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Tracking market and non-traditional sources of risks in procyclical and countercyclical hedge fund strategies under extreme scenarios:a nonlinear VAR approach

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Financial Innovation 2022年第1期8卷 696-751页

作者： françois-Éric Racicot Raymond Théoret Telfer School of Management University of Ottawa55 Laurier Avenue EastOttawaONCanada IPAG Business School ParisFrance École des Sciences de la Gestion Universitédu Québec(Montréal)315 est Ste-CatherineR2915MontréalQCCanada Chaire d’Information Financière et Organisationnelle ESG-UQAMMonntréalQuébecUniversitédu Québec(Outaouais)MontréalCanada

The subprime crisis was quite damaging for hedge *** the local projection method(Jordà2004,2005,2009),we forecast the dynamic responses of the betas of hedge fund strategies to macroeconomic and financial shocks—especially volatility and illiquidity shocks—over the subprime crisis in order to investigate their market timing *** a robustness check,using TVAR(Balke 2000),we simulate the reaction of hedge fund strategies’betas in extreme scenarios allowing moderate and strong adverse *** results show that the behavior of hedge fund strategies regarding the monitoring of systematic risk is highly nonlinear in extreme scenarios—especially during the subprime *** find that countercyclical strategies have an investment technology which differs from procyclical *** crises,the former seek to capture non-traditional risk premia by deliberately increasing their systematic risk while the later focus more on minimizing *** results suggest that the hedge fund strategies’betas respond more to illiquidity uncertainty than to illiquidity risk during *** find that illiquidity and VIX shocks are the major drivers of systemic risk in the hedge fund industry.

关键词： Hedge fund Procyclicality Illiquidity risk shock Illiquidity uncertainty shock Local projection model TVAR Optimal forecast Measurement errors

Synthesis of phosphanaphthalenes and nido-carborane fused six-membered phosphacycles

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Chinese Chemical Letters 2021年第1期32卷 194-197页

作者： Guanyu Tao Feichao Yang Lujun Zhang Yang Li Zheng Duan françois Mathey College of Chemistry Green Catalysis CenterInternational Phosphorus LaboratoryInternational Joint Research Laboratory for Functional Organophosphorus Materials of Henan ProvinceZhengzhou UniversityZhengzhou 450001China

A simple method to synthesize luminescent λ^(5)-phosphanaphthalenes and zwitterionic nido-carborane fused six-membered phosphacycles was developed from the reaction of ortho-phosphinobenzoaldehydes or ortho-phosphino... 详细信息

关键词： Phosphorus λ^(5)-Phosphanaphthalenes Zwitterionic nido-Carborane Electron-deficient alkyne

Pharmacological manipulation of transcription factor protein-protein interactions:opportunities and obstacles

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Cell Regeneration 2015年第1期4卷 8-19页

作者： frank Fontaine Jeroen Overman Mathias françois Division of Genomics of Development and Diseases Institute for Molecular BioscienceThe University of Queensland306 Carmody RoadSt LuciaQLD 4072Australia

Much research on transcription factor biology and their genetic pathways has been undertaken over the last30 years, especially in the field of developmental biology and cancer. Yet, very little is known about the molecularmodalities of highly dynamic interactions between transcription factors, genomic DNA, and protein *** breakthroughs such as RNA-seq (RNA-sequencing), ChIP-seq (chromatin immunoprecipitationsequencing), RIME (rapid immunoprecipitation mass spectrometry of endogenous proteins), and single-moleculeimaging will dramatically accelerate the discovery rate of their molecular mode of action in the next few *** a pharmacological viewpoint, conventional methods used to target transcription factor activity withmolecules mimicking endogenous ligands fail to achieve high specificity and are limited by a lack of identificationof new molecular targets. Protein-protein interactions are likely to represent one of the next major classes oftherapeutic targets. Transcription factors, known to act mostly via protein-protein interaction, may well be atthe forefront of this type of drug development. One hurdle in this field remains the difficulty to collate structuraldata into meaningful information for rational drug design. Another hurdle is the lack of chemical libraries meeting thestructural requirements of protein-protein interaction *** more attempts at modulating transcription factor activity are undertaken, valuable knowledge will be accumulatedon the modality of action required to modulate transcription and how these findings can be applied to developingtranscription factor drugs. Key discoveries will spawn into new therapeutic approaches not only as anticancer targetsbut also for other indications, such as those with an inflammatory component including neurodegenerative disorders,diabetes, and chronic liver and kidney diseases.

关键词： Transcription Screening Proteomics Interactome Pharmacology Specificity Cancer Genomics

Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2-negative breast cancer

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Cancer Communications 2023年第8期43卷 943-946页

作者： françois Bertucci Alexandre De Nonneville Pascal Finetti Emilie Mamessier11Laboratory of Predictive Oncology Label Team“Ligue contre le cancer”Cancer Research Center of MarseillePaoli-Calmettes InstituteAix-Marseille UniversityInserm UMR1068CNRS UMR725MarseilleFrance Department of Medical Oncology Paoli-Calmettes InstituteMarseilleFrance

Dear Editor,Pembrolizumab,an immune checkpoint inhibitor(ICI),was recently approved for early-stage triple-negative breast cancer(eTNBC),and promising results have been reported in advanced hormone receptor-positive/human epidermal growth factor receptor 2-negative(HR+/HER2-)and HER2+BCs[1].Given the costs and potential toxicity,markers predictive of ICI benefits are ***,neither programmed death-ligand 1(PD-L1)expression nor other tested markers(i.e.,tumor mutational burden,microsatellite instability)effectively predict ICI benefit[2].Tertiary lymphoid structures(TLS)are secondary lymphoid organ-like aggregates that reside in the tumor microenvironment and are associated with clinical response to ICIs in metastatic melanoma,renal cell carcinoma.

关键词： lymphoid breast cancer

Non-glide effects and dislocation core fields in BCC metals

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npj Computational Materials 2019年第1期5卷 178-185页

作者： Antoine Kraych Emmanuel Clouet Lucile Dezerald Lisa Ventelon françois Willaime David Rodney Institut Lumière Matière UniversitéLyon 1-CNRSVilleurbanne F-69622France DEN-Service de Recherches de Métallurgie Physique CEAUniversitéParis-SaclayGif-sur-Yvette F-91191France Institut Jean Lamour CNRS UMR 7198Universitéde LorraineF-54000 NancyFrance DEN-Département des Matériaux pour le Nucléaire CEAUniversitéParis-SaclayGif-sur-Yvette F-91191France

A hallmark of low-temperature plasticity in body-centered cubic(BCC)metals is its departure from Schmid’s *** aspect is that non-glide stresses,which do not produce any driving force on the dislocations,may affect the yield *** show here that this effect is due to a variation of the relaxation volume of the 1/2screw dislocations during *** predict quantitatively nonglide effects by modeling the dislocation core as an Eshelby inclusion,which couples elastically to the applied *** model explains the physical origin of the generalized yield criterion classically used to include non-Schmid effects in constitutive models of BCC *** use first-principles calculations to properly account for dislocation cores and use tungsten as a reference BCC ***,the methodology developed here applies to other BCC metals,other energy models and other solids showing nonglide effects.

关键词： dislocation metals plasticity

Comment on:a multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 270-272页

作者： Christian Hobeika Mickaël Lesurtel françois Cauchy Department of HPB and Liver Transplantation PitiéSalpêtrière HospitalUniversity Paris-SorbonneAP-HPParisFrance Department of HPB and Liver Transplantation Beaujon HospitalUniversity of ParisAPHPClichyFrance Inflammation Research Center UMR INSERM 1149ParisFrance

In this multicenter,international retrospective study,Schlegel et *** at determining reference results of liver transplantation(LT)with Maastricht type 3 donation after cardiac death(DCD)grafts using the well-known benchmark methodology(1).Seventeen European(n=11)and North American(n=6)centers enrolling more than 2,000 DCD LT over a period of 16 years were *** harvested and preserved using“dynamic”(regional normothermic circulation and/or machine perfusion)techniques were not included.

关键词： centers analysis global

Alpha-fetoprotein:A controversial prognostic biomarker for small hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第3期19卷 328-330页

作者： Mohamed Asrih Sébastien Lenglet franois Mach Fabrizio Montecucco Cardiology Division Department of MedicineGeneva University HospitalFoundation for Medical Research1211 GenevaSwitzerland Clinic of Internal Medicine 1 Department of Internal MedicineUniversity of Genoa16126 GenoaItaly

The assessment of the prognosis in patients with early hepatocellular carcinoma represents a hot-topic issue that requires further improvements and clarifications. The life expectancy of the patients has been shown to depend on several clinical and histological parameters (such as patient's general conditions,macroscopic tumor morphology and histopathology).Recently,the prognostic role of some biomarkers[i.e.,alpha-fetoprotein(AFP)] has been also investigated with controversial findings mainly on the assessment of patient *** study by Giannini et al failed to show a prognostic value of AFP on survival of patients with well-compensated cirrhosis and small hepatocellular *** the study presents some limitations,a larger clinical trial is needed to clarify the potential prognostic role of serum AFP levels in these patients.

关键词： Hepatocellular carcinoma Alpha-fetopro-tein Prognosis Cirrhosis Biomarker

Baossi–Warack monogenetic volcanoes, Adamawa Plateau,Cameroon: petrography, mineralogy and geochemistry

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Acta Geochimica 2019年第1期38卷 40-67页

作者： Anicet Feudjio Tiabou Robert Temdjim pierre Wandji Jacques-Marie Bardintzeff Vivian Bih Che Edith Ekatah Bate Tibang Caroline Neh Ngwa fran?ois Xavier Onana Mebara Remote Sensing Unit Faculty of Science Department of Geology University of Buea Department of Earth Sciences Faculty of Science University of Yaoundé 1 Laboratoire de Géologie Ecole Normale Supérieure de Yaoundé Univ.Paris-Sud Sciences de la Terre VolcanologiePlanétologie UMR CNRS 8148 GEOPS Bat.504 Université Paris-Saclay Higher Teacher Training College Department of GeologyUniversity of Bamenda Institute for Geological and Mining Research (IRGM) Institute for Geological and Mining Research (IRGM) Branch of Volcanologic and Geophysics Research (ARGV)

Three monogenetic cones in the Baossi–Warack area, Ngaoundéré, Adamawa Plateau forming part of the Cameroon Volcanic Line(CVL) are documented in this study. Basaltic lavas(<1 km^3) scattered around these vents and restricted volcaniclastic deposits were emplaced by Hawaiian and mild strombolian style eruptions. The lavas are porphyritic, mainly composed of olivine(chrysolite) and clinopyroxene(diopside and augite) phenocrysts and plagioclase(andesine) microphenocrysts. Accessory minerals include titano-magnetite and titano-hematite, nepheline,apatite and amphibole xenocrysts. Sanidine occurs in some samples and sodi-potassic albite in others. Some olivines and clinopyroxenes exhibit resorbed margins and thin reaction rims while plagioclase displays oscillatory zoning, and sieved textures as a result of magma mixing. Whole-rock geochemistry data indicates that the lavas are silica-undersaturated, composed of basanites and basalts, showing little compositional variations(SiO_2: 39.20 wt.%–48.01 wt.%,MgO: 5.29 wt.%–9.70 wt.%). Trace elements patterns of these lavas suggest they are enriched in LILE including Pb,probably due to crustal contamination. REE patterns suggest cogenetic magmas below Baossi 1 and Baossi 2 volcanoes,and distinct sources below Warack volcano and nearby *** lavas studied show affinity to high-μ(HIMU), enriched type Ⅰ(EM1) and Oceanic Island Basalt(OIB)-like mantle signatures and thus indicate a heterogeneous mantle source underneath the vents as noted at other monogenetic and polygenetic volcanoes along the CVL. Primary melts derived from low degrees of partial melting(0.5%–2%) and encountered low rates of fractionation, and crustal contamination coupled with magma mixing. These melts evolved independently through structural weaknesses in the basement.

关键词： Cameroon volcanic line Adamawa Plateau Volcanic field Monogenetic volcano Magma mixing Petrogenesis

Double cholecystectomy in case of accessory gallbladder:Not as easy as two cholecystectomies

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 93-95页

作者： Benjamin Darnis Kayvan Mohkam fran?ois Cauchy Jean-Yves Mabrut Department of General Surgery and Liver Transplantation Hospices Civils de Lyon Croix-Rousse University Hospital Ecole Doctorale EDISS 205 Université Lyon 1 HPB Surgery and Liver Transplantation Unit Beaujon Hospital

To the Editor:Accessory gallbladders(AG)are rare and their management are usually *** variations are related with an abnormal division of the bile ducts precursors between the 5th and the 12th week of *** et al.[1]proposed an anatomical classification of these variations based on the embryologic abnormalities *** type 1 both gallbladders are connected to the common bile duct at the same *** type 2 the AG can reach either the common bile duct(ductular type)or an intrahepatic biliary duct(trabecular type).In type 3,three gallbladders are present.

关键词： gallbladders Harlaftis