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Enzymatic co-crosslinking of star-shaped poly(ethylene glycol)tyramine and hyaluronic acid tyramine conjugates provides elastic biocompatible and biodegradable hydrogels

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Bioactive Materials 2023年第2期20卷 53-63页

作者： Rong Wang Xiaobin Huang Bram Zoetebier pieter jdijkstra Marcel Karperien Department of Developmental BioEngineering Faculty of Science and TechnologyTech Med CentreUniversity of TwenteP.O.Box 2177500 AEEnschedethe Netherlands Radboudumc Dept.of Dentistry-Regenerative BiomaterialsRadboud University Medical CenterPhilips van Leydenlaan 256525 EX NijmegenThe Netherlands Department of Oral and Maxillofacial Surgery School of Dental MedicineUniversity of Pennsylvania240 South 40th StreetPhiladelphiaPA 19104-6030US

A combination of the viscoelastic properties of hyaluronic acid(HA)and the elastic properties of star shaped 8-arm poly(ethylene glycol)(8-arm PEG)was used to design in-situ forming *** were prepared by the enzymatic crosslinking of a partially tyramine modified 8-arm PEG and a tyramine conjugated HA using horseradish peroxidase in the presence of hydrogen *** of the homopolymer conjugates and mixtures thereof were rapidly formed within seconds under physiological conditions at low polymer and enzyme *** hydrogels with high gel content(≥95%)and high storage moduli(up to 22.4 kPa)were *** in vitro study in the presence of hyaluronidase(100 U/mL)revealed that with increasing PEG content the degradation time of the hybrid hydrogels increased up to several weeks,whereas hydrogels composed of only hyaluronic acid degraded within 2 *** mesenchymal stem cells(hMSCs)incorporated in the hybrid hydrogels remained viable as shown by a PrestoBlue and a live-dead assay,confirming the biocompatibility of the *** production of an extracellular matrix by re-differentiation of encapsulated human chondrocytes was followed over a period of 28 *** expression indicated that these highly elastic hydrogels induced an enhanced production of collagen type *** low PEG-TA/HA-TA ratios a higher expression of SOX 9 and ACAN was *** results indicate that by modulating the ratio of PEG/HA,injectable hydrogels can be prepared applicable as scaffolds for tissue regeneration applications.

关键词： PEG-OH8 HA Enzymatic crosslinking hydrogel Degradation Proliferation&differentiation

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