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Stricturing Crohn's disease-like colitis in a patient treated with belatacept

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World Journal of Gastroenterology 2017年第48期23卷 8660-8665页

作者： Anne Bozon Guillaume Jeantet Benjamin Rivière Natalie Funakoshi Gaspard Dufour Roman Combes Jean-Christophe Valats Sylvie Delmas Jean Emmanuel Serre Michael Bismuth Jeanne Ramos Moglie Le Quintrec pierre blanc Guillaume Pineton de Chambrun Gastroenterology Department Saint-Eloi HospitalMontpellier University Hospital Nephrology Department Lapeyronie HospitalMontpellier University Hospital Pathology Department Guy de Chauliac HospitalMontpellier University Hospital

Cytotoxic T-lymphocyte-associated antigen 4(CTLA-4) modifying agents have been involved in the development of intestinal inflammation,especially therapeutic monoclonal antibodies directed against CTLA-4. Here we report the appearance of a severe stricturing Crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept,a recombinant CTLA-4-Ig fusion protein.

关键词： Crohn’s disease Colitis Belatacept HHV-6 Inflammatory bowel disease

Analysis of a Prototypical Multiscale Method Coupling Atomistic and Continuum Mechanics:the Convex Case

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Acta Mathematicae Applicatae Sinica 2007年第2期23卷 209-216页

作者： Xavier blanc Claude Le Bris FrédéricLegoll Laboratoire J.L.-Lions Université Pierre et Marie CurieBoite courrier 187F-75252 ParisFrance CERMICS Ecole Nationale des Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance CERMICS Ecole Nationale des Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance EDF R & D1 avenue du Général de GaulleF-92140 ClamartFrance

In order to describe a solid which deforms smoothly in some region, but non smoothly in some other region, many multiscale methods have been recently proposed that aim at coupling an atomistic model （discrete mechanics） with a macroscopic model （continuum mechanics）. We provide here a theoretical basis for such a coupling in a one-dimensional setting, in the case of convex energy.

关键词： Multiscale methods variational problems continuum mechanics discrete mechanics

Barcelona clinic liver cancer nomogram and others staging/scoring systems in a French hepatocellular carcinoma cohort

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World Journal of Gastroenterology 2017年第14期23卷 2545-2555页

作者： Xavier Adhoute Guillaume Pénaranda Jean Luc Raoul Julien Edeline Jean-Frédéric blanc Bernard Pol Manuela Campanile HervéPerrierO livier Bayle Olivier Monnet Patrick Beaurain Cyril Muller Paul Castellani Yves Patrice Le Treut Jean pierre Bronowicki Marc Bourlière Department of Hepato-Gastroenterology Hopital Saint-Joseph Marseille Alpha Bio Laboratory Marseille Department of Hepato-Gastroenterology and Digestive Oncology Institut Paoli-Calmette Marseille Department of Hepato-Gastroenterology and Digestive Oncology Centre Eugène Marquis Rennes Department of Hepato-Gastroenterology Centre Hospitalo-Universitaire Saint-AndréBordeaux Department of Hepatobiliary Surgery Hopital Saint-Joseph Marseille Department of Radiology Hopital Saint-Joseph Marseille Department of Hepatobiliary Surgery Centre Hospitalo-Universitaire Timone Marseille Department of Hepato-Gastroenterology Centre Hospitalo-Universitaire de Nancy INSERM U954 Universitéde LorraineCHU de NancyVandoeuvre les Nancy

AIM To compare the performances of the Barcelona clinic liver cancer(BCLC) nomogram and others systems(BCLC, HKLC, CLIP, NIACE) for survival prediction in a large hepatocellular carcinoma(HCC) French *** Data were collected retrospectively from 01/2007 to 12/2013 in five French centers. Newly diagnosed HCC patients were analyzed. The discriminatory ability, homogeneity ability, prognostic stratification ability Akaike information criterion(AIC) and C-index were compared among scoring systems. RESULTS The cohort included 1102 patients, mostly men, median age 68 [60-74] years with cirrhosis(81%), child-Pugh A(73%), alcohol-related(41%), HCV-related(27%). HCC were multinodular(59%) and vascular invasion was present in 41% of cases. At time of HCC diagnosis BCLC stages were A(17%), B(16%), C(60%) and D(7%). First line HCC treatment was curative in 23.5%, palliative in 59.5%, BSC in 17% of our population. Median OS was 10.8 mo [4.9-28.0]. Each system distinguished different survival prognosis groups(P < 0.0001). The nomogram had the highest discriminatory ability, the highest C-index value. NIACE score had the lowest AIC value. The nomogram distinguished sixteen different prognosis groups. By classifying unifocal large HCC into tumor burden 1, the nomogram was less powerful. CONCLUSION In this French cohort, the BCLC nomogram and the NIACE score provided the best prognostic information, but the NIACE could even help treatment strategies.

关键词： Barcelona clinical liver cancer Hong kong liver cancer NIACE CLIP Hepatocellular carcinoma

Interest of thoracic ultrasound after cardiac surgery or interventional cardiology

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World Journal of Cardiology 2024年第3期16卷 118-125页

作者： Martin Boussuges Philippe blanc Fabienne Bregeon Alain Boussuges Service de Pneumologie Centre Hospitalier Universitaire Sud ReunionSaint Pierre 97410Ile de la ReunionFrance Department of Cardiac and Pulmonary Rehabilitation Ste Clotilde&YlangYlang Rehabilitation CenterSainte Clotilde 97491Ile de la ReunionFrance Service d’Explorations Fonctionnelles Respiratoires Centre Hospitalier Universitaire NordAssistance Publique des Hôpitaux de MarseilleMarseille 13015France Institut Hospitalo-Universitaire-Méditerranée Infection Aix Marseille UniversitéMarseille 13005France Center for Cardiovascular and Nutrition Research Aix Marseille UniversitéInstitut National de la Santéet de la Recherche MédicaleInstitut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementMarseille 13005France

Thoracic ultrasound has attracted much interest in detecting pleural effusion or pulmonary consolidation after cardiac *** 2016,Trovato reported,in the World Journal of Cardiology,the interest of using,in addition to echocardiography,thoracic *** this editorial,we highlight the value of assessing diaphragm function after cardiac surgery and interventional cardiology *** factors are able to impair diaphragm function after such *** motion may be decreased by chest pain secondary to sternotomy,pleural effusion or impaired muscle *** paralysis may be secondary to phrenic nerve damage complicating cardiac surgery or atrial fibrillation *** may be ***,respi-ratory troubles induced by diaphragm dysfunction are frequently attributed to pre-existing heart disease or pulmonary complications secondary to *** addition,elevated hemidiaphragm secondary to diaphragm dysfunction is sometimes not observed on chest X-ray performed in supine position in the intensive care *** of diaphragm function by ultrasound during the recovery period appears *** hemidiaphragms can be studied by two complementary ultrasound *** mobility of each hemidiaphragms is measured by M-mode *** addition,recording the percentage of inspiratory thickening provides important information about the quality of muscle *** two approaches make it possible to detect hemidiaphragm paralysis or *** a diagnosis is important because persistent diaphragm dysfunction after cardiac surgery has been shown to be associated with adverse respiratory *** respiratory physio-therapy is able to improve respiratory function through strengthening of the inspiratory muscles *** and accessory inspiratory muscles.

关键词： Ultrasonography Diaphragm Phrenic nerve Hemidiaphragm Thickening fraction Physiotherapy

Expert group syndrome at high altitude

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Sports Medicine and Health Science 2022年第3期4卷 215-218页

作者： Jean-Paul Richalet Marie-Anne Magnan Alice Gavet pierre Lafère UniversitéSorbonne Paris Nord Laboratoire Hypoxie et PoumonUMR INSERM U1272BobignyFrance Institut National des Sports de l’Expertise et de la PerformancePôle médicalParisFrance Hôpitaux universitaires de Genève Département de médecine aiguëUnitéde médecine subaquatique et hyperbareGenevaSwitzerland Hôpitaux du Mont-blanc Soins de suite et réadaptationChamonixFrance Universitéde Bretagne Occidentale Laboratoire ORPHYEA 44324BrestFrance HauteÉcole Bruxelles-Brabant(HE2B) EnvironmentalOccupationalAgeing(Integrative)Physiology LaboratoryBrusselsBelgium

During a training session for the university diploma of Mountain medicine delivered by University Sorbonne Paris Nord for medical doctors,one of the participants developed signs of maladaptation to high altitude at 3600 m,the severity of which was incorrectly *** was sparingly given by the patient(an anesthetist)to several of his colleagues and no one was in charge to collect clinical data,take a history,and provide appropriate *** combination of the absence of designation of a supervising doctor and the difficulty of communicating with the patient led to a lack of coordinated management and to an evolution of the symptoms towards severe acute mountain ***,the very rapid management of the patient and a rapid helicopter evacuation,as soon as the symptoms worsened towards the onset of a suspected high altitude cerebral and/or pulmonary edema,allowed rapid resolution without ***,medical,psychological,and managerial factors led to this Expert Group Syndrome.

关键词： Acute mountain sickness High altitude cerebral edema Psychology Group management

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白兔

法语学习 2014年第2期 4-16页

作者： pierre Bellemare et Jacques Antoine 吴琼

“开门!警察!”警察局的韦伯警长刚刚敲过里昂市一条巷子深处一座阴森森的老公寓的木门。他来搜查一个名叫图贝、绰号“吹哨者”的人的住所。没人应声，他开始不耐烦地用雨伞敲击百叶窗。在他身后，两名警察正检查着后院和迷宫般迂回曲... 详细信息

“开门!警察!”警察局的韦伯警长刚刚敲过里昂市一条巷子深处一座阴森森的老公寓的木门。他来搜查一个名叫图贝、绰号“吹哨者”的人的住所。没人应声，他开始不耐烦地用雨伞敲击百叶窗。在他身后，两名警察正检查着后院和迷宫般迂回曲折的楼梯。裂了缝的房屋在这位警官的反复敲击下似乎快要崩塌。随后，又恢复了寂静。屋内没有人。

关键词：警察局兔房屋

单克隆抗体对体外培养恶性疟原虫的保护性抑制作用

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基础医学与临床 1988年第5期 429-429页

作者：李泽琳,L.Monjour,pierre.Bayarel,Desgranges-blanc.Claud 中国中医研究院中药所法国INSERM 法国INSERM 法国INSERM

采自非洲恶性疟患者的带虫血、用EBY转化方法培养出五株人恶性疟原虫单克隆抗体:11_n13 （IgG）、CE22-14 D10（IgM）、38.16（IgM）39.53Ⅱ（IgM）及HOO2-2G9（IgG）、经过FPLC纯化、Amicon膜浓缩、ELSA或FSPC测定含量。含量在15～100g... 详细信息

采自非洲恶性疟患者的带虫血、用EBY转化方法培养出五株人恶性疟原虫单克隆抗体:11_n13 （IgG）、CE22-14 D10（IgM）、38.16（IgM）39.53Ⅱ（IgM）及HOO2-2G9（IgG）、经过FPLC纯化、Amicon膜浓缩、ELSA或FSPC测定含量。含量在15～100g/ml。以3H-次黄瞟呤渗入疟原虫DNA方法,放射活性的高低表示症原虫生长或受抑制、用不同浓度的上述单克隆抗体与症原虫共同培养,同时加入3H-次黄嘌呤,48小时后测定放射活

关键词：单克隆抗体恶性疟原虫抑制作用基因互作