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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-pierre Clémence Rouxel Line Berthiaume pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

A Construction of Beam Propagation Methods for Optical Waveguides

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Communications in Computational Physics 2009年第8期6卷 565-576页

作者： Xavier antoine pierre Dreyfuss Karim Ramdani Institut Elie Cartan Nancy Nancy-UniversiteCNRSINRIACORIDA TeamBoulevard des Aiguillettes B.P.239 F-54506 Vandoeuvre-les-NancyFrance Laboratoire J.A.Dieudonne(Mathematiques) Universite de Nice-Parc Valrose06000 NiceFrance INRIA CORIDA Teamand Institut Elie Cartan NancyNancy-UniversiteCNRSINRIABoulevard des Aiguillettes B.P.239 F-54506 Vandoeuvre-les-NancyFrance

This paper presents a systematic method to derive Beam Propagation Models for optical *** technique is based on the use of the symbolic calculus rules for pseudodifferential *** cases of straight and bent optical wave... 详细信息

关键词： Bent waveguides Beam Propagation Method optics

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone Michael R.Hamblin pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Chiral supramolecular gold-cysteine nanoparticles: Chiroptical and nonlinear optical properties

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Progress in Natural Science:Materials International 2016年第5期26卷 455-460页

作者： Isabelle Russier-antoine Franck Bertorelle Alexander Kulesza Antonin Soleilhac Amina Bensalah-Ledoux Stephan Guy Philippe Dugourd pierre-Fran?ois Brevet Rodolphe antoine Univ Lyon Université Claude Bernard Lyon 1 CNRS Institut Lumière Matière

Cysteine is a sulfur-containing amino acid that easily coordinates to soft metal ions and grafts to noble metal surfaces. We report a simple synthetic approach for the production of chiral gold-cysteine polymeric nanoparticles soluble in water. Conjugation of cysteine with gold in a polymeric way, leading to;0 nm diameter nanoparticles, resulted in the generation of new characteristic circular dichroism（CD） signals in the region of 250–400 nm, whereas no CD signal changes were found with cysteine alone. We also investigate their nonlinear optical properties after two-photon absorption. Two-photon emission spectra and first hyperpolarizabilities, as obtained by the hyper-Rayleigh scattering technique, of these particles are presented.

关键词： Gold Cysteine Supramolecular chemistry Nanoparticles Chirality Nonlinear optics

Brachioradialis tendon transfer and palmaris longus tendon graft for thumb avulsion:A case report and review of literature

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World Journal of Clinical Cases 2025年第4期13卷 48-55页

作者： pierre Curings Sonia Ramos-Pascual Kinga Michalewska Nicolas Gibert Lionel Erhard Mo Saffarini AlexisNogier Department of Hand Surgery Clinique TrenelSainte-Colombe 69560France Medical Research ReSurg SANyon 1260VaudSwitzerland Department of Hand Surgery Hand and Upper Limb Surgical InstituteVilleurbanne 69100France Department of Orthopaedics Clinique TrenelSainte-Colombe 69560France

BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of the flexor pollicis longus(FPL)at the musculotendinous *** treatments include direct tendon suture or tendon transfer,most commonly from the ring *** optimize function and avoid donor finger complications,we performed thumb replantation with flexion restoration using brachioradialis(BR)tendon transfer with palmaris longus(PL)tendon *** SUMMARY A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a *** patient presented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor pollicis longus tendon(zone T3),and avulsion of the thumb’s collateral arteries and *** patient was treated with two stage thumb *** first intervention consisted of thumb replantation with MCP I arthrodesis,resection of avulsed FPL tendon and implantation of a silicone tendon *** second intervention consisted of PL tendon graft and BR tendon ***-up at 10 months showed good outcomes with active interphalangeal flexion of 70°,grip strength of 45 kg,key pinch strength of 15 kg and two-point discrimination threshold of 4 *** Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.

关键词： Brachioradialis tendon transfer Flexor pollicis longus Palmaris longus tendon graft Replantation Thumb amputation Thumb avulsion Case report

tuning the properties of confined water in standard and lybrid nanotubes： An infrared spectroscopic study

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Nano Research 2018年第9期11卷 4759-4773页

作者： Yuanyuan Liao pierre Picot Maxime Laine Jean-Blaise Brubach Pascale Roy antoine Thill Sophie Le Caer LIONS NIMBE UMR 3685 CEA CNRS Universite Paris-Saclay CEA Saclay Bt. 546 F-91191 Gif-sur-Yvette Cedex France Synchrotron SOLEIL AILES Beamline L'Orme des Mefisier Saint-Aubin BP 48 F-91192 Gif-sur-Yvette Cedex France

Imogolite is a natural nanotubular aluminum silicate clay mineral found in volcanic soils. Its well-defined, tunable structure makes it a good candidate for studying water confinement in a one-dimensional （1D） structure. Water confinement in self-sustaining imogolite thin films was studied using infrared spectroscopy. Two types of synthetic imogolites were investigated： pristine imogolite （IMO-OH） with a hydrophilic inner surface covered with Si-OH groups and hybrid imogolite （IMO-CH3） with a hydrophobic inner surface covered with Si-CH3 groups. Both imogolites have an outer surface that is covered with Al-OH groups. Infrared spectra were recorded in the 20-4,000 cm^-1 spectral range as a function of relative humidity. Analysis of the O-H stretching band provides information on the H bonding of confined water molecules inside and outside the IMO-OH tubes. The scenario for water filling as a function of relative humidity is determined for both systems. Adsorption begins in the IMO-OH tubes at the lowest relative humidity （〈 10%）. The inner surface of the tubes is first covered with water molecules; then, the central part of the tubes is filled, leading to very strong H bonds and a structured spectrum. In contrast, the H bonds of water adsorbed on the outer surfaces of these tubes are weaker. A different scenario is observed for water inside IMO-CH3： Weakly H-bonded water molecules are present, similar to that observed in carbon nanotubes. Water confinement in imogolites is governed by the hydrophilicity of the inner walls. At similar partial pressures, the degree of H bonding depends on the interactions between water and the nanotube wall.

关键词： imogolite nanotubes confinement infrared spectroscopy water isotherms hydrophilic hydrophobic

A novel route for the synthesis of androgen receptor antagonist enzalutamide

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Chinese Chemical Letters 2023年第6期34卷 449-453页

作者： Xiangguo Meng Siju Bi Shixin Jin Kai Wu Shanchao Wu Lei Shao pierre-antoine Bonnet Chunquan Sheng College of Pharmacy Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Medicinal Chemistry School of PharmacySecond Military Medical UniversityShanghai 200433China State Key Lab of Anti-Infectives Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China IBMM Faculty of PharmacyMontpellier UniversityCNRSENSCM34093 Montpellier Cedex 5France

A novel route of enzalutamide was developed in five *** from 4-amino-2-(trifluoromethyl)benzonitrile(7)and Boc-2-aminoisobutyric acid(16),condensation,deprotection,Ullmann coupling,cyclization and amination provided enzalutamide in 41.0%total *** route avoids the using of toxic chemical,unstable intermediate and high-risk *** is a potential efficient and economical procedure for industrialization.

关键词： Enzalutamide Condensation Deprotection Ullmann coupling Cyclization Amination

The Colors of the Eiffel Tower: A Case Study

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Journal of Civil Engineering and Architecture 2023年第11期17卷 539-541页

作者： pierre-antoine Gatier Architecte en chef des Monuments Historiques(Chief Architect of Historic Monuments) Agency PAG Pierre-Antoine Gatier 30 rue GuynemerParis 75006France

Architectures undergoing restoration often have numerous layers of color related to their history and previous *** layer takes on its own precise meaning related to a specific history and cultural *** case of the Eiff... 详细信息

关键词： 20th century architecture Eiffel Tower colors history preservation

A Review on Complex System Engineering

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Journal of Systems Science & Complexity 2020年第6期33卷 1755-1784页

作者： PARREND pierre COLLET pierre ECAM Strasbourg-Europe 2Rue de MadridSchiltigheimFrance University of Strasbourg StrasbourgFrance

Complexity is commonly summarized as‘the actions of the whole are more than the sum of the actions of the parts’.Understanding how the coherence emerges from these natural and artificial systems provides a radical shift in the process of thought,and brings huge promises for controlling and fostering this *** authors define the term‘Complex System Engineering’to denote this approach,which aims at transferring the radical insights from Complex System Science to the pragmatic world of engineering,especially in the Computing System Engineering domain.A theoretical framework for Complex System Engineering is built by the morphogenetic engineering framework,which identifies a graduation of models,in growing order of generative *** implementation of Complex System Engineering requires a portfolio of operational solutions:The authors therefore provide a classification of Complex System application approaches to answer this challenge and support the emergence of Complex System Engineers capable of addressing the issues of an ever more connected world.

关键词： Complex networks complex software engineering complex systems design structure matrix emergent engineering evolutionary algorithms organically grown architectures