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Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 132-142页

作者： Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau pierre-fran?ois laterre pierre Goffette Chantal De Reyck Beno?t Lengelé pierre Gianello Jan Lerut Starzl Abdominal Transplant Unit Cliniques Universitaires Saint-Luc Institut de Recherche Expérimentale et Clinique Université catholique de Louvain Department of Biotechnological and Applied Clinical Sciences University of L’Aquila Hepatobiliopancreatic Unit Las Higueras Hospital Cirugía de Trasplantes Centro Médico Imbanaco Department of Intensive Care Cliniques Universitaires Saint-Luc Université catholique de Louvain Department of Radiology Cliniques Universitaires Saint-Luc Université catholique de Louvain Department of Plastic and Reconstructive Surgery Cliniques Universitaires Saint-Luc Université catholique de Louvain P?le de Chirurgie Expérimentale et Transplantation Institut de Recherche Expérimentale et Clinique Université catholique de Louvain

Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely

关键词： Liver transplantation Living-donor Hepatocellular cancer Secondary liver tumor Small-for-size syndrome Small-for-size graft

sTREM-1 is a specific biomarker of TREM-1 pathway activation

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Cellular & Molecular Immunology 2021年第8期18卷 2054-2056页

作者： Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa pierre-françois laterre Sebastien Gibot Amir Boufenzer Marc Derive Inotrem Vandœuvre-lès-NancyFrance Division of Infectious Diseases Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands Intensive Care Unit Saint Louis-Lariboisière-Fernand Widal University HospitalAssistance Publique Hôpitaux de Parisand Universitéde ParisInserm MASCOTParisFrance Intensive Care Unit UniversitéCatholique de LouvainLouvain-la-NeuveBelgium Intensive Care Unit CHRU de Nancyand Universitéde LorraineNancyFrance

TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and ***-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3].

关键词： immune myeloid activation

SEPARATION OF SCALES IN ELASTICITY IMAGING:A NUMERICAL STUDY

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Journal of Computational Mathematics 2010年第3期28卷 354-370页

作者： Habib Ammari pierre Garapon franois Jouve Institut Langevin Laboratoire Ondes et Acoustique Laboratoire J.L.Lions Universite Paris Ⅶ Laboratoire J.L.Lions Université Paris Ⅶ

In magnetic resonance elastography, one seeks to reconstruct the shear modulus from measurements of the displacement field in the whole body. In this paper, we present an optimization approach which solves the problem by simply minimizing a discrepancy functional. In order to recover a complex anomaly in a homogenous medium, we first observe that the information contained in the wavefield should be decomposed into two parts, a ＂near-field＂ part in the region around the anomaly and a ＂far-field＂ part in the region away from the anomaly. As will be justified both theoretically and numerically, separating these scales provides a local and precise reconstruction.

关键词： Elastography multi-scale imaging anomaly reconstruction.

Triaxial tension and compression tests on saturated lime-treated plastic clay upon consolidated undrained conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第12期15卷 3328-3342页

作者： Kuchvichea Kan Bertrand françois Department of Civil Engineering Institute of Technology of CambodiaPhnom PenhCambodia BATir Department UniversitéLibre de BruxellesBrusselsBelgium ArGEnCo Departement Universitéde LiègeLiègeBelgium

Lime-treatment of clayey soil significantly increases its shear and tensile ***,the tensile strength of lime-treated soils deserves careful investigation because it may provide an appreciable benefit for the stability of earth *** study investigates the tensile and shear strengths of an untreated and lime-treated(3%of lime)plastic clay at different curing times(7 d,56 d and 300 d),through triaxial tension and compression *** tension tests are performed using“diabolo-shaped”soil samples with reduced central section,such that the central part of the specimen can be under axial tension while both end-sections remain in axial *** undrained(CU)conditions with measurement of pore water pressure allow analyzing the failure conditions through effective stress and total stress *** results of triaxial tension tests reveal that the failure occurs under tensile mode at low confining pressure while extensional shear failure mode is observed under higher confining ***,a classical Mohr-Coulomb shear failure criterion must be combined with a cut-off tensile strength criterion that is not affected by the confining *** comparing shear failure under compression and tension,a slight anisotropy is observed.

关键词： Tensile strength Consolidated undrained(CU)triaxial test Lime-treated soils Failure criterion

Influence of the iodide/iodine redox system on the self-discharge of AC/AC electrochemical capacitors in salt aqueous electrolyte

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Progress in Natural Science:Materials International 2015年第6期25卷 622-630页

作者： Qamar Abbas fran?ois Béguin Institute of Chemistry and Technical Electrochemistry Poznan University of Technology

Self-discharge(SD) of AC/AC(AC ? activated carbon) electrochemical capacitors in aqueous solutions of lithium sulfate(Li2SO4) and lithium sulfate t iodide salts(Li2SO4tKI or Li2SO4tLi I) was investigated at 24 1C and 40 1C after cell potential hold at values from 1 V to 1.6 ***24 1C,the cells exhibit lower SD in Li2SO4tKI than in Li2SO4,owing to the redox activity of the 2I /I2 system which drives the positive AC electrode to operate in narrow potential range and display lower potential drop than in *** 401 C,the capacitors exhibit comparable and reduced SD both in Li2SO4tLi I and Li2SO4,whatever the holding cell ***-electrode cell experiments demonstrate that,at 40 1C,hydrogen chemisorption is thermodynamically unfavored under negative polarization,while the activity of the 2I /I2 redox system under positive polarization is only slightly *** a consequence,the AC/AC cells in Li2SO4 exhibit a typical electrical double-layer performance at 401 C,whereas they still behave as hybrid ones in Li2SO4tLi I,with twice higher capacitance than in ***(Ui-Ut) vs t1/2plots demonstrate that SD is essentially controlled by diffusion at 401 C,suggesting that it originates from bulkier hydrated ***,in the investigated temperature range,the AC/AC capacitors in Li2SO4tLi I demonstrate low self-discharge and high capacitance,while being able to operate up to 1.6 V.

关键词： Supercapacitors Activated carbon Self-discharge Salt aqueous electrolyte Iodide/iodine redox system Activation and diffusion controlled mechanisms

Modeling of 3-D Losses and Deviations in a Throughflow Analysis Tool

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Journal of Thermal Science 2007年第3期16卷 208-214页

作者： Jean-fran■ois Simon OlivierLéonard Techspace Aero-Aerodynamic Group University

This contribution is dedicated to the modeling of the end-wall flows in a throughflow model for turbomachinery applications. The throughflow model is based on the Euler or Navier-Stokes equations solved by a Finite-Volume technique. Two approaches are presented for the end-wall modeling. The first one is based on an inviscid formulation with dedicated 3-D distributions of loss coefficient and deviation in the end-wall regions. The second approach is directly based on a viscous formulation with no-slip boundary condition along the annular end-walls and blade force modification in the region close to the end-walls. The throughflow results are compared to a series of 3-D Navier-Stokes calculations averaged in the circumferential direction. These 3-D calculations were performed on the three rotors of a low pressure axial compressor, for a series of tip clearance values.

关键词： throughflow losses deviations axial compressors

Diversity considerations in wideband radar detection of migrating targets in clutter

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Science China(Information Sciences) 2019年第4期62卷 31-40页

作者： franois LE CHEVALIER Nikita PETROV Department Microwave Sensing Signals and Systems (MS3) Delft University of Technology

Wideband radars have been proposed for detection of moving targets, with unique capability of non-ambiguous detection due to range migration. Moreover, frequency diversity has long been used for mitigating the fading effects caused by target and clutter fluctuations. The real benefits of wideband radars are difficult to analyze, since they derive from the combined effects of target resolution in range, migration over successive cells of clutter, Doppler resolution and instantaneous bandwidth, and residual ambiguities in Doppler. In order to contribute to a better understanding of the benefits of agile transmissions for detection of moving targets, clutter cancelling performances of wideband radars are examined, demonstrating clear benefits from diversity on clutter and target, primarily – but not only – obtained through target migration effects. Special attention is given to long-range surveillance and tracking, and new results on detection of moving targets in clutter will be provided to demonstrate the effectiveness of these new architectures for small targets detection at long range, in difficult environments. Finally, recommendations for system designs that improve the discrimination of moving targets against fixed and diffuse clutter are presented.

关键词： radar extended target frequency diversity wideband detection target migration clutter cancelling

One-Dimensional Symmetry and Liouville Type Results for the Fourth Order Allen-Cahn Equation in R^N

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 149-172页

作者： Denis BONHEURE franois HAMEL Département de Mathématique Université libre de Bruxelles INRIA-Team MEPHYSTO Aix Marseille Univ CNRSCentrale Marseille

In this paper, the authors prove an analogue of Gibbons' conjecture for the extended fourth order Allen-Cahn equation in R^N, as well as Liouville type results for some solutions converging to the same value at infinity in a given direction. The authors also prove a priori bounds and further one-dimensional symmetry and rigidity results for semilinear fourth order elliptic equations with more general nonlinearities.

关键词： Fourth order elliptic equation Allen-Cahn equation Extended Fisher-Kolmogorov equation One-dimensional symmetry Liouville type results

Former athletes’ lifestyle and self-definition changes after retirement from sports

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Journal of Sport and Health Science 2020年第4期9卷 376-383页

作者： pierre-Luc Yao Louis Laurencelle fran¸cois Trudeau Department of Human Kinetics Universite du Quebeca Trois-RivieresTrois-RivieresQuebec 999040Canada Department of Psychology Universite duQuebeca Trois-RivieresTrois-RivieresQuebec 999040Canada

Background:Every high-level athlete will eventually see his or her sport career come to an *** former athletes will experience changes in their self-definition and everyday behaviors as they accept a nonathletic way of *** present study aimed to identify discrepancies between actual and former athletes regarding athletic identity,physical activity(PA),and nutrition ***:Actual athletes(AA;n=122),former athletes(FA;n=230),and nonathletes(NA;n=74)were asked to complete an online questionnaire on athletic identity,duration and intensity levels of occupational and leisure time PA,and nutritional ***:FA healthy nutrition score was the lowest of the 3 groups and significantly different from that of *** identity and intense and moderate PA during leisure time consistently decreased(pFA>NA).No significant difference between FA and NA was found regarding either nutritional habits or type of ***:Sport retirement may affect FA quality of nutritional habits that tends to decline below the NA level,as well as the amount of time spent practicing physical activities during leisure *** status does not ensure PA practice during sport postcareer.

关键词： Athletic identity Nutrition Physical activity Sport retirement