检索结果-南通市图书馆

Relationship of calcitonin gene-related peptide with disease progression and prognosis of patients with severe traumatic brain injury

引用

Neural Regeneration Research 2018年第10期13卷 1782-1786页

作者： Li-Xiong Chen Wei-feng Zhang Ming Wang pi-feng jia Department of Critical Care Medicine North Hospital of Ruijin Hospital Department of Neurosurgery North Hospital of Ruijin Hospital

Calcitonin gene-related peptide（CGRP） has been implicated in multiple functions across many bioprocesses; however, whether CGRP is associated with severe traumatic brain injury（TBI） remains poorly understood. In this study, 96 adult patients with TBI（enrolled from September 2015 to December 2016） were divided into a mild/moderate TBI group（36 males and 25 females, aged 38 ± 13 years） and severe TBI group（22 males and 13 females, aged 38 ± 11 years） according to Glasgow Coma Scale scores. In addition, 25 healthy individuals were selected as controls（15 males and 10 females, aged 39 ± 13 years）. Radioimmunoassay was used to detect serum levels of CGRP and endothelin-1 at admission and at 12, 24, 48, 72 hours, and 7 days after admission. CGRP levels were remarkably lower, but endothelin-1 levels were obviously higher in the severe TBI group compared with mild/moderate TBI and control groups. Levels of CGRP were remarkably lower, but endothelin-1 levels were obviously higher in deceased patients compared with patients who survived. Survival analysis and logistic regression showed that both CGRP and endothelin-1 levels were associated with patient mortality, with each serving as an independent risk factor for 6-month mortality of severe TBI patients. Moreover, TBI patients with lower serum CGRP levels had a higher risk of death. Thus, our retrospective analysis demonstrates the potential utility of CGRP as a new biomarker, monitoring method, and therapeutic target for TBI.

关键词： nerve regeneration calcitonin gene-related peptide severe traumatic brain injury prognosis biomarkers endothelin-1 mortality dynamic serum levels critical care medicine neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Response to letter to the editor “Calcitonin gene-related peptide and traumatic brain injury”

引用

Neural Regeneration Research 2019年第4期14卷 736-736页

作者： pi-feng jia Department of Neurosurgery North Hospital of Ruijin Hospital

Dear Sir,Since the present study is mainly an observational study,though prospective,we did not use any particular treatment methods for all traumatic brain injury(TBI)patients.The main purpose of the research is to investigate the relationship between calcitonin gene-related peptide(CGRP)and clinical outcomes.Thus we did not describe the details of surgery and treatment procedures for all patients.All patients underwent a regular treatment routine.We had included a sentence of“All patients were treated according to the locally agreed management protocols for head injury.”However,it was asked to be deleted during revision.

关键词： peptide procedures surgery did Sir had was is

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The noise spectral characteristics and noise reduction schemes of screw air-source heat pump:A case study

引用

Building Simulation 2024年第1期17卷 53-70页

作者： Dongsheng Liu Yaohan feng Jikang jia Pengfei Si Ya feng China Southwest Architecture Design and Research Institute Co.Ltd. Chengdu 610041China CSCEC Green Construction Engineering Research Center Chengdu 610041China

The screw air-source heat pump can cause incessant high noise levels during operation,which might hinder adoption of this energy-efficient heat pump.First,acoustic measurements and comparison testing were performed in this research.The measurements revealed that the compressor is the main noise source of the heat pump,and it shows a multipeak frequency distribution and a wide frequency spectrum under different work conditions,with multiple peaks at 63,250,and 1000 Hz.Then,a compressor sound insulation cover with broadband absorption was proposed,and it was experimentally proven that the insulation cover can reduce the maximum sound pressure level of one unit from 89.8 dBA to 79.1 dBA.Third,we proposed several noise reduction strategies and compared their noise reduction effects using computer simulation.The results showed that the noise problem can be effectively improved through the rational design of the sound barrier and the layout and opening options of heat pump.The distance between the sound barrier and heat pump and the sound attenuation due to diffraction ALa exhibit a U-shaped relation.For buildings of different heights,the optimal heights of noise barrier are proposed.The 5.5-meter is the optimal height of the sound barrier for single-story buildings.The conclusions can be applied to other building projects for heat pump noise reduction.

关键词： acoustic simulation broadband noise noise reduction air-source heat pump sound barrier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contributors to tidal duration asymmetry with varied coastline configurations on western shelf of Yellow Sea

引用

Water Science and Engineering 2024年第1期17卷 1-12页

作者： Xi feng Zheng Li Hui feng jia-yan Yang Shou-peng Xie Wei-bing Fenag College of Harbor Coastal and Offshore Engineering Hohai UniversityNanjing 210098China China Harbour Engineering Co. LidBeijing 100027China Key Laboratory of Port Waterway and Sedimentation Engineering of the Ministry of CommunicationsNanjing 210029China China South-to-North Water Diversion Corporation Limited Beijing 100036China

Coastal management in China is confronted with an urgent choice between natural restoration and maintenance of existing seawalls and reclaimed land for economic development.A key criterion for making this decision is the resilience to coastal flooding,which depends on the ability to predict tidal level.Tidal duration asymmetry(TDA)is a key parameter in determination of the arrival and duration of flood tides.This study selected the western inner shelf of the Yellow Sea(WYS)as the study area and investigated the responses of TDA to different shoreline configurations and relative sea level rise.The responses of TDA to shoreline reconstruction yielded spatial variability locally and remotely.In the nearshore area,the responses of TDA to the complex ocean environment mainly originated from the combined functions of reflection,bottom friction,and advection,which controlled the energy transfer from M2 or S2 constituents to their overtides or compound tides.The sensitivity of TDA to coastline typologies was not limited to coastal waters but could stretch over the entire inner shelf.The vulnerability of tidal responses was due to the displacement of the M2 amphidrome of the Kelvin wave on the WYS,which in turn changed tidal energy fluxes over the regime.The relative sea level rise could intensify the feedback of TDA to seawalls and land reclamation.

关键词： Tidal duration asymmetry Western inner shelf of Yellow Sea Natural restoration Relative sea level rise Tidal amphidrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimal V_(2)O_(3) extraction by sustainable vanadate electrolysis in molten salts

引用

Tungsten 2024年第1期6卷 141-149页

作者： Bao-Yan feng Zhong-Hua Zhao Yong-Zheng jia jia-Liang An Ming-Yong Wang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Green Recovery and Extraction of Rare and Precious Metals University of Science and Technology BeijingBeijing 100083China

Recently,an environmentally friendly electrolysis process of soluble vanadates is proposed and successfully confirmed for V_(2)O_(3) extraction.In this paper,the solubilities of various vanadates(i.e.NaVO_(3),Na_(4)V_(2)O_(7) and Na_(3)VO_(4))in NaCl molten salt are measured.The dependences of V_(2)O_(3) extraction on vanadate form,anode material and molten salt system are studied.A long-term electrolysis is carried out.The result indicates that the solubilities of all vanadates are high and meet electrolytic requirements.Compared to Na_(4)V_(2)O_(7) and Na_(3)VO_(4),NaVO_(3) exhibits larger current efficiency and lower electricity consumption.By using SnO_(2) anode instead of graphite anode,the current efficiency of NaVO_(3) electrolysis can be increased to 58.1%and carbon pollution is avoided at 700℃.The extraction rate of V_(2)O_(3) reaches 81.3%after long-term electrolysis of 51 h.This work optimizes the electrochemical preparation process of V_(2)O_(3) from various vanadates and contributes to the improvement of current efficiency and extraction rate.

关键词： Molten salt electrolysis Vanadate Vanadium trioxide Current efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

引用

Military Medical Research 2024年第1期11卷 80-97页

作者： Qian-Yun Guo jia-Qi Yang Xun-Xun feng Yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Sc on Al_(3)Fe phase and mechanical properties of as-cast AA5052 aluminum alloy

引用

China Foundry 2024年第3期21卷 257-264页

作者： Yang Li Qing Yu feng-feng Chen jia-wen He Hong-mei Yang Meng-nie Li Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing,and with the development of light-weight alloys,it is required that these materials exhibit better mechanical properties.Previous studies have demonstrated that the addition of Sc to aluminum alloys can improve both the microstructure and properties of the alloys.In this study,the effect of Sc on the Fe-rich phase and properties of the AA5052 aluminum alloy was studied by adding 0%,0.05%,0.2%,and 0.3%Sc.The results show that with the increase of Sc,the coarse needle-like Fe-rich phase gradually transforms into Chinese-script and then nearly spherical particles,reduce the size of Fe-rich phase,and refine the grain with increase of high angle grain boundaries(HAGBs).These microstructure changes enhance the strength of the AA5052 alloy through Sc addition.The ductility of the alloy is obviously improved because the addition of a lower amount of Sc changes the morphology of Fe-rich phase from needle-like into a Chinese-script,and it is subsequently reduced as a result of significant increase in HAGBs with increasing Sc content.

关键词： AA5052 aluminum alloy Al3Fe phase mechanical properties grain boundary

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sedimentary architecture of submarine channel-lobe systems under different seafloor topography:Insights from the Rovuma Basin offshore East Africa

引用

Petroleum Science 2024年第1期21卷 125-142页

作者： Mei Chen Sheng-He Wu Rui-feng Wang jia-jia Zhang Peng-Fei Xie Min Wang Xiao-feng Wang Ji-Tao Yu Qi-Cong Xiong State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Faculty of Geosciences University of BremenBremen28359Germany MARUM-Center for Marine and Environmental Sciences University of BremenBremen28359Germany Research institute of Petroleum Exploration and Development PetroChinaBeijing10083China School of Geosciences Yangtze UniversityWuhan 100083HubeiChina CNODC Mozambique Ltd. Beijing 100034China

Seafloor topography plays an important role in the evolution of submarine lobes.However,it is still not so clear how the shape of slope affects the three-dimensional(3-D)architecture of submarine lobes.In this study,we analyze the effect of topography factors on different hierarchical lobe architectures that formed during Pliocene to Quaternary in the Rovuma Basin offshore East Africa.We characterize the shape,size and growth pattern of different hierarchical lobe architectures using 3-D seismic data.We find that the relief of the topographic slope determines the location of preferential deposition of lobe complexes and single lobes.When the topography is irregular and presents topographic lows,lobe complexes first infill these depressions.Single lobes are deposited preferentially at positions with higher longitudinal(i.***.across-slope)slope gradients.As the longitudinal slope becomes higher,the aspect ratio of the single lobes increases.Lateral(i.***.along-slope)topography does not seem to have a strong influence on the shape of single lobe,but it seems to affect the overlap of single lobes.When the lateral slope gradient is relatively high,the single lobes tend to have a larger overlap surface.Furthermore,as the average of lateral slope and longitudinal slope gets greater,the width/thickness ratio of the single lobe is smaller,i.***.sediments tend to accumulate vertically.The results demonstrate that the shape of slopes more comprehensively influences the 3-D architecture of lobes in natural deep-sea systems than previously other lobe deposits and analogue experiments,which helps us better understand the development and evolution of the distal parts of turbidite systems.

关键词： Submarine fan Seafloor topography Sedimentary architecture Slope system SW Indian ocean

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-surrogate framework with an adaptive selection mechanism for production optimization

引用

Petroleum Science 2024年第1期21卷 366-383页

作者： jia-Lin Wang Li-Ming Zhang Kai Zhang jian Wang jian-ping Zhou Wen-feng Peng Fa-Liang Yin Chao Zhong Xia Yan pi-Yang Liu Hua-Qing Zhang Yong-Fei Yang Hai Sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Qingdao University of Technology Qingdao266580ShandongChina College of Science China University of PetroleumQingdao266580ShandongChina Zepu Oil and Gas Development Department PetroChina Tarim Oilfield CompanyKorla841000XinjiangChina Hainan Branch of CNOOC Ltd Haikou70311HainanChina

Data-driven surrogate models that assist with efficient evolutionary algorithms to find the optimal development scheme have been widely used to solve reservoir production optimization problems.However,existing research suggests that the effectiveness of a surrogate model can vary depending on the complexity of the design problem.A surrogate model that has demonstrated success in one scenario may not perform as well in others.In the absence of prior knowledge,finding a promising surrogate model that performs well for an unknown reservoir is challenging.Moreover,the optimization process often relies on a single evolutionary algorithm,which can yield varying results across different cases.To address these limitations,this paper introduces a novel approach called the multi-surrogate framework with an adaptive selection mechanism(MSFASM)to tackle production optimization problems.MSFASM consists of two stages.In the first stage,a reduced-dimensional broad learning system(BLS)is used to adaptively select the evolutionary algorithm with the best performance during the current optimization period.In the second stage,the multi-objective algorithm,non-dominated sorting genetic algorithm II(NSGA-II),is used as an optimizer to find a set of Pareto solutions with good performance on multiple surrogate models.A novel optimal point criterion is utilized in this stage to select the Pareto solutions,thereby obtaining the desired development schemes without increasing the computational load of the numerical simulator.The two stages are combined using sequential transfer learning.From the two most important perspectives of an evolutionary algorithm and a surrogate model,the proposed method improves adaptability to optimization problems of various reservoir types.To verify the effectiveness of the proposed method,four 100-dimensional benchmark functions and two reservoir models are tested,and the results are compared with those obtained by six other surrogate-model-based methods.The results demonstrate that our approach can obtain th

关键词： Production optimization Multi-surrogate models Multi-evolutionary algorithms Dimension reduction Broad learning system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbon preservation in sedimentary deposits: Beyond mineral protection

引用

The Innovation 2024年第2期5卷 5-6页

作者： Yunpeng Zhao Juan jia Chengzhu Liu Xiaojuan feng State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

The deposition and preservation of organic carbon(OC)in sedimentary environments(including soils and sediments)play major roles in mediating the global carbon cycle.More than 90%of OC burial in the ocean occurs in continental margin sediments,which contributes to the evolution of the Earth’s atmosphere,such as oxygen content,over geological timescales.1 However,how OC escapes mineralization and persists in such sedimentary deposits has long been a puzzle.Mineral protection through physicochemical associations of organic matter with minerals and cations is considered to be one of the primary mechanisms contributing to the environmental persistence of sedimentary OC.

关键词： sedimentary mineralization environments

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：