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中国矫形外科杂志 2017年第11期25卷 1038-1041页

作者：曹洪赵飞 Sauro Angelici pier giulio davini 程鑫华湖北医药学院附属人民医院骨关节外科湖北十堰442000 湖北医药学院附属人民医院显微骨科湖北十堰442000 意大利佛罗伦萨卫生署直属San Giuseppe医院骨科意大利恩波利50121

[目的]评价经跗骨窦Hy Pro Cure螺钉的距下关节制动术治疗儿童柔韧性平足症的短期临床疗效。[方法]采用经跗骨窦Hy Pro Cure螺钉的距下关节制动术治疗儿童柔韧性平足症16例(19足)。对照比较术前、术后正位X线片上的距舟覆盖角,侧位X线... 详细信息

[目的]评价经跗骨窦Hy Pro Cure螺钉的距下关节制动术治疗儿童柔韧性平足症的短期临床疗效。[方法]采用经跗骨窦Hy Pro Cure螺钉的距下关节制动术治疗儿童柔韧性平足症16例(19足)。对照比较术前、术后正位X线片上的距舟覆盖角,侧位X线片上的距骨第1跖骨角、跟骨倾斜角变化;并采用美国足踝外科协会(American Orthopedic Foot and Ankle Society,AOFAS)踝与后足功能评分和视觉模拟评分(visual analogue score,VAS)进行疗效评定。[结果]16例(19足)患儿均获随访,平均随访时间6.70个月(3.50~12月)。正位X线片上的距舟覆盖角;侧位X线片上的距骨第1跖骨角(Meary角)、跟骨倾斜角(Pitch角)均较术前改善(P<0.05)。末次随访时AOFAS评分及VAS评分与术前比较,差异均有统计学意义(P<0.05)。[结论]经跗骨窦Hy Pro Cure螺钉的距下关节制动术是治疗儿童柔韧性平足的有效方法,具有简单、创伤小、术后并发症少等优点,但还需长期随访观察远期疗效。

关键词：跗骨窦 Hy Pro Cure螺钉距下关节制动术柔韧性平足

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Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells:Potential implications for their clinical use

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World Journal of Stem Cells 2023年第5期15卷 400-420页

作者： Vitale Miceli Giovanni Zito Matteo Bulati Alessia Gallo Rosalia Busà Gioacchin Iannolo pier giulio Conaldi Department of Research IRCCS ISMETT(Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione)Palermo 90127Italy

Mesenchymal stromal/stem cells(MSCs)have shown significant therapeutic potential,and have therefore been extensively investigated in preclinical studies of regenerative ***,while MSCs have been shown to be safe as a cellular treatment,they have usually been therapeutically ineffective in human *** fact,in many clinical trials it has been shown that MSCs have moderate or poor *** inefficacy appears to be ascribable primarily to the heterogeneity of ***,specific priming strategies have been used to improve the therapeutic properties of *** this review,we explore the literature on the principal priming approaches used to enhance the preclinical inefficacy of *** found that different priming strategies have been used to direct the therapeutic effects of MSCs toward specific pathological ***,while hypoxic priming can be used primarily for the treatment of acute diseases,inflammatory cytokines can be used mainly to prime MSCs in order to treat chronic immune-related *** shift in approach from regeneration to inflammation implies,in MSCs,a shift in the production of functional factors that stimulate regenerative or anti-inflammatory *** opportunity to fine-tune the therapeutic properties of MSCs through different priming strategies could conceivably pave the way for optimizing their therapeutic potential.

关键词： Mesenchymal stromal/stem cells Mesenchymal stromal/stem cell therapeutic properties Mesenchymal stromal/stem cell paracrine effects Mesenchymal stromal/stem cell priming Pro-inflammatory priming Hypoxic priming,3D culture priming

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Hepatocellular carcinoma,hepatitis C virus infection and miRNA involvement:Perspectives for new therapeutic approaches

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World Journal of Gastroenterology 2022年第22期28卷 2417-2428页

作者： Ester Badami Rosalia Busà Bruno Douradinha Giovanna Russelli Vitale Miceli Alessia Gallo Giovanni Zito pier giulio Conaldi Gioacchin Iannolo Regenerative Medicine and Immunotherapy Area Fondazione Ri.MEDPalermo 90127Italy Department of Research Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IRCCS-ISMETT)Palermo 90127Italy

Chronic hepatitis C virus(HCV)infection is the principal etiology of cirrhosis and,ultimately,hepatocellular carcinoma(HCC).At present,approximately 71 million people are chronically infected with HCV,and 10%–20%of these are expected to develop severe liver complications throughout their *** evidence has clearly shown the causal association between miRNAs,HCV infection and *** it is not completely clear whether miRNA dysregulation in HCC is the cause or the consequence of its development,variations in miRNA patterns have been described in different liver diseases,including *** studies have analyzed the importance of circulating miRNAs and their effect on cell proliferation and *** this Review,we aim to summarize current knowledge on the association between miRNA,HCV and HCC from a diagnostic point of view,and also the potential implications for therapeutic approaches.

关键词： Hepatocellular carcinoma miRNA Liver Hepatitis C virus miRNAs Directacting antivirals Extracellular vesicles Transplantation

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Mesenchymal stromal cell secretome in liver failure:Perspectives on COVID-19 infection treatment

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World Journal of Gastroenterology 2021年第17期27卷 1905-1919页

作者： Cinzia Maria Chinnici Giovanna Russelli Matteo Bulati Vitale Miceli Alessia Gallo Rosalia Busà Rosaria Tinnirello pier giulio Conaldi Gioacchin Iannolo Department of Research Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IRCCS-ISMETT)Palermo 90127Italy Department of Regenerative Medicine Fondazione Ri.MEDPalermo 90127Italy Neuroscience Unit CNR Institute of Biomedicine and Molecular ImmunologyPalermo 90146Italy

Due to their immunomodulatory potential and release of trophic factors that promote healing,mesenchymal stromal cells(MSCs)are considered important players in tissue homeostasis and *** have been widely used in clinical trials to treat multiple conditions associated with inflammation and tissue *** evidence suggests that most of the MSC therapeutic effects are derived from their secretome,including the extracellular vesicles,representing a promising approach in regenerative medicine application to treat organ failure as a result of inflammation/*** recent outbreak of respiratory syndrome coronavirus,caused by the newly identified agent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has forced scientists worldwide to use all available instruments to fight the infection,including the inflammatory cascade caused by this pandemic *** use of MSCs is a valid approach to combat organ inflammation in different *** addition to the lungs,which are considered the main inflammatory target for this virus,other organs are compromised by the *** particular,the liver is involved in the inflammatory response to SARS-CoV-2 infection,which causes organ failure,leading to death in coronavirus disease 2019(COVID-19)*** herein summarize the current implications derived from the use of MSCs and their soluble derivatives in COVID-19 treatment,and emphasize the potential of MSCbased therapy in this clinical setting.

关键词： Mesenchymal stromal cell COVID-19 SARS-CoV-2 Organ failure Inflammation Transplantation

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