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Hepatitis C treatment in patients with substance use disorder:the faster the better

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 129-131页

作者： Antonio Saviano Lucile Heroin pierre mayer Thomas F.Baumert Institut de Recherche sur les Maladies et Hépatiques(IVH) Inserm U1110StrasbourgFrance Institut Hospitalo-Universitaire Service d’hépato-gastroentérologieHôpitaux Universitaires de StrasbourgStrasbourgFrance University of Strasbourg StrasbourgFrance Institut Universitaire de France(IUF) ParisFrance

Hepatitis C virus(HCV)infection is a major cause of liver disease and hepatocellular carcinoma worldwide(1).HCV is a blood-borne infection and prevalence is particularly high in patients with a history of injective drug use or unsafe health care or sexual *** use disorder(SUD),and especially opioid misuse is a growing problem worldwide(2).This is particularly relevant in the United States(US)where opioid misuse has raised sharply in the last years(3,4),termed also opioid *** is associated with an increase incidence of HCV infections and reinfections and associated liver disease(2,4).Moreover,alcohol use disorder is frequent in patients with SUD(5),representing another major risk factor for chronic liver disease in this *** with SUD often experience poor access to health care resulting in higher mortality(5,6).Finally,SUD is associated with psychiatric conditions and social problems such as housing instability,unemployment,and reduced access to medical care(7)which could result in a reduced access and compliance to HCV treatment.

关键词： patients mortality faster

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使用ERP软件改善生产流程

现代制造 2016年第4期 32-34页

作者： pierre mayer

在一家金属钻头的专业生产企业中，尽管生产规模不大，但其对生产流程的要求却很高。在其生产中，要求多部机床完成最多15种不同加工作业的生产流程，且部分加工作业流程较为复杂：如先将原料加工成与钻头相近的外形尺寸。

关键词：生产流程 ERP软件原料加工作业流程生产企业生产规模外形尺寸钻头

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-pierre Clémence Rouxel Line Berthiaume pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone Michael R.Hamblin pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Brachioradialis tendon transfer and palmaris longus tendon graft for thumb avulsion:A case report and review of literature

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World Journal of Clinical Cases 2025年第4期13卷 48-55页

作者： pierre Curings Sonia Ramos-Pascual Kinga Michalewska Nicolas Gibert Lionel Erhard Mo Saffarini AlexisNogier Department of Hand Surgery Clinique TrenelSainte-Colombe 69560France Medical Research ReSurg SANyon 1260VaudSwitzerland Department of Hand Surgery Hand and Upper Limb Surgical InstituteVilleurbanne 69100France Department of Orthopaedics Clinique TrenelSainte-Colombe 69560France

BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of the flexor pollicis longus(FPL)at the musculotendinous *** treatments include direct tendon suture or tendon transfer,most commonly from the ring *** optimize function and avoid donor finger complications,we performed thumb replantation with flexion restoration using brachioradialis(BR)tendon transfer with palmaris longus(PL)tendon *** SUMMARY A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a *** patient presented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor pollicis longus tendon(zone T3),and avulsion of the thumb’s collateral arteries and *** patient was treated with two stage thumb *** first intervention consisted of thumb replantation with MCP I arthrodesis,resection of avulsed FPL tendon and implantation of a silicone tendon *** second intervention consisted of PL tendon graft and BR tendon ***-up at 10 months showed good outcomes with active interphalangeal flexion of 70°,grip strength of 45 kg,key pinch strength of 15 kg and two-point discrimination threshold of 4 *** Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.

关键词： Brachioradialis tendon transfer Flexor pollicis longus Palmaris longus tendon graft Replantation Thumb amputation Thumb avulsion Case report

A Review on Complex System Engineering

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Journal of Systems Science & Complexity 2020年第6期33卷 1755-1784页

作者： PARREND pierre COLLET pierre ECAM Strasbourg-Europe 2Rue de MadridSchiltigheimFrance University of Strasbourg StrasbourgFrance

Complexity is commonly summarized as‘the actions of the whole are more than the sum of the actions of the parts’.Understanding how the coherence emerges from these natural and artificial systems provides a radical shift in the process of thought,and brings huge promises for controlling and fostering this *** authors define the term‘Complex System Engineering’to denote this approach,which aims at transferring the radical insights from Complex System Science to the pragmatic world of engineering,especially in the Computing System Engineering domain.A theoretical framework for Complex System Engineering is built by the morphogenetic engineering framework,which identifies a graduation of models,in growing order of generative *** implementation of Complex System Engineering requires a portfolio of operational solutions:The authors therefore provide a classification of Complex System application approaches to answer this challenge and support the emergence of Complex System Engineers capable of addressing the issues of an ever more connected world.

关键词： Complex networks complex software engineering complex systems design structure matrix emergent engineering evolutionary algorithms organically grown architectures

What May Future Electricity Markets Look Like?

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 705-713页

作者： pierre Pinson Dyson School of Design Engineering Imperial College LondonLondonU.K Department of Technology Management and EconomicsTechnical University of DenmarkKongens Lyngby IEEE

Should the organization,design and functioning of electricity markets be taken for granted?Definitely *** decades of evolution of electricity markets in countries that committed early to restructure their electric power sector made us believe that we may have found the right and future-proof model,the substantially and rapidly evolving context of our power and energy systems is challenging this idea in many ***,that situation brings both challenges and *** include accommodation of renewable energy generation,decentralization and support to investment,while opportunities are mainly that advances in technical and social sciences provide us with many more options in terms of future market *** here take a holistic point of view,by trying to understand where we are coming from with electricity markets and where we may be *** electricity markets should be made fit for purpose by considering them as a way to organize and operate a socio-techno-economic system.

关键词： Digitalization electricity markets mechanism design optimization renewable energy

USE OF CHRONOLITHOTHERAPY FOR BETTER INDIVIDUAL HEALTHCARE AND WELFARE

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Journal of Systems Science and Systems Engineering 2017年第3期26卷 336-358页

作者： pierre Bricage Faculty of Sciences Health and Social Sciences University of Pau & Pays de l'AdourUPPA 64000 Pau France

Man＇s innate clocks functioning allows to understand WHEN and WHY therapies are efficient. Vigil chronotypes determination and respect allows to avoid scholars＇ failure. Performances depend on chronotypes and time changes. Both minimal and maxima/durations of night sleep cycles result from interactions between endogenous and exogenous clocks. Our ecoexotope is structured by solar, lunar and terrestrial rhythms which are synchronisers for endophysiotope clocks. Man night sleep changes depend on lunar cycles entrainment. Sleep analyses point to circa-annual solar rhythms used as controls to evidence circa-monthly lunar ones. To evidence physiological responses individual longitudinal records are used. To evidence lithotherapeutic effects, stimuli responses are tested according to a double-blind placebo-controlled survey. WHAT mineral to chose？, WHY？, HOW to treat？, WHEN？ Compared with controls, jadeite or nephrite enhances night sleep quality with a 15 fold decrease of awakenings and urinations. The highest placebo effect was below 4 fold increase. Depending on minerals and trace elements, properties change. The mineral crystal structure is evidenced to have an action. The contact area with the skin is a limiting factor. Placebo effects are greater during the day phase. Red jasper treatment enhances the number and intensity of diurnal physical working. Minerals act in a dose-dependent manner and in synergy. Hematite sole gives a placebo effect, but increases the effect of serpentinite by a 15 fold value. Within a clocks network, the latency phase of the whole is shorter than the shortest latency phase of each clock, enhancing the system reactivity.

关键词： Chronobiology dose-dependent effect double-blind placebo-controlled trials ecoexotope,endophysiotope latency lithotherapy unexpected emergence

Determination of the Apparent Gas Permeability in a Macrocracked Concrete

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Engineering 2022年第10期17卷 93-98页

作者： pierre Rossi Univ Gustave Eiffel French Institute of Science and Technology for TransportDevelopment and Networks(IFSTTAR)Marne-la-Vallée F-77447France

This paper reports on analysis of an expermental study that armed to determine the apparent gas permeability in cracked *** is a lack of research on this topic in the international literature,due to the difficulty of performing reliable experimental testing for gas *** principal interest of this work is to present new and reliable experimental *** functions between the evolution of the apparent crack permeability and the apparent crack opening are also *** functions appear to be relevant in consideration of Poiseuille theory.

关键词： Concrete Macrocrack Gas transfer Permeability