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Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2024年第13期30卷 1899-1910页

作者： Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic piero Marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males Josko Bozic Biology of Neoplasms University of Split School of MedicineSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Gastroenterology University Hospital of SplitSplit 21000Croatia Department of Pharmacy University of Split School of MedicineSplit 21000Croatia Department of Medical Laboratory Diagnostics University Hospital of SplitSplit 21000Croatia Department of Health Studies University of SplitSplit 21000Croatia Department of Internal Medicine University of Split School of MedicineSplit 21000Croatia Department of Surgery University Hospital of SplitSplit 21000Croatia

BACKGROUND Population of patients with inflammatory bowel disease(IBD)is burdened by various extraintestinal manifestations which substantially contribute to greater morbidity and ***-differentiation factor-15(GDF-15)is often overexpressed under stress conditions,such as inflammation,malignancies,heart failure,myocardial ischemia,and many *** To explore the association between GDF-15 and IBD as serum concentrations of GDF-15 were shown to be an independent predictor of poor outcomes in multiple *** additional aim was to determine possible associations between GDF-15 and multiple clinical,anthropometric and laboratory parameters in patients with *** This cross-sectional study included 90 adult patients diagnosed with IBD,encompassing both Crohn’s disease(CD)and ulcerative colitis(UC),and 67 healthy age-and sex-matched *** patients underwent an extensive workup,including colonoscopy with subsequent histopathological *** activity was assessed by two independent gastroenterology consultants specialized in IBD,employing well-established clinical and endoscopic scoring ***-15 serum concentrations were determined following an overnight fasting,using electrochemiluminescence *** In patients with IBD,serum GDF-15 concentrations were significantly higher in comparison to the healthy controls[800(512-1154)pg/mL vs 412(407-424)pg/mL,P<0.001],whereas no difference in GDF-15 was found between patients with CD and UC[807(554-1451)pg/mL vs 790(509-956)pg/mL,P=0.324].Moreover,multiple linear regression analysis showed that GDF-15 levels predict CD and UC severity independent of age,sex,and C-reactive protein levels(P=0.016 and P=0.049,respectively).Finally,an association between GDF-15 and indices of anemia was ***,negative correlations were found between GDF-15 and serum iron levels(r=-0.248,P=0.021),as well as GDF-15 and hemoglobin(r=-0.351,P=0.021).Accordingly,in comparison to I

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Growth-differentiation factor-15 Anemia Extraintestinal manifestations

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Can rifaximin for hepatic encephalopathy be discontinued during broad-spectrum antibiotic treatment?

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World Journal of Hepatology 2024年第2期16卷 115-119页

作者： Chien-Hao Huang piero Amodio Division of Hepatology Department of Gastroenterology and HepatologyChang-Gung Memorial HospitalLinkou Medical CenterTaoyuan 333Taiwan Department of Clinical and Experimental Medicine University of PaduaPadova 35122Italy

Hepatic encephalopathy(HE)is a formidable complication in patients with decompensated cirrhosis,often necessitating the administration of rifaximin(RFX)for effective ***,is a gut-restricted,poorly-absorbable oral rifamycin derived antibiotic that can be used in addition to lactulose for the secondary prophylaxis of *** has shown notable reductions in infection,hospital readmission,duration of hospital stay,and ***,limited data exist about the concurrent use of RFX with broad-spectrum antibiotics,because the patients are typically excluded from studies assessing RFX efficacy in HE.A pharmacist-driven quasi-experimental pilot study was done to address this *** argue against the necessity of RFX in HE during broad-spectrum antibiotic treatment,particularly in critically ill patients in intensive care unit(ICU).The potential for safe RFX discontinuation without adverse effects is clearly illuminated and valuable insight into the optimization of therapeutic strategies is *** findings also indicate that RFX discontinuation during broadspectrum antibiotic therapy was not associated with higher rates of delirium or coma,and this result remained robust after adjustment in multivariate ***,rates of other secondary clinical and safety outcomes,including ICU mortality and 48-hour changes in vasopressor requirements,were ***,since the activity of RFX is mainly confined to the modulation of gut microbiota,its potential utility in patients undergoing extensive systemic antibiotic therapy is debatable,given the overlapping antibiotic ***,this suggests that the action of RFX on HE is class-specific(related to its activity on gut microbiota),rather than drug-specific.A recent double-blind randomized controlled(ARiE)trial provided further evidence-based support for RFX withdrawal in critically ill cirrhotic ICU patients receiving broad-spectrum *** studies prompt further discussion about

关键词： Rifaximin discontinuation Hepatic encephalopathy Broad-spectrum antibiotics Crit-ically ill Medical intensive care unit Pharmacist-driven protocol

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Antioxidant treatment for oligoasthenoteratozoospermia and varicocele:a DBPC trial to evaluate the impact of age and body mass index

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Asian Journal of Andrology 2024年第3期26卷 239-244页

作者： Gian Maria Busetto Bernarde F Rodrigues Ashraf Virmani Andrea Checchia Antonella Ninivaggi Anna Ricapito Giovanni Barbieri piero Fischetti Ugo G Falagario Pasquale Annese Nicola d’Altilia Vito Mancini Matteo Ferro Felice Crocetto Angelo Porreca Carlo Bettocchi Luigi Cormio Ashok Agarwal Giuseppe Carrieri University of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Department of Urology Human Reproduction SectionFederal University of Sao PauloSao Paulo 05403-000Brazil Alfasigma Healthscience Utrecht 3528 BGThe Netherlands Urology Unit “G.Tatarella”HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IEO)IRCCSMilan 20142Italy University of Naples Federico II Naples80126Italy Department of Oncological Urology Veneto Institute of Oncology(IOV)IRCCSPadua 35039Italy Urology Unit “L.Bonomo”HospitalAndria 70031Italy Global Andrology Forum Moreland HillsOH 44022USA

Oxidative stress is one of the main mechanisms responsible for male *** conditions such as varicocele,obesity,advanced age,and lifestyle can lead to an increase in reactive oxygen species,causing an oxidative imbalance in the *** are sensitive to reactive oxygen species and require energy to carry out their main function of fertilizingthe *** reactive oxygen species can affect sperm metabolism,leading to immobility,impaired acrosome reaction,and celldeath,thereby impairing reproductive *** double-blind randomized study evaluated the effect of supplementation withL-carnitine,acetyl-L-carnitine,vitamins,and other nutrients on semen quality in 104 infertile patients with or without varicocele,while also investigating the impact of factors such as obesity and advanced age on *** concentration significantlyincreased in the supplemented group compared to the placebo group(P=0.0186).Total sperm count also significantly increasedin the supplemented group(P=0.0117),as did sperm motility(P=0.0120).The treatment had a positive effect on patients upto 35 years of age in terms of sperm concentration(P=0.0352),while a body mass index(BMI)above 25 kg m^(−2) had a negativeeffect on sperm concentration(P=0.0110).Results were not showing a net benefit in stratifying patients in accordance withtheir BMI since sperm quality increase was not affected by this *** conclusion,antioxidant supplementation may bebeneficial for infertile patients and has a more positive effect on younger patients with a normal weight.

关键词： aging antioxidants body mass index oligoasthenoteratozoospermia varicocele

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Advanced methodologies for the cleaning of works of art

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Science China(Technological Sciences) 2023年第8期66卷 2162-2182页

作者： CASINI Andrea CHELAZZI David BAGLIONI piero CSGI and Department of Chemistry“Ugo Schiff” University of FlorenceSesto FiorentinoFlorence 50019Italy Department of Chemistry“Ugo Schiff”and CSGI University of FlorenceSesto FiorentinoFlorence 50019Italy

Cultural heritage assets constitute a fundamental socioeconomic resource,but the actual works of art need to be maintained,counteracting degradation processes,to transfer these benefits to future *** particular,the removal of soil,aged coatings,and vandalism/overpaints is one of the most needed interventions in art *** cleaning methodologies,based on classical solution and polymer chemistry,only grant limited control of the cleaning interventions,with the risk of affecting the original components of the artifacts,and often involving the use of toxic or non-environmentally friendly ***,materials science,colloids,and soft matter have provided valuable and safe solutions in the last *** review provides a selection of the most recent and advanced methodologies for the wet cleaning of works of art,spanning from nanostructured cleaning fluids(microemulsions,surfactants swollen micelles)to physical and chemical *** new methodologies work on different physico-chemical mechanisms,such as processes for detaching/dewetting,to selectively remove the unwanted layers in sustainable and cost-effective *** best performing systems,like microemulsions confined in“twin-chain”polyvinyl alcohol gels,have been assessed in the cleaning of masterpieces such as works by Pablo Picasso,Jackson Pollock and Roy *** attention is dedicated to“green”chemistry systems,using low-toxicity solvents or bio-based/waste materials to build gel ***,current trends and future perspectives are given,showing that advanced systems for art cleaning link with transversal fields of crucial importance even beyond Cultural heritage conservation,e.g.,detergency,tissue engineering,drug-delivery,food industry and cosmetics.

关键词： cleaning conservation cultural heritage gels microemulsions surfactants colloids nanoscience

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Experimental characterization and CFD simulation of gas maldistribution in turbulent fluidization of Group A particles

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Particuology 2023年第11期82卷 192-203页

作者： Maurizio Troiano Benjamin Amblard Sina Tebianian Roberto Solimene piero Salatino Thierry Gauthier Dipartimento di Ingegneria Chimica dei Materiali e della Produzione IndustrialeUniversitàdegli Studi di Napoli Federico IIPiazzale Vincenzo Tecchio 8080125NapoliItaly IFP Energies nouvelles Rond-point de l'échangeur de Solaize BP 369360SolaizeFrance Istituto di Scienze e Tecnologie per l’Energia e la MobilitàSostenibili(STEMS) Consiglio Nazionale delle Ricerche(CNR)Piazzale Vincenzo Tecchio 8080125NapoliItaly

The study presented hereby investigates experimentally and with CFD simulations the gas distribution effect on the hydrodynamic of a Geldart Group A turbulent fluidized bed. Experiments were carried out on a cold flow fluidized bed column with an even and uneven gas distribution. Local solid volume fraction profiles were measured using optical probes at different bed heights and along two radial directions. Optical probe measurements allow catching a clear hydrodynamic difference between both even and uneven gas distributions. These results were then used to assess CFD simulations with the code Barracuda^(TM) (MP-PIC approach). It is noteworthy that the choice of drag correlation and boundary conditions strongly influences the agreement between the experimental and CFD results. Once the correct parameters are chosen, CFD simulations captured the effect of gas distribution changes.

关键词： Characterization of multiphase reactors Fluidized bed Turbulent Gas distribution Jet Optical probe CFD simulations

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Surveillance strategies following curative resection and nonoperative approach of rectal cancer:How and how long?Review of current recommendations

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 177-192页

作者： Andrea Lauretta Giulia Montori Gian piero Guerrini Department of Surgical Oncology Centro di Riferimento Oncologico di Aviano IRCCSAviano 33081Italy Department of General Surgery Vittorio Veneto HospitalULSS 2 Marca TrevigianaVittorio Veneto 31029Italy Hepato-Pancreato-Biliary Surgical Oncology and Liver Transplantation Unit Policlinico-AUO ModenaModena 41124Italy

Different follow-up strategies are available for patients with rectal cancer following curative treatment.A combination of biochemical testing and imaging investigation,associated with physical examination are commonly ***,there is currently no consensus about the types of tests to perform,the timing of the testing,and even the need for follow-up at all has been *** aim of this study was to review the evidence of the impact of different followup tests and programs in patients with non-metastatic disease after definitive treatment of the primary.A literature review was performed of studies published on MEDLINE,EMBASE,the Cochrane Library and Web of Science up to November *** published guidelines from the most authoritative specialty societies were also *** to the follow-up strategies available,the office visit is not efficient but represents the only way to maintain direct contact with the patient and is recommended by all authoritative specialty *** colorectal cancer surveillance,carcinoembryonic antigen represents the only established tumor *** and chest computed tomography scan is recommended considering that the liver and lungs are the most common sites of *** local relapse in rectal cancer is higher than in colon cancer,endoscopic surveillance is *** follow-up regimens have been published but randomized comparisons and meta-analyses do not allow to determine whether intensive or less intensive follow-up had any significant influence on survival and recurrence detection *** available data do not allow the drawing of final conclusions on the ideal surveillance methods and the frequency with which they should be *** is very useful and urgent for clinicians to identify a cost-effective strategy that allows early identification of recurrence with a special focus for highrisk patients and patients undergoing a“watch and wait”approach.

关键词： Rectal cancer Follow-up Surveillance Recurrence Carcinoembryonic antigen Computed tomography

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Portal Hypertension in Nonalcoholic Fatty Liver Disease: Challenges and Paradigms

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1201-1211页

作者： Emilie K.Mitten piero Portincasa György Baffy Division of Gastroenterology Department of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Division of Internal Medicine and Department of Precision and Regenerative Medicine and Ionian Area University‘Aldo Moro’Medical SchoolBariItaly Division of Gastroenterology Hepatology and EndoscopyDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Section of Gastroenterology Department of MedicineVA Boston Healthcare SystemBostonMAUSA

Portal hypertension in cirrhosis is defined as an increase in the portal pressure gradient(PPG)between the portal and hepatic veins and is traditionally estimated by the hepatic venous pressure gradient(HVPG),which is the difference in pressure between the free-floating and wedged positions of a balloon catheter in the hepatic *** convention,􀀫HVPG≥10mmHg indicates clinically significant portal hypertension,which is associated with adverse clinical *** fatty liver disease(NAFLD)is a common disorder with a heterogeneous clinical course,which includes the development of portal *** is increasing evidence that portal hypertension in NAFLD deserves special ***,elevated PPG often precedes fibrosis in NAFLD,suggesting a bidirectional relationship between these pathological ***,HVPG underestimates PPG in NAFLD,suggesting that portal hypertension is more prevalent in this condition than currently ***,cellular mechanoresponses generated early in the pathogenesis of NAFLD provide a mechanistic explanation for the pressurefibrosis ***,a better understanding of liver mechanobiology in NAFLD may aid in the development of novel pharmaceutical targets for prevention and management of this disease.

关键词： Sinusoidal microcirculation Hepatic vascular resistance Portal venous pressure Hepatic venous pressure gradient Mechanobiology Mechanotransduction

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Contamination of microgreens by Salmonella enterica and Escherichia coli is influenced by selection breeding in chicory(Cichorium intybus L.)

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Food Quality and Safety 2022年第2期6卷 244-251页

作者： Anna Lenzi Ada Baldi Letizia Lombardelli Stefania Truschi Massimiliano Marvasi piero Bruschi Department of Agriculture FoodEnvironment and Forestry(DAGRI)University of FlorenceFlorenceItaly Department of Biology University of FlorenceFlorenceItaly

The aim of this study was to assess whether selection breeding in chicory(Cichorium intybus L.)led changes in the susceptibility to Salmonella enterica and Escherichia coli contamination and whether the anatomical traits of the leaves are involved in the possible *** chicory genotypes subjected to different intensities of selection were compared at the microgreen *** retention was evaluated after leaf incubation for 1.5 h on the surface of the bacterial suspension,followed by rinsing,grinding,plating on selective media,and colony forming unit(CFU)*** density of stomata and trichomes,total stomatal length and width,stomatal pit width,surface roughness and sharpness were *** intensively selected genotype(Witloof)was significantly more prone to contamination(2.9±0.3 lg CFU/cm^(2))as the average of the two bacterial types than the wild accession(Wild;2.3±0.4 lg CFU/cm^(2))and the moderately selected genotypes(two leaf chicories,Catalogna type,and root chicory'Magdeburg';on average,1.9±0.3 lg CFU/cm^(2)).Witloof microgreens also showed larger stomata(on average+34%for stoma width and+44%for pit width),which could justify,at least in part,the higher susceptibility to enterobacterial *** fact,when contamination was performed in the dark(closed stomata),the bacterial retention in Witloof was significantly reduced in comparison with the opened stomata(-44%)and in Wild(-26%).Differences in retention between Witloof and Wild were still observed after UV *** hierarchical clustering performed by grouping the leaf anatomical features was consistent with the chicory genetic *** results suggest that the domestication process can affect the safety of produce and that the micromorphological traits of the leaves may be involved.

关键词： chicory genotypes enterobacteria contamination raw-consumed vegetables micro vegetables selective breeding food safety stoma

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Chapter 3 Extra-galactic gamma-ray sources

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Chinese Physics C 2022年第3期46卷 63-84页

作者：王祥玉毕效军曹臻 piero Vallania 吴含荣闫大海袁强 School of Astronomy and Space Sciences Nanjing UniversityNanjing 210093China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China INAF-Osservatorio Astrofisico di Torino Strada Osservatorio 2010025 Pino Torinese(TO)Italy and INFN Sezione di TorinoVia P.Giuria 110125 TorinoItaly Key Laboratory for the Structure and Evolution of Celestial Objects Yunnan ObservatoriesChinese Academy of SciencesKunming 650011China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China

Extra-galactic gammaray sources,such as gamma-ray bursts,active galactic nuclei,starburst galaxies,are interesting and important targets for LHAASO *** this chapter,the prospects of detecting these sources with LHAASO and their physical implications are *** upgrade plan for the Water Cherenkov Detector Array(WCDA),which aims to enhance the detectability of relatively lower energy photons,is also *** addition,a study on constraining the extragalactic background light with LHAASO observation of blazars is presented.

关键词： AGN Gamma-rays GRBs

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Surgical management of pancreatic neuroendocrine neoplasms

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Laparoscopic, Endoscopic and Robotic Surgery 2023年第3期6卷 83-90页

作者： piero Alberti David Martin Georgios Gemenetzis Rowan Parks General Surgery(Hepatopancreatobiliary Surgery) Royal Infirmary of EdinburghEdinburghUK Department of Visceral Surgery and Transplantation University Hospital CHUVUniversity of Lausanne(UNIL)LausanneSwitzerland Ninewells Hospital and Medical School DundeeUK University of Edinburgh Medical SchoolEdinburghUK

Pancreatic neuroendocrine neoplasms are a rare and complex group of neoplastic lesions that develop from pancreatic islet *** incidence has dramatically increased during the last two *** to its complex nature and pathophysiological behaviour,surgical management continues to *** remains the cornerstone of treatment for most non-functional and functional pancreatic neuroendocrine tumours,while lymphadenectomy remains a controversial *** techniques,such as pancreas-preserving and minimally invasive approaches,continue to evolve and offer the same overall outcomes as open *** comprehensive review describes in detail the current and most up-todate classification and staging of pancreatic neuroendocrine tumours,explores the rationale for nonsurgical and surgical management,and focuses on surgical treatment and more specifically,on minimally invasive approaches.

关键词： Pancreatic neuroendocrine neoplasms Non-functional pancreatic neuroendocrine tumours Functional pancreatic neuroendocrine tumours Lymphadenectomy Minimally invasive surgery Pancreas preserving techniques

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