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3D models of dilated cardiomyopathy:Shaping the chemical,physical and topographical properties of biomaterials to mimic the cardiac extracellular matrix

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Bioactive Materials 2022年第1期7卷 275-291页

作者： Marie Camman pierre joanne Onnik Agbulut Christophe Helary Sorbonne Universit´e CNRSUMR 7574Laboratoire de Chimie de la Matiere Condensee de Paris4 place Jussieu(case 174)F-75005ParisFrance Sorbonne Universite Institut de Biologie Paris-Seine(IBPS)CNRS UMR 8256Inserm ERL U1164Biological Adaptation and Ageing7 quai St-Bernard(case 256)F-75005ParisFrance

The pathophysiology of dilated cardiomyopathy(DCM),one major cause of heart failure,is characterized by the dilation of the heart but remains poorly understood because of the lack of adequate in vitro *** 2D models do not allow for the 3D organotypic organization of cardiomyocytes and do not reproduce the ECM *** this review,the different strategies to mimic the chemical,physical and topographical properties of the cardiac tissue affected by DCM are *** advantages and drawbacks of techniques generating anisotropy required for the cardiomyocytes alignment are *** addition,the different methods creating macroporosity and favoring organotypic organization are ***,the advances in the induced pluripotent stem cells technology to generate cardiac cells from healthy or DCM patients will be *** to the biomaterial design,some features of the DCM extracellular matrix such as stiffness,porosity,topography or chemical changes can impact the cardiomyocytes function in vitro and increase their *** mimicking the affected heart,both at the cellular and at the tissue level,3D models will enable a better understanding of the pathology and favor the discovery of novel therapies.

关键词： Biomaterials Dilated cardiomyopathies Induced pluripotent stem cells Porosity Anisotropy

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Determination and assessment of total mercury levels in local, frozen and canned fish in Lebanon

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Journal of Environmental Sciences 2011年第9期23卷 1564-1569页

作者： pierre J Obeid Bilal El-Khoury joanne Burger Samer Aouad Mira Younis Amal Aoun John Hanna El-Nakat University of Balamand Faculty of SciencesDepartment of Chemistry Nelson Biological Laboratory Division of Life SciencesRutgers University

Fish is an important constituent of the Lebanese ***,very little attention in our area is given to bring awareness regarding the effect of the toxicity of mercury （Hg） mainly through fish *** study aimed to report analytical data on total mercury levels in several fish species for the first time in thirty years and to also made individuals aware of the presence and danger from exposure to mercury through fish *** samples were selected from local Lebanese markets and fisheries and included 94 samples of which were fresh,frozen,processed,and canned *** values were reported as microgram of mercury per gram of fish based on wet *** level of mercury ranged from 0.0190 to 0.5700 μg/g in fresh samples,0.0059 to 0.0665 μg/g in frozen samples,and 0.0305 to 0.1190 μg/g in canned *** data clearly showed that higher levels of mercury were detected in local fresh fish as opposed to other types thus placing consumers at higher risk from mercury ***,the data revealed that Mallifa （yellowstripe barracuda/Sphyraena chrysotaenia）,Sargous （white seabream/Diplodus sargus）,Ghobbos （bogue/Boops boops）,and shrimp （Penaeus sp.） were among the types containing the highest amounts of *** the other hand,processed fish such as fish fillet,fish burger,small shrimp and crab are found to contain lower levels of mercury and are associated with lower exposure risks to *** population should therefore,be aware to consume limited amounts of fresh local fish to minimize exposure to mercury.

关键词： total mercury fish Lebanon

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The Effects of Preeclampsia on Perinatal Risks and Infant Temperaments Among Mothers With Antenatal Depression

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Psychology Research 2014年第6期4卷 451-461页

作者： Yoko Nomura Jackie Finik Jacquelyn Salzbank Jenny Ly Nancy Huynh Taira Davey Mariya Dineva AyeletAbelow Cindy Flores Rejina Daniel Holly Loudon joanne Stone Patricia pierre Gary Eglinton Jeffrey H. Newcorn Queens College (CUNY) & Icahn School of Medicine at Mount Sinai New York USA University of Maryland College Park Maryland USA Queens College (CUNY) &Icahn School of Medicine at Mount Sinai New York USA Icahn School of Medicineat Mount Sinai & CornellUniversity New YorkUSA Queens College (CUNY) New York USA Icahn School of Medicineat Mount Sinai New York USA New York Hospital Queens New York USA Icahn School of Medicineat Mount Sinai New York USA

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