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Effects of torularhodin against acetaminophen induced liver injury base on antioxidation, anti-inflammation and anti-apoptosis

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Food Bioscience 2023年第2期52卷 575-583页

作者： Jiayi Li He Qian Fuwei pi State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxiJiangsu214122People’s Republic of China School of Biotechnology Jiangnan UniversityWuxiJiangsu214122People’s Republic of China Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxiJiangsu214122People’s Republic of China

Oxidative stress,inflammatory,and excessive apoptosis are the crucial culprits of drug-induced liver injury(DILI).Torularhodin was judged to have good potential to intervene DILI due to its antioxidant and immunomodulation *** aim of this study was to clarify the preventive effect of torularhodin on hepatic injury caused by acetaminophen(APAP)and its mechanism in *** liver injury model of mice was established by injecting APAP into the tail’s veins to evaluate the intervention effect of torularhodin on liver *** mechanisms involved were investigated using Western blot and transcriptome *** results reflected that torularhodin significantly increased antioxidant enzyme capacities(Compared with the group Dam,the activities of SOD and GSH-Px in the group TorH increased by2.47 and 3.79 times,and the content of MDA decreased by 58.78%,respectively ppi3K/Akt/mTOR and Nrf2/HO-1 to increase antioxidant enzyme activity,thus intervening in *** suggested that torularhodin might provide a promising preventive strategy for DILI.

关键词： Torularhodin Anti-inflammation Transcriptome analysis Apoptosis signaling pathway

Zircon U–Pb dating of Pubei granite and strontium isotope from sphalerite of the Xinhua Pb–Zn–(Ag) deposit,Yunkai Area of Guangxi Province,South China

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Acta Geochimica 2016年第2期35卷 156-171页

作者： Minfang Wang Xubo Zhang Daohui pi Xiaonan Guo Faculty of Earth Resources China University of GeosciencesWuhan 430074 China State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan 430074China The Second Geological Survey of Henan Province Xuchang 461000China

The Yunkai Area is located at the southern South China Block and is part of the Qinzhou Bay-Hangzhou Bay Metallogenic Belt, which is a famous polymetallic mineralization belt. The Xinhua Pb–Zn–(Ag)deposit is located in the western part of Yunkai Area, with an abundance of Pubei batholiths. Zircon U–Pb geochronology of Pubei batholiths shows that crystallization age ranges from 251.9 ± 2.2 to 244.3 ± 1.8 Ma, thus belonging to Indosinian orogeny. Geochemistry and Sr isotopic compositions of the Pubei batholiths show that it is derived from the partial melting of large scale crustal melting during the stage of exhumation and uplifting of the lower-middle crust. In addition, strontium isotope of sphalerite from the Xinhua Pb–Zn–(Ag) deposit, has limited ranges in ^(87)Rb/^(86)Sr and ^(87)Sr/^(86)Sr, ranging from 0.4077 to 1.0449, and 0.718720 to 0.725245, respectively. The initial ^(87)Sr/^(86)Sr ratios of sphalerite ranges between 0.718720 and 0.725245, which is higher than that of upper continental crust and lower than that of the Pubei batholiths, illustrating the fluid might be derived from the mixing of Pubei pluton and upper continental crust.

关键词： Zircon U-Pb Strontium isotope XinhuaPb-Zn-(Ag) deposit Yunkai Area - South China

A 3D porous WP2 nanosheets@carbon cloth flexible electrode for efficient electrocatalytic hydrogen evolution

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 425-432页

作者： Mingyu pi Xiaodeng Wang Dingke Zhang Shuxia Wang Shijian Chen College of Physics Chongqing University Chongqing 401331 China College of Physics and Electronic Engineering Chongqing Normal University Chongqing 401331 China

Self-standing porous WP2 nanosheet arrays on carbon fiber cloth （WP2 NSs/CC） were synthesized and used as a 3D flexible hydrogen evolution electrode. Because of its 3D porous nanoarray structure, the WP2 NSs/CC exhibits a remarkable catalytic activity and a high stability. By using the experimental measurements and first-principle calculations, the underlying reasons for the excellent catalytic activity were further explored. Our work makes the present WPz NSs as a promising electrocatalyst for hydrogen evolution and provides a way to design and fabricate efficient hydrogen evolution electrodes through 3D porous nano-arrays architecture.

关键词： WP2 nanosheet arrays hydrogen evolution electrocatalyst flexible electrode

Synthesis and Crystal Structure of N,N′-4-aminomethyl-pyromellitic diimide

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Chinese Journal of Structural Chemistry 2005年第10期24卷 1176-1180页

作者： LU Xing-Qiang pi Xiang-Dong SU Cheng-Yong School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 China Chemtcal Envtronmental Protectton Monitoring Station of Hubei Wuhan 430060 China

The title compound N,N′-4-aminomethyl-pyromellitic diimide （4-pmpmd） crystallizes in monoclinic, space group P21/c with a = 4.785（1）, b = 6.200（1）, c = 29.907（2） A, β = 93.583（11）°, V= 885.5（2） A^3, Dc = 1.494 g/cm^3, Z= 2, C22H14N4O4, Mr = 398.37,/t（MoKα） = 0.106 mm^-1 and F（000） = 412, and its structure was refined to R = 0.0469 and wR = 0.1017 for 1194 observed reflections （F0 〉 4σ（F0））. The X-ray diffraction shows the existence of the staggered strong intermolecular C-H…O （DA） hydrogen bonds between adjacent molecules, the intermo- lecular C-H…π hydrogen bonds and the weak π…π stacking interactions, leading to the formation of multi-dimensional supramolecular network based on the Z-mode conformation of the title compound.

关键词： N,N′-4-aminomethyl-pyromellitic diimide intermolecular weak interactions,supramolecular network

骨髓间充质干细胞移植治疗大鼠心肌梗死:急性和慢性运动的影响

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中国组织工程研究 2025年第23期29卷 4868-4877页

作者：冯强皮亦华黄华生黄德伦张艳广西中医药大学体育部广西壮族自治区南宁市530021 广西中医药大学基础医学院生理教研室广西壮族自治区南宁市530021

背景:干细胞移植对治疗心肌梗死具有可观的治疗前景,但移植细胞向心脏归巢效率及在心脏内的滞留率和存活率较低限制了干细胞疗效。运动疗法是心肌梗死患者心脏康复的重要有机组成部分,然而运动在干细胞移植治疗心肌梗死中的作用尚未明... 详细信息

背景:干细胞移植对治疗心肌梗死具有可观的治疗前景,但移植细胞向心脏归巢效率及在心脏内的滞留率和存活率较低限制了干细胞疗效。运动疗法是心肌梗死患者心脏康复的重要有机组成部分,然而运动在干细胞移植治疗心肌梗死中的作用尚未明确。目的:探讨运动(包括急性和慢性运动)对骨髓间充质干细胞移植治疗大鼠心肌梗死的影响。方法:取80只雌性SD大鼠,采用随机数字表法分为假手术组、模型组、移植组或联合组,每组20只。模型组、移植组或联合组大鼠通过冠状动脉结扎术制作心肌梗死模型,造模24 h后,联合组进行8周有氧运动(慢性运动,30 min/d,每周运动5 d),于首次运动(急性运动)后5 min内,移植组和联合组尾静脉输注绿色荧光蛋白标记的SD大鼠骨髓间充质干细胞,首次运动后24 h取部分大鼠,检测大鼠心肌内移植的干细胞存活率、Y染色体性别决定区mRNA表达、归巢因子蛋白表达以及氧化应激和炎症反应参数;末次运动后72 h取剩余大鼠,检测心脏结构与功能、心肌组织学变化和Ki67^(+)细胞数量。结果与结论:(1)急性运动后:与假手术组比较,模型组心肌活性氧、丙二醛、肿瘤坏死因子α和白细胞介素1β水平升高(P <0.05),超氧化物歧化酶活性降低(P <0.05);与模型组比较,移植组和联合组活性氧、丙二醛水平及肿瘤坏死因子α和白细胞介素1β蛋白表达降低(P <0.05),超氧化物歧化酶活性及基质细胞衍生因子1α、CXC趋化因子受体4蛋白表达升高(P <0.05);与移植组比较,联合组活性氧、丙二醛水平及肿瘤坏死因子α和白细胞介素1β蛋白表达降低(P <0.05),干细胞存活率、Y染色体性别决定区mRNA表达、超氧化物歧化酶活性及基质细胞衍生因子1α和CXC趋化因子受体4蛋白表达升高(P <0.05)。(2)慢性运动后:与假手术组比较,模型组心肌细胞横截面积、胶原含量增加(P <0.05),左心室射血分数、左心室短轴缩短率下降(P <0.05);与模型组比较,移植组心肌细胞横截面积与胶原含量降低(P <0.05),Ki67+细胞升高(P <0.05);与移植组比较,联合组胶原含量降低(P <0.05),心肌细胞横截面积、左心室射血分数、左心室短轴缩短率、Ki67+细胞升高(P <0.05)。(3)急性运动通过促进干细胞归巢、改善心肌微环境提高外源性干细胞存活率,慢性运动可刺激干细胞移植后心肌细胞增殖、抑制心脏重塑并增强心功能,提示运动有助于优化大鼠心肌梗死后干细胞移植疗效。

关键词：急性运动慢性运动干细胞移植骨髓间充质干细胞心肌梗死归巢

Ring opening [3+2] cyclization of azaoxyallyl cations with benzo[d]-isoxazoles:Efficient access to 2-hydroxyaryl-oxazolines

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Chinese Chemical Letters 2020年第2期31卷 396-400页

作者： Yicheng He Chao pi Yangjie Wu Xiuling Cui Department of Chemistry Henan Key Laboratory of Chemical Biology and Organic ChemistryKey Laboratory of Applied Chemistry of Henan UniversitiesZhengzhou UniversityZhengzhou 450052China

A selective ring-opening [3+2] cyclization reaction of benzo[d]isoxazoles with 2-bromo-propanamides has been *** azaoxyallyl cation intermediates are employed as C^O 3-atom synthon to build oxa-heterocycles via the selectivity of suitable cyclization *** transformation provides rapid access to highly functionalized 2-hydroxyaryl-oxazolines under mild conditions and excellent regioselectivity.

关键词： Azaoxyallylic cations Ring-opening [3+2]Cycloaddition 2-Hydroxyaryl-oxazolines C^O 3-atom synthon

Morphologies and Superhydrophobicity of Hybrid Film Surfaces Based on Silica and Fluoropolymer

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Journal of Materials Science & Technology 2008年第5期24卷 693-699页

作者： Ailan QU Xiufang WEN pihui pi Jiang CHENG Zhuoru YANG School of-Chemical and Energy Engineering South China University of Technology Guangzhou 510640 China

Fluoropolymer and different kinds of silica particles were used for controlling surface chemistry and morphology, respectively. A superhydrophobic surface originated from strawberry-like or quincunx-shaped composite silica particles was obtained. The dual size particles are obtained by utilizing the graft of different modified silica particles with epoxy functional group and amine functional group, This makes the surface of film form a composite interface to have irregular binary structure which plays an essential role in trapping air between the substrate surface and the liquid droplets to be necessary for high contact angle and low contact angle hysteresis. The maximum contact angle for water on the hybrid film is about 174±2° and the contact angle hysteresis is less than 2°. The surface morphologies, roughness and the wettability on the surface of films containing different structural silica particles were compared. It was shown that the hierarchical irregularly structure with a low roughness factor and high air-trapped ratio is indispensable for superhydrophobic surface. Although this structural surfaces based on composite silica particles play a vital role in governing the surface wettability, it is necessary to combine with a low surface energy to make the surface superhydrophobic.

关键词： Superhydrophobicity Hierarchical irregularly structure Silica particles Fluoropolymer

A Fluorescent Supramolecular Crosslinked Polymer Gel Formed by Crown Ether Based Host-Guest Interactions and Aggregation Induced Emission

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Chinese Journal of Polymer Science 2015年第6期33卷 890-898页

作者： Xiao-fan Ji pi Wang Hu Wang 黄飞鹤 State Key Laboratory of Chemical Engineering Department of ChemistryZhejiang University

Based on the combination of B21C7/dialkylammonium salt host-guest interactions and tetraphenylethylene （TPE）-based aggregation-induced emission （AIE） effect, a fluorescent supramolecular crosslinked polymer gel was successfully prepared. Compared with the solution of TPE-containing small molecules, this gel exhibited remarkable fluorescence enhancement due to the AIE effect of TPE units. The ＂gelation induced fluorescence emission＂ phenomenon can be explained by the hindered intramolecular rotation of phenyl rings of TPE. Because of the reversibility and stimuli-responsiveness of the B21C7/dialkylammonium salt host-guest interactions, the transition between the fluorescent supramolecular crosslinked polymer gel and the disassembled sol with very weak fluorescence can be realized by adding pH and thermal stimuli. This novel material contributes to the development of supramolecular chemistry, polymer science and fluorescent materials and offers a new method to construct functional supramolecular materials.

关键词： Fluorescent polymer gel Aggregation-induced emission Host-guest interactions Responsiveness.

Pathway of the ozonation of 2,4,6-trichlorophenol in aqueous solution

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Frontiers of Environmental Science & Engineering 2007年第2期1卷 179-183页

作者： pi Yunzheng WANG Jianlong Laboratory of Environmental Technology Institute of Nuclear and New Energy TechnologyTsinghua UniversityBeijing 100084China

The reaction mechanism and pathway of the ozonation of 2,4,6-trichlorophenol(2,4,6-TCP)in aqueous solution were *** removal efficiency and the variation of H_(2)O_(2),Cl^(−),formic acid,and oxalic acid were studied during the semi-batch ozonation experiments(con-tinuous for ozone gas supply,fixed volume of water sample).The results showed that when there was no scavenger,the removal efficiency of 0.1 mmol/L 2,4,6-TCP could reach 99%within 6 min by adding 24 mg/L *** reaction of molecular ozone with 2,4,6-TCP resulted in the formation of *** maximal concentration of H_(2)O_(2) detected during the ozonation could reach 22.5%of the original concentration of 2,4,*** reaction of ozone with H_(2)O_(2) resulted in the generation of a lot of OH·***,2,4,6-TCP was degraded to formic acid and oxalic acid by ozone and OH·radicals *** the inhibition of OH·radicals,ozone molecule firstly degraded 2,4,6-TCP to form chlorinated quinone,which was subsequently oxidized to formic acid and oxalic *** reaction pathways of the degradation of 2,4,6-TCP by ozone and O_(3)/OH·were proposed in this study.

关键词： 2,4,6-trichlorophenol ozone hydrogen perox-ide hydroxyl radicals reaction pathway