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IN VIVO TRANS-RECTAL ULTRASOUND-COUPLED NEAR-INFRARED OPTICAL TOMOGRAPHY OF INTACT NORMAL CANINE PROSTATE

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 215-225页

作者： DAQING piao ZHEN JIANG KENNETH E.BARTELS G.REED HOLYOAK JERRY W.RITCHEY GUAN xu CHARLES F.BUNTING GENNADY SLOBODOV School of Electrical and Computer Engineering Oklahoma State University StillwaterOK 74078 USA Department of Veterinary Clinical Sciences Oklahoma State University StillwaterOK 74078 USA Department of Veterinary Pathobiology Oklahoma State University StillwaterOK 74078 USA Department of Urology University of Oklahoma Health Sciences CenterOklahoma CityOK 73104 USA

This is the first tomography-presentation of the optical properties of a normal canine prostate,in vivo,in its native intact environment in the pelvic *** imaging was performed by trans-rectal near-infrared(NIR)optical tomography in steady-state measurement at 840 nm on three sagittal planes across the right lobe,middle-line,and left lobe,respectively,of the prostate *** NIR imaging planes were position-correlated with concurrently applied trans-rectal ultrasound,albeit there was no spatial prior employed in the NIR tomography *** reconstructed peak absorption coefficients of the prostate on the three planes were 0.014,0.012,and 0.014mm^(−1).The peak reduced scattering coefficients were 5.28,5.56,and 6.53 mm^(−1).The peak effective attenuation coefficients were 0.45,0.43,and 0.50 mm^(−1).The absorption and effective attenuation coefficients were within the ranges predictable at 840 nm by literature values which clustered sparsely from 355 nm to 1064 nm,none of which were performed on a canine prostate with similar *** effective attenuation coefficients of the gland were shown to be generally higher in the internal aspects than in the peripheral aspects,which is consistent with the previous findings that the urethral regions were statistically more attenuating than the capsular regions.

关键词： Prostate canine optical property optical tomography trans-rectal ultrasound

Intake of Vitamin A,Thiamine,Riboflavin,Vitamin C,and Niacin Among Children Aged 6−11 Years Old—China,2016−2017

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China CDC weekly 2021年第11期3卷 237-241页

作者： Wei piao Lahong Ju Hongyun Fang Qiya Guo Shuya Cai Xiaoli xu Shujuan Li xue Cheng Liyun Zhao Dongmei Yu National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionKey Laboratory of Trace Element NutritionNational Health Commission of the People's Republic of ChinaBeijingChina.

Summary What is already known on this topic?Insufficient intake of vitamins is one of the major nutritional problems in children aged 6-11 years old in China,and the problem is particularly severe for rural *** is add... 详细信息

关键词： vitamin intake Vitamin

Cooking Oil and Salt Intakes Among Children Aged 6−17 Years——China,2016−2017

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China CDC weekly 2021年第31期3卷 657-660页

作者： Lahong Ju Dongmei Yu Wei piao Hongyun Fang Qiya Guo Xiaoli xu Shujuan Li xue Cheng Shuya Cai Liyun Zhao National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known on this topic?High-level intakes of both cooking oil and salt are issues of concern in China as they can lead to an increased risk of chronic diseases later in *** intakes of cooking oil and salt should be prioritized in *** is added by this report?Among children aged 6-17 years in China in 2016-2017,the median intake of cooking oil and salt were 27.7 and 6.1 g/d,*** percentages of children with intake of cooking oil and salt that exceeded the recommended guidelines were 50.4%and 67.8%,respectively.

关键词： cooking children intake

Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer

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Nano Research 2023年第7期16卷 9688-9700页

作者： Pengyuan Liu Yajun Wu Xiaogang xu xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing Wu Jun Chen Ji-Gang piao Zhibing Wu Department of Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Radiation Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China Geriatrics Institute of Zhejiang Province Department of GeriatricsAffiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310030China Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhou 310058China TCM Dispensary Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China Department of Breast Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China

Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat *** treatment options that can accurately target CPRC is an important issue with urgent *** this study,a novel nanotechnologybased strategy had been developed for the precise target treatment of *** combining microwaves and photothermal therapy(PTT),this nanoplatform,cmHSP70-PL-AuNC-DOX,targets tumor tissues with outstanding precision and achieves better anti-tumor activity by simultaneously eliciting photothermal and chemotherapeutic *** nanotechnology,cmHSP70-modified and thermo-sensitive liposome-coated AuNC-DOX were prepared and used for CRPC-targeted photothermal ablation and ***(DOX)was selected as the chemotherapeutic agent for *** terms of the curative scheme,prostate tissues were firstly pre-treated with microwaves to induce the expression of heat shock protein 70(HSP70)and its migration to the cell membrane,which was then targeted by HSP70 antibody(cmHSP70)coated on the nanoparticles to achieve accurate drug *** nanoplatform then achieved precise ablation and controlled release of DOX under external near-infrared(NIR)*** the implementation,the targeting,cell killing,and safety of this therapeutical strategy had been verified in vivo and in *** work establishes an accurate,controllable,efficient,non-invasive,and safe treatment platform for targeting CRPC,provides a rational design for CRPC’s PTT,and offers new prospects for nanomedicines with great precision.

关键词： castration-resistant prostate cancer gold nanocage heat shock protein 70 targeted drug delivery photothermalchemotherapy

Processes,feedbacks,and morphodynamic evolution of tidal flat-marsh systems:Progress and challenges

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Water Science and Engineering 2022年第2期15卷 89-102页

作者： Zeng Zhou Meng-jiao Liang Lei Chen Meng-piao xu xue Chen Liang Geng Huan Li Daniel Serrano He-yue Zhang Zheng Gong Chang-kuan Zhang State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Jiangsu Key Laboratory of Coast Ocean Resources Development and Environment Security Hohai UniversityNanjing 210098China Department of Civil Environmental and Architectural EngineeringUniversity of PaduaPadua 35122Italy

Tidal flats and saltmarshes have been a long-standing research focus because of their high socio-economic and ecological *** evolution of tidal flat-marsh systems is highly complex due to the intertwined processes operating over a variety of spatial and temporal *** a traditional research highlight,the role of regular hydrodynamic processes such as tides,waves,and river flows have been explored comprehensively with fruitful *** past decades,the changing environment(e.g.,sea level rise,increasing anthropogenic activities,and extreme weather conditions)has attracted more attention with many reported insightful *** recent advances indicate that biological activities play a critical role in tidal flat-marsh morphodynamics but are still poorly *** field of research that connects the bio-logical and physical processes is commonly described as"biogeomorphology"and requires the joint efforts by scientists from multiple dis-ciplines ranging from hydraulics,ecology,and geography to *** review aims to provide a synthesis of the current research status of tidal flat-marsh morphodynamics,with a particular emphasis on the understanding of various processes and feedbacks underlying the devel-opment of morphodynamic *** future research needs and challenges are identified to facilitate a more sustainable management strategy for tidal flats and saltmarshes under climate change.

关键词： Tidal flats Coastal wetlands Morphodynamics Saltmarshes Tidal channels Morphodynamic modeling

Energy and Macronutrient Intake Among Children Aged 6−11 Years Old—China,2016−2017

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China CDC weekly 2021年第9期3卷 181-184页

作者： Lahong Ju Wei piao Hongyun Fang Qiya Guo Shuya Cai Xiaoli xu Shujuan Li xue Cheng Dongmei Yu Liyun Zhao National Institute for Nutrition and Health China Center for Disease Control and PreventionBeijingChina.

Summary What is already known on this topic?Low level energy and macronutrient intakes and dietary imbalances are still important issues and should be prioritized in children aged 6-11 years old in *** is added by this report?Among children aged 6-11 years in China in 2016-2017,the average protein intake was 55.2 g/d in urban areas and was higher than the estimated 45.4 g/d in rural areas.

关键词： intake dietary China.

Higher plant photosynthetic capability in autumn responding to low atmospheric vapor pressure deficit

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The Innovation 2021年第4期2卷 74-81页

作者： Yawen Wang Wenfang xu Wenping Yuan Xiuzhi Chen Bingwei Zhang Lei Fan Bin He Zhongmin Hu Shuguang Liu Wei Liu Shilong piao Physical Oceanography Laboratory College of Oceanic and Atmospheric SciencesOcean University of ChinaQingdao 266100China School of Atmospheric Sciences Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Sun Yat-sen UniversityZhuhai 519082China Zhuhai Branch of State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University at ZhuhaiZhuhai 519087China School of Geographical Sciences Nanjing University of Information Science and TechnologyNanjing 210044China College of Global Change and Earth System Science Beijing Normal UniversityBeijing 100038China School of Geography South China Normal UniversityGuangzhou 510631China National Engineering Laboratory for Applied Technology of Forestry&Ecology in South China and College of Biological Science and Technology Central South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China

It has been long established that the terrestrial vegetation in spring has stronger photosynthetic capability than in ***,this study challenges this consensus by comparing photosynthetic capability of terrestrial vegetation between the spring and autumn seasons based on measurements of 100 in situ eddy covariance towers over global extratropical *** the majority of these sites,photosynthetic capability,indicated by light use efficiency(LUE)and apparent quantum efficiency,is significantly higher in autumn than in spring,due to lower atmosphere vapor pressure deficit(VPD)at the same air *** VPD differences also substantially explain the interannual variability of the differences in photosynthetic capability between spring and *** further reveal that VPD in autumn is significantly lower than in spring over 74.14% of extratropical areas,based on a global climate *** contrast,LUE derived from a data-driven vegetation production dataset is significantly higher in autumn in over 61.02% of extratropical vegetated *** Earth system models consistently projected continuous larger VPD values in spring compared with autumn,which implies that the impacts on vegetation growth will long exist and should be adequately considered when assessing the seasonal responses of terrestrial ecosystems to future climate conditions.

关键词： light use efficiency vapor pressure deficit vegetation index carbon cycle

结构性去杠杆对中国宏观经济的影响——基于杠杆转移的视角

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金融论坛 2020年第9期25卷 40-53页

作者：徐飘洋王博南开大学金融学院天津300350

本文通过构建TVP-VAR模型和DSGE模型,从杠杆转移的视角出发,对结构性去杠杆对中国宏观经济的影响及不同转杠杆政策之间的差异进行研究。研究结果表明:(1)紧缩国有企业信贷可以有效降低国有企业杠杆率,但也会导致经济下滑;(2)在紧缩国有... 详细信息

本文通过构建TVP-VAR模型和DSGE模型,从杠杆转移的视角出发,对结构性去杠杆对中国宏观经济的影响及不同转杠杆政策之间的差异进行研究。研究结果表明:(1)紧缩国有企业信贷可以有效降低国有企业杠杆率,但也会导致经济下滑;(2)在紧缩国有企业信贷的同时,增加对民营企业的信贷,即杠杆转移,可以同时实现结构性去杠杆和稳增长;(3)从社会福利的角度来看,引导银行部门对国有企业和民营企业的风险预期比定向调整准备金率更优。

关键词：结构性去杠杆中国宏观经济杠杆转移风险预期国有企业民营企业

The role of bone marrow-derived cells in the origin of liver cancer revealed by single-cell sequencing

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Cancer Biology & Medicine 2020年第1期17卷 142-153页

作者： Lu Chen Xianfu Yi piao Guo Hua Guo Ziye Chen Chunyu Hou Lisha Qi Yongrong Wang Chengwen Li Peng Liu Yucun Liu Yuanfu xu Ning Zhang The concrete information of affiliations should be presented for instanceDepartment of Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300070China School of Biomedical Engineering and Technology Tianjin Medical UniversityTianjin 300070China The Center for Translational Cancer Research Peking University First HospitalBeijing 100034China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China CAMS Key Laboratory for Prevention and Control of Hematological Disease Treatment Related Infection Tianjin 300020China Cytogenetics Laboratory Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

Objective:Epithelial cancers often originate from progenitor cells,while the origin of hepatocellular carcinoma(HCC)is still ***,one of the deadliest cancers,is closely linked with liver injuries and chronic inflammation,which trigger massive infiltration of bone marrow-derived cells(BMDCs)during liver ***:To address the possible roles of BMDCs in HCC origination,we established a diethylnitrosamine(DEN)-induced HCC model in bone marrow transplanted *** and frozen tissue immunofluorescence were used to verify DENinduced HCC in the pathology of the *** cellular origin of DEN-induced HCC was further studied by single cell sequencing,single-cell nested PCR,and immunofluorescence-fluorescence in situ ***:Studies by using single cell sequencing and biochemical analysis revealed that HCC cells in these mice were coming from donor mice BMDCs,and not from recipient ***,the copy numbers of mouse orthologs of several HCC-related genes previously reported in human HCC were also altered in our mouse ***-induced HCCs exhibited a similar histological phenotype and genomic profile as human ***:These results suggested that BMDCs are an important origin of HCC,which provide important clues to HCC prevention,detection,and treatments.

关键词： Hepatocellular carcinoma bone marrow-derived cells(BMDCs) origination genome sequencing copy number alteration