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Optical coherence tomography angiography at the acute phase of optic disc edema

Eye and Vision 2018年第1期5卷 144-150页

作者： Marie-Bénédicte Rougier Mélanie Le Goff Jean-françois Korobelnik Service d’Ophtalmologie CHU de BordeauxBordeauxFrance Bordeaux Population Health Research Center Team LEHAUniversity BordeauxINSERMUMR 1219F-33000 BordeauxFrance

Background:The differential diagnosis of optic disc edema at the acute phase can be *** angiography(OCTA)is a new technology allowing the visualization of the peripapillary vascular network and optic disc *** peripapillary network alterations of glaucoma and chronic non-arteritic anterior ischemic optic neuropathy(NAION)were ***,no OCTA studies on acute optic disc edema from various *** aim of this project was to use OCTA to demonstrate the vascular changes the optic nerve head of various types of optic disc edema at the acute ***:In this retrospective study,patients with non-arteritic anterior ischemic optic neuropathy(NAION),papillitis or papilledema were *** patient was imaged using the AngioPlex^(TM)CIRRUS^(TM)HD-OCT device(model 5000,Carl Zeiss Meditec,Inc.,Dublin,USA)with a scanning area of 6×6 mm^(2) centered on the optic disc.A morphological analysis of the peripapillary network was *** some patients with unilateral optic disc edema,a quantitative analysis was performed using a swept-source OCT-A system(PLEX®Elite 9000,Carl Zeiss Meditec,Inc.,Dublin,USA).Vessel perfusion density and flux index of the peripapillary area were ***:Eight eyes with NAION(4 patients),12 eyes with papillitis(6 patients)and 25 eyes with papilledema(13 patients)were *** apparent disappearance or moderate pattern alteration of the peripapillary capillary vessels were observed in patients with NAION or papillitis,*** papilledema,the capillaries at the surface of the optic disc were dilated and tortuous,but no peripapillary network pattern changes were *** quantitative analysis did not show any difference of peripapillary network between NAION and healthy *** papillitis,the flux index was higher in inflammatory eyes compared to the healthy eyes in average(p=0.03).Conclusion:At the acute phase,the morphological analysis of OCT-A appeared to be more useful than the q

关键词： Optical coherence tomography angiography Optic nerve head Edema NAION Microvascular network And morphology

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Potential Use of Polyelectrolyte Multilayer thin Films in Vascular Tissue Engineering:Evaluation of the Viability and Adhesion of Endothelial Cells

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生物医学工程学杂志 2005年第S1期22卷 117-118页

作者： Cédric BOURA Halima KERDJOUDJ Vanessa MOBY pierre SCHAAJ Jean Claude VOEGEL Jean-fran·ois STOLTZ Patrick MENU Mécanique et Ingénierie Cellulaire et Tissulaire LEMTA-UMR CNRS 7563Facultéde Médecine54505 Vandoeuvre-lès-NancyFrance Institut Charles Sadron(CNRS-ULP) UPR 22 CNRS67083 StrasbourgFrance INSERM U 595 Facultéde Médecine67085 StrasbourgFrance

1 Introduction A method in vascular tissue engineering to obtain hemocompatible synthetic prosthesis consist s to cover the luminal surface by a monolayer of endothelial cell s(ECs).Nevertheless,the surface of current prosthesi s does not favour the development of an ECs ***,a new versatile method of self2assembled archi2 tectures based on the alternate adsorption of polycations and polyanions has been developed to lead to the build2up of multilayered polyelectrolyte films(MPF).This new type of surface modification offers also large possibilities for varying the physico2chemical properties such as rough2 ness or surface charges,film thickness and viscoelastic properties.

关键词： Tissue Engineering thin Films viscoelastic properties surface modification tissue engineering endothelial cells method of type of

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Printing accuracy tracking with 2D optical microscopy and super-resolution metamaterial-assisted 1D terahertz spectroscopy

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npj Flexible Electronics 2020年第1期4卷 178-184页

作者： Mariia Zhuldybina Xavier Ropagnol ChloéBois Ricardo J.Zednik françois Blanchard Département de génieélectrique École de technologie supérieure(ÉTS)MontréalQCCanada Institut national de la recherche scientifique Énergiematériaux et télécommunications(INRS-EMT)VarennesQCCanada Institut des Communications Graphiques et de l’imprimabilité MontréalQCCanada Collège Ahuntsic MontréalQCCanada Département de génie mécanique École de technologie supérieure(ÉTS)MontréalQCCanada

Printable electronics is a promising manufacturing technology for the potential production of low-cost flexible electronic devices,ranging from displays to active *** is known that rapid printing of conductive ink on a flexible substrate is vulnerable to several sources of variation during the manufacturing ***,this process is still not being subjected to a quality control method that is both non-invasive and in *** address this issue,we propose controlling the printing accuracy by monitoring the spatial distribution of the deposited ink using terahertz(THz)*** parameters studied are the printing speed of an industrial roll-to-roll press with flexography printing units and the pre-calibration compression,or expansion factor,for a pattern printed on a flexible plastic *** pattern,which is carefully selected,has Babinet’s electromagnetic transmission properties in the THz frequency *** validate our choice,we quantified the geometric variations of the printed pattern by visible microscopy and compared its accuracy using one-dimensional THz *** study shows a remarkable agreement between visible microscopic observation of the printing performance and the signature of the THz ***,under specific conditions,one-dimensional(1D)THz information from a resonant pattern can be more accurate than two-dimensional(2D)microscopy *** result paves the way for a simple strategy for non-invasive and contactless in situ monitoring of printable electronics production.

关键词： printing visible pattern

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World Journal of Hepatology 2011年第6期3卷 170-174页

作者： Nourr-Eddine Farouj Jean-franois D Cadranel Ali Mofredj Vincent Jouannaud Maria Lahmiri pierre LeLann Alain Cazier Intensive Care Department Centre Hospitalier Laёnnec BP 72 60100 CreilFrance Liver Gastroenteroly and Nutrition DepartmentCentre Hospitalier Laёnnec BP 72 60100 CreilFrance Chest and Lung Department Centre Hospitalier Laёnnec BP 72 60100 CreilFrance Pathological Centre Hospitalier Laёnnec BP 72 60100 CreilFrance

Sarcoidosis is a systemic granulomatous disease which may involve many *** approximately 95% of patients there is liver involvement,with noncaseating hepatic granulomas occurring in 21 to 99% of patients with *** involvement is usually asymptomatic and limited to mild to moderate abnormalities in liver *** occurrence of jaundice in sarcoidosis is rare;extensive imaging procedures and the examination of liver biopsies permit a precise *** associated with sarcoidosis has been reported in less than 20 cases and can lead to biliary cirrhosis and liver-related *** report here on a case of ductopenia-related sarcoidosis in which primary biliary cirrhosis and extrahepatic cholestasis have been carefully *** patient follow up was 8 *** ursodesoxycholic acid appears to improve liver biochemistry it does not preclude the rapid occurrence of extensive fibrosis.A review of the literature of reported cases of ductopenia related to sarcoidosis is provided.

关键词： Sarcoidosis Cholestasis ductopenia Ursodeoxycholic acid

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Efficacy,Safety and Characteristics of the Amplatzer Vascular Plug II and IV Utilization for Various Percutaneous Occlusions in Children under 10 Years

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Congenital Heart Disease 2022年第4期17卷 421-436页

作者： Hugues Lucron Alban-Elouen Baruteau Caroline Ovaert Ali Houeijeh Mélanie Brard Patrice Guerin françois Bourlon Claire Dauphin Saskia Tuttle Maha Tagorti Rishika Banydeen françois Godart Antilles-Guyane M3C Paediatric Cardiology Center University Hospital of MartiniqueFort-de-FranceFrance L’institut du Thorax INSERMCNRSUNIV NantesCHU NantesNantesFrance Department of Paediatric Cardiology and Pediatric Cardiac Surgery University Hospital of NantesNantesFrance Department of Paediatric and Congenital Heart Disease University Hospital of MarseilleMarseilleFrance Department of Paediatric and Congenital Heart Disease University Hospital of Lille-Nord de FranceLilleFrance Department of Paediatric and Congenital Heart Disease Cardiothoracic Center of MonacoMonaco Department of Paediatric and Congenital Heart Disease University Hospital of Clermont-FerrandClermont-FerrandFrance Clinical Research Department CHU Martinique(University Hospital of Martinique)Fort-de-FranceFrance

Objectives:We aim to describe the efficacy,safety,and characteristics of the Amplatzer Vascular Plug(AVP)II and IV“off-label”use for multiple cardiovascular occlusions in children under 10 ***:Observational retrospective multicenter(2007–2020,6 centers)review of paediatric procedures using AVP II or ***:A total of 125 children(49.6%aged≤1 year,147 lesions)underwent 136 successive procedures(success rate:98.5%)using 169 devices(109 AVP IV,60 AVP II).The mean device diameter was 7.7±3.2 mm(4–20 mm).The median AVP size to vessel diameter ratio was 1.3(0–2).The median age and weight at implantation were 1.0 year(0.01–9.98)and 8.4 kg(1–69).Procedures were heterogeneous(55 patent ductus arteriosus(PDA),28 collaterals,18 sequestrations,22 arteriovenous/veinovenous/coronary fistulas,6 vertical veins,6 conduits,5 ventricular septal defects,7 miscellaneous).Day 1 and 6-month occlusion rates were respectively 94.8%and 98.5%.Major adverse events(MAE)occurred in 5.2%of cases(no procedure-related deaths),and more frequently in weight≤5 kg(p=0.01),younger patients(p=0.03)during PDA closure(p=0.02)of tubular types(p=0.02)using larger devices(p=0.03)and AVP II(p=0.003).Independent predictor of MAE risk was a higher AVP diameter to patient weight ratio(Odds-ratio:2.33,95%confidence interval 1.31–4.13,p=0.004,optimal cut off:1.45).Conclusions:Both AVPs are safe and effective for percutaneous occlusions in children under *** devices represent an alternative“off label”use for well selected paediatric patients.

关键词： Amplatzer vascular plug(AVP)II and IV cardiovascular occlusions off-label use children under 10 years efficacy safety

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Influence of primary tumor location and resection on survival in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1296-1310页

作者： ZoéTharin Julie Blanc Ikram Charifi Alaoui Aurélie Bertaut françois Ghiringhelli Department of Medical Oncology Centre Georges-François LeclercDijon 21000France Department of Bioastatistics Centre Georges-François LeclercDijon 21000France

BACKGROUND Patients with right sided colorectal cancer are known to have a poorer prognosis than patients with left sided colorectal cancer, whatever the cancer stage. To this day, primary tumor resection(PTR) is still controversial in a metastatic, non resectable *** To explore the survival impact of PTR in patients with metastatic colorectal cancer(mCRC) depending on *** We retrospectively collected data from all consecutive patients treated for mCRC at the Centre Georges francois Leclerc Hospital. Univariate and multivariate Cox proportional hazard regression models were used to assess the influence of PTR on survival. We then evaluated the association between PTL and overall survival among patients who previously underwent or did not undergo PTR. A propensity score was performed to match *** Four hundred and sixty-six patients were included. A total of 153(32.8%) patients had unresected synchronous mCRC and 313(67.2%) patients had resected synchronous mCRC. The number of patients with right colic cancer, left colic cancer and rectal cancer was respectively 174(37.3%), 203(43.6%) and 89(19.1%). In the multivariate analysis only PTL, PTR, resection of hepatic and or pulmonary metastases and the use of oxaliplatin, EGFR inhibitors or bevacizumab throughout treatment were associated to higher overall survival rates. Survival evaluation depending on PTR and PTL found that PTR improved the prognosis of both left and right sided mCRC. Results were confirmed by using a weighted propensity *** In mCRC, PTR seems to confer a higher survival rate to patients whatever the PTL.

关键词： Colorectal cancer Metastatic Primary tumor resection Chemotherapy Primary tumor location Synchronous

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Selection of patients and staging of peritoneal surface malignancies

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World Journal of Gastrointestinal Oncology 2010年第1期2卷 31-35页

作者： Eddy Cotte Guillaume Passot franois-Noёl Gilly Olivier Glehen Department of Digestive Surgery Lyon-Sud HospitalF-69495 Pierre Bénite Cédex équipe Accueil 3738 Claude Bernard Lyon 1 University Department of Digestive Surgery Lyon-Sud HospitalF-69495 Pierre Bénite Cédex

Peritoneal carcinomatosis (PC) is a common evolution of cancer of the gastrointestinal tract, and has been traditionally regarded as a terminal disease with short median survival. During the last 20 years, thanks to its favourable oncologic results, a new loco-regional therapeutic approach, combining cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), has an important development. Due to its significant, but acceptable, morbidity and mortality, and high cost, this comprehensive management plan requires knowledgeable patient selection. Quantitative prognostic indicators are required to assess a patient’s eligibility. Large multicenter studies have identified several prognostic factors, which can be used for a better selection of patients who would benefit from the combination of cytoreductive surgery with HIPEC. Indications for treatment of PC with cytoreduction and HIPEC are now validated for several diseases: peritoneal mesothelioma, pseudomyxoma peritonei, PC from the appendix, and colorectal cancer. Indications are still under discussion for gastric and ovarian carcinomatosis. Computed tomography is the best radiological for staging the disease. The extent of peritoneal carcinomatosis is, however, difficult to evaluate preoperatively, and precise evaluation is most often performed during surgical exploration. Cytoreductive surgery associated with HIPEC for the treatment of peritoneal carcinomatosis should be performed for young patients with limited and resectable carcino-matosis, in specialized institutions involved in the management of peritoneal surface malignancies.

关键词： Peritoneal carcinomatosis Staging Selection Performance status Peritoneal Cancer Index

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Kinetics of remnant liver volume and function after a major hepatectomy

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 975-977页

作者： Stéphanie Truant Mehdi El Amrani françois-RenéPruvot Department of Digestive Surgery and Transplantation Hôpital HuriezCHU LilleUniv.LilleLilleFrance CANTHER Laboratory“Cancer Heterogeneity Plasticity and Resistance to Therapies”UMR-S1277Team“MucinsCancer and Drug Resistance”LilleFrance

Liver regeneration after a major hepatectomy(MH)is crucial for the patient postoperative recovery,with the first postoperative month(1M)being a critical period for the liver regeneration *** risk of post hepatectomy liver failure(PHLF),which is the leading cause of death,is usually anticipated in the preoperative period by the measurement of the future remnant liver volume(RLV)via computed tomography(CT)with volumetry.

关键词： Liver regeneration remnant liver volume(RLV) remnant liver function major hepatectomy(MH)

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Implementation of a choline bis(trifluoromethylsulfonyl)imide aqueous electrolyte for low temperature EDLCs enabled by a cosolvent

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Journal of Energy Chemistry 2022年第7期31卷 84-94,I0004页

作者： Zhuanpei Wang francois Béguin Institute of Chemistry and Technical Electrochemistry Poznan University of TechnologyBerdychowo 460-965 PoznanPoland

We report a carbon/carbon capacitor based on micro/mesoporous carbon electrodes with cost-effective and eco-friendly aqueous choline bis(trifluoromethylsulfonyl)imide(Ch TFSI)electrolyte with a cosolvent enabling low-temperature operation down to-30℃.For this purpose,a Mg O-templated hierarchical carbon(MP98B)with an average mesopore diameter of 3.5 nm was prepared by pyrolysis of magnesium citrate hydrate at 900℃.To reach lower temperatures,the melting point and viscosity of the aqueous electrolyte were reduced by mixing water(W)with an organic solvent(methanol,M,or isopropanol,I)of high dielectric constant and low viscosity.5 mol kg^(-1)(5 m)Ch TFSI in an optimized volume fraction of cosolvent,M_(0.75)W_(0.25),and I_(0.75)W_(0.25),showed the highest conductivity;the higher conductivity in M_(0.75)W_(0.25)(22.8 and 3.1 m S cm^(-1) at 20 and-30℃,respectively)than in I_(0.75)W_(0.25)(8.5 and0.5 m S cm^(-1)at 20 and-30℃,respectively)is attributed to the lower viscosity of the M_(0.75)W_(0.25)*** electrochemical stability window(ESW)of 5 m Ch TFSI in M_(0.75)W_(0.25)and I_(0.75)W_(0.25)(1.6 V)on an MP98B electrode was determined by applying the ***,by adjusting the mass ratio of the two electrodes,a MP98B/MP98B capacitor using the 5 m electrolyte in M_(0.75)W_(0.25)could operate with a good life span up to 1.6 V while exhibiting a better charge propagation,greater specific capacitance,and higher specific energy than in I_(0.75)W_(0.25).

关键词： Carbon/carbon capacitor Choline bis(trifluoromethylsulfonyl)imide Low-temperature Aqueous electrolyte Cosolvent electrolyte Methanol Isopropanol

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sTREM-1 is a specific biomarker of TREM-1 pathway activation

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Cellular & Molecular Immunology 2021年第8期18卷 2054-2056页

作者： Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa pierre-françois Laterre Sebastien Gibot Amir Boufenzer Marc Derive Inotrem Vandœuvre-lès-NancyFrance Division of Infectious Diseases Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands Intensive Care Unit Saint Louis-Lariboisière-Fernand Widal University HospitalAssistance Publique Hôpitaux de Parisand Universitéde ParisInserm MASCOTParisFrance Intensive Care Unit UniversitéCatholique de LouvainLouvain-la-NeuveBelgium Intensive Care Unit CHRU de Nancyand Universitéde LorraineNancyFrance

TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and ***-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3].

关键词： immune myeloid activation

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