized the field of optical *** fact,the invention of holographic interferometry enabled the exploitation of interferometry on non-mirror surfaces and full-scale *** holography-based measurement methods has been implemented to several industrial systems or in support of R&D with the aim of improving new products in many fields(automotive,aerospace,electronics,etc.).To date,holography has been considered an important measurement tool for non-destructive inspection(Ndi),strain-stress measurement,and vibration analysis at various engineering ***,the new paradigm of Industry4.0 has seen the introduction of new technologies and methods of processing materials as well as the development of manufacturing approaches for the realization of innovative *** example,direct printing,additive,and bottom-up manufacturing processes are expected to involve new ways of making products in future,and most innovative fabrication processes will be based on the manipulation of soft matter(e.g.,starting from the liquid phase)that will be shaped at the *** inherent characteristics of digital holography(DH)make it a powerful and accurate tool for the visualization and testing of final products,as well as for in situ and real-time monitoring and quantitative characterization of the processes involved during the fabrication *** review aims to report on the most useful applications of soft matter,where the capabilities offered by DH,such as three-dimensional(3D)imaging,extended focus,3D tracking,full-field analysis,high sensitivity,and a wide range of measurements from nanometers to centimeters,permit completely non-invasive characterizations on a *** holographic experimental results of typical samples are reported and discussed where DH plays a primary role as a tool gauge for soft matter.

关键词： digital holography Soft matter Microscopy Thin film Polymers Liquids Characterization Interferometry Inkjet printing

Mulching as best management practice to reduce surface runoff and erosion in steep clayey olive groves

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International Soil and Water Conservation Research 2021年第1期9卷 26-36页

作者： giuseppe Bombino pietro Denisi JoséAlfonso gómez Demetrio Antonio Zema Mediterranea University of Reggio Calabria Department"Agraria"LocalitàFeo di Vito1-89122Reggio CalabriaItaly Institute for Sustainable Agriculture(IAS-CSIC) Agronomy DepartmentAvenida Menéndez Pidal s/nE-14004CórdobaSpain

No-tillage and soil mulching with pruning residues,applied in olive groves of the semi-arid Mediter-ranean environment,as erosion control practices still practice not fully *** study has evaluated the saturated hydraulic conductivity(Ksat),surface runoff(SR)and soil erosion(SL)under rainfall at plot scale throughout two years in four different management practices,total soil cover with a net(SP),mechanical tillage(MT)and mulching by vegetal residues at 3,5·10^(3) and 17,5·10^(3) kg ha^(-1) of dry matter(NTR350 and NTR1750),in an olive grove of Southern *** varied between 1.6(MT)and 25.1(NTR1750)mm/h.A clear reduction in runoff and soil losses was detected for the mulch-based practices when compared to MT,from 20 to 32%in the runoff coefficient and 75-80%in SL,with higher reductions in the *** reduction in SL can be mainly explained by the reduction in SR and rain-splash,interrill and rill erosion,due to protection by mulch residues,which increased the vegetal cover and organic matter content of mulched *** vegetal cover was on average higher in SP(33%),NTR1750(25%)and NTR350(22%),and lower in MT(12%).The mean organic matter content of soil was 2.01%,1.69%,1.34%and 0.82%for NTR1750,NTR350,SP and MT ***,the results quantify the impact of soil mulching with pruning residues at different doses,which will provide guidelines to control and mitigate the hydrological response of clayey and steep soils in Mediterranean olive groves,analysing the associated environmental and economic benefits.

关键词： Pruning residues Tillage Soil loss Vegetal cover Organic matter Soil hydraulic conductivity