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A Clinical Study to Assess the Effectiveness of Oral Combination Kit Therapy in Syndromic Management of Abnormal Vaginal Discharge (FEMINE Study) in Kinshasa, Democratic Republic of Congo

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 193-208页

作者： Feruzi Michel Mangala Muela Andy Mbangama Di-Mosi-Nkoy Roger Wumba Ambis Joëlle Lumaya Nkongolo Freddy Muamba Tshitadi Jean Mukendi Ndombasi Neilda Lemba Otem Christian Ndesanzim Nkashama Bienvenu Kazadi Banza Jesual Lotoy Umba adrien Tandu Mushengezi Dieudonné Sengeyi Mwimba Roger Mbungu Department of Gynecology and Obstetrics University Clinics of Kinshasa Kinshasa DR Congo Congolese Society of Gynecology and Obstetrics Kinshasa DR Congo Department of Gynecology and Obstetrics Kinshasa Provincial General Reference Hospital Kinshasa DR Congo Departement of Tropical Medicine University Clinics of Kinshasa Kinshasa DR Congo

Background: Vaginal discharge is one of most common and nagging problems that women face. About 20% - 25% of women who visit gynecology department complain of vaginal discharge and leucorrhoea. An orally administered combination kit, containing 2 g secnidazole, 1 g azithromycin and 150 mg fluconazole (Azimyn FS Kit), has been successfully evaluated in clinical trials and used in several countries for management syndromic vaginal discharge due to infections. Methods: This is a longitudinal study which aimed to verify the clinical efficacy of the combined oral kit containing secnidazole, azithromycin and fluconazole (Azimyn FS Kit®) in the syndromic treatment of abnormal vaginal discharge in patients received in outpatient consultations in Kinshasa/DR Congo from March to September 2023. Results: Majority of patients had whitish vaginal discharge (51.6%) of average abundance (56.2%), accompanied by pruritus in 72.1% of cases, and dyspareunia in 23.5% of cases and hypogastralgia in 40.2% of cases. One week after treatment with the Azimyn FS® combined kit, at the greatest majority of patients (97.3%), abnormal vaginal discharge had decreased by more than 50% (84.1%). Two weeks after treatment with the Azimyn FS® combined kit, almost all patients (97.3%) no longer had abnormal vaginal discharge which had completely disappeared. Conclusion: A single dose of secnidazole, azithromycin and fluconazole in the form of an oral combi-kit (Azimyn FS Kit) has shown excellent therapeutic effectiveness in the syndromic treatment of abnormal vaginal discharge wherein patients were treated without diagnostic confirmation.

关键词： Oral Combination Kit Therapy Syndromic Management Abnormal Vaginal Discharge

A Review on Complex System Engineering

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Journal of Systems Science & Complexity 2020年第6期33卷 1755-1784页

作者： PARREND pierre COLLET pierre ECAM Strasbourg-Europe 2Rue de MadridSchiltigheimFrance University of Strasbourg StrasbourgFrance

Complexity is commonly summarized as‘the actions of the whole are more than the sum of the actions of the parts’.Understanding how the coherence emerges from these natural and artificial systems provides a radical shift in the process of thought,and brings huge promises for controlling and fostering this *** authors define the term‘Complex System Engineering’to denote this approach,which aims at transferring the radical insights from Complex System Science to the pragmatic world of engineering,especially in the Computing System Engineering domain.A theoretical framework for Complex System Engineering is built by the morphogenetic engineering framework,which identifies a graduation of models,in growing order of generative *** implementation of Complex System Engineering requires a portfolio of operational solutions:The authors therefore provide a classification of Complex System application approaches to answer this challenge and support the emergence of Complex System Engineers capable of addressing the issues of an ever more connected world.

关键词： Complex networks complex software engineering complex systems design structure matrix emergent engineering evolutionary algorithms organically grown architectures

Implementation of Presolving and Interior-Point Algorithm for Linear & Mixed Integer Programming: SOFTWARE

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Journal of Systems Science and Information 2020年第3期11卷 195-223页

作者： adrien NDAYIKENGURUTSE Siming HUANG School of Management Science and Engineering Institute of Science and DevelopmentChinese Academy of SciencesBeijing 100190China Chinese Academy of Sciences Beijing 100190China

Linear and mixed integer programming are very popular and important methods to make efficient scientific management *** large size of real application data,the use of linear-mixed integer programming is facing problems with more complexity;therefore,preprocessing techniques become very *** aims to check and delete redundant information from the problem *** is a collection of techniques that reduce the size of the problem and try to strengthen the *** and effective preprocessing techniques are very important and essential for solving linear or mixed integer programming *** this paper,we demonstrate a set of techniques to presolve linear and mixed integer programming *** results showed that when preprocessing is well done,then it becomes easier for the solver;we implemented interior-point algorithm for computational ***,preprocessing is not enough to reduce the size and total nonzero elements from the constraints ***,we also demonstrate the impact of minimum degree reordering on the speed and storage requirements of a matrix *** techniques mentioned above are presented in a multifunctional software to facilitate users.

关键词： integer programming formulation

Resistant Pulmonary TB-HIV Co-Infection in an Infant: About a Case

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Open Journal of Pediatrics 2024年第2期14卷 420-425页

作者： Mariam Maiga pierre Togo Tati Simaga Mariam Traoré Moussa Konaté Mamadou Diallo Alou Samaké Mamadou Keïta Korotoumou Wélé Diallo Djibril Kassogué Pediatrics Department Distric VI Reference Health Center Bamako Mali Paediatrics Department Gabriel Touré Teaching Hospital Bamako Mali Pediatrics Department Mali Hospital Bamako Mali Paediatrics Department Timbuktu Regional Hospital Bamako Mali

Diagnosis of childhood tuberculosis (TB) is difficult, especially in resource-limited countries where the number of reported cases of TB-HIV co-infection continues to rise. This co-infection poses a diagnostic and therapeutic problem for caregivers. We report a case of rifampicin-resistant HIV-TB pulmonary coinfection in a 19-month-old infant.

关键词： Tuberculosis Rifampicin Resistance HIV Infants

Biodiversity of Edible Caterpillars of Imbrasia and Host Plants in Boukoko (Central African Republic)

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Advances in Entomology 2024年第1期12卷 38-55页

作者： Lucie Aba-Toumnou Solange-Patrica Wango Denis Beina Jean-pierre Moalbaye Gorgon Igor Touckia Rufin Reo-Ndouba Felix Allah-Barem Olga Diane Yongo Laboratory of Biological and Agronomical Sciences for Development Faculty of Sciences University of Bangui Bangui Central African Republic Laboratory of Applied Animal Biology and Biodiversity University of Bangui Bangui Central African Republic Center of Studies and Research on Pharmacopoeia and Traditional African Medicine (CERPHAMETA) University of Bangui Bangui Central African Republic Plant and Fungal Biodiversity Laboratory Faculty of Science University of Bangui Bangui Central African Republic Higher Institute for Rural Development (ISDR) University of Bangui Mba&iumlki Central African Republic Central African Republic Institute of Agriculture Research Bangui Central African Republic

In Central African Republic, edible caterpillars of Imbrasia gender are income of rural populations, present an opportunity to improve food security and belonging to the category of Non-wood forest products. The goal of this study is to document the ecology of caterpillars of genre Imbrasia in relation to its host plants in Boukoko. The questionnaire was addressed to the actors of the collection and consumption of caterpillars in this Commune, to their local knowledge concerning this food resource as well as the plants of their locality on which caterpillars are collected. The survey took place in September to October 2022 and as a general rule, the 120 respondents were elderly people whose age range varied from 35 to 70 years old. Plant samples are collected in their natural environment. Based on local names;herbaria are mounted, plants photographed and samples collected. The types of edible caterpillars have been inventoried in the field in collaboration with the local populations who consume them. Based on local names, the caterpillars are captured manually from morphological traits and then stored in bottles containing 70% ethanol. The specimens were identified. The data was entered into the Excel spreadsheet which also made it possible to produce histograms with the frequencies of the plant species most valued by the different caterpillars. A Principal Component Analysis (PCA) was then performed using R software to highlight the correlation between caterpillars and host plants. The main economic importance trees hosting edible caterpillars of Imbrasia gender in Boukoko region are: Entandrophragma cylindricum, Pentaclethra macrophylla, Maesopsis eminii, Albizia ferruginea, Macaranga spinosa, Amphimas ferrugineus, Pentaclethra macrophylla, Racosperma auriculiforme, Eribroma oblonga. The Principal Component Analysis (PCA) carried out to assess the variability between the different species of caterpillars according to their host plants shows that the first two axes

关键词： Forest Degradation Losing Biodiversity of Consumed Insects Local Population

Massive Epistaxis Revealing a Post-Traumatic Aneurysm of the Internal Carotid Artery: A Clinical Case and Review of the Literature

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第2期13卷 120-125页

作者： Yannick Mossus Maguy Mbede Roger Meva’a Biouélé Leonel Atanga Adèle-Rose Ngo Nyeki pierre Ongolo Zogo François Djomou Alexis Ndjolo Department of Ophthalmology ENT and Stomatology Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Department of Medical Imaging Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon

Internal carotid artery (ICA) aneurysms are an unusual but serious cause of epistaxis. This epistaxis is massive and sometimes uncontrollable threatening the vital prognosis of patients. We report the case of a 16-year-old adolescent received in emergency with severe bilateral epistaxis, asthenia and grade-3 left exophthalmos. In his history, the subject had been the victim of an assault six months before consultation. He had received blows on the cephalic extremity with light but repeated epistaxis. The treatment consisted to blood products transfusion and local compression by sterile gazes. An ICA aneurysm in sphenoid sinus has been confirmed in a craniofacial CT scan coupled to vascular opacification. Although the ICA has a variable course in contact with the sphenoid sinus, massive epistaxis would be the consequence of a pronounced dehiscence of the ICA in the sphenoid sinus, particularly in a traumatic context. In front of this type of epistaxis in our context, general practitioners must be able to suspect a ruptured ICA aneurysm in the presence of exophthalmos and a notion of old or recent cranio-encephalic injury. Additionally, due to the high morbidity and mortality of this condition, a monitoring algorithm is necessary for patients with head trauma to facilitate early detection.

关键词： Aneurysm Internal Carotid Artery Head Trauma Epistaxis

Mg-3Al-1Zn alloy deformed along different strain paths: Role of latent hardening

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Journal of Magnesium and Alloys 2023年第2期11卷 522-532页

作者： Yao Cheng adrien Chapuis Yunchang Xin Qing Liu Peidong Wu College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing 210009China Department of Mechanical Engineering McMaster UniversityHamiltonOntario L8S 4L7Canada

The mechanical properties of magnesium alloy AZ31 were investigated experimentally with visco-plastic self-consistent modeling. Tension,compression and plane strain compression(PSC) tests were performed along 3 directions of a hot rolled plate, and the material parameters input in the model were fitted with the uniaxial stress-strain curves. The critical resolved shear stress(CRSS) for tension twinning was modeled with a modified Voce hardening law first decreasing, and then increasing with strain, that could reproduce better the flow stress for twin-predominant deformation. Such CRSS evolution may better model twin nucleation, propagation and growth. Firstly simulations were carried out assuming latent hardening coefficients for slip by other slip systems equal to self-hardening. Then different heterogeneous latent hardening were used, whose values were based on dislocation dynamics simulations from the literature. This study shows that equal self and latent hardening can reproduce the stress strain curves and plastic anisotropy as well as heterogeneous mode on mode latent *** between simulations and experimental results from PSC are explained by an under-estimation of twinning for some PSC strain paths.

关键词： Crystal plasticity Mg alloy Mechanical properties Latent hardening

Postoperative Complications in the General Surgery Department of the Cs Ref of Commune I of the District of Bamako Mali

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Surgical Science 2024年第6期15卷 409-419页

作者： Tounkara Cheickna Samake Hamidou Dembele Lamine Diarra Issaka Togola Modibo Sanogo Modibo Dembele Bakary Tientigui Traore Alhassane Togo Adégné pierre Kante Lassana Department of General Surgery Reference Health Center of Commune I of Bamako Bamako Mali Directorate of Social and Health Services of the Armies Bamako Mali Department of General Surgery CHU Gabriel Tour Bamako Mali

Postoperative complications represent important indicators for the quality of surgical care. The objectives of this work were to study post-operative complications in the general surgery department of the Cs ref of commune I in Mali, to determine the frequency of post-operative complications, to identify the factors of occurrence, to describe the clinical aspects, diagnostic and therapeutic in order to assess the additional cost linked to post-operative complications. This study was prospective, carried out in the general surgery department on 300 cases of surgical interventions. It covered all patients aged at least 15 years, operated on and hospitalized or not, and who presented complications during the 30 days postoperatively. Patients under the age of 15 were not included (our general surgery department is not a pediatric surgery department). We collected 300 patients among whom 199 (66.33%) were men and 101 (33.66%) women, i.e. a sex ratio = 1.9. The average age was 38 years with extremes of 15 and 87 years. The main initial diagnoses were: acute appendicitis, peritonitis, occlusions, wall hernias, hemorrhoids, uterine prolapse, uterine myomas, ovarian cysts and acute cholecystitis. Emergencies represented 43% (N = 129) of interventions with 6.98% post-operative complications (POC). Postoperative complications were dominated by surgical site infections, 75% of cases (N = 20), wall hemorrhage 5% (N = 1), testicular necrosis 5% (N = 1) and testicular calcification 5% (N = 1), wire rejection 5% (N = 1) and death 5% (N = 1). The management of postoperative complications was surgical in 95% and medical in 100%. Their occurrence extended the hospital stay by 3.65 days and increased the average cost of care by 60541.85 CFA francs. The mortality index lowered by efficient management of complications (IMAGE) calculated in relation to deaths was 95% of cases. Anemia, ASA score ≥ III, Alteimeir II and IV classes, duration of surgery and post-operative hospitalization were

关键词： Complications Post Opératoires Chirurgie Cs Ref CI Bamako Mali

What May Future Electricity Markets Look Like?

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 705-713页

作者： pierre Pinson Dyson School of Design Engineering Imperial College LondonLondonU.K Department of Technology Management and EconomicsTechnical University of DenmarkKongens Lyngby IEEE

Should the organization,design and functioning of electricity markets be taken for granted?Definitely *** decades of evolution of electricity markets in countries that committed early to restructure their electric power sector made us believe that we may have found the right and future-proof model,the substantially and rapidly evolving context of our power and energy systems is challenging this idea in many ***,that situation brings both challenges and *** include accommodation of renewable energy generation,decentralization and support to investment,while opportunities are mainly that advances in technical and social sciences provide us with many more options in terms of future market *** here take a holistic point of view,by trying to understand where we are coming from with electricity markets and where we may be *** electricity markets should be made fit for purpose by considering them as a way to organize and operate a socio-techno-economic system.

关键词： Digitalization electricity markets mechanism design optimization renewable energy