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Towards a business model for second-life batteries: Barriers,opportunities, uncertainties, and technologies

Journal of Energy Chemistry 2023年第3期78卷 507-525,I0014页

作者： Carlos Antônio Rufino Júnior Eleonora Riva Sanseverino pierluigi Gallo Daniel Koch Yash Kotak Hans-Georg Schweiger Hudson Zanin Advanced Energy Storage Division New Energy Innovation CenterUniversity of Campinas(UNICAMP)Campinas 13083-852Brazil Engineering Department University of Palermo(UNIPA)Palermo 90128Italy Consorzio Nazionale Interuniversitario per le Telecomunicazioni(CNIT) Parma 43124Italy Technische Hochschule Ingolstadt Institute for ElectricConnected and Safe Mobility(C-ECOS)Ingolstadt 85049Germany

Electric vehicles(EVs) and the recent pandemic outbreak give cities a new trend to primarily private and shared mobility with low noise and less air *** factors for the widespread of EVs are the electrical charging infrastructure,driving range,and the reduction of the cost of battery *** this reason,there is a massive effort from manufacturers,governments,and the scientific community to reduce battery costs and boost sustainable electrical production and *** reuse is an alternative to reduce batteries’ costs and environmental ***-life batteries can be used in a wide variety of secondary ***-life batteries can be connected with off-grid or on-grid photovoltaic and wind systems,vehicle charging stations,forklifts,and frequency *** present work aims to analyze the main challenges imposed on the reuse of batteries,the leading technologies for their reuse,and the different types of batteries in terms of their feasibility for second-life *** main novelty of this work is the discussion about the barriers,opportunities,uncertainties,and technologies for the second life *** we summarize the present state of the art in reusing lithium-ion batteries discussing technical and economic feasibility,environmental impacts,and *** results show five business models that have been proposed in the literature,three types of markets for trading second-life batteries,and the main opportunities and barriers for each actor in the battery supply chain.

关键词： Business models Batteries Sustainability Electric vehicles Challenges Opportunities Lithium-ion batteries Reuse

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Functional Design for Customizing Sit-To-Stand Assisting Devices

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Journal of Bionic Engineering 2018年第1期15卷 83-93页

作者： pierluigi Rea Erika Ottaviano DICeM-Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio via Di Biasio 43 03043 Cassino (FR) Italy

Standing up refers to the transition from the seating to the standing postures to perform a movement that involves several body segments and requires both voluntary action and equilibrium control during an important displacement of the body Centre of Gravity （COG）. This task can be considered very important for people with reduced mobility to achieve minimal independence in Activity of Daily Living （ADL）. In this paper, we propose solutions for the homecare of persons with reduced mobility, describing a functional design to customize assisting devices for the Sit-to-Stand （STS）. In particular, the support mechanism that generates the requested motion and sustains the body of a person can be synthesized ad-hoc according to the experimental data of the subject. Experimental tests carried out during the Sit-To-Stand are used to track and record point trajectories and the orientation of the trunk of an individual, and they are used to design a 1-DOF mechanism able to reproduce the assigned rigid-body motion. A four-bar linkage has been synthesized according to the desired features. Simulation results are reported to illustrate the engineering soundness of the proposed mechatronic solution.

关键词： assisting device Sit-to-Stand bionic design kinematic synthesis experimental evaluation simulation

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Exhaled volatile organic compounds for diagnosis and monitoring of asthma

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World Journal of Clinical Cases 2023年第21期11卷 4996-5013页

作者： Luisa Savito Simone Scarlata Andras Bikov pierluigi Carratù Giovanna Elisiana Carpagnano Silvano Dragonieri Department of Internal Medicine Unit of Respiratory Pathophysiology and Thoracic EndoscopyFondazione Policlinico Universitario Campus Bio MedicoRome 00128Italy Wythenshawe Hospital Manchester University NHS Foundation TrustManchester Academic Health Science CentreManchester M139WLUnited Kingdom Division of Infection Immunity and Respiratory MedicineFaculty of BiologyMedicine and HealthThe University of ManchesterManchester M139PTUnited Kingdom Department of Internal Medicine"A.Murri" University of Bari"Aldo Moro"Bari 70124Italy Department of Respiratory Diseases University of BariBari 70124Italy

The asthmatic inflammatory process results in the generation of volatile organic compounds(VOCs),which are subsequently secreted by the *** study of these elements through gas chromatography-mass spectrometry(GC-MS),which can identify individual molecules with a discriminatory capacity of over 85%,and electronic-Nose(e-NOSE),which is able to perform a quick onboard pattern-recognition analysis of VOCs,has allowed new prospects for non-invasive analysis of the disease in an"omics"*** this review,we aim to collect and compare the progress made in VOCs analysis using the two methods and their instrumental *** have described the potential of GC-MS and e-NOSE in a multitude of relevant aspects of the disease in both children and adults,as well as differential diagnosis between asthma and other conditions such as wheezing,cystic fibrosis,COPD,allergic rhinitis and last but not least,the accuracy of these methods compared to other diagnostic tools such as lung function,FeNO and eosinophil *** to significant limitations of both methods,it is still necessary to improve and standardize ***,e-NOSE appears to be the most promising aid in clinical practice,whereas GC-MS,as the gold standard for the structural analysis of molecules,remains an essential tool in terms of research for further studies on the pathophysiologic pathways of the asthmatic inflammatory *** conclusion,the study of VOCs through GC-MS and e-NOSE appears to hold promise for the noninvasive diagnosis,assessment,and monitoring of asthma,as well as for further research studies on the disease.

关键词： Asthma Volatile organic compounds Gas chromatography-mass spectrometry Electronic-Nose Breathomics Non-invasive diagnosis

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A Procedure for the Design of Novel Assisting Devices for the Sit-to-Stand

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Journal of Bionic Engineering 2013年第4期10卷 488-496页

作者： pierluigi Rea Erika Ottaviano Gianni Castelli Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio via G. Di Biasio 43 03043 Cassino (FR) Italy

The Sit-to-Stand （STS） is an activity most people perform numerous times daily. Standing up deals with the transition from two stabilized postures, namely seated to standing, with movement of all body segments except the feet. During the STS the body＇s Center of Gravity （COG） is moved upward from a sitting position to a standing position without losing balance and requiring a good coordination of many muscles. Three main phases of the STS movement can be recognized. One begins to stand up by inclining the upper body forward, which moves body mass toward the feet in order to maintain balance after lift-off. Prior to leaving the chair, hip and knee extensor muscles are activated to provide antigravity support for these joints, this action is commonly referred to as ＂weight shift＂. Finally; after leaving the chair, the leg and trunk joints are straightened to achieve upright stance. The STS task can be considered of major importance for impaired and elderly people to achieve minimal mo- bility and independence. In this paper we detail a procedure for the design of assisting devices to be used for the STS. In par- ticular, an experimental procedure is described firstly to track and record point trajectories and the orientation of the trunk during the STS. This analysis is then used to get information for the design of assisting devices. A proposal and simulation results are presented for a novel mechatronic system. In particular, for the case under study experimental tests are used to drive the actua- tion system for the reported simulation. A functional mechatronic scheme is then proposed to control the device during its operation.

关键词： Sit-to-Stand assisting devices mechatronic design experimental evaluation simulation

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Stability of Nonlinear Differential-Algebraic Systems Via Additive Identity

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 929-941页

作者： pierluigi Di Franco Giordano Scarciotti Alessandro Astolfi the Electrical and Electronic Engineering Department Imperial College LondonLondon SW72AZUK

The stability analysis for nonlinear differentialalgebraic systems is addressed using tools from classical control theory. Sufficient stability conditions relying on matrix inequalities are established via Lyapunov Direct Method. In addition, a novel interpretation of differential-algebraic systems as feedback interconnection of a purely differential system and an algebraic system allows reducing the stability analysis to a smallgain-like condition. The study of stability properties for constrained mechanical systems, for a class of Lipschitz differential-algebraic systems and for an academic example is used to illustrate the theory.

关键词： Differential-algebraic systems Lyapunov method small-gain theorem stability analysis

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Virological and histological evaluation of intestinal samples in COVID-19 patients

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World Journal of Gastroenterology 2022年第44期28卷 6282-6293页

作者： Dajana Cuicchi Liliana Gabrielli Maria Lucia Tardio Giada Rossini Antonietta D’Errico pierluigi Viale Tiziana Lazzarotto Gilberto Poggioli Department of Medical and Surgical Sciences Surgery of the Alimentary TractIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Experimental Diagnostic and Specialty MedicineMicrobiology UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Experimental Diagnostic and Specialty MedicinePathology UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department for Integrated Infectious Risk Management Infectious Diseases UnitIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Infectious Diseases Unit Department for Integrated Infectious Risk ManagementUniversity of BolognaBologna 40138Italy Section of Microbiology Department of ExperimentalDiagnostic and Specialty MedicineUniversity of BolognaBologna 40138Italy Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy

BACKGROUND Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is the pathogen responsible for pandemic coronavirus disease 2019(COVID-19).It is a highly contagious virus which primarily affects the respiratory tract,nevertheless,the lungs are not the only target organs of the *** intestinal tract could represent an additional tropism site for *** observations have collectively suggested that enteric infections can occur in COVID-19 ***,the detection of viral RNA in gastrointestinal(GI)tissue samples has not been adequately investigated and results are *** To detect the presence of SARS-CoV-2 RNA in intestinal mucosa samples and to evaluate histological *** The COVID-19 patients hospitalized at an Italian tertiary hospital from April 2020 to March 2021 were evaluated for enrollment in an observational,monocentric *** study population was composed of two groups of adult *** the first group(biopsy group,30 patients),patients were eligible for inclusion if they had mild to moderate disease and if they agreed to have a rectal biopsy;in the second group(surgical specimen group,6 patients),patients were eligible for inclusion if they underwent intestinal resection during index ***-nine intestinal mucosal samples were *** Viral RNA was not detectable in any of the rectal biopsies performed(0/53).Histological examination showed no enterocyte damage,but slight edema of the lamina propria with mild inflammatory lymphoplasmacytic *** was no difference in inflammatory infiltrates in patients with and without GI ***-CoV-2 RNA was detected in fecal samples in 6 cases out of 14 cases examined(42.9%).In the surgical specimen group,all patients underwent emergency intestinal *** RNA was detected in 2 surgical specimens of the 6 examined,both of which were from patients with active neoplastic *** examination also pointed

关键词： COVID-19 SARS-CoV-2 Intestinal infection Intestinal samples Intestinal tropism Rectal samples

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Recalcitrant Cutaneous Mastocytosis Treated With Genetically Informed Targeted Therapy:A Case Report

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International Journal of Dermatology and Venereology 2023年第2期6卷 107-109页

作者： Laura Gleason Volkan Tekmen Alexa Cohen Safiyyah Bhatti Burcu Beksac Jisun Cha pierluigi Porcu Neda Nikbakht Department of Dermatology and Cutaneous Biology Thomas Jefferson UniversityPhiladelphiaPA 19107USA Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplant Department of Medical OncologySidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Dermatopathology Schweiger Dermatology GroupNew YorkNY 10006USA

Introduction:Mastocytosis,a clonal proliferation of mast cells commonly involving the skin and bone marrow,has a varied clinical presentation ranging from cutaneous lesions to systemic *** mastocytosis is managed symptomatically,but systemic mastocytosis is treated with targeted therapy against the mutated receptor tyrosine kinase c-KIT,the pathogenic driver of ***,there are no guidelines for the treatment of cutaneous mastocytosis refractory to symptomatic *** herein report a method to select genetically informed therapy for symptomatic and recalcitrant cutaneous *** presentation:We performed a mutational analysis of dermal mast cells after enrichment by laser capture in a 23-year-old woman with recalcitrant cutaneous *** analysis revealed a aspartic acid to valine substitution at codon 816(D816V)mutation in the protein *** on these results,we initiated treatment with the multi-kinase/KIT inhibitor midostaurin,a treatment effective against the D816V c-KIT *** 3 months of treatment,the patient exhibited a reduction in the number and size of cutaneous lesions and reported resolution of pruritus and decreased severity of other mast cell-related ***:The treatment of mastocytosis relies heavily on whether the disease is limited to the skin or ***,there are no guidelines for cutaneous mastocytosis that does not respond to symptomatic *** the present report describing a patient with recalcitrant cutaneous mastocytosis,we describe a strategy in which skin mutational analysis is used to guide the selection of targeted ***:Performing mast cell mutational analyses in the skin provides a means to select targeted therapy for symptomatic and refractory cutaneous mastocytosis.

关键词： mastocytosis c-KIT molecular genetics targeted therapy midostaurin

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Emerging issues in peripheral nerve repair

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Neural Regeneration Research 2012年第29期7卷 2267-2272页

作者： Stefano Geuna pierluigi Tos Bruno Battiston Neuroscience Institute of the "Cavalieri Ottolenghi" Foundation (NICO) & Department of Clinical and Biological Sciences University of TurinTorino 10043 Italy Department of Traumatology Microsurgery UnitC.T.O. HospitalTorino 10126Italy

It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that, to further improve clinical outcome, the involvement of different scientific disciplines is required. This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery, transplantation and biomaterials. In this paper, some of the most promising innovations for the tissue engineering of nerves, emerging from basic science investigation, are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation.

关键词： nerve reconstruction tissue engineering cell and tissue transplantation gene therapy biomaterials peripheral nervous system microsurgery artificial hollow tubes muscle-vein-combined tubes non-nervous guides neural regeneration

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Design and optimization of equivalent consumption minimization strategy for 4WD hybrid electric vehicles incorporating vehicle connectivity

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Science China(Technological Sciences) 2018年第1期61卷 147-157页

作者： QIU LiHong QIAN LiJun ZOMORODI Hesam PISU pierluigi Department of Vehicle Engineering Hefei University of Technology International Center for Automotive Research Clemson University

This paper presents an optimized equivalent consumption minimization strategy(ECMS) for four-wheel-drive(4 WD) hybrid electric vehicles(HEVs) incorporating vehicle connectivity. In order to be applicable to the 4 WD architecture, the ECMS is designed based on a rule-based strategy and used under the condition that a certain propulsion mode is activated. Assuming that a group of 4 WD HEVs are connected and position information can be shared with each other, we formulate a decentralized model predictive control(MPC) framework that compromises fuel efficiency, mobility, and inter-vehicle distance to optimize the velocity profile of each individual vehicle. Based on the optimized velocity profile, an optimization problem considering both fuel economy and battery state of charge(SOC) sustainability is formulated to optimize the equivalent factors(EFs) of the ECMS for HEVs over an appropriate time window. MATLAB User Datagram Protocol(UDP) is used in the codes run on multiple computers to simulate the wireless communication among vehicles, which share position information via UDP-based communication, and dSPACE is used as a software-in-the-loop platform for the simulation of the optimized ECMS. Simulation results validate the control effectiveness of the proposed method.

关键词： equivalent consumption minimization strategy(ECMS) hybrid electric vehicles(HEVs) model predictive control(MPC) connected vehicles signal phase and timing(SPAT) optimization

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Gut microbiota and COVID-19: An intriguing pediatric perspective

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World Journal of Clinical Cases 2022年第23期10卷 8076-8087页

作者： Maria Sole Valentino Claudia Esposito Simone Colosimo Angela Maria Caprio Simona Puzone StefanoGuarino pierluigi Marzuillo Emanuele Miraglia del Giudice Anna Di Sessa Department of Woman Childand General and Specialized SurgeryUniversity of Campania Luigi VanvitelliNaples 80138Italy

Gastrointestinal(GI)involvement has been reported in approximately 50%of patients with coronavirus disease 2019(COVID-19),which is due to the pathogenic role of inflammation and the intestinal function of the angiotensinconverting enzyme 2 and its *** adult data has pointed out that gut dysbiosis might occur in these patients with a potential impact on the severity of the disease,however the role of gut microbiota in susceptibility and severity of COVID-19 disease in children is still poorly *** the last decades,the crosstalk between gut and lung has been largely recognized resulting in the concept of“gut-lung axis”as a central player in modulating the development of several *** organs are involved in the common mucosal immune system(including bronchus-associated and gut-associated lymphoid tissues)and their homeostasis is crucial for human *** this framework,it has been found that the role of GI dysbiosis is affecting the homeostasis of the gutliver *** note,a gut microbiome imbalance has been linked to COVID-19 severity in adult subjects,but it remains to be *** on the increased risk of inflammatory diseases in children with COVID-19,the potential correlation between gut microbiota dysfunction and COVID-19 needs to be studied in this *** aimed to summarize the most recent evidence on this striking aspect of COVID-19 in childhood.

关键词： Gut Microbiota Dysbiosis Microbiome COVID-19 Children

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