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关于大麻素-1受体阻断剂利莫那班对超重或肥胖患者体重和心脏代谢危险因素影响的随机对照试验:RIO-北美研究

世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 6-7页

作者： pi-sunyer f.x. Aronne L.J. Heshmati H.M. 任付先 Obesity Research Center St. Luke's- Roosevelt Hospital WH1020 1111 Amsterdam Ave New York NY 10025 United States Dr.

Context: Rimonabant, a selective cannabinoid- 1 receptor blocker, may reduce body weight and improve cardiometabolic risk factors in patients who are overweight or obese. Objective: To compare the efficacy and safety of rimonabant with placebo each in conjunction with diet and exercise for sustained changes in weight and cardiometabolic risk factors over 2 years. Design, Setting, and Participants: Randomized, double- blind, placebo- controlled trial of 3045 obese(body mass index ≥ 30) or overweight(body mass index >27 and treated or untreated hypertension or dyslipidemia) adult patients at 64 US and 8 Canadian clinical research centers from August 2001 to April 2004. Intervention: After a 4- week single- blind placebo plus diet(600 kcal/d deficit) run- in period, patients were randomized to receive placebo, 5 mg/d of rimonabant, or 20 mg/d of rimonabant for 1 year. Rimonabant- treated patients were rerandomized to receive placebo or continued to receive the same rimonabant dose while the placebo group continued to receive placebo during year 2. Main Outcome Measures: Body weight change over year 1 and prevention of weight regain during year 2. Additional efficacy measures included changes in waist circumference, plasma lipid levels, and other cardiometabolic risk factors. Results: At year 1, the completion rate was 309(51% ) patients in the placebo group, 620(51% ) patients in the 5 mg of rimonabant group, and 673(55% ) patients in the 20 mg of rimonabant group. Compared with the placebo group, the 20 mg of rimonabant group produced greater mean(SEM) reductions in weight(- 6.3 [0.2] kg vs - 1.6[0.2] kg; Pference(- 6.1 [0.2] cm vs- 2.5[0.3] cm; Pf triglycerides(percentage change,- 5.3[1.2] vs 7.9 [2.0]; Pf high- density lipoprotein cholesterol(percentage change, 12.6 [0.5] vs 5.4 [0.7]; Pfrom the 20 mg of rimonabant group to the placebo group during y

关键词：随机对照试验肥胖患者受体阻断剂危险因素心脏代谢大麻素体重超重北美限制饮食

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Performance evaluation of seven multi-label classification methods on real-world patent and publication datasets

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Journal of Data and Information Science 2024年第2期9卷 81-103页

作者： Shuo xu Yuefu Zhang xin An Sainan pi College of Economics and Management Beijing University of TechnologyBeijing 100124China School of Economics&Management Beijing Forestry UniversityBeijing 100083China

Purpose:Many science,technology and innovation(STI)resources are attached with several different *** assign automatically the resulting labels to an interested instance,many approaches with good performance on the benchmark datasets have been proposed for multi-label classification task in the ***,several open-source tools implementing these approaches have also been ***,the characteristics of real-world multi-label patent and publication datasets are not completely in line with those of benchmark ***,the main purpose of this paper is to evaluate comprehensively seven multi-label classification methods on real-world *** limitations:Three real-world datasets differ in the following aspects:statement,data quality,and ***,open-source tools designed for multi-label classification also have intrinsic differences in their approaches for data processing and feature selection,which in turn impacts the performance of a multi-label classification *** the near future,we will enhance experimental precision and reinforce the validity of conclusions by employing more rigorous control over variables through introducing expanded parameter *** implications:The observed Macro f1 and Micro f1 scores on real-world datasets typically fall short of those achieved on benchmark datasets,underscoring the complexity of real-world multi-label classification *** leveraging deep learning techniques offer promising solutions by accommodating the hierarchical relationships and interdependencies among *** ongoing enhancements in deep learning algorithms and large-scale models,it is expected that the efficacy of multi-label classification tasks will be significantly improved,reaching a level of practical utility in the foreseeable ***/value:(1)Seven multi-label classification methods are comprehensively compared on three real-world datasets.(2)The TextCNN and

关键词： Multi-label classification Real-World datasets Hierarchical structure Classification system Label correlation Machine learning

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多项正则化约束的伪标签传播优化脑电信号聚类

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计算机研究与发展 2024年第1期61卷 156-171页

作者：代成龙李光辉李栋申佳华皮德常江南大学人工智能与计算机学院江苏无锡214122 南京航空航天大学计算机科学与技术学院南京211106

作为一种非侵入式分析载体,脑电信号目前被广泛应用于脑-机接口、医疗辅助诊断及康复领域,但这些应用通常依赖需要完整标签的有监督分析技术,如分类.随着无标签脑电信号的与日俱增,现有的有监督方法不能有效解决无标签脑电信号分析问题... 详细信息

作为一种非侵入式分析载体,脑电信号目前被广泛应用于脑-机接口、医疗辅助诊断及康复领域,但这些应用通常依赖需要完整标签的有监督分析技术,如分类.随着无标签脑电信号的与日俱增,现有的有监督方法不能有效解决无标签脑电信号分析问题,也在一定程度上限制了无标签脑电信号这类新型数据的应用拓展.为了解决无标签脑电信号的无监督分析问题,提出了一种基于多项正则化约束的伪标签传播优化聚类模型.该模型通过同时优化学习伪标签传播矩阵、脑电信号相似度邻接矩阵、标签分类器的方式实现聚类.将提出的脑电信号聚类模型转化为一个多目标优化问题,并提出了一种基于梯度下降策略的聚类算法EEGapc(electroencephalogram clustering with pseudo label propagation).该算法不仅充分考虑了脑电信号之间的相关性及脑电信号间的信息传递,还能快速收敛到局部最优.在14个真实脑电信号数据集上的实验结果表明,提出的EEGapc脑电信号聚类算法比现有的8种聚类算法性能更好,且在平均NMI(normalized mutual information),ARI(adjusted rand index),f-score,kappa这4个指标上,EEGapc与现有的8种聚类算法相比,分别至少提升了86.88%,58.01%,6.29%,61.17%.

关键词：脑电信号聚类伪标签传播邻接矩阵优化伪标签分类器多目标优化

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On the Characterization of Maximal Planar Graphs with a Given Signed Cycle Domination Number

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Acta Mathematica Sinica,English Series 2018年第5期34卷 911-920页

作者： xiao Ming pi Department of Mathematics Harbin Normal University

Let G = （V, E） be a simple graph. A function f ： E → {＋1,-1} is called a signed cycle domination function （SCDf） of G if ∑e∈E（C） f（e） ≥ 1 for every induced cycle C of G. The signed cycle domination number of G is defined as γ′sc（G） = min{∑e∈E f（e）｜ f is an SCDf of G}. This paper will characterize all maxima] planar graphs G with order n ≥ 6 and γ′sc（G） =n.

关键词： Domination number signed cycle domination function signed cycle domination number planar graph maximal planar graph

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On the friction effects on rigid-body penetration in concrete and aluminium-alloy targets

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Defence Technology（防务技术） 2019年第4期15卷 576-581页

作者： C.G. Chai A.G. pi Q.M. Li f.L. Huang Institute of Chemical Materials China Academy of Engineering Physics Mianyang Sichuan 621900 China State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology Beijing 100081 China School of Mechanical Aerospace and Civil Engineering University of Manchester Manchester M13 9PL UK

The friction on the projectile shank is usually excluded in the penetration analysis due to the difficulties to measure the pressure and frictional *** this article,the frictional force on projectile shank is discussed indirectly through the comparison between experimental data and empirical/analytical formulas of the penetration depth for both concrete and aluminium-alloy *** is found that the effect of the frictional force along the projectile shank can be further discussed by the afore comparison and discussion and cannot be ignored because of the relatively large effecting area,especially for deep penetration of concrete and aluminium-alloy targets,where the friction will account for more proportion of penetration resistance.

关键词： Penetration friction Concrete Aluminium

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Acta Mechanica Sinica 2020年第6期36卷 1294-1301,I0003页

作者： C.G.Chai A.G.pi Q.M.Li f.L.Huang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang621900China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK

Similarity can reflect common laws in the mechanism of rigid-body *** this paper,the similarities in rigid-body penetration depth are demonstrated by three non-dimensional but physically meaningful quantities,i.e.,ρkinetic,I∗ln and N′*** three quantities represent the non-dimensional areal density of projectile kinetic energy,the effect of nose geometry,and the friction at the interactive cross section between projectile and target *** is shown that experimental data of rigid projectile penetration,from shallow to deep penetration,can be uniquely unified by these three similarity quantities and their ***,for ogival nose projectiles,their penetration capacities are dominated byρkinetic,which is consisted by non-dimensional effective length Leff and non-dimensional quantity Dpn=ρpv20AY which has the same form as Johnson’s damage *** the sacrifice of minor theoretical accuracy,the non-dimensional penetration depth P/d can be understood as directly controlled by Dpn,enhanced by projectile effective length Leff under a multiplication relation,and optimized by projectile nose geometry in the formation of I∗ln.

关键词： Concrete target Deep penetration Similarity-Johnson's damage number

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A review:the mechanism of plant-derived polysaccharides on osteoblasts and osteoclasts

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未来食品学报(英文) 2024年第3期4卷 183-192页

作者： Mengjie Ren Adel f.Ahmed Meng Li Menghan Li Zhiruo Yan Jinmei Wang National R&D Center for Edible fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of food&Medicine Resource function Henan ProvinceKaifeng 475004China Medicinal and Aromatic Plants Researches Department Horticulture Research InstituteAgricultural Research CenterGiza 12511Egypt

Bone loss and deterioration of bone microarchitecture would increase the bone fragility and fracture risk,leading to the *** and more evidences proved that plant-derived polysaccharides could have a remarkable influence on osteoblasts and osteoclasts,exerting anti-osteoporosis *** to the previous research,the extract of Cibotium barumoz,Achyranthes bidentata,Curculigo orchioides,Epimedium brevicornum,Angelica sinensis,Polygonatum sibiricum,Dendrobium officinale,Morinda officinalis,Nelumbo mucifera,Diospyros kaki,Hordeum vulgare,Cistanche deserticola,Commiphora Myrrha and other plant-derived polysaccharides could benefit to the osteoblasts and *** essential mechanisms are mainly related to the activation or inhibition of many factors,including runt-related transcription factor 2(Runx2),B-catenin,osterix(Osx),activator protein-1(AP-1),osteocalcin(OCN/BGP),alkaline phosphatase(ALP),osteopontin(OPN),bone morphogenetic protein(BMP),phosphatidylinositol 3-kinase(pi3K)/C-Jun N-terminal kinase(JNK)/extracellular regulated protein kinase(ERK),osteoprotegerin(OPG),receptor activator of nuclear factor-kB(RANK),monocyte/macrophage colony-stimulating factor(M-CSf),tumor necrosis factor receptor-associated factor 6(TRAf-6),receptor activator of nuclear factor(Nf)-KB ligand(RANKL),nuclear factor of activated T cells 1(NfATc1),c-fos,matrix metallopeptidase-9(MMP-9),glycogen synthase kinase 3β(GSK3B)/B-catenin,nuclear factor E2-related factor 2(Nf2),as well as these related pathways,such as Wnt/p-catenin,BMP-2/SMAD1/5/8,pi3K/AKT,OPG/RANKL/RANK,Nf-κB,MAPKs,*** plant-derived polysaccharides could improve the dynamic balance of bone formation and resorption through promoting the differentiation and maturation of osteoblast or inhibiting its *** reviewed plant-derived polysaccharides and their regulating mechanisms on the osteoclasts and osteoblasts provide the evidences for the development of osteoporosis therapeutics.

关键词： Osteoporosis Plant-derived polysaccharides Osteogenesis promotion Osteoclasts inhibition

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Effect of airflow on biodrying of gardening wastes in reactors

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Journal of Environmental Sciences 2013年第5期25卷 865-872页

作者： f.J.Colomer-Mendoza L.Herrera-Prats f.Robles-Martínez A.Gallardo-Izquierdo A.B.pia-Guzmn Department of Mechanical Engineering and Construction (Universidad Jaume I)Jaume 1st University.Ave.Sos Baynat s/nCastellón 12071Spain Biotechnology Multidisciplinary Professional Unit (Instituto Politcnico Nacional)National Politechnic Institute.Ave.Acueduct of Guadalupe s/n Barrio la Laguna TicomnGustavo A.Madero 07340Mxico DF.Mxico

Biodrying consists of reducing moisture by using the heat from aerobic *** parameters that control the process are：aeration,temperature during the process,initial moisture of biowaste,and temperature and relative humidity of the input *** mowing and garden waste from the gardens of the University Jaume I,Castellón（Spain）were used as a *** was performed in 10 reactors with known air volumes from 0.88 to 6.42 L/（min·kg dry weight）.To promote aeration,5 of the reactors had 15% of a bulking agent *** experiment lasted 20 *** the experiments it was found that the bulking agent led to greater weight ***,the increased airflow rate was not linearly proportional to the weight loss.

关键词： biodrying biowaste stabilization aerobic fermentation bulking agent

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基于磁驱动的合页接触式摩擦纳米发电机

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机械设计与研究 2024年第4期40卷 89-97,103页

作者：韩念春曹凯肖纵纵柳军皮杰江苏大学农业工程学院江苏镇江212013 江苏省农业科学院农业设施与装备研究所南京210014

基于接触起电和静电感应的耦合原理,本文创新性地设计并制作了一种利用磁场驱动的合页接触式摩擦纳米发电机(MDH-TENG),实现了对合页开合过程产生电荷的直接提取。通过深入的理论分析和有限元模拟,搭建了实验平台并得出以下发现:MDH-TEN... 详细信息

基于接触起电和静电感应的耦合原理,本文创新性地设计并制作了一种利用磁场驱动的合页接触式摩擦纳米发电机(MDH-TENG),实现了对合页开合过程产生电荷的直接提取。通过深入的理论分析和有限元模拟,搭建了实验平台并得出以下发现:MDH-TENG的输出电压与电极尺寸大小和接触压力成正比,与电极厚度成反比;MDH-TENG输出的电能经整流电路处理后,可实现对电容的快速充电,仅需89 s即可将47μf的电容充至4.4 V。经过电压衰减电路处理后,MDH-TENG的输出电压可供单片机采集,结合滤波算法与定时器功能,可实现风速的准确测量。该设计为能量收集和自驱动传感领域开辟了新的可能性,展示了其在智能传感时代的巨大潜力。

关键词：摩擦纳米发电机合页结构微风能收集风速传感器

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ExISTENCE RESULTS fOR THE KIRCHHOff TYPE EQUATION WITH A GENERAL NONLINEAR TERM

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Acta Mathematica Scientia 2022年第5期42卷 2063-2077页

作者： Huirong pi Yong ZENG School of Mathematics and Information Guangci UniversityNanning 530004China

This paper is mainly concerned with existence and nonexistence results for solutions to the Kirchhoff type equation−(a+b∫_(R^(3))|∇u|^(2))Δu+V(x)u=f(u)in R^(3),with the general hypotheses on the nonlinearity f being as introduced by Berestycki and *** analysis introduces variational techniques to the analysis of the effect of the nonlinearity,especially for those cases when the concentration-compactness principle cannot be applied in terms of obtaining the compactness of the bounded Palais-Smale sequences and a minimizing problem related to the existence of a ground state on the Pohozaev manifold rather than the Nehari manifold associated with the equation.

关键词： Kirchhoff type equation general nonlinearity variational methods Pohozaev identity

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