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Molecular Characterization of Gastrointestinal Stromal Tumors (Gist) and Contribution of Immunohistochemistry in Congolese from Kinshasa

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Open Journal of Gastroenterology 2024年第4期14卷 109-116页

作者： Rive Lukuaku Jérémie Okumadi Fabrice Bokambandja Andy Mbangama Vincent Mbatu Georges Mvumbi Jean-louis Mumbere David Azako Serge Pezo Dieudonné Mvumbi Faculty of Medicine Bel Campus Technological University Kinshasa DR Congo Department of Anatomy and Pathological Cytology University Clinics of Kinshasa Kinshasa DR Congo Department of Gyneco-Obstetrics University Clinics of Kinshasa Kinshasa DR Congo Molecular Biology Department Faculty of Medicine University of Kinshasa Kinshasa DR Congo Institute of Medical Immunology Free University of Brussels Ixelles Belgium

Introduction: The differentiation of digestive tumors very often requires the use of techniques currently not widely in use in the Democratic Republic of Congo (DRC), such as immunohistochemistry. This is perfectly verified for GISTs whose precise, or at least highly certain, diagnosis can only be made using immunohistochemical markers. This underuse of these techniques due to lack of equipment and human skills explains the limited epidemiological data available to date, thus leading to untargeted and too often late treatment of patients. Research question: What contribution can immunohistochemical markers make to the diagnosis of digestive tract tumours? Objective: Discuss the contribution of immunohistochemical markers in the diagnosis of GIST and provide basic data on the epidemiology of these nosological entities in Kinshasa. Methodology: This was a retrospective study carried out at the LEBOMA private anatomy and pathological cytology centre. The main inclusion criterion was any digestive tract block or slide whose diagnosis of GIST had been requalified after review by at least 2 pathologists. An immuhistochemical study was performed using an automated technique (with a Ventana XT machine) using a panel of antibodies: CD-117 and DOG-1 which are listed in the literature as strongly correlated with the occurrence of GIST, all slides were made at Hj Hospital using an OLYMPUS BX41 co-observation microscope. Results: Of 601 cases of digestive tumors recorded during the concerned period, 32 (5.32%) concerned GIST. This prevalence was confirmed by our immunohistochemical results where the expression of CD117 and that of DOG-1 were positive in 90.6% and 100% of cases which prevalence is high compared with the worldwide prevalence according to the literature, respectively. The distribution of the patients concerned was made with a sex ratio of 1.6 women/men with a median age of 53 years. Most cases (81%) had a gastric location and were fusiform GISTs. Conclusion: Gastro

关键词： Digestive Tumors GIST Immunohistochemistry CD117 DOG-1

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备用电池的扩展运用

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国外铁道机车与动车 2024年第2期 46-48页

作者： [美]pierre Prenleloup 李梦斐(译) 不详

镍电池最早装载于地铁车辆用作车载备用电源,当车辆需要紧急牵引时,镍电池也可提供动力,相较于安装独立的电池包,其具有很好的成本优势。

关键词： Saft公司 MSX电池莫斯科-2020车队

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Kinematic History and Changes in the Tectonic Stress Regime during the Cenozoic along the Qinling and Southern Tanlu Fault Zones

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Acta Geologica Sinica(English Edition) 1999年第3期73卷 264-274页

作者： ZHANG Yueqiao pierre Vergèly Jacques-louis Mercier WANG Yongmin ZHANG Yong HUANG Dezhi Institute of Geomechanics Chinese Academy of GeologyBeijing 100081China URA-CNRS:Géophysique et Géodynamique Interne Universitéde Parie-SudBatment 509F-91405Orsay-CedexFrance Institute of Geology Bureau of Geology and Mineral Resouces of Anhui ProvinceHefeiChina

Since the mid-late Eocene, North China has been subjected to extensional stress, resulting in the formation and development of basins. The dynamic origin of this crustal extension has long been an issue of debate. This paper presents the results of kinematic analyses of faults obtained from two seperated areas in North China. In the Weihe graben situated on the southernmost margin of the Ordos block, analyses of fault kinematics were coupled with an analysis of the basin's subsidence history. Three successive extensional tectonic phases accompaning the basin's formation and development have been distinguished. The Palaeogene extension was oriented in a WNW-ESE direction; the Neogene extension in a NE-SW direction and the Pliocene-Quaternary extension in a NW-SE direction. Such changes have also been recorded by fault kinematics along the southern Tanlu fault zone. This has been demonstrated by three successive sets of fault striations indicating normal dip slip resulting from NW-SE extension, then left-lateral slip with a normal component resulting from NE-SW extension, and right-lateral slip with a minor normal component, respectively. The kinematic history of faults and their chronological evolution indicate changes in continental dynamics acting in North China over Cenozoic time.

关键词： fault kinematics tectonic stress regime Qinling and Tanlu fault zones

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Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer

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World Journal of Gastroenterology 2014年第31期20卷 10758-10768页

作者： Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves pierre Cordelier louis Buscail Department of Gastroenterology CHU Toulouse Rangueil University of Toulouse INSERM UMR 1037 CHU Toulouse Rangueil University of Toulouse Department of Pathology CHU Toulouse Purpan University of Toulouse

Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials.

关键词： Pancreatic ductal adenocarcinoma Endoscopic ultrasound-guided fine-needle aspiration Solid pancreatic mass KRAS-mutation assay qPCR analysis Micro-RNA Chronic pancreatitis

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在不同文化间架起沟通的桥梁

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紫禁城 2024年第3期350卷 120-125页

作者：皮埃尔·雷诺(pierre Rainero) 杨锐(译) 卡地亚

卡地亚,创立于一八四七年的法国巴黎,是皇室御用珠宝商。同时作为一家有着深厚历史和自身文化的国际品牌,卡地亚一直积极推动与支持全球艺术与文化交流,与法国凡尔赛宫和故宫博物馆两座世界级艺术殿堂都保持着长久而密切的关系,多次参... 详细信息

卡地亚,创立于一八四七年的法国巴黎,是皇室御用珠宝商。同时作为一家有着深厚历史和自身文化的国际品牌,卡地亚一直积极推动与支持全球艺术与文化交流,与法国凡尔赛宫和故宫博物馆两座世界级艺术殿堂都保持着长久而密切的关系,多次参与支持展现中西方文化相互影响的展览。

关键词：国际品牌卡地亚凡尔赛宫艺术殿堂艺术与文化中西方文化珠宝商相互影响

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Associated Factors with Early Sexual Intercourse among In-School Adolescents in Brazzaville

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Open Journal of Pediatrics 2024年第5期14卷 898-907页

作者： Aymar pierre Gildas Oko Dumez Ngoma Judicaël Kambourou Eryx Darius Mbou Essie Neli Yvette Ngakengni Lynda Tchidjo Ngamo Georges Marius Moyen Faculty of Health Sciences Marien Ngouabi University of Brazzaville Brazzaville Congo Department of Pediatrics Teaching Hospital Center of Brazzaville Brazzaville Congo

Background: Early sexual intercourse (ESI) is a global public health problem. In Congo, associated factors with ESI have been under-studied. Objective: To analyse factors associated with early sexual intercourse among in-school adolescents in Brazzaville. Method: A cross-sectional analytic study with three-stage random sampling was carried out from March 2 to June 2, 2022 in Brazzaville secondary and high schools. Adolescents in the selected schools were interviewed about their sexual and social behaviour, and their family and school environment. Multivariate analysis using logistic regression was used to identify factors associated with ESI. The significance level of the p-value was set at 5% and the confidence interval at 95%. Results: Of a total of 1100 adolescents surveyed, 800 (72.7%) had ESI, 98% of them were female. The main reason for early initiation of sexual intercourse was curiosity (81.8%). Non-use of condoms and multiple sexual partnerships were noted respectively in 98.7% and 68.7% of adolescents who had experienced ESI. Female gender (p Conclusion: The prevalence of ESI is high, and the factors identified in this study may help to reduce it.

关键词： Associated Factors Early Sex Adolescents Brazzaville

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Projected Changes in the Climate Zoning of Côte d’Ivoire

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Atmospheric and Climate Sciences 2024年第1期14卷 62-84页

作者： Mamadou Diarrassouba Adama Diawara Assi louis Martial Yapo Benjamin Komenan Kouassi Fidèle Yoroba Kouakou Kouadio Dro Touré Tiemoko Dianikoura Ibrahim Koné Arona Diedhiou Laboratory of Sciences Matter Environment and Solar Energy (LASMES) University Félix Houphou&#235t-Boigny Abidjan C&#244te d’Ivoire Geophysical Station of Lamto (GSL) N’douci C&#244te d’Ivoire Laboratory of Fundamental and Applied Physics University Nangui Abrogoua Abidjan C&#244te d’Ivoire Université Grenoble Alpes (UGA) Institut des Géosciences de l’Environnement (IGE) Institut de Recherche pour le Développement (IRD) Centre National de Recherche Scientifique (CNRS) Institut National Polytechnique (INP) Grenoble France African Centre of Excellence on Climate Change Biodiversity and Sustainable Agriculture (ACE-CCBAD)/University Felix Houphou&#235t-Boigny (UFHB) Abidjan C&#244te d’Ivoire

This study assesses the projected changes in the climate zoning of Côte d’Ivoire using the hierarchical classification of principal components (HCPC) method applied to the daily precipitation data of an ensemble of 14 CORDEX-AFRICA simulations under RCP4.5 and RCP8.5 scenarios. The results indicate the existence of three climate zones in Côte d’Ivoire (the coastal, the centre and the north) over the historical period (1981-2005). Moreover, CORDEX simulations project an extension of the surface area of drier climatic zones while a reduction of wetter zones, associated with the appearance of an intermediate climate zone with surface area varying from 77,560 km2 to 134,960 km2 depending on the period and the scenario. These results highlight the potential impacts of climate change on the delimitation of the climate zones of Côte d’Ivoire under the greenhouse gas emission scenarios. Thus, there is a reduction in the surface areas suitable for the production of cash crops such as cocoa and coffee. This could hinder the country’s economy and development, mainly based on these cash crops.

关键词： Climate Projection Climate Zone Principal Component Analysis Hierarchical Classification on Principal Components CORDEX Côte d’Ivoire

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A Review on Complex System Engineering

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Journal of Systems Science & Complexity 2020年第6期33卷 1755-1784页

作者： PARREND pierre COLLET pierre ECAM Strasbourg-Europe 2Rue de MadridSchiltigheimFrance University of Strasbourg StrasbourgFrance

Complexity is commonly summarized as‘the actions of the whole are more than the sum of the actions of the parts’.Understanding how the coherence emerges from these natural and artificial systems provides a radical shift in the process of thought,and brings huge promises for controlling and fostering this *** authors define the term‘Complex System Engineering’to denote this approach,which aims at transferring the radical insights from Complex System Science to the pragmatic world of engineering,especially in the Computing System Engineering domain.A theoretical framework for Complex System Engineering is built by the morphogenetic engineering framework,which identifies a graduation of models,in growing order of generative *** implementation of Complex System Engineering requires a portfolio of operational solutions:The authors therefore provide a classification of Complex System application approaches to answer this challenge and support the emergence of Complex System Engineers capable of addressing the issues of an ever more connected world.

关键词： Complex networks complex software engineering complex systems design structure matrix emergent engineering evolutionary algorithms organically grown architectures

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Resistant Pulmonary TB-HIV Co-Infection in an Infant: About a Case

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Open Journal of Pediatrics 2024年第2期14卷 420-425页

作者： Mariam Maiga pierre Togo Tati Simaga Mariam Traoré Moussa Konaté Mamadou Diallo Alou Samaké Mamadou Keïta Korotoumou Wélé Diallo Djibril Kassogué Pediatrics Department Distric VI Reference Health Center Bamako Mali Paediatrics Department Gabriel Touré Teaching Hospital Bamako Mali Pediatrics Department Mali Hospital Bamako Mali Paediatrics Department Timbuktu Regional Hospital Bamako Mali

Diagnosis of childhood tuberculosis (TB) is difficult, especially in resource-limited countries where the number of reported cases of TB-HIV co-infection continues to rise. This co-infection poses a diagnostic and therapeutic problem for caregivers. We report a case of rifampicin-resistant HIV-TB pulmonary coinfection in a 19-month-old infant.

关键词： Tuberculosis Rifampicin Resistance HIV Infants

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Biodiversity of Edible Caterpillars of Imbrasia and Host Plants in Boukoko (Central African Republic)

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Advances in Entomology 2024年第1期12卷 38-55页

作者： Lucie Aba-Toumnou Solange-Patrica Wango Denis Beina Jean-pierre Moalbaye Gorgon Igor Touckia Rufin Reo-Ndouba Felix Allah-Barem Olga Diane Yongo Laboratory of Biological and Agronomical Sciences for Development Faculty of Sciences University of Bangui Bangui Central African Republic Laboratory of Applied Animal Biology and Biodiversity University of Bangui Bangui Central African Republic Center of Studies and Research on Pharmacopoeia and Traditional African Medicine (CERPHAMETA) University of Bangui Bangui Central African Republic Plant and Fungal Biodiversity Laboratory Faculty of Science University of Bangui Bangui Central African Republic Higher Institute for Rural Development (ISDR) University of Bangui Mba&iumlki Central African Republic Central African Republic Institute of Agriculture Research Bangui Central African Republic

In Central African Republic, edible caterpillars of Imbrasia gender are income of rural populations, present an opportunity to improve food security and belonging to the category of Non-wood forest products. The goal of this study is to document the ecology of caterpillars of genre Imbrasia in relation to its host plants in Boukoko. The questionnaire was addressed to the actors of the collection and consumption of caterpillars in this Commune, to their local knowledge concerning this food resource as well as the plants of their locality on which caterpillars are collected. The survey took place in September to October 2022 and as a general rule, the 120 respondents were elderly people whose age range varied from 35 to 70 years old. Plant samples are collected in their natural environment. Based on local names;herbaria are mounted, plants photographed and samples collected. The types of edible caterpillars have been inventoried in the field in collaboration with the local populations who consume them. Based on local names, the caterpillars are captured manually from morphological traits and then stored in bottles containing 70% ethanol. The specimens were identified. The data was entered into the Excel spreadsheet which also made it possible to produce histograms with the frequencies of the plant species most valued by the different caterpillars. A Principal Component Analysis (PCA) was then performed using R software to highlight the correlation between caterpillars and host plants. The main economic importance trees hosting edible caterpillars of Imbrasia gender in Boukoko region are: Entandrophragma cylindricum, Pentaclethra macrophylla, Maesopsis eminii, Albizia ferruginea, Macaranga spinosa, Amphimas ferrugineus, Pentaclethra macrophylla, Racosperma auriculiforme, Eribroma oblonga. The Principal Component Analysis (PCA) carried out to assess the variability between the different species of caterpillars according to their host plants shows that the first two axes

关键词： Forest Degradation Losing Biodiversity of Consumed Insects Local Population

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