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Visual Disorders Outcome after Endoscopic Endonasal Trans-Sphenoidal Surgery of Pituitary Macroadenomas

International Journal of Otolaryngology and Head & Neck Surgery 2016年第3期5卷 134-140页

作者： Wissame El Bakkouri picard hervé Brice Dzidzinyo Abdellaoui Anis Boyeldieu Louise Corr&eacute Alain Vignal Catherine Boucenna Malika Ayache Denis ENT Department Fondation Ophtalmologique Adolphe de Rothschild Paris France Clinical Research Unit Fondation Ophtalmologique Adolphe de Rothschild Paris France OPH Department Fondation Ophtalmologique Adolphe de Rothschild Paris France Radiological Department Fondation Ophtalmologique Adolphe de Rothschild Paris France

Objective: Describe the outcome of visual disorders after endonasal transsphenoidal (EET) surgery of pituitary macroadenomas with preoperative chiasmal compression. Patients and Methods: From 2009 to 2013, 225 patients underwent EET surgery for sellar tumor. Among them, 168 suffered from visual disorders induced by chiasmatic compression, of which 88 met the inclusion criteria for this study. Average duration of follow up was 1.8 yrs ± 0.4 yrs. All patients had sellar MRI before surgery and yearly postoperatively, visual acuity (VA) and/or visual field (VF) measurements before, 3 months after surgery and yearly postoperatively. Results: All tumors were macroadenomas with a mean preoperative MRI-estimated volume of 10.0 {plus minus} 9.07 cm3. Preoperative VA was impaired with an average of 0.43 ± 0.13 LogMAR (left eye) and 0.36 ± 0.14 LogMAR (right eye) and VF was disturbed in 99% ± 2% of the cases with the most frequent disorder being bitemporal hemianopsia (38 patients). Post-operatively, the mean residual MRI-estimated tumor volume was 3.15 ± 3.71 cm3. Mean tumor volume reduction was 62% ± 9% (p < 0.001). Optic chiasmal compression resolved in 72% ± 10% of the cases. Visual function improved in 86% ± 7% of cases (p < 0.001). Conclusion: Endoscopic endonasal management of pituitary gland neoplasms is effective to reduce tumor volume. This technique achieved significant visual improvement in the majority of cases presenting with chiasmal compression syndrome.

关键词： Pituitary Macroadenoma Visual Disorder Chiasm Compression Endoscopy Transsphenoidal

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The energetics of cellular life transitions

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Life Metabolism 2024年第3期3卷 12-20页

作者： Anna S.Monzel Michael Levin Martin picard Department of Psychiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States Department of Biology Tufts UniversityMedfordMA 02155United States Allen Discovery Center at Tufts University MedfordMA 02155United States Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115United States Department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York State Psychiatric Institute New YorkNY 10032United States Robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life transitions are always difficult because change costs *** findings have demonstrated how mitochondrial oxidative phosphorylation(OxPhos)defects increase the energetic cost of living and that excessive integrated stress response(ISR)signaling may prevent cellular identity transitions during *** this perspective,we discuss general bioenergetic principles of life transitions and the costly molecular processes involved in reprograming the cellular hardware/software as cells shift *** energetic cost of cellular differentiation has not been directly quantified,representing a gap in *** propose that the ISR is an energetic checkpoint evolved to(i)prevent OxPhos-deficient cells from engaging in excessively costly transitions and(ii)allow ISR-positive cells to recruit systemic energetic resources by signaling via GDF15 and the brain.

关键词： energy mitochondria signaling pathway growth differentiation factor 15 energy balance development

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A code-independent technique for computational verification of fluid mechanics and heat transfer problems

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Acta Mechanica Sinica 2008年第4期24卷 387-397页

作者： M.Garbey C.picard Department of Computer Science University of Houston Houston TX 77204 USA

The goal of this paper is to present a versatile framework for solution verification of PDE＇s. We first generalize the Richardson Extrapolation technique to an optimized extrapolation solution procedure that constructs the best consistent solution from a set of two or three coarse grid solution in the discrete norm of choice. This technique generalizes the Least Square Extrapolation method introduced by one of the author and W. Shyy. We second establish the conditioning number of the problem in a reduced space that approximates the main feature of the numerical solution thanks to a sensitivity analysis. Overall our method produces an a posteriori error estimation in this reduced space of approximation. The key feature of our method is that our construction does not require an internal knowledge of the software neither the source code that produces the solution to be verified. It can be applied in principle as a postprocessing procedure to off the shelf commercial code. We demonstrate the robustness of our method with two steady problems that are separately an incompressible back step flow test case and a heat transfer problem for a battery. Our error estimate might be ultimately verified with a near by manufactured solution. While our pro- cedure is systematic and requires numerous computation of residuals, one can take advantage of distributed computing to get quickly the error estimate.

关键词： Solution verification PDE's Navier Stokes ·Heat transfer. Aposteriori estimate·Distributed Computing

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Catch-as-catch-can:mRNA vaccination boosts immune responses to SARS-CoV-2 variants

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2255-2256页

作者： Graham Pawelec Emilie picard Department of Immunology University of TubingenTubingenGermany Health Sciences North Research Institute SudburyONCanada

In a recent article published in Science,Stamatatos et al.1 show that vaccination with mRNA vaccines containing the ancestral form of the SARS-CoV-2 virus boosts cross-variant neutralizing antibodies elicited by infec... 详细信息

关键词： vaccination boost

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Nanostructured gold films exhibiting almost complete absorption of light at visible wavelengths

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 247-251页

作者： Hanbin Zheng Christine picard Serge Ravaine CNRS CRPP UMR 5031 Universite de Bordeaux F-33600 Pessac France

Nanostructured known to exhibit properties metal surfaces have been that deviate from that of the bulk material. By simply modifying the texture of a metal surface, various unique optical properties can be observed. In this paper, we present a simple two step electrochemical process combining electrodeposition and anodization to generate black gold surfaces. This process is simple, versatile and up-scalable for the production of large surfaces. The black gold films have remarkable optical behavior as they absorb more than 93% of incident light over the entire visible spectrum and also exhibit no specular reflectance. A careful analysis by scanning electron microscopy reveals that these unique optical properties are due to their randomly rough surface, as they consist in a forest of dendritic microstructures with a nanoscale roughness. This new type of black films can be fabricated to a large variety of substrates, turning them to super absorbers with potential applications in photovoltaic solar cells or highly sensitive detectors and so on.

关键词： nanostructuration light absorption coating gold electrodeposifion anodization

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NeuroAid (MLC601) versus piracetam in the recovery of post-infarct homonymous hemianopsia

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Neural Regeneration Research 2011年第6期6卷 418-422页

作者： Kavian Ghandehari Zahra Izadi Mood Saeed Ebrahimzadeh David picard Yue Zhang Neuroscience Research Center Mashhad University of Medical Sciences Mashhad Iran P.O. Box 91766-99199 Department of Traditional Medicine Mashhad University of Medical Sciences Mashhad Iran P.O. Box 91766-99199 Department of Biostatistics Mashhad University of Medical Sciences Mashhad Iran P.O. Box 91766-99199 National Neuroscience Institute Singapore Moleac Ltd Helios 09-08 11Biopolis Way Singapore 138667 National Neuroscience Institute Singapore Moleac Ltd Helios 09-08 11Biopolis Way Singapore 138667

In the clinic, the natural recovery rate of homonymous hemianopsia caused by occipital lobe infamtion is low. At present, ideal therapeutic effects of piracetam for improving visual field defects following homonymous hemianopsia do not exist. The present randomized, controlled study compared the effects of NeuroAid （MLC601） versus piracetam for improving visual field defects in post-infarct homonymous hemianopsia patients matched for age and sex. After 3 months of treatment with NeuroAid （MLC601） or piracetam, visual field defects were significantly improved, compared with prior to treatment （P 〈 0.001）. After treatment with MLC601, relative reduction of right and left visual field defects was 45% and 45.7%, respectively, while relative reduction after treatment with piracetam was 32.7% and 30.3%, respectively. These findings suggested that MLC601 was superior to piracetam for reducing visual field defects in homonymous hemianopsia patients.

关键词： MLC601 piracetam post-infarct recovery stroke

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Practising insight mediation

Practising insight mediation

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作者： (author.)picard Cheryl Ann

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从法国公共电力企业的视角看大数据带来的挑战和机遇

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电网技术 2015年第11期39卷 3109-3113页

作者： Marie-Luce picard 潘旭阳法国电力集团研究院市场环境分析及商业革新研究所法国克拉马92140 法国电力集团研究院中国研发中心北京市东城区100005

大数据、数据分析、数据科学,以及与数据相关的创新技术正广泛应用在各领域企业的技术研发和商业模式中。其中,基于大数据的应用和决策制定是能源企业的核心发展方向,大数据和数据分析也是智能电网的核心内容之一。广泛地说,数据及其相... 详细信息

大数据、数据分析、数据科学,以及与数据相关的创新技术正广泛应用在各领域企业的技术研发和商业模式中。其中,基于大数据的应用和决策制定是能源企业的核心发展方向,大数据和数据分析也是智能电网的核心内容之一。广泛地说,数据及其相关应用是技术创新和附加价值的载体,对企业的战略发展以及创新产品和服务的开发至关重要。因此,大量数据的产生和新一代信息系统的开发为国际能源大舞台的参与者们提供了新的可能性和商机。文章首先概述大数据的相关背景,然后介绍法国电力集团研究院在大数据领域的相关研究工作,最后对下一步的研究工作进行了展望。

关键词：大数据数据分析公共事业公司智能电网

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Synthesis of alkynes and alkynyl iodides bearing a protected amino alcohol moiety as functionalized amino acids precursors

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Science China Chemistry 2010年第9期53卷 1921-1926页

作者： AYED Charfedinne picard Julien LUBIN-GERMAIN Nadège UZIEL Jacques AUGE Jacques Université de Cergy-Pontoise Laboratoire de Synthèse Organique Sélective et Chimie bioOrganique-EA 4505

Amino acid precursors in protected amino alcohol form are important synthons that can be used as building-blocks for the hemisynthesis of non-natural amino *** can be used as a common starting material for the synthesis of such compounds differently ***,protected amino alcohols bearing an ethynyl and/or an iodoethynyl group can be used in cross-couplings,in 1,3-dipolar cycloadditions and/or in Nozaki-Hiyama-Kishi type *** thus demonstrated that the efficiently protected amino alcohols derived from serine can be coupled to a sugar derivative by an indium mediated alkynylation *** conditions of this coupling are compatible with such functionalized derivatives and allow envisaging an access to C-glycosylated amino acids.

关键词： amino alcohols amino acids oxazolidines alkynyl iodides C-glycoside indium alkynylation

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Molecular Frame Photoemission： Probe of the Photoionization Dynamics for Molecules in the Gas Phase

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Chinese Journal of Chemical Physics 2009年第2期22卷 178-186页

作者： D. Dowek Y. J. picard P. Billaud C. Elkharrat J. C. Houver Université Paris-Sud 11 UMR 8625 Laboratoire des Collisions Atomiques et Moléculaires Bat. 351 Université Paris-Sud 91405 Orsay France CNRS UMR 8625 Laboratoire des Collisions Atomiques et Moléculaires Bat. 351 Université Paris-5ud 91405 Orsay France

Molecular frame photoemission is a very sensitive probe of the photoionization （PI） dynamics of molecules. This paper reports a comparative study of non-resonant and resonant photoionization of D2 induced by VUV circularly polarized synchrotron radiation at SOLEIL at the level of the molecular frame photoelectron angular distributions （MFPADs）. We use the vector correlation method which combines imaging and time-of-flight resolved electron-ion coincidence techniques, and a generalized formalism for the expression of the Ⅰ（χ, θe, Фe） MFPADs, where χ is the orientation of the molecular axis with respect to the light quantization axis and （θe, Фe） the electron emission direction in the molecular frame. Selected MFPADs for a molecule aligned parallel or perpendicular to linearly polarized light, or perpendicular to the propagation axis of circularly polarized light, are presented for dissociative photoionization （DPI） of D2 at two photon excitation energies, hv=19 eV, where direct PI is the only channel opened, and hv=32.5 eV, i.e. in the region involving resonant excitation of Q1 and Q2 doubly excited state series. We discuss in particular the properties of the circular dichroism characterizing photoemission in the molecular frame for direct and resonant PI. In the latter case, a remarkable behavior is observed which may be attributed to the interference occurring between undistinguishable autoionization decay channels.

关键词： Dissociative photoionization Molecular frame photoemission Circular dichroism in photoemission Autoionization dynamics Synchrotron radiation Vector correlation

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