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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,pi3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Mechatronic Design of a Synergetic Upper Limb Exoskeletal Robot and Wrench-based Assistive Control

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Journal of Bionic Engineering 2018年第2期15卷 247-259页

作者： Lei He Caihua Xiong kai Liu Jian Huang chang He Wenbin Chen School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China School of Automation Huazhong University of Science and Technology Wuhan 430074 China

Upper limb exoskeletal rehabilitation robots are required to assist patients＇ arms to perform activities of daily living according to their motion intentions. In this paper, we address two questions： how to design an exoskeletal robot which can mechanically reconstruct functional movements using only a few actuators and how to establish wrench-based assistive control. We first show that the mechanism replicating the synergic feature of the human upper limb can be designed in a recursive manner, meaning that the entire robot can be constructed from two basic mechanical units. Next, we illustrate that the assistive control for the synergetic exoskeletal robot can be transformed into an optimization problem and a Riemannian metric is proposed to generate anthropomorphic reaching movements according to contact forces and torques. Finally, experiments are carried out to verify the functionality of the proposed theory.

关键词： upper limb exoskeletal robot postural synergy wrench based assistive control

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HBD:Towards Efficient Reactive Rule Dispatching in Software-Defined Networks

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Tsinghua Science and Technology 2016年第2期21卷 196-209页

作者： chang Chen Xiaohe Hu kai Zheng Xiang Wang Yang Xiang Jun Li Department of Automation Research Institute of Information TechnologyTsinghua UniversityBeijing 100084China. IBM China Research Lab Beijing 100084China Research Institute of Information Technology Tsinghua UniversityBeijing 100084China. Research Institute of Information Technology Tsinghua National Lab for Information Science and TechnologyTsinghua UniversityBeijing 100084China.

Most types of Software-Defined Networking （SDN） architectures employ reactive rule dispatching to enhance real-time network control. The rule dispatcher, as one of the key components of the network controller, generates and dispatches the cache rules with response for the packet-in messages from the forwarding devices. It is important not only for ensuring semantic integrity between the control plane and the data plane, but also for preserving the performance and efficiency of the forwarding devices. In theory, generating the optimal cache rules on demands is a knotty problem due to its high theoretical complexity. In practice, however, the characteristics lying in real-life traffic and rule sets demonstrate that temporal and spacial localities can be leveraged by the rule dispatcher to significantly reduce computational overhead. In this paper, we take a deep-dive into the reactive rule dispatching problem through modeling and complexity analysis, and then we propose a set of algorithms named Hierarchy-Based Dispatching （HBD）, which exploits the nesting hierarchy of rules to simplify the theoretical model of the problem, and trade the strict coverage optimality off for a more practical but still superior rule generation result. Experimental result shows that HBD achieves performance gain in terms of rule cache capability and rule storage efficiency against the existing approaches.

关键词： Software-Defined Networking (SDN) reactive rule dispatching rule cache performance

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Simultaneous denoising and resolution enhancement of seismic data based on elastic convolution dictionary learning

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Petroleum Science 2023年第4期20卷 2127-2140页

作者： Nan-Ying Lan Fan-chang Zhang kai-Heng Sang Xing-Yao Yin School of Geosciences China University of Petroleum(East China)QingdaoShandong266580China

Enhancing seismic resolution is a key component in seismic data processing, which plays a valuable role in raising the prospecting accuracy of oil reservoirs. However, in noisy situations, existing resolution enhancement methods are difficult to yield satisfactory processing outcomes for reservoir characterization. To solve this problem, we develop a new approach for simultaneous denoising and resolution enhancement of seismic data based on convolution dictionary learning. First, an elastic convolution dictionary learning algorithm is presented to efficiently learn a convolution dictionary with stronger representation capability from the noisy data to be processed. Specifically, the algorithm introduces the elastic L1/2 norm as a sparsity constraint and employs a steepest gradient descent strategy to efficiently solve the frequency-domain linear system with substantial computational cost in a half-quadratic splitting framework. Then, based on the learned convolution dictionary, a weighted convolutional sparse representation paradigm is designed to encode the noisy data to acquire an optimal sparse approximation of the effective signal. Subsequently, a high-resolution dictionary with a broadband spectrum is constructed by the proposed parameter scaling strategy and matched filtering technique on the basis of atomic spectrum modeling. Finally, the optimal sparse approximation of the effective signal and the constructed high-resolution dictionary are used for data reconstruction to obtain the seismic signal with high resolution and high signal-to-noise ratio. Synthetic and field dataset examples are executed to check the effectiveness and reliability of the developed method. The results indicate that this method has a more competitive performance in seismic applications compared with the conventional deconvolution and spectral whitening methods.

关键词： Simultaneous denoising and resolution enhancement Elastic convolution dictionary learning Weighted convolutional sparse representation Matched filtering

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Facile Synthesis and in situ TEM Observation of Nanoporous Pd for Enhanced Catalytic Applications

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Chinese Journal of Chemistry 2019年第6期37卷 565-569,I0002页

作者： Haiyang Liu kai Ke chang Li Xin Chen Yulian Wu Key Laboratory for Ultrafine Materials of Ministry of Education and Shanghai Key Laboratory of Advanced Polymeric MaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

A facile, efficient and green photochemical synthetic approach has been used to prepare sponge-like porous Pd nanoparticles. Obtained by ultraviolet irradiation using a K2PdCl4 precursor solution, the final products exhibited three dimensionally interconnected porous structures made up of ~3.6 nm sized Pd nanoparticles. In situ liquid cell TEM results indicated such porous structures are in a dynamic stable state when the particles are distributed in aqueous solution. The porous Pd nanoparticles exhibited electrochemical active surface area (ECSA) of up to 43 m^2·g^–1 and mass activity of 1144 mA·mg^–1 in menthol oxidation, kapp of 0.22 min^–1 and normalized kapp/m (kn) of 8.3×10^4 min^–1·g^-1 in 4-nitrophenol (4-NP) reduction reactions. Comparing with the literature, it is demonstrated that our porous Pd nanoparticles with clean surfaces exhibited very high catalytic performances. This work may shed a light on facile and green synthesis of noble-metal particles with better catalytic performances.

关键词： palladium catalyst in situ TEM porous structure 4-nitrophenol reduction

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阿尔泰地区巴泽雷克文化马鞍毛毡贴花艺术研究

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丝绸 2025年第1期62卷 101页

作者：常艳西安外国语大学艺术遗产研究中心西安710128

针对阿尔泰地区巴泽雷克文化马鞍毛毡贴花艺术,文章采用文献分析、图像分析、类型与历史比较的研究方法,对遗存情况、贴花工艺、历史溯源及盛行的原因、文化信仰几个方面进行梳理和分析。归纳巴泽雷克文化马鞍毛毡及其贴花工艺的制作流... 详细信息

针对阿尔泰地区巴泽雷克文化马鞍毛毡贴花艺术,文章采用文献分析、图像分析、类型与历史比较的研究方法,对遗存情况、贴花工艺、历史溯源及盛行的原因、文化信仰几个方面进行梳理和分析。归纳巴泽雷克文化马鞍毛毡及其贴花工艺的制作流程,探讨其用色的工艺和风格。研究认为,这种艺术形式经历了从本土到融合外来艺术样式,再到新本土风格形成的几个发展阶段。其显著特色是多种材料的搭配使用、强烈的冷暖对比配色及独特的动物贴花装饰。同时,毛毡贴花艺术不仅作为生活物资,更是原始宗教信仰的载体。无论从工艺水准还是地域特色,都是同时期甚至更晚时期其他地域无法相比的,因此具有重要的史料价值和艺术价值。

关键词：阿尔泰巴泽雷克文化马鞍毛毡贴花艺术

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Facile preparation of Nb_(2)O_(5) microspheres and their excellent electrochemical performance in aqueous zinc-ion hybrid supercapacitors

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Rare Metals 2022年第9期41卷 3129-3141页

作者： Si-Jia Zhang Han Chen Yi-Xue Xu chang-Sheng An kai-Xiong Xiang School of Materials and Advanced Manufacturing Liling Ceramic InstituteHunan University of TechnologyZhuzhou412007China Hunan Institute of Science and Technology Yueyang414000China Hunan Key Laboratory of Applied Environmental Photocatalysis Changsha UniversityChangsha410022China

The aqueous solution-based zinc-ion hybrid supercapacitors(ZHSCs)have attracted immense attention as they are characterized by high power and energy *** materials with high performance should be developed for ZHSCs to resolve power imbalances between capacitor-and battery-type electrode *** address this issue,Nb_(2)O_(5) microspheres(with the structure like sweet dumplings with exposed stuffing)were produced following a hydrothermal process which was followed by a high-temperature calcination *** specific capacity of the as-synthesized Nb_(2)O_(5) microspheres was up to 324 F·g^(-1) when the current density was 0.1 A·g^(-1),and the long-term capacity retention was 85%at the end of 5000 *** results revealed that the nanospheres could be used as battery-type electrode materials for the fabrication of ***_(2)O_(5)//AC ZHSCs were fabricated with Nb_(2)O_(5) microspheres as the negative electrode materials,and activated carbon(AC)was used as the positive electrode *** a result,a specific capacity of 108 F·g^(-1) was achieved when the current density was 0.1 A·g^(-1).The power density was high(8020 W·kg^(-1))at 28 Wh·kg^(-1),and the energy density was high(60 Wh·kg^(-1))at 100 W·kg^(-1).The structurally novel Nb_(2)O_(5) microspheres can be potentially used for the development of the next-generation ZHSCs that exhibit excellent performance.

关键词： Hydrothermal Microspheres Nb_(2)O_(5) Zincion hybrid supercapacitors(ZHSCs) Fast kinetics

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Accelerated Stochastic Peaceman–Rachford Method for Empirical Risk Minimization

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Journal of the Operations Research Society of China 2023年第4期11卷 783-807页

作者： Jian-Chao Bai Feng-Miao Bian Xiao-kai chang Lin Du Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518057GuangdongChina School of Mathematics and Statistics Northwestern Polytechnical UniversityXi’an 710129ShaanxiChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Science Lanzhou University of TechnologyLanzhou730050GansuChina School of Mathematics and Statistics the MIIT Key Laboratory of Dynamics and Control of Complex SystemsNorthwestern Polytechnical UniversityXi’an 710129ShaanxiChina

This work is devoted to studying an accelerated stochastic Peaceman–Rachford splitting method(AS-PRSM)for solving a family of structural empirical risk minimization *** objective function to be optimized is the sum of a possibly nonsmooth convex function and a finite sum of smooth convex component *** smooth subproblem in AS-PRSM is solved by a stochastic gradient method using variance reduction technique and accelerated techniques,while the possibly nonsmooth subproblem is solved by introducing an indefinite proximal term to transform its solution into a proximity *** a proper choice for the involved parameters,we show that AS-PRSM converges in a sublinear convergence rate measured by the function value residual and constraint violation in the sense of expectation and *** experiments on testing the popular graph-guided fused lasso problem in machine learning and the 3D CT reconstruction problem in medical image processing show that the proposed AS-PRSM is very efficient.

关键词： Empirical risk minimization Convex optimization Stochastic Peaceman-Rachford method Indefinite proximal term Complexity

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Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

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Current Medical Science 2024年第2期44卷 391-398页

作者： kai-kai GUO chang-ya LIU Gao-hui LI Jian-ping XIANG Xiao-chang LENG Yi-ke CAI Xue-bin HU Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Artery Flow Technology Co. Ltd.Hangzhou 310051China

Objective:The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries,utilizing computational fluid dynamics as a tool for ***:In line with the designated inclusion criteria,this study covered 160 aneurysms identified in 131 patients who received treatment at Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,China,from January 2021 to September *** follow-up digital subtraction angiography(DSA)data,these cases were classified into two distinct groups:the sidewall aneurysm group and the bifurcation aneurysm *** and hemodynamic parameters in the immediate preoperative period were meticulously calculated and examined in both groups using a three-dimensional DSA reconstruction ***:No significant differences were found in the morphological or hemodynamic parameters of bifurcation aneurysms at varied locations within the anterior ***,pronounced differences were identified between sidewall and bifurcation aneurysms in terms of morphological parameters such as the diameter of the parent vessel(Dvessel),inflow angle(θF),and size ratio(SR),as well as the hemodynamic parameter of inflow concentration index(ICI)(P0.5,P<0.001).Conclusions:The significant differences in certain morphological and hemodynamic parameters between sidewall and bifurcation aneurysms emphasize the importance to contemplate variances in threshold values for these parameters when evaluating the risk of rupture in anterior circulation *** it is a bifurcation or sidewall aneurysm,these disparities should be *** morphological parameter SR has the potential to be a val

关键词： sidewall bifurcation unruptured aneurysms computational fluid dynamics

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Human eye ocular component analysis for refractive state and refractive surgery

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1076-1080页

作者： Chao-kai chang Jui-Teng Lin Yong Zhang Nobel Eye Institute New Vision Inc Gong-Rui Medical Technology Department of Ophthalmology Shandong Provincial Hospital

AIM： To analyze the clinical factors influencing the human vision corrections via the changing of ocular components of human eye in various applications; and to analyze refractive state via a new effective axial ***： An effective eye model was introduced by the ocular components of human eye including refractive indexes, surface radius（r1, r2, R1, R2） and thickness（t, T） of the cornea and lens, the anterior chamber depth（S1） and the vitreous length（S2）. Gaussian optics was used to calculate the change rate of refractive error per unit amount of ocular components of a human eye（the rate function M）. A new criterion of myopia was presented via an effective axial ***： For typical corneal and lens power of 42 and 21.9 diopters, the rate function Mj（j=1 to 6） were calculated for a 1% change of r1, r2, R1, R2, t, T（in diopters） M1=＋0.485, M2=-0.063, M3=＋0.053, M4=＋0.091, M5=＋0.012, and M6=-0.021 diopters. For 1.0 mm increase of S1 and S2, the rate functions were M7=＋1.35, and M8=-2.67 diopter/mm, respectively. These rate functions were used to analyze the clinical outcomes in various applications including laser in situ keratomileusis surgery, corneal cross linking procedure, femtosecond laser surgery and scleral ablation for ***： Using Gaussian optics, analytic formulas are presented for the change of refractive power due to various ocular parameter changes. These formulas provide useful clinical guidance in refractive surgery and other related procedures.

关键词： Gaussian optics human eye ocular components refractive errors vision correction laser in situ keratomileusis corneal collagen crosslinking

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