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Evaluation of.Oxidative Status of.Patients with Gout Attack in a Cameroonian Urban Hospital

Open Journal of.Rheumatology and Autoimmune Diseases 2017年第2期7卷 111-119页

作者： Jan René Nkeck Madeleine Singwé-Ngandeu Vicky Ama Moor Jean-pierre Chedjou Marie-Sollange Doualla Wilf.ed f. Mbacham f.culty of.Medicine and Biomedical Sciences of.the University of.Yaoundé I Yaoundé Cameroon Rheumatology unit of.the Yaoundé Central Hospital Yaoundé Cameroon Biochemistry laboratory of.the Yaoundé University Hospital Centre Yaoundé Cameroon Biotechnology Centre of.the University of.Yaoundé I Yaoundé Cameroon

Background: Gout is the leading cause of.microcrystalline arthritis worldwide and the most common cause of.arthritis in adult men. The prevalence of.cardiovascular disease, type II diabetes and metabolic syndrome is high among gout patients;one of.the current hypotheses that may explain this relationship is based on oxidative stress;however, f.w studies have sought to investigate this relationship. Objective: The aim of.this study was to determine the oxidative status of.patients with gout attack. Methods: We conducted a case-control study over a 4 months period at the Rheumatology service of.the Yaoundé Central Hospital. Cases were patients with an acute gout attack and controls were healthy subjects matched f.r sex and age. We evaluated uricemia, serum levels of.Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase and Malondialdehyde (MDA). Oxidative stress was def.ned by an increase in MDA and/or a decrease in SOD, Catalase and GPx. Statistical analysis was perf.rmed by the S.P.S.S. 21.0 sof.ware. The Student’s T-test was used to compare means;the signif.cance threshold was 0.05. Results: Sixty subjects were recruited of.which 30 with an acute gout attack and 30 healthy subjects. The mean ages of.the cases and controls were respectively 58 ± 8 years and 57.6 ± 8 years. Uricemia was statistically higher in cases (81 ± 20 mg/L) compared to controls (47 ± 11 mg/L) (p f.cant dif.erence in serum levels of.catalase, SOD and GPx between cases and controls. Conclusion: Patients with gout attack have an elevated serum level of.malondialdehyde but their oxidative status seems similar to that of.normal individuals.

关键词： Gout Oxidative Stress

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Strong Spatial Aggregation of.Martian Surf.ce Temperature Shaped by Spatial and Seasonal Variations in Meteorological and Environmental f.ctors

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Research in Astronomy and Astrophysics 2022年第1期22卷 156-173页

作者： Yao-Wen Luo f.i Li Jian-Guo Yan Jean-pierre Barriot Chinese Antarctic Center of.Surveying and Mapping Wuhan UniversityWuhan430070China State Key Laboratory of.Inf.rmation Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan430070China Observatoire Geodesique de Tahiti University of French PolynesiaBP 6570F-98702 Faa'aTahitiFrench Polynesia

Spatio-temporal variation in the Martian surf.ce temperature(MST)is an indicator of.ground level thermal processes and hence a building block f.r climate ***,the distribution of.MST exhibits dif.erent levels of.spatial aggregation or heterogeneity,and varies in space and ***,the ef.ect of.regional dif.erences in meteorological or environmental f.ctors on the MST is not well ***,we investigated the degree of.spatial autocorrelation of.MST across the surf.ce of.Mars globally by Moran’s I,and identif.ed the hot spots by GetisOrd G;*.We also estimated the regional dif.erences in the inf.uence of.seasonally dominant f.ctors including thermal inertia(TI),albedo,surf.ce pressure,latitude,dust and slope on MST by a geographically weighted regression *** results indicate(1)that MST is spatially aggregated and hot and cold spots varied over time and space.(2)Hemispheric dif.erences in topography,surf.ce TI and albedo were primarily responsible f.r the hemispheric asymmetry of.hot spots.(3)The dominant f.ctors varied by geographical locations and *** example,the seasonal Hadley circulation dominates at the low-latitudes and CO;circulation at the high-latitudes.(4)Regions with extreme variations in topography and low TI were sensitive to meteorological and environmental f.ctors such as dust and CO_(2)*** conclude that the spatial autocorrelation of.MST and the spatial and seasonal heterogeneity of.inf.uencing f.ctors must be considered when simulating Martian climate *** work provides a ref.rence f.r f.rther exploration of.Martian climatic processes.

关键词： methods:analytical planets and satellites:surf.ces methods:statistical planets and satellites:f.ndamental parameters

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旅游和民族性的再创造

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民俗研究 2006年第1期 129-136页

作者： pierre L.Van den Berghe Charles f.Keyes 徐赣丽美国华盛顿大学广西师范大学中文系

这是一篇对社会学家和人类学家编写的论文集做介绍的文章,主要论述旅游在保持、改变和重新创造民族边界中的作用。旅游被看成是民族交往的一种特别形式,导致了三个主要角色的形成,即游客、旅游对象和中间人。文章主要关涉：国家在发展... 详细信息

这是一篇对社会学家和人类学家编写的论文集做介绍的文章,主要论述旅游在保持、改变和重新创造民族边界中的作用。旅游被看成是民族交往的一种特别形式,导致了三个主要角色的形成,即游客、旅游对象和中间人。文章主要关涉：国家在发展民族旅游中扮演的角色、作为旅游结果的民族特征和民族意识的改变和再创造、在旅游交易中艺术形式的转变、旅游代理商的角色以及在民族旅游主客互动交往中形成了民族“刻板印象”。

关键词：旅游对象民族性再创造民族旅游人类学家社会学家民族交往民族意识民族特征艺术形式

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Preventive Ef.ects of.Ananas comosus Juice on Obesity Risk f.ctors in f.male Wistar Rats

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Open Journal of.Applied Sciences 2020年第8期10卷 534-542页

作者： Judith f. Ahounou Aïkpe André Hamadou Lamou Bonoy Analbert T. Kotinan Joachim D. Gbenou pierre H. Dansou Research Unit in Exercise Physiology (URPEf. University of Abomey Calavi Porto-Novo Bénin Laboratory of.Pharmacognosy and Essential Oils (LAPHE) University of Abomey Calavi Cotonou Benin Laboratory of.Biology Physical Activity National Institute of Youth and Sports (NIYS) Yaoundé Cameroon

The present study aim was to assess the preventive ef.ects of.Ananas comosus juice consumption on the risk f.ctors of.obesity in f.male Wistar rats. 108 rats were tested f.r 90 days. Af.er randomization, they were shared out into six groups including f.ur experimental groups (GTc, GPlp, GEns and GBrS) and two control groups (). The control group consumed 1.20 ml of distilled water, the experimental rats received in oral, 1.20 ml of drinks made from the different parts of Ananas comosus fruit. The measurements of morphometric and biochemical parameters were carried out on Day 0 (D0), Day 30 (D30), Day 60 (D60) and Day 90 (D90). The analysis showed that compared to the positive control rats, the consumption of the various drinks slowed down significantly (P

关键词： Obesity Ananas comosus Morphometric Biochemical Parameters

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Ef.ect of.Substrate Type on Deposition Behavior and Wear Perf.rmance of.Ni-Coated Graphite/Al Composite Coatings Deposited by Cold Spraying

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Journal of.Materials Science & Technology 2017年第4期33卷 338-346页

作者： Chunjie Huang Wenya Li Yingchun Xie Marie-pierre Planche Hanlin Liao Ghislain Montavon ICB UMR 6303 CNRSUniversite Bourgogne Franche-ComteUTBMF-90100 BelfortFrance State Key Laboratory of.Solidif.cation Processing Shaanxi Key Laboratory of Friction Welding TechnologiesNorthwestern Polytechnical UniversityXi'an 710072China

This work f.cused on the deposition characteristics and wear behavior of.Ni-coated graphite mixed with40 vol.% Al（Ni-Gr/Al） composite coatings sprayed on an Al alloy and a steel substrate by cold spraying（CS）. The morphology of.the f.attened Ni-Gr particles was examined by single-impact tests. Crosssectional microstructure and wear perf.rmance of.the Ni-Gr/Al composite coatings were studied. Results showed that a larger number of.Ni-Gr particles were f.nally bonded with the steel substrate, whereas many craters existed on the Al alloy substrate af.er the single-impact tests. The coating on the steel substrate had a high thickness, high graphite content and low coef.cient of.f.iction（COf. compared to those on the Al alloy substrate. In addition, the CS coatings presented a homogeneous distribution and unif.rm morphology of.graphite, and a comparative COf.to that of.conventional thermal sprayed coatings. It was shown that CS could avoid the decomposition and transf.rmation of.graphite phase.

关键词： Cold spraying Ni-coated graphite Deposition behavior Microstructure Wear perf.rmance

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The Potential Application of.<i>Syzygium aromaticum</i>and <i>Cymbopogon citratus</i>Essential Oils as Natural Preservatives of.Beef.Patties

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f.od and Nutrition Sciences 2015年第3期6卷 374-385页

作者： f.brice Bruno Siewe pierre Désiré Mbougueng Léopold Ngoune Tatsadjieu Thierry Ngangmou Noumo Carl M. f. Mbof.ng Department of.f.od Science and Nutrition National School of Agro-Industrial Sciences University of Ngaoundere Ngaoundere Cameroon Department of.Process Engineering National School of Agro-Industrial Sciences University of Ngaoundere Ngaoundere Cameroon Department of.f.od Engineering and Quality Control University Institute of Technology University of Ngaoundere Ngaoundere Cameroon College of.Technology University of Bamenda Bamenda Cameroon

The ef.ect of.essential oils f.om Syzygium aromaticum and Cymbopogon citratus on the lipid oxidation and microbial growth in beef.patties was investigated in the present study. Essential oils were incorporated into the beef.patties at 0.1% and 0.2% (w/w). The beef.patties were then inoculated with cultures of.E. coli and S. aureus and stored at 4°C. The control patties were processed without essential oil but inoculated with E. coli or S. aureus. The proximate composition, lipid oxidation and microbial counts were carried out af.er 7, 14, 21 and 28 days. Results showed that the incorporation of.essential oils in beef.patties did not signif.cantly (P S. aromaticum at 0.2% reduced the E. coli growth by 1.48 log Cf./g and that of.S. aureus by 6.52 log Cf./g while the incorporation of.C. citratus at 0.2% reduced the E. coli growth by 1.21 log Cf./g and that of.S. aureus by 1.4 log Cf./g af.er 28 days of.storage. The pH measurement during the storage period showed a slight drop during the f.rst 7 days of.storage and an increase during the last 21 days in all samples. The sensory test of.the beef.patties showed that the consumers accepted patties f.rmulated with the two essential oils. But the one made with 0.1% essential oil of.S. aromaticum was the most accepted. The analysis of.the color of.beef.patties between 0 and 28 days of.storage revealed that the incorporation of.essential oils retarded the degradation of.the color of.patties. Results obtained in the present study indicate the possibility of.exploiting Syzygium aromaticum and Cymbopogon citratus essential oils to protect beef.patties against lipid oxidation and microbial growth.

关键词： S. aromaticum C. citratus Essential Oil Beef Patties Lipid Oxidation Microbial Stability Escherichia coli Staphylococcus aureus

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Mutations of.the aurora kinase C gene causing macrozoospermia are the most f.equent genetic cause of.male inf.rtility in Algerian men

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Asian Journal of.Andrology 2015年第1期17卷 68-73,I0008页

作者： Leyla Ounis Abdelali Zoghmar Charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez Ines Bellil Douadi Khelif. Christophe Arnoult Julien f.ure Sebti Benbouhedja Abdelkader Rouabah pierre f.Ray Laboratoire de Biologie Moleculaire et Cellulaire Faculte des Sciences de la Nature et de la Vie Universite Constantine I Algerie Clinique Ibn Rochd Centre de Medecine de la Reproduction Constantine Algerie Universite Grenoble Alpes Grenoble France Equipe Genetique Epigenetique et Therapies de I'lnf.rtilitE CNRS AGIM Grenoble France Laboratoire de GEnetique Chromosomique CHU Grenoble Grenoble France Laboratoire de Biochimie et Genetique Moleculaire CHU Grenoble Grenoble France Equipe Muscle et Pathologies INSERM U836 Grenoble Institut des Neurosciences Grenoble France.

Klinef.lter syndrome and Y-chromosomal microdeletion analyses were once the only two genetic tests of.ered to inf.rtile men. Analyses of.aurora kinase C （AURKCj and DPY19L2 are now recommended f.r patients presenting macrozoospermia and globozoospermia, respectively, two rare f.rms of.teratozoospermia particularly f.equent among North Af.ican men. We carried out genetic analyses on Algerian patients, to evaluate the prevalence of.these syndromes in this population and to compare it with the expected f.equency of.Klinef.lter syndrome and Y-microdeletions. We carried out a retrospective study on 599 consecutive patients consulting f.r couple inf.rtility at the assisted reproduction unit of.the Ibn Rochd Clinique, Constantine, Algeria. Abnormal sperm parameters were observed in 404 men. f.urteen and seven men had typical macrozoospermia and globozoospermia prof.les, respectively. Molecular diagnosis was carried out f.r these patients, f.r the AURKC and DPY19L2 genes. Eleven men with macrozoospermia had a homozygous AURKC mutation （79%）, corresponding to 2.7% of.all patients with abnormal spermograms. All the men with globozoospermia studied （n = 5）, corresponding to 1.2% of.all inf.rtile men, presented a homozygous DPY19L2deletion. By comparison, we would expect 1.6% of.the patients in this cohort to have Klinef.lter syndrome and 0.23% to have Y-microdeletion. Our f.ndings thus indicate that AURKCmutations are more f.equent than Klinef.lter syndrome and constitute the leading genetic cause of.inf.rtility in North Af.ican men. f.rthermore, we estimate that AURKCand DPY19L2 molecular def.cts are 10 and 5 times more f.equent, respectively, than Y-microdeletions.

关键词： aurora kinase C DPY19L2 globozoospermia intracytoplasmic sperm injection inf.rtility macrozoospermia

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Commentary on ＂morphological characteristics and initial genetic study of.multiple morphological anomalies of.the f.agella in China＂

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Asian Journal of.Andrology 2016年第5期18卷 812-812页

作者： Charles Coutton Christophe Arnoult pierre f.Ray Universite Grenoble Alpes Grenoble F-38000 France Equipe 'Genetics Epigenetics and Therapies of.Inf.rtility' Institut Albert Bonniot INSERM U823 La Tronche F-38706 France Departement de Genetique et Procreation Hopital Couple Enfant CHU Grenoble Grenoble F-38000 France Laboratoire de Biochimie Genetique et Moleculaire CHU Grenoble Grenoble F-38000 France.

Dear Editor, We have read with a great interest, the excellent article by Yang et al.1 which, f.r the f.rst time, f.lly describes the structural and ultrastructural def.cts of.spermatozoa with multiple morphological anomalies of.the f.agella （MMAf. in Chinese patients. This study revealed in these patient＇s spermatozoa, a completely disorganized axoneme and, in particular, the displacement or absence of.the central pair （CP） in most of.the cross sections were analyzed.

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A large epeiric methanogenic Bambuí sea in the core of.Gondwana supercontinent?

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Geoscience f.ontiers 2021年第1期12卷 203-218页

作者： Sergio Caetano-f.lho pierre Sansjof.e Magali Ader Gustavo M.Paula-Santos Cristian Guacaneme Marly Babinski Carolina Bedoya-Rueda Matheus Kuchenbecker Humberto L.S.Reis Ricardo I.f.Trindade Universidade de Sao Paulo Instituto de GeocienciasRua do Lago562-Sao Paulo05508-080Brazil MNHN Sorbonne UniversiteCNRS UMR 7590Institut de Mineralogiede Physique des Materiaux et de Cosmochimie75005ParisFrance Universite de Paris Institut de Physique du Globe de ParisCNRSF-75005ParisFrance Universidade Estadual de Campinas Instituto de GeocienciasRua Carlos Gomes250-Campinas13083-855Brazil Universidade f.deral dos Vales do Jequitinhonha e Mucuri Instituto de Ciencia e TecnologiaLaboratorio de Estudos TectonicosRodovia MGT 367Km 583-Diamantina39100-000Brazil Universidade f.deral de Ouro Preto Departamento de Geologia-Escola de MinasLaboratiorio de Modelagem TectonicaCampus Morro do Cruzeiro-Ouro Preto35400-000Brazil Universidade de Sao Paulo Instituto de AstronomiaGeofísica e Ciencias AtmosfericasRua do Matao1226-Sao Paulo05508-090Brazil

Carbon isotope compositions of.both sedimentary carbonate and organic matter can be used as key proxies of.the global carbon cycle and of.its evolution through time,as long as they are acquired f.om waters where the dissolved inorganic carbon(DIC)is in isotope equilibrium with the atmospheric ***,in shallow water platf.rms and epeiric settings,the inf.uence of.local to regional parameters on carbon cycling may lead to DIG isotope variations unrelated to the global carbon *** may be especially true f.r the terminal Neoproterozoic,when Gondwana assembly isolated waters masses f.om the global ocean,and extreme positive and negative carbon isotope excursions are recorded,potentially decoupled f.om global *** improve our understanding on the type of.inf.rmation recorded by these excursions,we investigate the pairedδ^13Ccarb andδ^13Corg evolution f.r an increasingly restricted late Ediacaran-Cambrian f.reland system in the West Gondwana interior:the basal Bambui *** succession represents a 1~(st)-order sedimentary sequence and records two majorδ^13Ccarb excursions in its two lowermost lower-rank *** basal cap carbonate interval at the base of.the f.rst sequence,deposited when the basin was connected to the ocean,hosts antithetical negative and positive excursions f.rδ^13Ccarb andδ^13Corg,respectively,resulting inΔ^13C values lower than 25‰.f.om the top of.the basal sequence upwards,an extremely positiveδ^13Ccarb excursion is coupled toδ^13Corg,reaching values of.14‰and-14‰,*** positive excursion represents a remarkable basin-wide carbon isotope f.ature of.the Bambui Group that occurs with only minor changes inΔ^13C values,suggesting change in the DIC isotope *** argue that this regional isotopic excursion is related to a disconnection between the intrabasinal and the global carbon *** extreme carbon isotope excursion may have been a product of.a disequilibria between the basin DIC and atmospheric CO2

关键词： Methanogenesis Ediacaran Cambrian Carbon isotopes Sao f.ancisco Basin Bambui Group

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Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis,manchette structure and sperm tail assembly in humans and mice

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Science China Lif. Sciences 2025年第03期 777-792页

作者： Yiling Zhou Chaof.ng Tu Charles Coutton Jianan Tang Shixiong Tian Shuyan Tang Guillaume Martinez Dapeng Zhou Célia Tebbakh Jiaxiong Wang Raoudha Zouari Xuehai Zhou Selima f.urati Ben Mustapha Xuemei Wang Bangguo Wu Xinyan Geng Shuang Liu Li Jin Huijuan Shi Yue-Qiu Tan pierre f.Ray Lingbo Wang Xiaoyu Yang f.ng Zhang Chunyu Liu Obstetrics and Gynecology Hospital State Key Laboratory of Genetic Engineering Institute of Medical Genetics and Genomics Fudan University Institute of.Reproductive and Stem Cell Engineering NHC Key Laboratory of Human Stem Cell and Reproductive Engineering School of Basic Medical Science Central South University Clinical Research Center f.r Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC-XIANGYA Université Grenoble Alpes CNRS UMR 5309 INSERM U1209 Institute for Advanced Biosciences (IAB) Site Santé–Allée des Alpes CHU Grenoble Alpes H?pital Couple-Enfant UM de Génétique Chromosomique Shanghai-MOST Key Laboratory of.Health and Disease Genomics NHC Key Lab of Reproduction Regulation Shanghai Institute for Biomedical and Pharmaceutical Technologies School of Pharmacy Fudan University Shanghai Key Laboratory of.Metabolic Remodeling and Health Institute of Metabolism and Integrative Biology Fudan University State Key Laboratory of.Reproductive Medicine The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital Polyclinique les Jasmins Centre d’Aide Médicale à la Procréation Centre Urbain Nord Key Laboratory of.Systems Health Science of.Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Soong Ching Ling Institute of.Maternity and Child Health International Peace Maternity and Child Health Hospital Shanghai Jiao Tong University School of Medicine CHU Grenoble Alpes UM GI-DPI State Key Laboratory of.Reproductive Medicine and of.spring health Clinical Center for Reproductive Medicine The First Affiliated Hospital of Nanjing Medical University Shanghai Key Laboratory of.Embryo Original Diseases

Asthenoteratozoospermia is a common cause of.male inf.rtility. To f.rther def.ne the genetic causes underlying asthenoteratozoospermia, we perf.rmed whole-exome sequencing in a cohort of.Han Chinese men with asthenoteratozoospermia. Homozygous deleterious variants of.MYCBPAP were f.rst identif.ed in two unrelated Chinese cases. Replication analyses in a f.ench cohort revealed an additional asthenoteratozoospermia-af.ected case harboring a homozygous nonsense variant in MYCBPAP. All of.the identif.ed MYCBPAP variants were absent or extremely rare in the public human genome databases. f.rther f.nctional assays indicated remarkably reduced abundance of.MYCBPAP in the spermatozoa f.om MYCBPAP-associated cases. Subsequently, we generated a Mycbpap knockout(Mycbpap-/-) mouse model, which also exhibited male inf.rtility with reduced sperm motility and abnormal morphologies in sperm heads and f.agella. f.rther investigations demonstrated that Mycbpap-/-male mice presented disrupted acrosome biogenesis and abnormally elongated manchette during ***, proteomic analyses indicated that the proteins related to spermatogenesis, acrosomal and f.agellar f.nctions were signif.cantly down-regulated in the testes f.om Mycbpap-/-male mice. Endogenous immunoprecipitation combined with mass spectrometry revealed interactions of.MYCBPAP with a ribosome elimination related protein ARMC3 and central apparatus proteins including Cf.P65 and ***, MYCBPAP-associated male inf.rtility in humans and mice could be partially overcome by using intracytoplasmic sperm injections. Collectively, these f.ndings illustrate the essential role of.MYCBPAP in normal spermatogenesis and homozygous deleterious variants in MYCBPAP can be considered as a genetic diagnostic indicator f.r inf.rtile men with asthenoteratozoospermia. Our study will provide ef.ective guidance f.r genetic counseling, clinical diagnosis and assisted reproduction treatments of.MYCBPAP-associated male

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