检索结果-南通市图书馆

Phytochemical Screening, Study of Acute Toxicity and Hypoglycemic and Antihyperglycemic Activities of Silver Nanoparticles from Guibourtia tessmannii (Harms) J. Leonard (Caesalpiniaceae)

引用

Open Journal of Applied Sciences 2024年第1期14卷 118-130页

作者： Ngoulé Charles Christian Eya’ane Meva François Sone Enone Bertin Ngo Nyobe Biwole Caroline Tankeu Séverin Elisée Songue Pascal Nguene Jean pierre Etame-Loe Gisèle Department of Pharmaceutical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Biology of Plant Organisms Faculty of Sciences University of Douala Douala Cameroon

According to the World Health Organization, diabetes affects approximately 347 million people worldwide. Its management is not within the reach of all social classes, therefore medicinal plants are still the first resort for many populations in Africa. The biological material used in this study was the trunk bark of Guibourtia tessmannii. 50 g of trunk bark powder were decocted in 500 ml of distilled water for 5 minutes were carried out. The method used for the synthesis of silver nanoparticles (AgNps) was an organometallic bio-reduction of silver nitrate salts mediated by various secondary metabolites contained in the plant extract. The study of the toxicity acute was conducted according to guideline 423 of the OECD protocol. The pharmacological activities were each carried out with 28 female rats divided into 7 groups of four rats. It was a question for the hypoglycemic activity of administering various doses of silver nanoparticles and other substances to the rats thirty minutes after the carbohydrate intake and for the anti-hyperglycemic activity of administering the same substances to the rats thirty minutes before the carbohydrate intake. The extraction yield was 8.76%. Only the alkaloid test was negative. After acute toxicity study, the LD50 was greater than 2000 mg/kg. Blood sugar tests revealed that glibenclamide 5 mg/kg, which is the reference molecule, lowered blood sugar more than the other treatments applied in the other batches. It was followed by treatment with silver nanoparticles at a dose of 400 μg/kg in both tests. It was therefore concluded that silver nanoparticles from G. tessmannii are good for the formulation of improved traditional medicines and bring up their afficacity .

关键词： Guibourtia tessmannii Nanoparticles Hypoglycemia Anti-Hyperglycemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Physico-Chemical and Nutritional Properties of a Food Broth Based on Nere (Parkia biglobosa)

引用

Food and Nutrition Sciences 2024年第5期15卷 377-389页

作者： Lassana Bamba Gervais Melaine M’Boh N’Gbésso Amos Ekissi Kipré Laurent Séri Gnogbo Alexis Bahi Koffi pierre Valery Niaba Allico Joseph Djaman Grah Avit Maxwell Beugre Laboratory of Agro-Valorization Department of Agroforesterie Jean Lorougnon Gu&#233d&#233 University Daloa C&#244te d&#8217Ivoire Medical and Fundamental Biochemistry Department Institut Pasteur of C&#244te d&#8217Ivoire Abidjan C&#244te d&#8217Ivoire Laboratory of Biotechnology Agriculture and Valorization of Biological Resources Department of Biosciences Felix Houphouet-Boigny University Abidjan Cote d&#8217Ivoire Biology and Health Laboratory Department of Biosciences Felix Houphouet-Boigny University Abidjan C&#244te d&#8217Ivoire

Purpose: Diet and eating habits are major risk factors for the health and the development of disease, such as, for example, metabolic disorder leading to cardiovascular pathology and cancer, decreased immunity exposing to infections. This study of the physico-chemical and nutritional properties of a soumara-based food broth was carried out with the aim of promoting the consumption of organic broth made from nere seeds (soumara). That is to alleviate certain metabolic diseases, which is a matter of food safety, and also to limit the risk for the health about the consumption of some cooking stocks on the market. Methods: Several natural ingredients such as nere seeds (soumara), ginger, black pepper, parsley and garlic were used to create a nere-based stock. All these ingredients were freeze-dried and the powder obtained was used to make the broth, regarding their physical and chemical properties. Results: The broth had a good protein content of 17.41 ± 0.367 g/100g, a lipid content of 16.80 ± 0.08 g/100g and a fiber content of 8.66 ± 0.04 g/100g. In terms of nutritional values, the broth showed good levels of calcium 184.21 ± 0.09 mg/100g, potassium 50.04 ± 1.45 mg/100g and iron and zinc. In terms of antioxidant activity, the broth also showed good antioxidant activity. Conclusion: Regarding the properties of our food broth, whose composition is based on natural ingredients, could be recommended for consumption and, its properties, could play an important role in preventing and combating certain metabolic diseases.

关键词： Food Broth Nere Physico-Chemical Properties Nutrition Food Safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Local and systemic effects of IL-17 in joint inflammation:a historical perspective from discovery to targeting

引用

Cellular & Molecular Immunology 2021年第4期18卷 860-865页

作者： pierre Miossec Department of Clinical Immunology and Rheum atology and the Immunogenomics and Inflammation Research Unit University of Lyon Hdpital Edouard Herriot LyonFrance

The role of IL-17 in many inflammatory and autoimmune diseases is now well established,with three currently registered anti-IL-17-targeted *** story has taken place over a period of 20 years and led to the demonstration that a T cell product could regulate,and often amplify,the inflammatory *** first results described the contribution of IL-17 to local features in ***,understanding was extended to its systemic effects,with a focus on cardiovascular *** review provides a historical perspective of these discoveries focused on arthritis,which started in 1995,followed 10 years later by the description of Th17 ***,IL-17 inhibitors for three chronic inflammatory diseases have been *** options are now being tested in ongoing and future clinical *** of IL-17 family members and Th17 cells ranging from antibodies to small molecules are under active *** identification of patients with IL-17-driven disease is a key target for the improved selection of patients expected to have a strongly positive response.

关键词： Interleukin-17 Th17 cells Inflammation Arthritis,targeting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

C*-Algebraic Intertwiners for Degenerate Principal Series of Special Linear Groups

引用

Chinese Annals of Mathematics,Series B 2014年第5期35卷 691-702页

作者： pierre CLARE Department of Mathematics Pennsylvania State University McAllister Building University Park

The author constructs unitary intertwiners for degenerate C*-algebraic universal principal series of SL(n + 1) over a local field by explicitely normalizing standard intertwining integrals at the level of Hilbert modu... 详细信息

关键词： Group C*-algebras Hilbert modules Semisimple Lie groups Principalseries representations Intertwining operators

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine learning for enumeration of cell colony forming units

引用

Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 315-322页

作者： louis Zhang Department of Molecular Biosciences College of Natural SciencesUniversity of Texas at AustinAustin TX 78713-8058USA

As one of the most widely used assays in biological research,an enumeration of the bacterial cell colonies is an important but time-consuming and labor-intensive *** speed up the colony counting,a machine learning method is presented for counting the colony forming units(CFUs),which is referred to as *** cellcounting program processes digital images and segments bacterial *** algorithm combines unsupervised machine learning,iterative adaptive thresholding,and local-minima-based watershed segmentation to enable an accurate and robust cell *** to a manual counting method,CFUCounter supports color-based CFU classification,allows plates containing heterologous colonies to be counted individually,and demonstrates overall performance(slope 0.996,SD 0.013,95%CI:0.97–1.02,p value<1e-11,r=0.999)indistinguishable from the gold standard of point-and-click *** CFUCounter application is open-source and easy to use as a unique addition to the arsenal of colony-counting tools.

关键词： Colony forming unit Enumeration Image analysis Blue/white screen Colony count

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Profile of SARS-CoV-2 Infected Patients Hospitalized at the Epidemic Treatment Center (ETC) in Saint-louis, Senegal during the First Two Waves

引用

Advances in Infectious Diseases 2024年第2期14卷 322-337页

作者： Alassane Dièye Papa Latyr Junior Diouf Bourama Diémé Moustapha Diedhiou Diatou Dia-Gueye Amadou Diop Dia Samba Niang Ibrahima louis Martin Dieng Ameth Dieng Seynabou Lô Ndéye Méry Dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Emergency Department of Regional Hospital Center Saint-Louis Senegal Department of Infectious and Tropical Diseases of Fann Dakar Senegal

Introduction: The SARS-CoV-2 infection is a major public health emergency. Several risk factors are involved in the occurrence of respiratory distress that can lead to death despite resuscitation measures. Objectives: The aim of this study was to describe the epidemiological, clinical, paraclinical, therapeutic, and evolution profile of patients infected with SARS-CoV-2 hospitalized at the CTE of Saint-louis (Senegal) during the first two waves. Patients and Methods: We conducted a retrospective, cross-sectional, descriptive, and analytical study that included all patients hospitalized at the ETC of Saint-louis (Senegal) with SARS-CoV-2 infection from March 2020 to April 2021. Results: A total of 358 cases were collected, 256 (71.5%) during the first wave and 102 (28.5%) during the second wave. The mean age was 49.5 years (19.5). There was a male predominance (58.4%), with a sex ratio of 1.4. Hypertension was the main comorbidity, with 87 cases (24.3%). The most common functional signs were cough in 194 cases (54.2%), dyspnea in 143 cases (40%) and ageusia in 134 cases (37.4%). Thoracic CT scans were performed on 20 patients (5.6%), with severe involvement (50% - 75%) observed in 50% of cases. Hydroxychloroquine-azithromycin was prescribed to 351 patients (98%). Overall, 338 (94.4%) recovered and 17 (4.7%) died. In multivariate analysis, factors associated with death were male sex [OR = 2.645;95% CI: 1.530 - 4.785;p = 0.011], age 60 years [OR = 1.039;95% CI: 0.564 - 1.914;p = 0.002], the presence of comorbidities [OR = 2.171;95% CI: 0.564 - 3.429;p = 0.033], SpO2 (ambient air) 95% [OR = 2.061;95% CI: 0.616 - 3.827;p = 0.03], acute respiratory distress syndrome (ARDS) [OR = 0.635;95% CI: 0.316 - 1.275;p = 0.001], severe form [OR = 1.664;95% CI: 0.298 - 2.478;p = 0.016], occurrence of complications [OR = 0.521;95% CI: 0.287 - 0.944;p = 0.032], high creatinine levels [OR = 2.061;95% CI: 1.616 - 3.827;p = 0.026], and lymphopenia [OR = 0.485;95% CI: 0.370 - 0.636;p = 0.0

关键词： SARS-CoV-2 Saint-louis Senegal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

COVID-19/Tuberculosis Co-Infection at the Epidemic Treatment Center (ETC) of Saint-louis (Senegal): About 9 Cases

引用

Advances in Infectious Diseases 2024年第1期14卷 56-66页

作者： Alassane Dièye Moustapha Diedhiou Papa Latyr Junior Diouf Mba Bambo Diakhaby Demba Makalou Samba Niang Diatou Dia-Gueye Amadou Diop Dia Ibrahima louis Martin Dieng Seynabou Lô Ndéye Méry Dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Department of Medicine Saint-Louis Regional Hospital Saint-Louis Senegal Infectious and Tropical Diseases Clinic of Fann Dakar Senegal

Introduction: COVID-19 is a global public health emergency that can cause acute respiratory distress syndrome. In countries where tuberculosis (TB) is endemic, coinfection of COVID-19 and TB is often encountered, which increases the risk of developing severe forms of COVID-19. Objectives: The aim of this study was to determine the prevalence of COVID-19/TB coinfection at the Epidemic treatment center (ETC) in Saint-louis (Senegal) and to describe the epidemiological, clinical, paraclinical, and outcome profile of co-infected patients. Patients and Methods: This is a retrospective, cross-sectional, descriptive cohort study based on the records of COVID-19/ TB co-infected patients who were hospitalized at the ETC in Saint-louis (Senegal) over an 18-month period from March 2020 to September 2021. Results: Out of a total of 454 hospitalizations, we collected records of 9 patients co-infected with COVID-19/TB, resulting in a prevalence of 2%. The study included patients with a median age of 34 years (range: 10-86 years), with a male predominance (7 cases) and a sex ratio of 3.5. The majority of patients (88.9%) had severe forms of COVID-19. Dyspnea and cough were reported in all patients (100%). Pulmonary TB was the most frequent localization, with 9 cases. The diagnosis of COVID-19 was confirmed by nasopharyngeal PCR in all patients (100%). Bacilloscopy was positive in 3 out of 5 cases. One patient tested positive for GeneXpert? MTB/RIF without rifampicin resistance. All patients were prescribed the hydroxychloroquine-azithromycin combination and anti-tuberculosis treatment. Out of the nine patients, four recovered (44.4%) and five died (55.5%). Conclusion: COVID-19/TB coinfection had a low prevalence in our cohort, but was associated with a high mortality due to the frequent occurrence of severe forms of the disease.

关键词： COVID-19 Tuberculosis Saint-louis Senegal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phytochemical Composition and Insecticidal Property of Native Plants against the Cowpea Weevil Callosobruchus maculatus Fab. (Coleoptera: Bruchidae) for Natural Preservation of Cowpea Seeds

引用

Advances in Entomology 2024年第1期12卷 56-66页

作者： Elias Mano Rabièta Simde Koï Wenceslas Kam Nadjatou Ouédraogo Désiré Dramane Abdoul Khader Sanou Rasmané Abdou Ouédraogo Boubakar Ouattara pierre Alexandre Eric Djifaby Sombié Souleymane Nacro Laboratory of Natural Substances and Technologies of Natural Products and the Environment (LABTECH-PRONE) Institute of Research in Applied Sciences and Technologies (IRSAT) Ouagadougou Burkina Faso Central Horticulture Laboratory of the Regional Center of Excellence in Fruits and Vegetables of Bobo-Dioulasso Institute of Environment and Agricultural Research (INERA) Bobo Dioulasso Burkina Faso Department of Animal Biology and Physiology University Joseph Ki-Zerbo Ouagadougou Burkina Faso National Agricultural Training School of Matourkou (ENAFA) Bobo Dioulasso Burkina Faso Institute of Rural Development (IDR) Nazi Boni University Bobo Dioulasso Burkina Faso

About 80% of cowpea seeds are lost along with 30% of their weight after six months of unprotected storage due to attacks by Callosobruchus maculatus. This study aimed at evaluating the effect of applying bioinsecticides on the biological parameters of C. maculatus to reduce its damage to cowpea stocks. Four treatments including an untreated control and three doses of powdery extracts of C. nigricans, Z. zanthoxyloides and H. suaveolens, were compared in a Fischer block with four completely randomized repetitions. One hundred undamaged cowpea seeds were mixed with doses of each extract in Petri dishes and then fed as food substrates to ten pairs of C. maculatus for eight days. The extracts of H. suaveolens, C. nigricans and Z. zanthoxyloides all contain active ingredients including polyphenols, flavonoids, anthocyanins and alkaloids, etc. The extract of Z. zanthoxyloides was found to be more active on adults (100.00% mortality) followed by C. nigricans (98.75% mortality) and H. suaveolens (97.50% mortality) at 80 mg/g. Fecundity per female decreased significantly in the treated batches of 13.82 eggs for H. suaveolens at 10.12 eggs for C. nigricans at a dose of 80 mg/g. Germination rate of seeds was statistically raised to 100% at 60 and 80 mg/g by C. nigricans powder and lowered to 83.00% at 20 mg/g by Z. zanthoxyloides extracts. The application of Z. zanthoxyloides extract would be a less expensive alternative for the sustainable management of C. maculatus in cowpea stocks.

关键词： Cassia nigricans Hyptis suaveolens Zanthoxylum zanthoxyloides Biological Activities Vigna unguiculata Pest Burkina Faso

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Should cross-sex hormone treatment of transsexual subjects vary with ethnic group？

引用

Asian Journal of Andrology 2014年第6期16卷 809-810页

作者： louis J Gooren Department of Endocrinology VU University MedicalCenter Amsterdam the Netherlands Androconsult ChiangMai Thailand

Guidelines for cross-sex hormone treatment of transsexual people have been developed, but no attention has been paid to the specifics of ethnic groups. South East （SE） Asian male-to-female （MtoF） transsexual people may be able to transition to the female sex with lower doses of estrogens/progestins than Caucasians thus reducing health risks. Female-to-male （FtoM） may virilize less profoundly with standard doses of androgens, but this is probably sufficient to pass acceptably as men in view of the less pronounced sex differences in physique in Asians compared with Caucasians. It is timely that studies in Asians are conducted to get a better insight into their specific needs and risks of cross-sex hormone treatment.

关键词： FAT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of the Care of Children Aged 0 to 10 Years Hospitalized for Severe Malaria at the Tambacounda Health Center, Senegal

引用

Advances in Infectious Diseases 2024年第3期14卷 581-594页

作者： Tidiane Gadiaga Aminata Fall Alioune Badara Gueye Siré Sagna Bayal Cissé Mouhamadou Faly Ba Médoune Ndiop Babacar Gueye Samba Cor Sarr Sylla Thiam Elhadji Ba Konko Ciré Jean louis Abdou Ndiaye Issa Wone Directorate of Research Planning and Statistics Ministry of Health and Social Action Dakar Senegal Faculty of Medicine Assane Seck University of Ziguinchor Ziguinchor Senegal Presidents Malaria Initiative USAID Dakar Senegal Tambacounda Health District Ministry of Health and Social Action Tambacounda Senegal Institute of Health and Development Faculty of Medicine Cheikh Anta Diop University Dakar Senegal National Malaria Control Program (NMCP) Dakar Senegal UFR Sant Faculty of Medicine Iba Der Thiam University of This This Senegal

Introduction: Malaria remains a public health priority in Senegal, particularly in Tambacounda, where it is one of the main causes of child mortality. The objective of this work was to evaluate the care of children under 10 years of age hospitalized at the Tambacounda Health Center and the factors associated with recovery. Methods: An analytical, retrospective, and descriptive cross-sectional study with exhaustive recruitment of children 0 to 120 months hospitalized at the Tambacounda reference health center for severe malaria (according to WHO criteria) between 1 January 2018 and 31 December 2021 was performed. Data collection was done through a questionnaire. Records, hospitalization records, and treatment records were the sources of collection. Data entry and analysis were performed on Epi Info 7.2 and R. Results: A total of 481 children hospitalized with severe malaria were recruited. The highest number of cases was recorded in 2018 (33.05%). In the four years of the study, peaks were always observed between October and November and the highest peak in November 2020 with 95 cases. The mean age was 65.64 months with a standard deviation of 29.28 months and a predominance of male (53.43%). The majority of people were admitted from the outpatient clinic (57.79%) and the rest (42.21%) on the recommendation of a peripheral health post. All hospitalized patients had a positive RDT and/or a positive thick drop. However, the sharp decline at admission or during hospitalization was positive in 93.80% of patients in our series, negative in 5.20% and not achieved in 1.00%. Seizures and severe anemia topped the list of signs of severity with 45.94% and 8.11%, respectively. In terms of evolution, for all hospitalized patients, there were 81.29% recovery, 10.19% referral to the Tambacounda regional hospital center for hospitalization, 4.99% death, 0.83% discharge and 2.70% unknown evolution. There was a statistically significant association between recovery without referral f

关键词： Severe Malaria Children Tambacounda Senegal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：