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Virological and histological evaluation of intestinal samples in COVID-19 patients

World Journal of Gastroenterology 2022年第44期28卷 6282-6293页

作者： Dajana Cuicchi Liliana Gabrielli Maria Lucia Tardio Giada Rossini Antonietta D’Errico pierluigi viale Tiziana Lazzarotto Gilberto Poggioli Department of Medical and Surgical Sciences Surgery of the Alimentary TractIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Experimental Diagnostic and Specialty MedicineMicrobiology UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Experimental Diagnostic and Specialty MedicinePathology UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department for Integrated Infectious Risk Management Infectious Diseases UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Infectious Diseases Unit Department for Integrated Infectious Risk ManagementUniversity of BolognaBologna 40138Italy Section of Microbiology Department of ExperimentalDiagnostic and Specialty MedicineUniversity of BolognaBologna 40138Italy Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy

BACKGROUND Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is the pathogen responsible for pandemic coronavirus disease 2019(COVID-19).It is a highly contagious virus which primarily affects the respiratory tract,nevertheless,the lungs are not the only target organs of the *** intestinal tract could represent an additional tropism site for *** observations have collectively suggested that enteric infections can occur in COVID-19 ***,the detection of viral RNA in gastrointestinal(GI)tissue samples has not been adequately investigated and results are *** To detect the presence of SARS-CoV-2 RNA in intestinal mucosa samples and to evaluate histological *** The COVID-19 patients hospitalized at an Italian tertiary hospital from April 2020 to March 2021 were evaluated for enrollment in an observational,monocentric *** study population was composed of two groups of adult *** the first group(biopsy group,30 patients),patients were eligible for inclusion if they had mild to moderate disease and if they agreed to have a rectal biopsy;in the second group(surgical specimen group,6 patients),patients were eligible for inclusion if they underwent intestinal resection during index ***-nine intestinal mucosal samples were *** Viral RNA was not detectable in any of the rectal biopsies performed(0/53).Histological examination showed no enterocyte damage,but slight edema of the lamina propria with mild inflammatory lymphoplasmacytic *** was no difference in inflammatory infiltrates in patients with and without GI ***-CoV-2 RNA was detected in fecal samples in 6 cases out of 14 cases examined(42.9%).In the surgical specimen group,all patients underwent emergency intestinal *** RNA was detected in 2 surgical specimens of the 6 examined,both of which were from patients with active neoplastic *** examination also pointed

关键词： COVID-19 SARS-CoV-2 Intestinal infection Intestinal samples Intestinal tropism Rectal samples

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Resilence Control of DC Microgrid Integrated with Multi-Nanogrids Considering Connected-Islanded States

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 786-796页

作者： Hossien Faraji Reza Hemmati pierluigi Siano Department of Electrical Engineering Amirkabir University of TechnologyTehranIran Department of Electrical Engineering Kermanshah University of TechnologyKermanshahIran Department of Management&Innovation Systems University of Salernoand also with the Department of Electrical and Electronic Engineering ScienceUniversity of JohannesburgJohannesburg 2006South Africa

In this paper, a DC microgrid (DCMG) integrated with a set of nano-grids (NG) is studied. DCMG exchanges predetermined active and reactive power with the upstream network. DCMG and NGs are coordinately controlled and managed in such a way the exchanged P-Q power with external grid are kept on scheduled level following all events and operating conditions. The proposed control system, in addition to the ability of mutual support between DCMG and NGs, makes NGs support each other in critical situations. On the other hand, in all operating conditions, DCMG not only feeds three-phase loads with time-varying active and reactive power on the grid side but also injects constant active power into the grid. During events, NGs support each other, NGs support DCMG, and DCMG supports NGs. Such control strategies are realized by the proposed control method to increase resilience of the system. For these purposes, all resources and loads in DCMG and NGs are equipped with individual controllers. Then, a central control unit analyzes, monitors, and regularizes performance of individual controllers in DCMG and NGs. Nonlinear simulations show the proposed model can effectively control DCMG and NGs under normal and critical conditions.

关键词： Control system DC microgrid nanogrid resilience

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Guest Editorial:Special Section on Battery Energy Storage Systems for Net-zero Power Systems and Markets

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 321-322页

作者： pierluigi Mancarella Nikos Hatziargyriou Chongqing Kang The University of Melbourne MelbourneAustralia The University of Manchester ManchesterUK National Technical University of Athens(NTUA) AthensGreece Tsinghua University BeijingChina IEEE

Battery energy storage technologies have witnessed both dramatic cost reduction and technical evolution in recent *** is leading to widespread deployment of battery energy storage systems(BESSs)worldwide,particularly to support operation of power grids with already deep penetration of *** the development of new battery technologies with different power-to-energy ratios and for various engineering applications,BESSs could play a strategic role towards a net-zero energy *** opportunities are emerging for BESSs to participate in several markets,provide different grid services,and perform“value stacking”,eventually allowing development of new business cases and improved BESS *** configurations that are“behind the meter”,“in front of the meter”,hybrid plants co-located with renewables,and so forth,are only some of the exciting propositions that are being seen in different countries and at different scales,from highly distributed(virtual power plants),to neighbourhood-level(community batteries),to utility scale.

关键词： Battery battery eventually

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Distributed Energy and Reserve Scheduling in Local Energy Communities Using L-BFGS Optimization

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 942-952页

作者： Mohammad Dolatabadi Alireza Zakariazadeh Alberto Borghetti pierluigi Siano Department of Management&Innovation Systems University of SalernoSalernoItaly Department of Electrical Electronicand Information EngineeringUniversity of BolognaBolognaItaly University of Science and Technology of Mazandaran BehshahrIran Department of Power Systems National University of Science and Technology POLITEHNICA BucharestBucharestRomania IEEE

Encouraging citizens to invest in small-scale renewable resources is crucial for transitioning towards a sustainable and clean energy *** energy communities(LECs)are expected to play a vital role in this ***,energy scheduling in LECs presents various challenges,including the preservation of customer privacy,adherence to distribution network constraints,and the management of computational *** paper introduces a novel approach for energy scheduling in renewable-based LECs using a decentralized optimization *** proposed approach uses the Limitedmemory Broyden–Fletcher–Goldfarb–Shanno(L-BFGS)method,significantly reducing the computational effort required for solving the mixed integer programming(MIP)*** incorporates network constraints,evaluates energy losses,and enables community participants to provide ancillary services like a regulation reserve to the grid *** assess its robustness and efficiency,the proposed approach is tested on an 84-bus radial distribution *** indicate that the proposed distributed approach not only matches the accuracy of the corresponding centralized model but also exhibits scalability and preserves participant privacy.

关键词： Distributed optimization flexibility services L-BFGS method local energy community renewables reserve

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Liver decompensation predicts ribavirin overexposure in hepatitis C virus patients treated with direct-acting antivirals

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World Journal of Hepatology 2017年第34期9卷 1270-1277页

作者： Viola Guardigni Lorenzo Badia Matteo Conti Matteo Rinaldi Rita Mancini pierluigi viale Gabriella Verucchi Department of Medical and Surgical Sciences University of Bologna S.Orsola-Malpighi Hospital Research Centre for the Study of Hepatitis University of Bologna Metropolitan Laboratory Maggiore Hospital

AIM To determine whether ribavirin(RBV) concentrations differ according to cirrhosis stage among cirrhotic patients treated with interferon-free regimens. METHODS We included patients with hepatitis C virus and cirrhosis [Child-Pugh(CP) A or B], Glomerular Filtration Rate ≥ 60 mL/min, who started therapy with DAAs and weightbased RBV between October 2014 and February 2016. RBV plasma levels were assessed during the treatment. We focused our analysis on the first 8 wk of therapy. RESULTS We studied 68 patients: 54 with compensated(CP-B) and 14 with decompensated(CP-A) cirrhosis. Patients withdecompensated cirrhosis displayed significantly higher RBV concentrations than those with compensated cirrhosis at week 1, 2, 4 and 8(P < 0.035). RBV levels were positively correlated with Hb loss over the treatment(P < 0.04). Majority(71%) of CP-B patients required a RBV dosage reduction during the treatment. After adjustment for confounders, Child-Pugh class remained significantly associated(95%CI: 35, 348, P = 0.017) to RBV levels, independently from baseline per-Kg RBV dosage. CONCLUSION Liver decompensation might affect RBV clearance leading to an overexposure and increased related toxicities in decompensated cirrhosis. Our findings underscore the importance of an early ribavirin therapeutic drug monitoring and suggest that an initial lower RBV dose, rather than weight-based, might be considered in those with advanced liver disease(CP-B) treated with directacting antivirals.

关键词：丙肝直接行动的 antivirals Ribavirin 监视的治疗学的药患心脏代偿失调的肝硬化

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Co-Optimization of Behind-the-Meter and Front-of-Meter Value Streams in Community Batteries

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 334-345页

作者： Carmen Bas Domenech Antonella Maria De Corato pierluigi Mancarella University of Melbourne Parkville 2010VictoriaAustralia Department of Electrical and Electronic Engineering The University of ManchesterManchesterU.K. IEEE

Community batteries(CBs)are emerging to support and even enable energy communities and generally help consumers,especially space-constrained ones,to access potential techno-economic benefits from storage and support local grid ***,the economic viability of CB projects is often *** this regard,typical feasibility studies assess CB value for behind-the-meter(BTM)operation or whole-sale market participation,i.e.,front-of-meter(FOM).This work proposes a novel techno-economic operational framework that allows systematic assessment of the different options and introduces a two-meter architecture that co-optimizes both BTM and FOM benefits.A real CB project application in Australia is used to demonstrate the significant two-meter co-optimization opportunities that could enhance the business case of CB and energy communities by multi-service provision and value stacking.

关键词： Behind-the-meter community battery distributed energy resource(DER) energy community front-of-meter value stacking

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MIS 5e sea surface temperature estimation;a multi-proxy approach using a marine macrofossil assemblage(Mar Piccolo,Gulf of Taranto,Southern Italy)

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Journal of Palaeogeography 2024年第2期13卷 327-350页

作者： pierluigi Santagati Edoardo Perri Maria Pia Bernasconi Mario Borrelli Salvatore Guerrieri Salvatore Critelli Dipartimento di Biologia Ecologia e Scienze della TerraUniversita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly Dipartimento di Ingegneria Ambientale Universita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly

It is reported a multi-proxy palaeoclimatic study conducted on a MIS 5e calcarenite from the Mar Piccolo Basin(MP),Gulf of Taranto(GT)(Central Mediterranean).The calcarenite returned a rich malacofauna consisting of 120 extant species,including four of the tropical Senegalese Fauna,today absent in the *** biogeographic-climatic affinity of the assemblage shows,compared to today,a double percentage of warm affinity species,while the cold affinity species are nearly equally represented,indicating a warmer but not strictly tropical *** is confirmed by the most recurring preferred SST ranges of the assemblage,indicating an average of 20℃.The skeletal compositions of five well-preserved molluscan and coral specimens were analyzed for trace elements and stable isotopes for further mean SST *** the comparison of the results of several equations available in literature,it appears that only some SST estimations are realistic,converging into similar values of,on average,20.8±0.9℃.Considering all the used proxies,the MIS 5e SST difference compared to today falls in the range 1.2—2.0℃for the GT(being a more reasonable scenario)and 2.0—2.8℃for the *** is not a firmly tropical-like SST setting as suggested by the sole Senegalese fauna,indicating at least 2.7℃—3.5℃more than today’s GT and MP,*** approximations and assumptions made for obtaining SST values with any single proxy indicate the need of a multi-proxy approach to define the best SST estimation.

关键词： MiS 5e Sea surface temperature Palaeoclimate proxy Fossil fauna Gulf of Taranto

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ARBITRARILY HIGH-ORDER ENERGY-CONSERVING METHODS FOR HAMILTONIAN PROBLEMS WITH QUADRATIC HOLONOMIC CONSTRAINTS

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Journal of Computational Mathematics 2024年第4期42卷 1145-1171页

作者： pierluigi Amodio Dipartimento di Matematica Universita di Bari Italy Luigi Brugnano Gianluca Frasca-Caccia Felice Iavernaro 不详 Dipartimento di Matematica e Informatica"U.Dini" Universita di FirenzeItaly Dipartimento di Matematica Universita di SalernoItaly Dipartimento di Matematica Universita di BariItaly

In this paper,we define arbitrarily high-order energy-conserving methods for Hamilto-nian systems with quadratic holonomic *** derivation of the methods is made within the so-called line integral *** tests to illustra... 详细信息

关键词： Constrained Hamiltonian systems Quadratic holonomic constraints Energy-conserving methods Line integral methods Hamiltonian Boundary Value Methods HB-VMs

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Two big orifices in the second duodenal portion:A case of an atypical double papilla

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 83-85页

作者： Salvatore Francesco Vadalàdi Prampero Nikola Panic Marco Massidda Chiara Rocchi pierluigi Maria Rinaldi Ana Malenkovic Milutin Bulajic Gastroenterology and GI Endoscopy Department Mater Olbia HospitalOlbia 07026Italy Digestive Endoscopy Unit University Clinic"Dr Dragisa Misovic-Dedinje"Belgrade 11000Serbia Radiology Department Mater Olbia HospitalOlbia 07026Italy

With the advent of endoscopic retrograde cholangiopancreatography(ERCP)in the early 1970s,anatomic anomalies of the Vaterian system were described endoscopically[1].Although the occurrence is rare,the common bile duct(CBD)and the pancreatic duct may fail to coalesce during embryologic *** leads to double major papilla because both ducts open into the duodenum separately[1].In this way the cranial duct communicates with the CBD,while the caudal orifice communicates with the pancreatic duct[2].

关键词： orifice Vater atypical

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Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective

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World Journal of Gastroenterology 2024年第15期30卷 2081-2086页

作者： Michele Nardolillo Fabiola Rescigno Mario Bartiromo Dario Piatto Stefano Guarino pierluigi Marzuillo Emanuele Miraglia del Giudice Anna Di Sessa Department of Woman Child and of General and Specialized SurgeryUniversitàdegli Studi della Campania“Luigi Vanvitelli”Naples 80138Italy

Over recent years,the nomenclature of non-alcoholic fatty liver disease has undergone significant ***,in 2020,an expert consensus panel proposed the term“Metabolic(dysfunction)associated fatty liver disease”(MAFLD)to underscore the close association of fatty liver with metabolic abnormalities,thereby highlighting the cardiometabolic risks(such as metabolic syndrome,type 2 diabetes,insulin resistance,and cardiovascular disease)faced by these patients since *** recently,this term has been further replaced with metabolic associated steatotic liver *** is worth noting that emerging evidence not only supports a close and independent association of MAFLD with chronic kidney disease in adults but also indicates its interplay with metabolic ***,comparable pediatric data remain *** the progressive and chronic nature of both diseases and their prognostic cardiometabolic implications,this editorial aims to provide a pediatric perspective on the intriguing relationship between MAFLD and renal function in childhood.

关键词： Metabolic(dysfunction)associated fatty liver disease Renal Function Children Obesity

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