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TTF-1 positive small cell cancers:Don't think they're always primary pulmonary!

World Journal of Gastrointestinal Oncology 2011年第10期3卷 144-147页

作者： Laurine Verset Marianna Arvanitakis Patricia Loi Jean Closset Myriam Delhaye Myriam Remmelink pieter demetter Departments of Pathology Erasme University Hospital Université Libre de Bruxelles 1070 BrusselsBelgium Department of Gastroenterology Erasme University Hospital Department of Digestive Surgery Erasme University Hospital

Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell *** explains why this marker is frequently used in the search for the primary origin of metastatic endocrine *** we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be ***-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed,and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary ***,immunohistochem-istry for TTF-1 in such tumours should be interpreted with caution.

关键词： Thyroid transcription factor 1 Small cell carcinoma Mixed endocrine-exocrine tumour Common bile duct Immunohistochemistry

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New challenges in perioperative management of pancreatic cancer

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World Journal of Gastroenterology 2015年第8期21卷 2281-2293页

作者： Francesco Puleo Raphaёl Maréchal pieter demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem Department of Gastroenterology and Digestive Oncology Erasme Hospital Laboratory of Experimental Gastroenterology Free University of Brussels Department of Pathology Erasme Hospital Department of Radiology Erasme Hospital Department of Hepatogastroenterology Pitié Salpêtrière Hospital

Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized *** progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a *** decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic *** is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at *** strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve *** of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from *** review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized *** also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies.

关键词： Neoadjuvant chemotherapy Biomarkers Preoperative s

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Limited influences of chemotherapy on healthy and metastatic liver parenchyma

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World Journal of Gastroenterology 2005年第34期11卷 5322-5326页

作者： Nancy Van Damme pieter demetter Wouter De Bock Marianne Rottiers Marleen Praet Bernard de Hemptinne Marc Peeters Department of Gastroenterology Ghent University Hospital De Pintelaan 185 1K12IE Ghent 9000 Belgium Department of Pathology Ghent University Hospital De Pintelaan 185 Blok A Ghent 9000 Belgium Department of Surgery Ghent University Hospital De Pintelaan 185 2K12IC Ghent 9000 Belgium

AIM: To examine the expression of E-cadherin, β-catenin,γ-catenin, VEGF, and p53 in 39 patients with hepatic metastasis from colorectal cancer ***: The patients were divided into two groups:those (n = 16) who had no chemotherapy for at least 6 mo before the liver resections and those (n = 23)who were treated with chemotherapy before liver resections. A score from 0 to 3 was given for the number of positive cells and from 0 to 3 for the intensity of staining in these cells, in both healthy and metastatic liver ***: No significant differences in the expression of E-cadherin, β- and γ-catenin, VEGF and p53, could be observed between patients who received and did not receive chemotherapy, in both normal and metastatic liver ***: Despite the assumption that chemotherapy had an effect on liver metastasis, no influences were noticed immunohistochemically.

关键词： Chemotherapy Metastatic liver parenchyma Cadherin Catenin VEGF

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