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Precipitation behaviour of Al_3Zr precipitate in Al-Cu-Zr and Al-Cu-Zr-Ti-V alloys

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Transactions of nonferrous Metals Society of China 2012年第8期22卷 1860-1865页

作者：贾志宏 Jean-Philippe COUZInIé nadia CHERDOUDI Ivan GUILLOT larsRnBERG Petter SHOLT Stig BRUSETHAUG Bruno BARLAS5 Denis MASSInOn 重庆大学材料科学与工程学院重庆400044 Department of Materials Science and Engineering Norwegian University of Science and TechnologyNO-7491TrondheimNorway Institut de Chimie et des Matériaux Paris-Est UMR 7182 CNRS-UnversitéParis Val de Marne2-8 rue Henri Dunant94320 ThiaisFrance Hydro Aluminium Research and Technology Development N-6601 Sunndals raNorway Montupet SA60181 Nogent sur Oise CedexFrance Mentupet SA 60181 Nogent sur Oise CedexFrance

The precipitation behaviours of Al3Zr precipitate in the Al-Cu-Zr and Al-Cu-Zr-Ti-V alloys were studied by transmission electron microscopy. Metastable Al3Zr precipitates are homogeneously nucleated in dendrite centres resulting in homogeneous distribution. However, the precipitation in the interdendritic regions is complex and the precipitation morphologies, helical-like and stripe-like shapes, were observed, which are composed of many spherical Al3Zr precipitates. The stripe-like precipitate clusters have preferential orientations along with the -100- Al directions, which is inferred to be related to θ′（Al2Cu） and θ phases. Addition of Cu can accelerate the L12→D023 structural transformation of the Al3Zr precipitate.

关键词： aluminium alloys Al3Zr precipitate phase transformation

北方针叶林的氮沉降和生物多样性以及氮的临界负荷

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AMBIO－人类环境杂志 2005年第1期34卷 20-24页

作者： Annika nordin Joachim Strengbom Johanna Witzell Torgny nsholm lars Ericson 王胜 Umea PlantScience Centre Department of Forest Genetics and Plant PhysiologySwedish University of Agricultural SciencesSE-901 83 UmeaSweden.

可将临界负荷概念用于确定生态系统能够忍耐的无显著毒害作用的沉积水平。本文总结了瑞典研究课题"跨界大气污染的削减策略(ASTA)"中北方针叶林氮的临界负荷评估工作。不论是瑞典北方低水平氮背景沉降地区的野外实验,还是大尺度的监测研... 详细信息

可将临界负荷概念用于确定生态系统能够忍耐的无显著毒害作用的沉积水平。本文总结了瑞典研究课题"跨界大气污染的削减策略(ASTA)"中北方针叶林氮的临界负荷评估工作。不论是瑞典北方低水平氮背景沉降地区的野外实验,还是大尺度的监测研究,结果都表明:少量增加氮剂量会引发重大的植被变化;并且停止氮输入后,植被恢复非常缓慢。数据表明,即便氮输入的速率低于目前建议的临界负荷(北方针叶林下层植被的经验值为10～15kg n/hm^2·a),生态系统的关键成分也会发生变化。根据这些数据,我们认为临界负荷应降为6 kg n/hm^2·a。

关键词：临界负荷氮沉降针叶林生物多样性北方生态系统植被变化毒害作用评估工作

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糖尿病管理的未来——诺和诺德公司研发进展

国外医学（内分泌学分册） 2002年第3期22卷 159-160页

作者： larsn.Jorgensen 诺和诺德公司

目前对糖尿病的治疗主要有饮食控制或运动,口服降糖药(2型糖尿病)和注射胰岛素.90年代以来确立的治疗目标为:(1)血糖的精确控制.糖尿病控制和并发症研究(DCCT)及英国前瞻性糖尿病研究(UKPDS)实验表明严格地控制血糖可以减少微血管并发症... 详细信息

目前对糖尿病的治疗主要有饮食控制或运动,口服降糖药(2型糖尿病)和注射胰岛素.90年代以来确立的治疗目标为:(1)血糖的精确控制.糖尿病控制和并发症研究(DCCT)及英国前瞻性糖尿病研究(UKPDS)实验表明严格地控制血糖可以减少微血管并发症.(2)避免血糖高峰(餐后高血糖).

关键词：糖尿病管理诺和诺德公司研究发进展治疗饮食控制运动

Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours

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World Journal of Gastroenterology 2015年第47期21卷 13240-13249页

作者： Apostolos V Tsolakis lars Grimelius Göran Granerus Mats Stridsberg Sture E Falkmer Eva T Janson Section of Endocrine Oncology Department of Medical SciencesUppsala University Section of Genetics and Pathology Department of ImmunologyUppsala University Department of Medical and Health Sciences Linköping University Section of Biochemical Endocrinology Department of Medical SciencesUppsala University Department of Pathology Ryhov County Hospital

AIM: To study histidine decarboxylase(HDC) expression in normal and neoplastic gastric neuroendocrine cells in relationship to the main histamine metabolite. METHODS: Control tissues from fundus(n = 3) and corpus(n = 3) mucosa of six patients undergoing operations for gastric adenocarcinoma, biopsy and/or gastric surgical specimens from 64 patients with primary gastric neuroendocrine tumours(GnETs), as well as metastases from 22 of these patients, were investigated using conventional immunohistochemistry and double immunofluorescence with commercial antibodies vs vesicular monoamine transporter 2(VMAT-2), HDC and ghrelin. The urinary excretion of the main histamine metabolite methylimidazoleacetic acid(U-Me Im AA) was determined using highperformance liquid chromatography in 27 of the 64 ***: In the gastric mucosa of the control tissues, co-localization studies identified neuroendocrine cells that showed immunoreactivity only to VMAT-2 and others with reactivity only to HDC. A third cellpopulation co-expressed both antigens. There was no co-expression of HDC and ghrelin. Similar results were obtained in the foci of neuroendocrine cell hyperplasia associated with chronic atrophic gastritis type A and also in the tumours. The relative incidence of the three aforementioned markers varied in the tumours that were examined using conventional immunohistochemistry. All of these GnETs revealed both VMAT-2 and HDC immunoreactivity, and their metastases showed an immunohistochemical pattern and frequency similar to that of their primary tumours. In four patients, increased U-Me Im AA excretion was detected, but only two of the patients exhibited related endocrine symptoms. COnCLUSIOn: Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Coexpression of VMAT-2 and HDC might be required for increased histamine production in patients with GnETs.

关键词： Enterochromaffin-like cells High performance liquid chromatography Gastric neuroendocrine tumours Histidine decarboxylase Immunohistochemistry Urinary excretion of the main histamine metabolite methylimidazoleacetic acid Vesicular monoamine transporter 2

瑞典森林中不同地区的林下植被情况与氮沉积的关系

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AMBIO－人类环境杂志 2003年第2期32卷 91-97页

作者： Joachim Strengbom Mats Walheim Trogny nsholm lars Ericson 伍建榕 Department of Ecology and Environmental Science 瑞典国家森林调查队 Department of Forest Genetics and Plant Physiology

在557块针叶林分中进行调查,以图了解欧洲越桔(Vaccinium myrtillus)、越桔(***-idaea)和曲芒发草(Deschampsia flexuosa)与氮沉积率的相互联系。欧洲越桔在高氮地区比在低氮地区发生频度、丰富度都较少并且易感染叶部病原(Valdensia he... 详细信息

在557块针叶林分中进行调查,以图了解欧洲越桔(Vaccinium myrtillus)、越桔(***-idaea)和曲芒发草(Deschampsia flexuosa)与氮沉积率的相互联系。欧洲越桔在高氮地区比在低氮地区发生频度、丰富度都较少并且易感染叶部病原(Valdensia heterodoxa),越桔的发生与氮沉积的增加呈明显的负相关,曲芒发草却没有这种趋势。在高氮沉积地区,欧洲越桔在优势种为欧洲赤松的林分中比在挪威云杉为优势种的林分中更为最普遍。在氮沉积较低水平的地区不是这种情形。调查的情况与增施氮素实验的结果一致,氮沉积对植被显示了巨大的效应。数据表明即使是较低的氮沉积也可能减少针叶林分林下植被最优势种的丰富度。

关键词：瑞典森林林下植被氮沉积欧洲越桔越桔曲芒发草针叶林分

Single semen analysis as a predictor of semen quality： clinical and epidemiological implications

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Asian Journal of Andrology 2009年第6期11卷 723-730页

作者： lars Rylander Boel Wetterstrand Trine B Haugen Gunilla Malm Johan Malm Cathrine Bjorsvik Trine Henrichsen Thomas Saether Aleksander Giwercman Reproductive Medicine Centre Maltao University Hospital Lund University Maltao SE-20502 Sweden Division of Occupational and Environmental Medicine Lund University Lund SE-22185 Sweden Faculty of Health Sciences Oslo University College Oslo NO-O130 Norway Andrology Laboratory Dept of Gynecology and Obstetrics Rikshospitalet University Hospital Oslo N0-0027 Norway Department of Clinical Chemistry Malmo University Hospital Malmo SE-20502 Sweden Department of Molecular Biosciences University of Oslo Oslo N0-0316 Norway

It is generally thought that a single ejaculate is a bad predictor of semen quality of a subject, because of significant intra-individual variation. Therefore, we investigated the degree to which the results of a first semen analysis differ from that of a second analysis among men from a how the two different semen results mirrored the overall general population in norway. In addition, we analysed semen quality assessment. A total of 199 volunteers participated in the study and delivered two semen samples with an interval of 6 months. The semen parameters were determined according to the World Health Organization （WHO） 1999 guidelines, which were also used to determine whether semen quality was normal or abnormal. In addition, the DnA fragmentation index （DFI） was determined using the Sperm Chromatin Structure Assay. The two samples from each individual were very similar with regard to standard semen parameters and DFI （rs： 0.67-0.72）, and there were no significant systematic differences between the two samples. The result of the first sample （normal/abnormal） was highly predictive of the overall conclusion based on the two samples （sperm concentration： in 93% of the cases （95% confidence interval [CI]： 89%-96%）; sperm motility： in 85% of the cases （95% CI： 79%-89%）; overall semen quality： in 85% of the cases （95% CI： 80%-90%）. In epidemiological studies, one ejaculate is a sufficient indicator of semen quality in a group of subjects. In a clinical situation, when the question is whether the semen quality is normal or not, the first ejaculate will, in at least 85% of cases, give a correct overall conclusion.

关键词： DnA fragmentation intra-individual semen quality semen volume sperm concentration sperm motility

CT diagnosis of recurrence after pancreatic cancer:Is there a pattern?

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World Journal of Gastroenterology 2011年第9期17卷 1126-1134页

作者： Tobias Heye nicola Zausig Miriam Klauss Reinhard Singer Jens Werner Gtz Martin Richter Hans-Ulrich Kauczor lars Grenacher Department of Diagnostic and Interventional Radiology University Hospital Department of Surgery University Hospital Department of Diagnostic and Interventional Radiology Katharinen Hospital

AIM:To investigate predilection sites of recurrence of pancreatic cancer by computed tomography(CT)in follow-up after surgery. METHODS:Seventy seven patients with recurrence after pancreatic cancer surgery were retrospectively *** operative technique,R-status,T-stage and development of tumor markers were evaluated. Two radiologists analyzed CT scans with consensus *** of local recurrence,lymph node recurrence and organ metastases were *** and progression of findings on follow-up CT were con-sidered as reference standard. RESULTS:The mean follow-up interval was 3.9± 1.8 mo,with a mean relapse-free interval of 12.9± 10.4 *** predominant site of recurrence was local (65%),followed by lymph node(17%),liver metastasis (11%)and peritoneal carcinosis(7%).Local recurrence emerged at the superior mesenteric artery(n=28),the hepatic artery(n=8),in an area defined by the surrounding vessels:celiac trunk,portal vein,inferior vena cava(n=22),and in a space limited by the mesenteric artery,portal vein and inferior vena cava(n=17). Lymph node recurrence occurred in the mesenteric root and left lateral to the *** was confirmed by surgery(n=22)and follow-up CT(n=55).Tumor markers[carbohydrate antigen 19-9(CA19-9),carcinoembryonic antigen(CEA)]increased in accordance with signs of recurrence in most cases(86%CA19-9;79.2% CEA). COnCLUSIOn:Specific changes of local and lymph node recurrence can be found in the course of the cardinal peripancreatic *** superior mesenteric artery is the leading structure for recurrence.

关键词： Pancreatic cancer Recurrence Computed tomography Follow-up Tumor marker

Factors That Promote Remission in Individuals with Schizophrenia

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Open Journal of nursing 2019年第9期9卷 935-950页

作者： Maivor Olsson-Tall Bertil Marklund Sven Kylen Eric Carlstrom lars Helldin Siv Back-Pettersson Department of Psychiatry NU-Health Care HospitalTrollhattanSweden Academy of Sahlgrenska Institute of MedicineUniversity of GothenburgGothenburgSweden Centre on Health Care Improvement and Innovation Chalmers University of TechnologyGothenburgSweden narhalsan Research and Development Primary Health Care Region Vastra GotalandSweden Fyrbodal Health Academy County Administration of West SwedenSweden Academy of Sahlgrenska Institute of Health and Care SciencesUniversity of GothenburgGothenburgSweden University of South-East norway WestfoldNorway Institute of Psychology Karlstad UniversityKarlstadSweden

The knowledge about factors contributing to remission among individuals with schizophrenia is still missing. Studies show that the number of individuals’ reaching remission is varying among psychiatric outpatient care centres. Therefore, the purpose was to investigate case managers (CM) perception of care interventions promoting remission. Semi-structured interviews were conducted with CM (n = 12) and data were analysed with qualitative content analysis. The results show that CM needs to possess competence, master assessment structure and process. These key-points appear to be of crucial importance for a successful promotion of remission among individuals with schizophrenia.

关键词： Assessment Case Managers Remission Teamwork Schizophrenia

n-Acetylcysteine Amide(nACA) Reduces Cell Death after Oxidative Stress in a Porcine Embryonic Kidney Cell Line

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Journal of Biomedical Science and Engineering 2017年第2期10卷 31-36页

作者： Torkil Benterud Sophia Manueldas Svante norgren Ronnaug Solberg Ola Didrik Saugstad lars O.Baumbusch Department of Pediatric Research Division of Pediatric and Adolescent MedicineOslo University Hospital RikshospitaletOsloNorway Department of Pediatrics Vestre Viken Hospital TrustDrammenNorway Department of Women’s and Children’s Health Division of Paediatric EndocrinologyKarolinska InstitutetStockholmSweden Department of Pediatrics Vestfold Hospital TrustTonsbergNorway

Introduction: Oxidative stress may have detrimental effects on different structures of the cells, such as the DnA. Recently, we have published a study demonstrating that n-Acetylcysteine amide (nACA) displayed anti-inflammatory properties on the brain after exposure to oxidative stress in an established neonatal piglet model, imitating perinatal asphyxia. As different clinical studies have shown an association between the severity of hypoxic-ischemic encephalopathy and damage of the kidneys, we investigated a possible protective effect of nACA against H2O2-induced oxidative stress using a porcine epithelial-like embryonic kidney cell line (EFn-R). Objective: To investigate a potential protective effect of nACA on cells of a porcine embryonic kidney cell line exposed to H2O2. Methods: We subjected the cells to different concentrations of H2O2 for variable time periods, seeking the optimal dose-response for the experiments. Based on the results of these investigations, we exposed the cells to 100 μMol of H2O2 and/or 750 μM of nACA for 24 hours. Some of the cells would receive nACA either one hour before or one hour after exposure to H2O2. Results: The viability of the investigated EFn-R cells revealed that both, the group treated with nACA before exposure to H2O2 and the group treated with nACA after exposure to H2O2, exhibited significantly higher cell viability compared to the H2O2 group (p nd p n: The increased viability of the cells may indicate that nACA could play an important role in reducing oxidative stress. Taking the results from our previous study into consideration, our findings may strengthen the theory that nACA may have organ protective properties for neonates exposed to oxidative stress.

关键词： n-Acetylcysteine Amide(nACA) Cell Lines Oxidative Stress